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Carlos Ernesto Irarrazabal Muñoz

Full Professor

Universidad de Los Andes

Santiago, Chile

I am the Head of the Molecular and Integrative Physiology lab we studied Renal and Cardiovascular Physiology. Hypoxia Signaling pathways; Acute Kidney Injury; Renal Transplantation; Biomarkers, and fetal effect of uteroplacental restriction.

Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2000
Biouímica, UNIVERSIDAD DE CHILE. Chile, 1991
Bioquímico, UNIVERSIDAD DE CHILE. Chile, 1993

Profesor Ayudante Other

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

1994 - 2001
Profesor Auxiliar Full Time

Universidad de los Andes

Medicina

Santiago, Chile

2007 - 2011
Profesor Titular Full Time

Universidad de los Andes

Medicina

Santiago, Chile

2012 - At present

Fellow Researc Full Time

The National Institutes of Health

Bethesda, Estados Unidos

2002 - 2007
Ph.D. studient Full Time

Universidad de Chile

Santiago, Chile

1996 - 2001
Head of the Molecular and Integrative Physiology Lab Full Time

Universidad de los Andes

Santiago, Chile

2010 - At present
Scientific Director Full Time

Kinostics SpA

Santiago, Chile

2012 - 2016

2019. Post-Doctoral position. “Role of extracellular nanovesicles in the cardiac ischemis” Dr. Luis Osorio
2019. Post-Doctoral position. “Role of nanovesicles extracellulars in Cerebral infarcts” Dr. Guillermo Villamizar.
2016-2018. Post-Doctoral position. “Extracellular nanovesicles in plasma are involved in ischemic response” Dr. Daniel Hevia.
2017-2018. Post-Doctoral position. “NFAT5-target gene activated by hypoxia” Dr. Rodrigo Fuentealba.
2017-2019. Magister Thesis. Universidad de Concepción. “El estrés oxidativo y la iNOS promueven una disminución de elementos asociados a cardioprotección en el corazón fetal durante el retardo de crecimiento intrauterino (RCIU)”. Lissette Puentes.
2017. Undergraduate Thesis. “NFAT 5, a través de BCl–2, Juega un Papel Protector durante la Hipoxia”. Alexander Eggers
2017. Undergraduate Thesis. “NFAT5 prevented apoptosis durante la Hipoxia”. Ma del Pilar Espinosa.
2016-2017. Post-Doctoral position. “Effect of Intrauterine Growth Restriction in fetal Cardiovascular and Renal system” Dr. Cristobal Alvarado.
2015-2016 Undergraduate Thesis, Faculty of Sciences, P. Universidad Católica. “Efecto del óxido nítrico (NO) producido por iNOS en la regulación de NFAT5 en condiciones de hipoxia e hipoxia/reoxigenación en cultivo celular”. Yair Serman.
2014. Undergraduate Thesis, Universidad Andres Bello, "Evaluación de la respuesta celular al daño inducido por hipoxia" Carla Droguett
2014. Internship in Doctoral Program, Facultad de Medicina at Universidad de los Andes. "Association of NFAT5 and S100A/B in an animal model of stroke". Diego Gaete.
2013 Biochemistry Thesis, Faculty of Sciences, Pontificia Universidad Católica de Valparaíso. “Effect of Intrauterine Growth Restriction in gene expression of proteins related to nitric oxide in fetal kidney”. Jorge Cifuentes.
2013. Biochemistry Thesis, Faculty of Sciences, Pontificia Universidad Católica de Valparaíso. "Role of Oxidative stress on NFAT5 activation durong hypoxia and reoxygenation" Nicolás Muñoz.
2012. Biochemistry Thesis, Faculty of Sciences, Pontificia Universidad Católica de Valparaíso. "Role of NFAT5 in cellular response during hypoxia and reoxygenation" Albano Caceres Verschae.
2011. Biochemistry Thesis, Faculty of Sciences, Pontificia Universidad Católica de Valparaíso. "Relationchip between hif-1 alfa and TonEBP in response to hypoxia and hypertonicity. " Daniela Santapau Vignolo.

