Man

Fernando Figueroa Elizalde

Director

UNIVERSIDAD DE LOS ANDES

Santiago de Chile, Chile

Líneas de Investigación


Biología de Células Mesenquimales del Estroma (MSC) e interacción con el sistema inmune. Uso experimental en patología inflamatoria. Terapia celular en patología osteoarticular y Enfermedades del Tejido Conectivo

Educación

  •  Médico Cirujano, UNIVERSIDAD DE CHILE. Chile, 1978

Experiencia Académica

  •   Guest Investigator Other

    Rockefeller University

    New York, Estados Unidos

    1987 - 1988

  •   Fellow Full Time

    UNIVERSITY OF CALIFORNIA

    Medicina

    Los Angeles, Chile

    1985 - 1987

  •   Fellow Full Time

    UNIVERSIDAD MONTPELLIER I

    Medicina

    Montpellier, Francia

    1982 - 1982

Experiencia Profesional

  •   Decano Full Time

    Facultad de Medicina Universidad de los Andes

    Santiago , Chile

    1999 - 2004

  •   Miembro Consejo Superior de la Universidad de los Andes Full Time

    Universidad de los Andes

    Santiago, Chile

    1999 - 2018

  •   Director de investigación.Facultad de Medicina Full Time

    Universidad de los Andes

    Santiago, Chile

    2004 - 2010

  •   Jefe de la Unidad de Reumatología. Facultad de Medicina Full Time

    Universidad de los Andes

    Santiago, Chile

    2010 - At present

  •   Director. Programa de Terapia celular. Facultad de Medicina Full Time

    Universidad de los Andes

    Santiago, Chile

    2010 - At present

  •   Consejero. Programa de Doctorado en Biomedicina. Facultad de Medicina Full Time

    Universidad de los Andes

    Santiago, Chile

    2011 - At present

  •   Miembro. Consejo de Investigación Full Time

    Universidad de los Andes

    Santiago, Chile

    2012 - 2018

  •   Presidente. Comisión para la Calificación Académica de Profesores Facultad de Medicina. Full Time

    Universidad de los Andes

    Santiago, Chile

    2013 - 2016

  •   Miembro. Comité Consultivo de la Facultad de Medicina Full Time

    Universidad de Piura

    Lima, Peru

    2016 - At present


 

Article (47)

