PDI - Resultado de Búsqueda

Patricia Alejandra Luz Crawford

Profesor asistente

Universidad de los Andes

Santiago , Chile

Celulas Madre Mesenquimales ; Inmunologia y tratamiento enfermedades autoinmunes; Reprogramacion metabolica ; small extracellular vesicles, microRNA

Licenciatura en Ciencias c/m en Biotecnología, UNIVERSIDAD DE CHILE. Chile, 2005
Ingeniero en Biotecnología Molecular, UNIVERSIDAD DE CHILE. Chile, 2007
Biotecnologia, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 2012

Postdoctoral research Part Time

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

2013 - 2016
Profesor Asistente Full Time

Universidad de los Andes

Facultad de Medicina

Santiago, Chile

2016 - At present

Ayudantía quimica orgánica y bioquimica

Universidad del Desarrollo

Chile

2005 - 2006
Tesista

Universidad del Desarrollo

Chile

2004 - 2006
Tesista Doctorado

Universidad de los Andes

Chile

2008 - 2011
Pasantia doctoral

Unité Inserm 844

Francia

2011 - 2012
Investigador

Cell for Cell

Chile

2012 - 2013
Unidad de investigación

Universidad Santiago de Chile

Chile

2007 - 2008
Organización y coordinación curso precongreso de Células Madre: Usos y Aplicaciones

Universidad de los Andes

Chile

2009 - 2009
Ayudante en la elaboración proyectos Innova Corfo

INNPULSO

Chile

2007 - 2007
Postdoctoral research

Unité INSERM 1183

Francia

2013 - 2016
profesor asistente Full Time

Universidad de los andes

Santiago, Chile

2016 - At present
Profesor asistente Full Time

Universidad de los Andes

Santiago, Chile

2016 - At present

Dirección y Codirección tesis Post-grado:
Dirección de Tesis de Doctorado de Rafael Contreras: Fecha titulación 06 Noviembre 2019. Universidad de los Andes, Santiago, Chile
Dirección de Tesis de Doctorado de Noymar Luque: Año Ingreso 2017-Examen calificación 19 abril 2019. Año estipulado Término 2021. Universidad de los Andes, Santiago, Chile
CO-Dirección de Tesis de Doctorado Masyelly Rojas: Año Ingreso 2018-Fecha examen calificación Abril 2020. Año estipulado Término 2022. Universidad de los Andes, Santiago, Chile.
Dirección Tesis Especialidad en Periodontología Maria Paz Vega. Fecha titulación: 1 Agosto 2018. Universidad de los Andes
Dirección de tesis de Pregrado:
-Tesis para optar al titulo profesional de Ingeniería en Biotecnología molecular. Alumna: Luna Martinez: Fecha Titulación 31 enero 2019. Universidad de Chile, Santiago, Chile
-Tesis para optar al titulo profesional de Ingeniería en Biotecnología molecular. Alumna: Carolina Pradenas: En proceso. Universidad de Chile, Santiago, Chile
-Tesis para optar al titulo profesional de Ingeniería en Biotecnología molecular. Alumna: Cynthia García: En proceso. Universidad Mayor, Santiago, Chile
-Tesis para optar al titulo profesional de Ingeniería en Biotecnología molecular. Alumna: Maria Jesus Araya: En proceso. Universidad de Chile, Santiago, Chile