Scientific Research in Coronary Disease Award

Fundación Araucaria

Chile, 2016

Best Scientific Research in Coronary Disease Award in LIII Cardiology and Cardiovascular Surgery Congress
Fogarty

NATIONAL INSTITUTES OF HEALTH (NIH)

Estados Unidos, 2002

Global Health Program for Fellows and Scholars


Urinary Extracellular Vesicles as a Source of NGAL for Diabetic Kidney Disease Evaluation in Children and Adolescents With Type 1 Diabetes Mellitus Ugarte, Francisca; Santapau, Daniela; Gallardo, Victoria; Garfias, Carolina; Yismeyian, Anahí; Villanueva, Soledad; Sepúlveda, Carolina; Rocco, Jocelyn; Pastene, Maria; Urquidi, Cynthia; Cavada, Gabriel; San Martin, Pamela; Cano, Francisco; Irarrázabal, Carlos Article ISI FRONTIERS IN ENDOCRINOLOGY (2022)
Aminoguanidine Prevents the Oxidative Stress, Inhibiting Elements of Inflammation, EndotheliaActivation, Mesenchymal Markers, and Confers a Renoprotective Effect in Renal Ischemia and Reperfusion Injury Pastenes, C; Lozano, M.; Rocco, J; Carrion, F; Alvarado, C; Liberona, J; Michea, L.; Irarrazabal, CE Article Antioxidants (2076-3921) (2021)
Glutathione S-transferase and Clusterin, new players in the Ischemic preconditioning renal protection in a murine model of ischemia and reperfusion Pasten, C; Herrera-Luna, Y; Lozano, M; Rocco, J; Alvarado, C; Liberona, J; Michea, L; Irarrazabal, CE Article CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2021)
Emerging new role of NFAT5 in inducible nitric oxide synthase in response to hypoxia in mouse embryonic fibroblast cells Serman, Yair; Fuentealba, Rodrigo A.; Pasten, Consuelo; Rocco, Jocelyn; Ko, Ben C. B.; Carrión, Flavio; Irarrázabal, Carlos E. Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2019)
Extracellular vesicles from osteosarcoma cell lines contain miRNAs associated with cell adhesion and apoptosis Jerez, Sofía; Araya, Héctor; Hevia, Daniel; Irarrázaval, Carlos E.; Thaler, Roman; van Wijnen, Andre J.; Galindo, Mario Article ISI SCOPUS GENE (2019)
L-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice Pasten C.; Alvarado C.; Rocco J.; Contreras L.; Aracena P.; Liberona, J; Suazo C.; Michea L.; IrarrÃ¡zabal C.E. Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2019)
En el Infarto agudo al miocardio los niveles plasmáticos de microvesículas extracelulares se elevan más precozmente que el aumento de la Troponina-I Daniel Hevia, Jorge Cifuentes, Olga Alvarado, Pamela San Martín, Pía Venegas, Michel Coron, Ignacio Cabrera, Sofía López , Karin Oyarce, Francisca Rojas, Ximena Sazo, Martina Vallejos, Tania Weil, Ricardo Larrea, Carlos E. Irarrázabal Article Revista chilena de cardiología (2017)