Current Status of Cell-Based Therapies for Respiratory Virus Infections: Applicability to COVID-19
Magic realism: a Latin American paradigm for stem cell research & development?
Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response
Adipose tissue-derived mesenchymal stromal cells in patients with chronic kidney disease: A pilot study assessing safety and clinical feasibility
Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis=> Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial.
IL17/IL17RA as a Novel Signaling Axis Driving Mesenchymal Stem Cell Therapeutic Function in Experimental Autoimmune Encephalomyelitis
Safety and Efficacy of the Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Patients With Heart Failure A Phase 1/2 Randomized Controlled Trial (RIMECARD Trial [Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy])
Differential TLR activation of murine mesenchymal stem cells generates distinct immunomodulatory effects in EAE
Mesenchymal Stem Cells Regulate the Innate and Adaptive Immune Responses Dampening Arthritis Progression
Overexpression of Glutamate Decarboxylase in Mesenchymal Stem Cells Enhances Their Immunosuppressive Properties and Increases GABA and Nitric Oxide Levels
The Immunosuppressive Signature of Menstrual Blood Mesenchymal Stem Cells Entails Opposite Effects on Experimental Arthritis and Graft Versus Host Diseases
Toll-like receptor 3 pre-conditioning increases the therapeutic efficacy of umbilical cord mesenchymal stromal cells in a dextran sulfate sodium-induced colitis model
[Long-term results of intracoronary transplantation of autologous bone marrow cells in dilated cardiomyopathy].
Characterization of menstrual stem cells: angiogenic effect, migration and hematopoietic stem cell support in comparison with bone marrow mesenchymal stem cells
Chorion Mesenchymal Stem Cells Show Superior Differentiation, Immunosuppressive, and Angiogenic Potentials in Comparison With Haploidentical Maternal Placental Cells
Combination therapy of menstrual derived mesenchymal stem cells and antibiotics ameliorates survival in sepsis
Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cells Induces a Switch from Classical to Atypical Symptoms in Experimental Autoimmune Encephalomyelitis
Long-term results of intracoronary transplantation of autologous bone marrow cells in dilated cardiomyopathy
MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers
[Stem cells for the treatment of cardiovascular diseases. An update].
Novel approaches to lupus drug discovery using stem cell therapy. Role of mesenchymal-stem cell-secreted factors
Spironolactone Decreases DOCA-Salt-Induced Organ Damage by Blocking the Activation of T Helper 17 and the Downregulation of Regulatory T Lymphocytes
The promising potential of menstrual stem cells for antenatal diagnosis and cell therapy
El trasplante intracoronario de células mononucleares de medula ósea mejora la función ventricular izquierda en pacientes con cardiopatía dilatada de diferente etiología.
Human mesenchymal stem cells derived from adipose tissue reduce functional and tissue damage in a rat model of chronic renal failure
Increased inflammatory biomarkers in early pregnancy is associated with the development of pre-eclampsia in patients with periodontitis: a case control study
Mesenchymal stem cells generate a CD4(+)CD25(+) Foxp3(+) regulatory T cell population during the differentiation process of Th1 and Th17 cells
IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction.
Mesenchymal stem cell treatment for autoimmune diseases=> a critical review.
Mesenchymal Stem Cell treatment for autoinnmune diseases: a critical review
Mesenchymal Stem Cells Repress Th17 Molecular Program through the PD-1 Pathway
Mesenchymal stem cell injection ameliorates chronic renal failure in a rat model
Mesenchymal Stem Cells in Systemic Lupus Erythematosus: is the cure for connective tissue diseases within connective tissue?
Opposing effect of mesenchymal stem cells on Th1 and Th17 cell polarization according to the state of CD4(+) T cell activation
Aldosterone Promotes Autoimmune Damage by Enhancing Th17-Mediated Immunity
Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two systemic lupus erythematosus patients
Cardiovascular assessment of non diabetic patients on hemodialysis
Evolución del compromiso cardiovascular de pacientes insuficientes renales, en hemodiálisis, sin bloqueo del eje renina-angiotensina
Patient self-administered joint tenderness counts in rheumatoid arthritis are reliable and responsive to changes in disease activity
Presence of bacterial DNA in valvular tissue of patients with rheumatic heart disease
Presencia de ADN bacteriano en el tejido valvular de pacientes con cardiopatía reumática crónica
Polymorphisms of Fc gamma lla receptors in Chilean patients with systemic lupus erythematosus
Selective depletion of V beta 2+CD8+ T cells in peripheral blood from rheumatic heart disease patients
Eosinophilic fasciitis. Report of three cases
Restriction in the usage of variable beta regions in T-cells infiltrating valvular tissue from rheumatic heart disease patients
Prospective comparison of clinical and echocardiographic diagnosis of rheumatic carditis: long term follow up of patients with subclinical disease
A genetic and molecular perspective for present time clinical immunology

Abstract (9)

MITOCHONDRIAL TRANSFER FROM MSC TO HUMAN T CELLS: A FIRST EVIDENCE OF A STEM CELL-MEDIATED REPROGRAMMING OF MULTIPLE IMMUNE CELL FUNCTION
CONDITIONAL IMMUNOSUPRESSIVE PROPERTY OF MENSTRUAL BLOOD-DERIVED STEM CELLS IN VITRO
EVALUATION OF DIFFERENT SOURCES OF BIRTH-TISSUE-DERIVED MESENCHYMAL STEM CELLS FOR THEIR CARDIOVASCULAR REGENERATIVE POTENTIAL
TRANSPLANTATION OF AUTOLOGOUS BONE MARROW CELLS, IMPROVE THE EJECTION FRACTION IN PATIENTS WITH DILATED CARDIOMYOPATHY OF DIVERSE ETIOLOGY
Immunomodulatory properties of MSCs on Th17 cells: the role of cell-contact and IL-6
Intracoronary bone marrow derived CD34+cells improve left ventricular function in patients with severe dilated cardiopathy
PROINFLAMMATORY PHENOTYPE AND DECREASED EXPRESSION OF DUAL TH17/TREG CD4+CELLS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)
Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two SLE patients
Proinflammatory cytokines and cardiovascular damage in chronic hemodialysis patients

Proyecto (19)