MANF Produced by MRL Mouse-Derived Mesenchymal Stem Cells Is Pro-regenerative and Protects From Osteoarthritis Tejedor, Gautier; Luz-Crawford, Patricia; Barthelaix, Audrey; Toupet, Karine; Roudieres, Sebastien; Autelitano, Francois; Jorgensen, Christian; Djouad, Farida Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
The ATP synthase inhibition induces an AMPK-dependent glycolytic switch of mesenchymal stem cells that enhances their immunotherapeutic potential Contreras-Lopez, Rafael; Elizondo-Vega, Roberto; Luque-Campos, Noymar; Torres, Maria Jose; Pradenas, Carolina; Tejedor, Gautier; Jose Paredes-Martinez, Maria; Maria Vega-Letter, Ana; Campos-Mora, Mauricio; Rigual-Gonzalez, Yandi; Oyarce, Karina; Salgado, Magdiel; Jorgensen, Christian; Khoury, Maroun; de los Angeles Garcia-Robles, Maria; Altamirano, Claudia; Djouad, Farida; Luz-Crawford, Patricia Article ISI THERANOSTICS (2021)
The Impact of Estrogen and Estrogen-Like Molecules in Neurogenesis and Neurodegeneration: Beneficial or Harmful? Bustamante-Barrientos, Felipe A.; Mendez-Ruette, Maxs; Ortloff, Alexander; Luz-Crawford, Patricia; Rivera, Francisco J.; Figueroa, Carlos D.; Molina, Luis; Batiz, Luis Federico Article ISI FRONTIERS IN CELLULAR NEUROSCIENCE (2021)
HIF1α‐dependent metabolic reprogramming governs mesenchymal stem/stromal cell immunoregulatory functions Contreras-Lopez, Rafael; Elizondo-Vega, Roberto; Paredes, María Jose; Luque-Campos, Noymar; Torres, Maria Jose; Tejedor, Gautier; Vega-Letter, Ana María; Aliosha I. Figueroa-Valdés; Pradenas, Carolina; Oyarce, Karina; Jorgensen, Christian; Khoury, Maroun; Garcia Robles, Maria de los Angeles; Altamirano, Claudia; Djouad, Farida; Luz-Crawford, Patricia Article WOS core collection ISI FASEB JOURNAL (2020)
Inhibition of Hypothalamic MCT4 and MCT1-MCT4 Expressions Affects Food Intake and Alters Orexigenic and Anorexigenic Neuropeptide Expressions Elizondo-Vega, Roberto; Oyarce, Karina; SALGADO, MAGDIEL; Barahona, Maria Jose; Recabal, Antonia; Ordenes, Patricio; Lopez, Sergio; Pincheira, Roxana;; Luz-Crawford, Patricia; Garcia-Robles, Maria Angeles Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2020)
Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response Court, Angela; Le-Gatt, Alice; Luz-Crawford, Patricia; Parra, Eliseo; Aliaga-Tobar, Victor; Batiz, Luis Federico; Contreras, Rafael A.; Ortuzar, Maria Ignacia; Kurte, Monica; Elizondo-Vega, Roberto; Maracaja-Coutinho, Vinícius; Pino-Lagos, Karina; Figueroa, Fernando E; Khoury, M Article WOS core collection ISI *Co-first author AC, ALG and PLC EMBO REPORTS (2020)
PPARbeta/delta-dependent MSC metabolism determines their immunoregulatory properties Contreras-Lopez RA; Elizondo-Vega, R.; Torres, MJ; Vega-Letter, AM; Luque-Campos, N.; Paredes-Martinez, MJ; Pradenas, C.; Tejedor, G.; Oyarce, K.; Salgado, M.; Jorgensen, C.; Khoury, M; Kronke, G.; GARCIA-ROBLES, MA; Altamirano, C.; Luz-Crawford P; Djouad F Article WOS core collection ISI SCIENTIFIC REPORTS (2020)
Pro-resolving mediator protectin D1 promotes epimorphic regeneration by controlling immune cell function in vertebrates Nguyen-Chi, Mai; Luz-Crawford, Patricia; Balas, Laurence; Sipka, Tamara; Contreras-Lopez, Rafael; Barthelaix, Audrey; Lutfalla, Georges; Durand, Thierry; Jorgensen, Christian; Djouad, Farida Article ISI BRITISH JOURNAL OF PHARMACOLOGY (2020)
Single cell migration profiling on a microenvironmentally tunable hydrogel microstructure device that enables stem cell potency evaluation Ros E.; Encina M.; GonzÃ¡lez F.; Contreras R.; Luz-Crawford P.; Khoury M.; Acevedo J.P. Article ISI SCOPUS LAB ON A CHIP (2020)