Oxidative damage and nitric oxide synthase induction by surgical uteroplacental circulation restriction in the rabbit fetal heart Figueroa, Horacio; Alvarado, Cristobal; Cifuentes, Jorge; Lozano, Mauricio; Rocco, Jocelyn; Cabezas, Claudia; Illanes, Sebastián E.; Eixarch, Elisenda; Hernández-Andrade, Edgar; Gratacós, Eduard; Irarrazabal, Carlos E. Article ISI SCOPUS PRENATAL DIAGNOSIS (2017)
Impaired phosphorylation of JAK2-STAT5b signaling in fibroblasts from uremic children Ugarte, F.; Irarrázabal C.; Oh, J; Dettmar A.; Ceballos M.L.; Rojo A.; Ibacache M.J.; Suazo, C; Lozano, M.; Delgado, I; Cavada, G; Azocar, M; Delucchi, A; Cano, F Article ISI SCOPUS PEDIATRIC NEPHROLOGY (2016)
Nitric oxide synthase and changes in oxidative stress levels in embryonic kidney observed in a rabbit model of intrauterine growth restriction Figueroa H, Cifuentes J, Lozano M, Alvarado C, Cabezas C, Eixarch E, Fernández E, Contreras L, Illanes SE, Hernández-Andrade E, Gratacós E, Irarrazabal CE. Article ISI SCOPUS PRENATAL DIAGNOSIS (2016)
Overexpression of Glutamate Decarboxylase in Mesenchymal Stem Cells Enhances Their Immunosuppressive Properties and Increases GABA and Nitric Oxide Levels Urrutia, Mariana; Fernández, Sebastián; González, Marisol; Vilches, Rodrigo; Rojas, Pablo; Vásquez, Manuel; Kurte, Mónica; Vega-Letter, Ana María; Carrión, Flavio; Figueroa, Fernando; Rojas, Patricio; Irarrázabal, Carlos; Fuentealba, Rodrigo A.; Zhao, Feng Article ISI SCOPUS PLOS ONE (2016)
Toll-like receptor 3 pre-conditioning increases the therapeutic efficacy of umbilical cord mesenchymal stromal cells in a dextran sulfate sodium-induced colitis model Fuenzalida, P.; Kurte, M; Fernández-O'ryan C.; Ibáñez C; Gauthier-Abeliuk M.; Vega-Letter, A. M.; Gonzalez P.; Irarrázabal C.; Quezada, N; Figueroa F.; Carrion, F Article ISI SCOPUS CYTOTHERAPY (2016)
Incidence and consequences of acute kidney injury among patients admitted to critical care units Boltansky A, Bassa C, Melani S, Sepúlveda A, Maldonado I, Postigo J, Sotta E, Vidueira P, Cavagnaro C, Cavada G, Benavente C, Villamizar G, Vukusich A, Irarrázabal CE. Article REVISTA MEDICA DE CHILE (2015)
Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cells Induces a Switch from Classical to Atypical Symptoms in Experimental Autoimmune Encephalomyelitis Kurte, M; Bravo-Alegria, J; Torres A.; Carrasco, V; Ibáñez C; Vega-Letter, AM; Fernandez-O'Ryan, C; Irarrazabal, CE; Figueroa, FE; Fuentealba, RA; Riedel C.; Carrion, F Article ISI SCOPUS Stem Cells International (2015)
NFAT5 Is Up-Regulated by Hypoxia: Possible Implications in Preeclampsia and Intrauterine Growth Restriction Dobierzewska, A; Palominos, M; Irarrazabal, CE; Sánchez, M; Lozano, M.; Perez-Sepulveda, A; Monteiro, LJ; Burmeister, Y; Figueroa-Diesel, H; Rice, GE; Illanes, SE Article ISI SCOPUS Biology of Reproduction (2015)
Placental Aromatase Is Deficient in Placental Ischemia and Preeclampsia Perez-Sepulveda, A; Monteiro, LJ; Dobierzewska, A; Espana-Perrot, PP; Venegas-Araneda, P; Guzman-Rojas, AM; Gonzalez Mi; Palominos-Rivera, M; Irarrazabal, CE; Figueroa-Diesel, H; Varas-Godoy, M; Illanes, SE Article ISI SCOPUS PLOS ONE (2015)
Spironolactone inhibits the activity of the Na+/H+ exchanger in the aorta of mineralocorticoid-induced hypertensive rats Carreño JE; Verdugo, FJ; Contreras, F; Montellano, FA; Veloso S.; Schalper, KA; Sandoval M.; Villanueva, S.; Marusic, E; Irarrazabal, CE Article ISI SCOPUS JRAAS - Journal of the Renin-Angiotensin-Aldosterone System (2015)
Basic fibroblast growth factor reduces functional and structural damage in chronic kidney disease Villanueva, S.; Contreras, F; Tapia, A; Carreno, J.E.; Vergara C.; Ewertz, E; Cespedes, C; Irarrázabal C.; Sandoval M.; Velarde, V; Vio C.P. Article ISI AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2014)
Longitudinal FGF23 and Klotho axis characterization in children treated with chronic peritoneal dialysis Cano F.J.; Freundlich M.; Ceballos M.L.; Rojo A.P.; Azocar M.A.; Delgado I.O.; Ibacache M.J.; Delucchi M.A.; Lillo A.M.; Irarrázabal C.E.; Ugarte M.F. Article SCOPUS Clinical Kidney Journal (2014)
Human mesenchymal stem cells derived from adipose tissue reduce functional and tissue damage in a rat model of chronic renal failure Villanueva, S.; Carreño JE; Salazar, L; Vergara C.; Strodthoff R; Fajre F; Cespedes, C; Sáez PJ; Irarrázabal C.; Bartolucci J.; Figueroa F.; Vio, CP Article ISI SCOPUS Clinical Science (2013)
The mini-PET in pediatric peritoneal dialysis: A useful tool to predict volume overload? Cano, F; Rojo A.; Azocar, M; Ibacache, MJ; Delucchi, A; Ugarte, F.; Irarrázabal C.; Delgado, I Article ISI SCOPUS Pediatric Nephrology (2013)
Urinary Exosomes as a Source of Kidney Dysfunction Biomarker in Renal Transplantation Álvarez, S.; Suazo, C; Boltansky, A; Ursu, M; Carvajal, D; Innocenti, G; Vukusich A.; Hurtado, M.; Villanueva, S.; Carreño JE; Rogelio, A; Irarrazabal, CE Article ISI SCOPUS Transplantation Proceedings (2013)
Cyclooxygenase-2 and hypoxia-regulated proteins are modulated by basic fibroblast growth factor in acute renal failure Villanueva, S.; Escobar P.; Jacubovsky I.; Irarrázabal C.; Carreno, J.E.; Erpel J.M.; Cespedes, C; González A.A.; Vio C.P.; Velarde, V Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2012)
IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction Avalos A.M.; Apablaza F.A.; Quiroz M.; Toledo, V.; Pena J.P.; Michea, L.; Irarrázabal C.E.; Carrion F.A.; Figueroa F.E. Article ISI SCIELO SCOPUS Biological Research (2012)