Impact of Horizontal artificial Transfer of Mitochondria on umbilical cord blood transplantation and its clinical relevance in Graft versus Host Disease
Mitochondrial transfer within the osteoarthritic joint: restoration of the dysfunctional stress-response and metabolic pathway in cartilage in-vitro and in an animal model of disease
Functional impact of MSC mitochondrial transfer to T lymphocytes and its clinical relevance in a Graft versus Host Disease.
Toll-like Receptor mediates the immunosuppressive proinflammatory switch in Mesenchymal Stem Cells=> in-vitro and in-vivo evaluation in autoimmune models of Multiple Sclerosis and Rheumatoid Arthritis
TOLL-LIKE RECEPTOR MEDIATES THE IMMUNOSUPPRESSIVE TO PROINFLAMMATORY SWITCH IN MESENCHYMAL STEM CELLS=> IN VITRO AND IN VIVO EVALUATION IN AUTOIMMUNE MODELS OF MULTIPLE SCLEROSIS AND RHEUMATOID ARTHRITIS.
miRNAs in the pathogenesis of Systemic Lupus Erythematosus (SLE). Profile of expression in human disease and assessment of functional effects in a humanized mouse model of SLE
Desarrollo de Nuevos Productos Celulares en Base a Células Madre para Aplicación Clínica Comercial. Cells for Cells S.A.
Proyecto Franco- Chilean Iniciative for Cell Based Immunotherapy Laboratory
¿Es la artritis reumatoide un factor de riesgo para las complicaciones cardiovasculares popst cirugía? Estudio de cohorte retrospectiva caso control”.
• Proyecto Postdoctorado=> Participación del eje proinflamatorio IL-23/Th17 en la Insuficiencia cardíaca post-infarto de miocardio. Efectos de la antagonización del receptor de mineralocorticoide con Espironolactona
Células Madres Mesenquimales Adultas=> Una estirpe celular inmonosupresora con nuevas posibilidades terapéuticas. Coinvestigador.
Desarrollo e Implementacion de una Nueva Tecnologia Terapeutica para Pacientes con Infarto Agudo al Miocardio=> cultivo e infusión de Celulas Madres Pluripotenciales Autólogas.
PARTICIPACION DEL EJE PROINFLAMATORIO IL-2 TH17 EN LA INSUFICIENCIA CARDIACA POST-INFARTO DE MIOCARDIO. EFECTOS DE LA ANTAGONIZACION DEL RECEPTOR DE MINERALOCORTICOIDE CON ESPIRONOLACTONA.
Desarrollo e implementación de una nueva terapia para el tratamiento de pacientes con infarto agudo al miocardio=> Cultivo e infusión de células madres autólogas
• Estado inmunológico proinflamatorio mediado por aldosterona. Estudio clínico y experimental de la función inmune y endotelial en el daño cardiovascular inducido por hiperaldosteronemia. Investigador principal.
SUPERANTIGENOS EN LA FIEBRE REUMATICA=> ANALISIS DEL USO DE GENES DE LA REGION VARIABLE DEL RECEPTOR - T (TCR) Y TRANSCRIPCION DE CITOQUINAS EN PACIENTES CON ENFERMEDAD ACTIVA
PATHOGENIC MECHANISMS OF DISEASE IN ACUTE RHEUMATIC FEVER=> A PROSPECTIVE CLINICAL, SEROLOGICAL AND ECHOCARDIOGRAPHICAL FOLLOW-UP AND INVESTIGATION OF ANTIPHOSPHOLIPID ANTIBODY.....
EFECTO DE LA PROLACTINA Y SU MODULACION LA RESPUESTA INMUNE CELULAR EN INDIVIDUOS NORMALES.
ESTUDIO CLINICO, MICROBIOLOGICO E INMUNOLOGICO EN HOMOSEXUALES DE UNA POBLACION PENAL.

Review (5)

Novel approaches to lupus drug discovery using stem cell therapy. Role of mesenchymal-stem-cell-secreted factors
Stem cells for the treatment of cardiovascular diseases. An update
The promising potent a of menstrual stem cells for antenatal diagnosis and cell therapy
Mesenchymal stem cells for the treatment of systemic lupus erythematosus: is the cure for connective tissue diseases within connective tissue?
Infections in patients with systemic lupus erythematosus
54
Fernando Figueroa