Time-dependent LPS exposure commands MSC immunoplasticity through TLR4 activation leading to opposite therapeutic outcome in EAE Kurte, Monica; Vega-Letter, Ana Maria; Luz-Crawford, Patricia; Djouad, Farida; Noel, Daniele; Khoury, Maroun; Carrion, Flavio Article ISI STEM CELL RESEARCH & THERAPY (2020)
Whole embryo culture, transcriptomics and RNA interference identify TBX1 and FGF11 as novel regulators of limb development in the mouse Tejedor G.; Laplace-BuilhÃ© B.; Luz-Crawford P.; Assou S.; Barthelaix A.; Mathieu M.; Kissa K.; Jorgensen C.; Collignon J.; Chuchana P.; Djouad F. Article SCOPUS SCIENTIFIC REPORTS (2020)
Mesenchymal stem cell repression of Th17 cells is triggered by mitochondrial transfer Luz-Crawford P.; Hernandez J.; Djouad F.; Luque-Campos N.; Caicedo A.; CarrÃ¨re-Kremer S.; Brondello J.-M.; Vignais M.-L.; PÃ¨ne J.; Jorgensen C. Article ISI SCOPUS STEM CELL RESEARCH & THERAPY (2019)
Mesenchymal Stem Cells Improve Rheumatoid Arthritis Progression by Controlling Memory T Cell Response Luque-Campos, Noymar; Contreras-Lopez, Rafael A.; Jose Paredes-Martinez, Maria; Jose Torres, Maria; Bahraoui, Sarah; Wei, Mingxing; Espinoza, Francisco; Djouad, Farida; Javier Elizondo-Vega, Roberto; Luz-Crawford, Patricia Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2019)
Gilz-Activin A as a Novel Signaling Axis Orchestrating Mesenchymal Stem Cell and Th17 Cell Interplay Luz-Crawford, Patricia; Espinosa-Carrasco, Gabriel; Ipseiz, Natacha; Contreras, Rafael; Tejedor, Gautier; Medina, Daniel A.; Vega-Letter, Ana-Maria; Ngo, Devi; Morand, Eric F.; Pène, Jérôme; Hernandez, Javier; Jorgensen, Christian; Djouad, Farida Article ISI SCOPUS THERANOSTICS (2018)
IL17/IL17RA as a Novel Signaling Axis Driving Mesenchymal Stem Cell Therapeutic Function in Experimental Autoimmune Encephalomyelitis Kurte Monica, Luz-Crawford Patricia; Vega-Letter Ana María, Contreras Rafael A; Tejedor Gautier, Elizondo-Vega Roberto; Martinez-Viola Luna=> Fernández-O’Ryan Catalina, Figueroa Fernando E; Jorgensen Christian, Djouad Farida and Carrión Flavio Article FRONTIERS IN IMMUNOLOGY (2018)
Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis Cosenza, Stella; Toupet, Karine; Maumus, Marie; Luz-Crawford, Patricia; Blanc-Brude, Olivier; Jorgensen, Christian; Noël, Danièle Article Wos Core Collection ISI THERANOSTICS (2018)
PPAR beta/delta: A master regulator of mesenchymal stem cell functions Djouad, Farida; Ipseiz, Natacha; Luz-Crawford, Patricia; Scholtysek, Carina; Krönke, Gerhard; Jorgensen, Christian Article ISI SCOPUS BIOCHIMIE (2017)
TGF beta 3 secretion by three-dimensional cultures of human dental apical papilla mesenchymal stem cells Somoza, R. A.; Acevedo, C. A.; Albornoz F; Luz-Crawford P.; Carrión F.; Young M.E.; Weinstein-Oppenheimer C. Article ISI SCOPUS JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2017)
TNF signaling and macrophages govern fin regeneration in zebrafish larvae Nguyen-Chi, M; Laplace-Builhe, B; Travnickova, J; Luz-Crawford, P; Tejedor, G; Lutfalla, G; Kissa, K; Jorgensen, C; Djouad, F Article ISI CELL DEATH & DISEASE (2017)
Mesenchymal Stem Cell-Derived Interleukin 1 Receptor Antagonist Promotes Macrophage Polarization and Inhibits B Cell Differentiation Luz-Crawford, Patricia; Djouad, Farida; Toupet, Karine; Bony, Claire; Franquesa, Marcella; Hoogduijn, Martin J.; Jorgensen, Christian; Noël, Danièle Article WOS core collection ISI STEM CELLS (2016)
Mesenchymal Stem Cells Regulate the Innate and Adaptive Immune Responses Dampening Arthritis Progression Contreras, R. A.; Figueroa, F. E.; Djouad, F.; Luz-Crawford, P. Article ISI SCOPUS STEM CELLS INTERNATIONAL (2016)
PPAR beta/delta directs the therapeutic potential of mesenchymal stem cells in arthritis Luz-Crawford, P; Ipseiz, N; Espinosa-Carrasco, G; Caicedo, A; Tejedor, G; Toupet, K; Loriau, J; Scholtysek, C; Stoll, C; Khoury, M; Noël, D; Jorgensen, C; Krönke, G; Djouad, F Article ISI SCOPUS ANNALS OF THE RHEUMATIC DISEASES (2016)
The Immunosuppressive Signature of Menstrual Blood Mesenchymal Stem Cells Entails Opposite Effects on Experimental Arthritis and Graft Versus Host Diseases Luz-Crawford, P; Torres, MJ; Noel, D; Fernandez A.; Toupet, K; Alcayaga-Miranda, F; Tejedor G.; Jorgensen C.; Illanes, SE; Figueroa, FE; Djouad, F; Khoury, M Article ISI SCOPUS STEM CELLS (2016)
Characterization of menstrual stem cells: angiogenic effect, migration and hematopoietic stem cell support in comparison with bone marrow mesenchymal stem cells Alcayaga-Miranda, F; Cuenca J.; Luz-Crawford, P; Aguila-Diaz, C; Fernandez A.; Figueroa, FE; Khoury, M Article ISI SCOPUS Stem Cell Research and Therapy (2015)
Glucocorticoid-Induced Leucine Zipper Governs the Therapeutic Potential of Mesenchymal Stem Cells by Inducing a Switch From Pathogenic to Regulatory Th17 Cells in a Mouse Model of Collagen-Induced Arthritis Luz-Crawford, P.; Tejedor, G.; Mausset-Bonnefont, A. L.; Beaulieu, E.; Morand, E. F.; Jorgensen, C.; Noël, D.; Djouad, F. Article WOS core collection ISI ARTHRITIS & RHEUMATOLOGY (2015)
Identification of polarized macrophage subsets in zebrafish Nguyen-Chi, Mai; Laplace-Builhe, Béryl; Travnickova, Jana; Luz-Crawford, Patricia; Tejedor, Gautier; Phan, Quang Tien; Duroux-Richard, Isabelle; Levraud, Jean-Pierre; Kissa, Karima; Lutfalla, Georges; Jorgensen, Christian; Djouad, Farida Article WOS core collection ISI eLIFE (2015)
Survival and Biodistribution of Xenogenic Adipose Mesenchymal Stem Cells Is Not Affected by the Degree of Inflammation in Arthritis Toupet, Karine; Maumus, Marie; Luz-Crawford, Patricia; Lombardo, Eleuterio; Lopez-Belmonte, Juan; van Lent, Peter; Garin, Marina I.; van den Berg, Wim; Dalemans, Wilfried; Jorgensen, Christian; Noël, Danièle; Shi, Xing-Ming Article PLOS ONE (2015)
Isolation and Characterization of Mesenchymal Stem Cells from Human Dental Pulp and Follicle Brizuela, C; Galleguillos, S; Carrion, F; Cabrera, C; Luz, P; Inostroza C. Article ISI INTERNATIONAL JOURNAL OF MORPHOLOGY (2013)
Mesenchymal stem cells generate a CD4(+)CD25(+) Foxp3(+) regulatory T cell population during the differentiation process of Th1 and Th17 cells Luz-Crawford, P; Kurte, M; Bravo-Alegria, J; Contreras R.; Nova Lamperti, E; Tejedor G.; Noel, D; Jorgensen C.; Figueroa F.; Djouad, F; Carrion, F Article ISI SCOPUS STEM CELL RESEARCH & THERAPY (2013)
Mesenchymal Stem Cells Repress Th17 Molecular Program through the PD-1 Pathway Luz-Crawford, P; Noel, D; Fernández X.; Khoury, M; Figueroa F.; Carrion, F; Jorgensen C.; Djouad, F Article ISI SCOPUS PLOS ONE (2012)
Mesenchymal stem cell injection ameliorates chronic renal failure in a rat model Vio, Carlos P; Saez, Pablo J.; Villanueva, Sandra; Luz, Patricia; Carrion, Flavio; Irarrazabal Carlos; Vergara, Cesar; Carreno, Juan E.; Ewertz, Ernesto; Figueroa, Fernando; Cespedes, Carlos; Tapia, Andres Article ISI CLINICAL SCIENCE (2011)
Opposing effect of mesenchymal stem cells on Th1 and Th17 cell polarization according to the state of CD4(+) T cell activation Carrion, F; NOVA, E; Luz, P; Apablaza F.; Figueroa F. Article ISI SCOPUS Immunology Letters (2011)
Culture and Characterization of Mesenchymal Stem Cells From Human Gingival Tissue Mitrano, TI; Grob, MS; Carrion, F; Nova Lamperti, E; Luz PA; Fierro, FS; Quintero, A.; Chaparro, A; Sanz A. Article ISI SCOPUS JOURNAL OF PERIODONTOLOGY (2010)


method to enhance the therapeutic properties of Mesenchymal Stem Cells." Luz-Crawford, Patricia; Elizondo-Vega, Roberto; Djouad, Farida; Contreras-Lopez, RAfael Patent


Franco-Chilean initiative for Intra-Mitochondrial microRNAs as new mediators of mesenchymal stem cells immunoregulatory functions. Khoury, Maroun; Luz-Crawford, Patricia Proyecto (2021)
Immunoregulatory and anti-rheumatoid arthritis activities of small extracellular vesicles-shuttled bioactive microRNA derived from glycolytic mesenchymal stem cells. Luz-Crawford, Patricia; Elizondo-Vega, Roberto; Khoury, Maroun; Claudia, Altamirano; Estefania Nova Lamperti; Alcayaga-Miranda, Francisca Proyecto (2021)
Impact of Horizontal artificial Transfer of Mitochondria on umbilical cord blood transplantation and its clinical relevance in Graft versus Host Disease. Khoury, Maroun; Luz-Crawford, Patricia.; Court, Angela; Fernando Figueroa E Proyecto (2021)
Metabolic reprograming of effector CD4+T cells by mitochondrial mediated-signaling in oral cancer and its effect upon T helper and T-dependent B cell responses. Estefania Nova Lamperti; Luz-Crawford, Patricia.; Andy Perez Proyecto (2021)
Regulation of mesenchymal stem cells metabolic status to improve their therapeutic potential for arthritis PCI (180211) Proyecto 2018-2020 Inv. Responsable
Functional impact of MSC mitochondrial transfer to T lymphocytes and its clinical relevance in a Graft versus Host Disease FONDECYT (1170852) Proyecto 2017-2021 Coinvestigador(a)
STUDY OF THE METABOLIC PLASTICITY OF MESENCHYMAL STEM CELLS AND ITS ROLE IN THEIR IMMUNOMODULATORY EFFECTS ON PATHOGENIC T CELLS=> TOWARD AN OPTIMIZATION OF THEIR THERAPEUTIC POTENTIAL FOR AUTOIMMUNE DISEASES. FONDECYT (11160929) Proyecto 2016-2019 Inv. Responsable

Patricia Luz

Profesor asistente

Universidad de los Andes

Santiago , Chile

Flavio Carrion

Director Departamento de Investigación, Postgrado y Educación Continua

Facultad de Ciencias de la Salud

Universidad del Alba

Santiago, Chile

Fernando Figueroa

Director

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago de Chile, Chile

Estefania Nova

Assistant Professor

Clinical Biochemistry & Immunology

University of Concepcion

Concepción , Chile

Maroun Khoury

Professor

Faculty of Medicine

Universidad de Los Andes

santiago, Chile

Roberto Elizondo

Profesor Asistente

Departamento de Biología Celular

Universidad de Concepción

CONCEPCION, Chile

Rafael Contreras

PhD student

Facultad de Medicina

Universidad de los Andes

Santiago, Chile

Karina Oyarce

Profesora asistente - Investigadora

Facultad de Medicina y Ciencia

Universidad San Sebastián, sede Tres Pascualas

Concepción, Chile

Roxana Pincheira

Full Professor

Bioquímica y Biología Celular

Universidad de Concepcion

Concepción, Chile

María José Barahona

Investigadora posdoctoral

Biología Celular

Universidad de Concepción

Concepción, Chile

Juan Pablo Acevedo

Profesor Asistente

Universidad de los Andes

Santiago, Chile

María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Rodrigo Somoza

Senior Research Associate

Biology

Case Western Reserve University

Cleveland, Estados Unidos

carolina inostroza

investigador

Universidad de Los Andes

Santiago, Chile

Francisco Espinoza

Profesor Asistente

Medicina Interna

Universidad de los Andes

Santiago, Chile

Magdiel Salgado

INVESTIGADOR

BIOLOGIA CELULAR

Universidad de Concepción

CONCEPCION, Chile

Carlos Irarrazabal

Full Professor

Fisiología

Universidad de Los Andes

Santiago, Chile

Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Claudia Altamirano

Profesor Titular

Facultad de Ingeniería

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaíso, Chile

Mónica Kurte

Investigador

Laboratorio de Inmunologìa

Universidad de los Andes

Santiago, Chile

Daniel Medina

Investigador

Medicina Veterinaria

Universidad San Sebastián

Puerto Montt, Chile

Manuel Young

Francisco Rivera

Associate Professor in Integrative Neurobiology

Molecular and Integrative Biosciences Research Programme

University of Helsinki

Helsinki, Finlandia

antonio quintero

Profesor Asociado

Periodoncia e Implantología Oral

Universidad de los Andes

Santiago, Chile

Luis Molina

PROFESOR ASISTENTE

CIENCIAS BÁSICAS

Universidad San Sebastián

Puerto Montt, Chile

Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Jimena Cuenca

Investigador/profesor

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

Patricio Órdenes

Docente

Facultad de Ciencias de la Salud

Universidad San Sebastián

Concepción, Chile

Antonia Recabal

Profesor Asistente

Biología Celular

Universidad de Concepción

Concepción, Chile

Luis Federico Batiz

Full Professor

Center for Biomedical Research and Innovation (CIIB)

Universidad de Los Andes

Santiago, Chile

Alejandra Chaparro

Profesora Titular

Odontología

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Patricia Alejandra Luz Crawford

Líneas de Investigación

Educación

Licenciatura en Ciencias c/m en Biotecnología, UNIVERSIDAD DE CHILE. Chile, 2005

Ingeniero en Biotecnología Molecular, UNIVERSIDAD DE CHILE. Chile, 2007

Biotecnologia, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 2012

Experiencia Académica

Postdoctoral research Part Time

Profesor Asistente Full Time

Experiencia Profesional

Ayudantía quimica orgánica y bioquimica

Tesista

Tesista Doctorado

Pasantia doctoral

Investigador

Unidad de investigación

Organización y coordinación curso precongreso de Células Madre: Usos y Aplicaciones

Ayudante en la elaboración proyectos Innova Corfo

Postdoctoral research

profesor asistente Full Time

Profesor asistente Full Time

Formación de Capital Humano

Article (33)

Patent (1)

Proyecto (7)

Regulation of mesenchymal stem cells metabolic status to improve their therapeutic potential for arthritis

Functional impact of MSC mitochondrial transfer to T lymphocytes and its clinical relevance in a Graft versus Host Disease

STUDY OF THE METABOLIC PLASTICITY OF MESENCHYMAL STEM CELLS AND ITS ROLE IN THEIR IMMUNOMODULATORY EFFECTS ON PATHOGENIC T CELLS=> TOWARD AN OPTIMIZATION OF THEIR THERAPEUTIC POTENTIAL FOR AUTOIMMUNE DISEASES.