Intrauterine growth restriction modifies the normal gene expression in kidney from rabbit fetuses Figueroa H; Lozano M; Suazo C\|; Eixarc E; Illanes SE; Carreño JE; Villanueva S; Hernández-Andrade E; Gratacós E; Irarrazabal CE Article Early Human Development (2012)
Intrauterine growth restriction modifies the normal gene expression in kidney from rabbit fetuses Figueroa H.; Lozano, M.; Suazo, C; Eixarch, E; Illanes, SE; Carreño JE; Villanueva, S.; Hernandez-Andrade, E; Gratacos, E.; Irarrazabal, CE Article ISI SCOPUS Early Human Development (2012)
NFAT5 Is Activated by Hypoxia: Role in Ischemia and Reperfusion in the Rat Kidney Villanueva, S.; Suazo, C; Santapau, D; Pérez F.; Quiroz M.; Carreno, J.E.; Illanes, S; Lavandero S.; Michea, L.; Irarrázabal C.E. Article ISI SCOPUS PLOS ONE (2012)
Mesenchymal stem cell injection ameliorates chronic renal failure in a rat model Villanueva, S.; Ewertz, E; Carrion, F; Tapia, A; Vergara C.; Cespedes, C; Sáez PJ; Luz, P; Irarrázabal C.; Carreño JE; Figueroa F.; Vio, CP Article ISI SCOPUS Clinical Science (2011)
Phospholipase C-gamma 1 is involved in signaling the activation by high NaCl of the osmoprotective transcription factor TonEBP/OREBP Irarrazabal, CE; Gallazzini, M; Schnetz, MP; Kunin, M; Simons, BL; Williams, CK; Burg, MB; Ferraris, JD Article ISI SCOPUS Proceedings of the National Academy of Sciences of the United States of America (2010)
Association Between p53 codon 72 Genetic Polymorphism and Tobacco Use and Lung Cancer Risk Caceres, DD; Quinones, LA; Schroeder, JC; Gil, LD; Irarrazabal, CE Article ISI SCOPUS LUNG (2009)
Joint effect among p53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate cancer risk: an exploratory genotype-environment interaction study Quinones, LA; Irarrazabal, CE; Rojas, CR; Orellana, CE; Acevedo, C; Huidobro C.; Varela, NE; Caceres, DD Article ISI SCOPUS ASIAN JOURNAL OF ANDROLOGY (2006)
Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation Irarrazabal, C. E.; Burg, M. B.; Ward, S. G.; Ferraris, J. D. Article PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Ataxia telangiectasia-mutated, a DNA damage-inducible kinase, contributes to high NaCl-induced nuclear localization of transcription factor TonEBP/OREBP Zhang, Zheng; Ferraris, Joan D.; Irarrazabal, Carlos E.; Dmitrieva, Natalia I.; Park, Jong-Hwan; Burg, Maurice B. Article American Journal of Physiology-Renal Physiology (2005)
ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP Irarrazabal, C. E.; Liu, J. C.; Burg, M. B.; Ferraris, J. D. Article PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Chilean pilot study on the risk of lung cancer associated with codon 72 polymorphism in the gene of protein p53 Irarrazabal, CE; Rojas C.; Aracena, R; Márquez C.; Gil L. Article ISI TOXICOLOGY LETTERS (2003)


NFAT5 as a Novel Biomarker of Hypoxia: Role in Preeclampsia and Intra-Uterine Growth Restriction (IUGR) Palominos, M; Dobierzewska, A; Irarrazabal, CE; Sánchez, M; Burmeister, Y; Figueroa H.; Illanes, S Abstract ISI REPRODUCTIVE SCIENCES (2014)
FGF23 Is Modulated By Calcium In Children Under Chronic Peritoneal Dialysis. Cano, FJ; Azocar, MA; Ceballos, ML; Rojo, AM; Ibacache, MJ; Salgado I.; Delucchi MA; Delgado, IO; Irarrázabal C.; Ugarte, F. Abstract ISI PEDIATRIC NEPHROLOGY (2013)
Impaired growth hormone singnaling pathway in fibroblasts of children with chronic renal failure peritoneal dialysis treatment. Preliminary data Cano, FJ; Azocar, MA; Ceballos, ML; Irarrázabal C.; Suazo, C; Ugarte, F. Abstract ISI PEDIATRIC NEPHROLOGY (2013)


Method for monitoring, diagnosis and/or prognosis of hypoxia related disorders using NFAT5 UNIVERSIDAD DE LOS ANDES; Irarrazabal, Carlos E. Patent (2012)


Desarrollo de un Test de Diagnóstico temprano de Isquemia Cardíaca Silente (ICS), no invasivo y de bajo costo, basado en la detección de Hipoxia tisular CORFO (14IDL2-30168) Proyecto 2015-2016 Director(a)
THE PROTECTIVE ROLE OF NUCLEAR FACTOR OF ACTIVATED T-CELLS 5 (NFAT5) DURING RENAL ISCHEMIA/REPERFUSION IS DEPENDENT OF INDUCIBLE NITRIC OXIDE SYNTHASE (INOS)=> PARTICIPATION OF AQP-1 FONDECYT (1151157) Proyecto 2015-2018 Inv. Responsable
DESARROLLO DE UN PROTOTIPO DE KIT DE DIAGNÓSTICO EN ORINA PARA LA DETECCIÓN TEMPRANA DE INJURIA RENAL AGUDA (IRA) EN PACIENTES DE RIESGO CORFO (13ETN-18917) Proyecto 2013-2014 Director(a)
International SAE Consortium LTD. International Drug Induced Renal Injury Consortium (DIRECT) “Network” Consortium Private non-profit consortium (1997/1) Proyecto 2013-2014 Coinvestigador(a)
Toll-like Receptor Mediates the Immunosuppressive to Proinflammatory Switch in Mesenchymal Stem Cells=> In vitro and in vivo Evaluation in Autoimmune Models of Multiple Sclerosis and Rheumatoid Arthritis. FONDECYT (1130444) Proyecto 2013-2015 Coinvestigador(a)
Estudio de Biomarcadores de daño renal en niños con Diabetes Mellitus tipo 1 Fondo de Ayuda a la Investigación. Universidad de Los Andes Proyecto 2012-2014 Coinvestigador(a)
Intrauterine growth restriction induces changes in the embryonic kidney gene expression FONDECYT (1110869) Proyecto 2011-2013 Coinvestigador(a)
El Retardo del Crecimiento Intrauterino (RCIU) experimental produce la activación de genes asociados con estrés. Fondo de Ayuda a la Investigación. Universidad de Los Andes Proyecto 2010-2011 Coinvestigador(a)
Polimorfismos genéticos asociados a la susceptibilidad del cáncer colorrectal esporádico y su relación genotipo-fenotipo Fondo de Ayuda a la Investigación. Universidad de Los Andes Proyecto 2010-2012 Coinvestigador(a)
The transcrition factor Tonicity Enhancer Binding Protein (TonEBP) has a protective role in renal ischemia-reperfusion. FONDECYT (1100885) Proyecto 2010-2012 Inv. Principal
DETERMINACION DE MUTACIONES EN ONCOGENES RELACIONADOS CON CANCER PULMONAR FONDECYT (2990019) Proyecto 1999-2002 Inv. Responsable


Biosafety information management systems. A comparative analysis of the regulatory systems in Canada, Argentina, and Chile Flint, Jason; Gil, Lionel; Verastegui, Javier; Irarrazabal Carlos; Dellacha, Juan Review SCIELO ELECTRONIC JOURNAL OF BIOTECHNOLOGY (2000)

Carlos Irarrazabal

Full Professor

Fisiología

Universidad de Los Andes

Santiago, Chile

Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Mauricio Lozano

Asistente de Investigación

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

Fernando Figueroa

Director

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago de Chile, Chile

Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Flavio Carrion

Director Departamento de Investigación, Postgrado y Educación Continua

Facultad de Ciencias de la Salud

Universidad del Alba

Santiago, Chile

Carlos Cespedes

Tecnologo Medico

Fisiologia

P. Universidad Católica de Chile

Santiago, Chile

Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

Jorge Cifuentes

Investigador

Universidad de Los Andes

Santiago, Chile

Mónica Kurte

Investigador

Laboratorio de Inmunologìa

Universidad de los Andes

Santiago, Chile

Cristobal Alvarado

Jefe Unidad de Apoyo a la Investigación Biomédica.

Hospital Las Higueras de Talcahuano

Talcahuano, Chile

Lara Jorge

Profesora Asistente

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

HORACIO FIGUEROA

UNIVERSIDAD DE LOS ANDES

SANTIAGO, Chile

Rodrigo Fuentealba

Postdoctoral Research Associate

Departamento de Inmunología Clínica y Reumatología / Facultad de Medicina

Pontificia Universidad Católica

Santiago, Chile

Orozimba Delgado

Profesor Asociado

Facultad de Medicina Clinica Alemana Universidad del Desarrollo

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

Luis Quinones

PROFESOR TITULAR

ONCOLOGIA BASICO-CLINICA

UNIVERSIDAD DE CHILE

Santiago, Chile

Mauricio Sandoval

Lab Manager

Facultad de Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

DANTE CACERES

Académico

Programa de Salud Ambiental

ESCUELA DE SALUD PUBLICA, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

José Erpel

SUBDIRECTOR DE ESCUELA

SALUD

DUOC UC

SANTIAGO, Chile

Alexis Gonzalez

Adjunct Professor

Instituto de Química

Pontificia Universidad Católica de Valparaiso

Valparaíso, Chile

Gabriel Cavada

Académico, Jefe de Programa

Instituto de Salud Poblacional

Universidad de Chile

Santiago, Chile

Patricia Fuenzalida

Lab Manager

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

Lorena Salazar

Academico

Instituto Cs Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

Ioram Jacubovsky

Médico Cirujano

Servicio de Cirugía

Hospital Dr. Sótero Del Río

Santiago, Chile

Pia Venegas

Asesora Técnica

Dirección de salud

Desafío Levantemos Chile

Santiago, Chile

Nelson Varela

Académico

Oncología Básico-Clínico

UNIVERSIDAD DE CHILE

Santiago, Chile

MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Lorena Salazar

Profesora Asistente

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Lampa, Chile

Andrés Boltansky

CLINICA DÁVILA

Santiago, Chile

Antonio Vukusich

Decano Facultad de Medicina

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Fernando Verdugo

Cardiologo

Cardiologia

Hospital del Salvador

Santiago, Chile

Hector Araya

Ana Maria Vega

Investigador postdoctoral

Ingenieria Bioquimica

Potificia Universidad Catolica de Valpraiso

Valparaiso, Chile

Carlos Ernesto Irarrazabal Muñoz

Líneas de Investigación

Educación

Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2000

Biouímica, UNIVERSIDAD DE CHILE. Chile, 1991

Bioquímico, UNIVERSIDAD DE CHILE. Chile, 1993

Experiencia Académica

Profesor Ayudante Other

Profesor Auxiliar Full Time

Profesor Titular Full Time

Experiencia Profesional

Fellow Researc Full Time

Ph.D. studient Full Time

Head of the Molecular and Integrative Physiology Lab Full Time

Scientific Director Full Time

Formación de Capital Humano

Premios y Distinciones

Scientific Research in Coronary Disease Award

Fogarty

Article (35)

Abstract (3)

Patent (1)

Proyecto (11)

Desarrollo de un Test de Diagnóstico temprano de Isquemia Cardíaca Silente (ICS), no invasivo y de bajo costo, basado en la detección de Hipoxia tisular

THE PROTECTIVE ROLE OF NUCLEAR FACTOR OF ACTIVATED T-CELLS 5 (NFAT5) DURING RENAL ISCHEMIA/REPERFUSION IS DEPENDENT OF INDUCIBLE NITRIC OXIDE SYNTHASE (INOS)=> PARTICIPATION OF AQP-1

DESARROLLO DE UN PROTOTIPO DE KIT DE DIAGNÓSTICO EN ORINA PARA LA DETECCIÓN TEMPRANA DE INJURIA RENAL AGUDA (IRA) EN PACIENTES DE RIESGO

International SAE Consortium LTD. International Drug Induced Renal Injury Consortium (DIRECT) “Network” Consortium

Toll-like Receptor Mediates the Immunosuppressive to Proinflammatory Switch in Mesenchymal Stem Cells=> In vitro and in vivo Evaluation in Autoimmune Models of Multiple Sclerosis and Rheumatoid Arthritis.

Estudio de Biomarcadores de daño renal en niños con Diabetes Mellitus tipo 1

Intrauterine growth restriction induces changes in the embryonic kidney gene expression

El Retardo del Crecimiento Intrauterino (RCIU) experimental produce la activación de genes asociados con estrés.

Polimorfismos genéticos asociados a la susceptibilidad del cáncer colorrectal esporádico y su relación genotipo-fenotipo

The transcrition factor Tonicity Enhancer Binding Protein (TonEBP) has a protective role in renal ischemia-reperfusion.

DETERMINACION DE MUTACIONES EN ONCOGENES RELACIONADOS CON CANCER PULMONAR

Review (1)