Director

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago de Chile, Chile

23
Flavio Carrion

Director Departamento de Investigación, Postgrado y Educación Continua

Facultad de Ciencias de la Salud

Universidad del Alba

Santiago, Chile

17
Maroun Khoury

Professor

Faculty of Medicine

Universidad de Los Andes

santiago, Chile

8
Mónica Kurte

Investigador

Laboratorio de Inmunologìa

Universidad de los Andes

Santiago, Chile

6
Patricia Luz

Profesor asistente

Universidad de los Andes

Santiago , Chile

5
Jimena Cuenca

Investigador/profesor

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

5
Estefania Nova

Assistant Professor

Clinical Biochemistry & Immunology

University of Concepcion

Concepción , Chile

5
Carlos Irarrazabal

Full Professor

Fisiología

Universidad de Los Andes

Santiago, Chile

4
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

4
Lorena Salazar

Profesora Asistente

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Lampa, Chile

3
Antonio Vukusich

Decano Facultad de Medicina

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

3
Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

2
Gustavo Monckeberg

Profesor - investigador

Medicina interna

Universidad de Los Andes

Santiago, Chile

2
Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Francisca Alcayaga

Profesor Asociado

Facultad de Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

2
Alexis Kalergis

Full Professor

Microbiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

2
Ana Maria Vega

Investigador postdoctoral

Ingenieria Bioquimica

Potificia Universidad Catolica de Valpraiso

Valparaiso, Chile

2
CLAUDIA ALTAMIRANO

PROFESOR TITULAR

FACULTAD DE INGENIERÍA

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

VALPARAISO, Chile

2
Patricia Fuenzalida

Lab Manager

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Roberto Elizondo

Profesor Asistente

Departamento de Biología Celular

Universidad de Concepción

CONCEPCION, Chile

2
Fabio Valdes

Staff

Cirugia

Instituto Nacional del Cancer

Santiago, Chile

2
Rafael Contreras

PhD student

Facultad de Medicina

Universidad de los Andes

Santiago, Chile

2
carolina inostroza

investigador

Universidad de Los Andes

Santiago, Chile

2
Carolina Nazzal

Profesor Asociado

Instituto de Salud Poblacional

Universidad de Chile

Santiago, Chile

2
Carlos Cespedes

Tecnologo Medico

Fisiologia

P. Universidad Católica de Chile

Santiago, Chile

2
Cristián Amador

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

2
Rodrigo Fuentealba

Postdoctoral Research Associate

Departamento de Inmunología Clínica y Reumatología / Facultad de Medicina

Pontificia Universidad Católica

Santiago, Chile

1
RAMON SERRA

JEFE DE SERVICIO

GINECOLOGIA

HOSPITAL NAVAL FFAA

PUNTA ARENAS, Chile

1
Cristian Carvajal

Associate Professor

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Ricardo Larrea

Médico Jefe

Enfermedades Cardiovasculares

Clinica Dávila

Santiago, Chile

1
Valeria Ramirez

Profesor asociado

Facultad de Odontología

Universidad de Los Andes

Santiago, Chile

1
Claudia Altamirano

Profesor Titular

Facultad de Ingeniería

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaíso, Chile

1
antonio quintero

Profesor Asociado

Periodoncia e Implantología Oral

Universidad de los Andes

Santiago, Chile

1
Juan Peña

Director Medico

Servicios Veterinarios especializados VETCO

santiago, Chile

1
Lorena Salazar

Academico

Instituto Cs Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Rafael Armijo

Research Assistant

Universidad Autónoma de Chile

Santiago, Chile

1
eduardo lorca

Profesor Asistente

medicina oriente

Universidad de Chile-Facultad de Medicina

santiago, Chile

1
Angela Court

Asistente de Investigación

Medicina Nanoregenerativa

Universidad de Los Andes

Santiago, Chile

1
Paulina Maffud

Gerente regional de educación para Latinoamérica

Educación y Asuntos científicos

Paul Hartmann Latinoamérica

Santiago, Chile

1
Rodrigo Alzamora

ASSISTANT PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

1
Pablo González

Associate Professor

Molecular Genetics and MIcrobiology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Karina Pino

Group Leader/Associate Professor

Centro de Investigación Biomédica

Universidad de los Andes

Santiago, Chile

1
Mirentxu Iruretagoyena

Jefe Seccion Inmunologia

Laboratorio Clinico

Clinica Alemana de Santiago

Santiago, Chile

1
Vinicius Ramos Henriques

Associate Professor

Advanced Center for Chronic Diseases - ACCDiS

Univesidad de Chile

Santiago, Chile

1
Luis Federico Batiz

Full Professor

Center for Biomedical Research and Innovation (CIIB)

Universidad de Los Andes

Santiago, Chile

1
Alejandra Chaparro

Profesora Titular

Odontología

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Fernando Verdugo

Cardiologo

Cardiologia

Hospital del Salvador

Santiago, Chile

1
Victor Aliaga

Postdoctorante

Universidad de O'Higgins

Santiago, Chile

1
Carlos Fardella

Profesor Titular

Endocrinología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Andres Herrada

Principal Investigator

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Talca, Chile

1
Fernando Lanas

Profesor titular

Medicina Interna

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile