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Rodrigo Ricardo Alzamora Miranda

ASSISTANT PROFESSOR

UNIVERSIDAD DE CHILE

Santiago, Chile

Regulation of renal epithelial ion transport by protein kinases. Physiopathological mechanisms of arterial hypertension. Physiopathological mechanisms of chronic kidney disease.

Biochemistry, Universidad de Chile. Chile, 2000
Biochemist, Universidad de Chile. Chile, 2000
Physiology, ROYAL COLLEGE OF SURGEONS IN IRELAND. Irlanda, 2007

ASSISTANT PROFESSOR Full Time

Universidad de Chile

MEDICINE

Santiago, Chile

2014 - At present
POSTDOCTORAL FELLOW Full Time

UNIVERSIDAD DE CHILE

MEDICINE

Santiago, Chile

2013 - 2014
POSTDOCTORAL FELLOW Full Time

UNIVERSITY OF PITTSBURGH

MEDICINE

Pittsburgh, Estados Unidos

2007 - 2012
POSTDOCTORAL FELLOW Full Time

ROYAL COLLEGE OF SURGEONS IN IRELAND

MEDICINE

Dublin, Irlanda

2006 - 2007

RESEARCH ASSISTANT Full Time

UNIVERSITY COLLEGE CORK

Cork, Irlanda

2000 - 2001

SUPERVISION OF RESEARCH UNITS
2008 Summer medical student Miss Rula Kanj. “Role of AMPK in metabolic stress-induced ENaC inhibition in kidney cells”.
2007 Supervisor Transition Year Programme
2005 Summer student Miss Laura Brown. “An investigation into the localization of the binding sites of 17?-estradiol within the PKC-? isozyme”.
2002 Summer student Mr. Shane Harrington. “Rapid anti-secretory effect of 17?-estradiol on rat distal colon”.

Sheppard Prize

ROYAL COLLEGE OF SURGEONS IN IRELAND

Irlanda, 2003

Prize for best poster at the Royal College of Surgeons in Ireland Research Day
Sheppard Prize

ROYAL COLLEGE OF SURGEONS IN IRELAND

Chile, 2006

Best poster presentation at the Royal College of Surgeons in Ireland Research Day.
Best Postgraduate Poster FASEB Summer Conference

FASEB

Estados Unidos, 2006

Best Postgraduate Poster at the FASEB Summer Conference, Tucson AZ, USA
Best Oral Communication DMMC

DUBLIN MOLECULAR MEDICINE CENTRE

Irlanda, 2006

Best Oral Communication at the Dublin Molecular Medicine Centre Research Day


Mineralocorticoids modulate the expression of the-3 subunit of the Na+, K+-ATPase in the renal collecting duct Rojas, Macarena; D?az, Pablo; Le?n, Pablo; Gonz?lez, Alexis A.; Gonz?lez, Magdalena; Barrientos, V?ctor; Pestov, Nikolay B.; Alzamora, Rodrigo; Michea, Luis Article ISI SCOPUS CHANNELS (2017)
Aurora kinase A activates the vacuolar H + -ATPase (V-ATPase) in kidney carcinoma cells Al-bataineh, Mohammad M.; Alzamora, Rodrigo; Ohmi, Kazuhiro; Ho, Pei-Yin; Marciszyn, Allison L.; Gong, Fan; Li, Hui; Hallows, Kenneth R.; Pastor-Soler, Núria M. Article ISI American Journal of Physiology-Renal Physiology (2016)
Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis Ocaranza, Maria Paz; Moya, Jackeline; Barrientos, Victor; Alzamora, Rodrigo; Hevia, Daniel; Morales, Cristobal; Pinto, Melissa; Escudero, Nicolas; Garcia, Lorena; Novoa, Ulises; Ayala, Pedro; Diaz-Araya, Guillermo; Godoy, Ivan; Chiong, Mario; Lavandero, Sergio; Jalil, Jorge E.; Michea, Luis Article ISI SCOPUS JOURNAL OF HYPERTENSION (2014)
Spironolactone Decreases DOCA-Salt-Induced Organ Damage by Blocking the Activation of T Helper 17 and the Downregulation of Regulatory T Lymphocytes Amador, Cristian A; Barrientos, Victor; Peña, Juan; Herrada, Andres A.; Gonzalez, Magdalena; Valdes, Solange; Carrasco, Loreto; Alzamora, Rodrigo; Figueroa, Fernando; Kalergis, Alexis M; Michea, Luis Article ISI SCOPUS HYPERTENSION (2014)
AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney Alzamora, Rodrigo; Al-Bataineh, Mohammad M.; Liu Wen; Gong, Fan; Li, Hui; Thali, Ramon F.; Joho-Auchli, Yolanda; Brunisholz, Rene A.; Satlin, Lisa M.; Neumann, Dietbert; Hallows, Kenneth R.; Pastor-Soler, Nuria M. Article American Journal of Physiology-Renal Physiology (2013)
Resveratrol inhibits the epithelial sodium channel via phopshoinositides and AMP-activated protein kinase in kidney collecting duct cells. Weixel, Kelly M.; Marciszyn, Allison; Alzamora, Rodrigo; Li, Hui; Fischer, Oliver; Edinger, Robert S.; Hallows, Kenneth R.; Johnson, John P. Article PLOS ONE (2013)
Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels. Alzamora, Rodrigo; O´Mahony, Fiona; Ko, Wing-Hung; Yip, Tiffany Wai-Nga; Carter, Derek; Irnaten, Mustapha; Harvey, Brian J. Article FRONTIERS IN PHYSIOLOGY (2011)
Estrogen inhibits chloride secretion caused by cholera and Escherichia coli enterotoxins in female rat distal colon. Alzamora, Rodrigo; O´Mahony, Fiona; Harvey, Brian J. Article STEROIDS (2011)
Sexual dimorphism and oestrogen regulation of KCNE3 expression modulates the functional properties of KCNQ1 K+ channels Alzamora, R; O'Mahony, F; Bustos, V; Rapetti-Mauss, R; Urbach, V; Cid, LP; Sepulveda, FV; Harvey, BJ Article ISI SCOPUS Journal of Physiology (2011)
AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells Alzamora, Rodrigo; Gong, Fan; Rondanino, Christine; Lee, Jeffrey K.; Smolak, Christy; Pastor-Soler, Nuria M.; Hallows, Kenneth R. Article American Journal of Physiology-Renal Physiology (2010)
PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells. Alzamora, Rodrigo; Thali, Ramon F.; Gong, Fan; Smolak, Christy; Li, Hui; Baty, Catherine J.; Bertrand, Carol A.; Auchli, Yolanda; Brunisholz, Rene A.; Neumann, Dietbert; Hallows, Kenneth R.; Pastor-Soler, Nuria M. Article JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. Li, Hui; Thali, Ramon F.; Smolak, Christy; Gong, Fan; Alzamora, Rodrigo; Wallimann, Theo; Scholz, Roland; Pastor-Soler, Nuria M.; Neumann, Dietbert; Hallows, Kenneth R. Article American Journal of Physiology-Renal Physiology (2010)
SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy Banerjee, Sanjay K.; Wang, David W.; Alzamora, Rodrigo; Huang, Xueyin N.; Pastor-Soler, Nuria M.; Hallows, Kenneth R.; McGaffin, Kenneth R.; Ahmad, Ferhaan Article JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2010)
Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase. Gong, Fan; Alzamora, Rodrigo; Smolak, Christy; Li, Hui; Naveed, Sajid; Neumann, Dietbert; Hallows, Kenneth R.; Pastor-Soler, Nuria M. Article American Journal of Physiology-Renal Physiology (2010)
AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells Hallows, Kenneth R.; Alzamora, Rodrigo; Li, Hui; Gong, Fan; Smolak, Christy; Neumann, Dietbert; Pastor-Soler, Nuria M. Article ISI AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2009)
Functional Regulation of the Epithelial Na+ Channel by I kappa B Kinase-beta Occurs via Phosphorylation of the Ubiquitin Ligase Nedd4-2 Edinger, Robert S.; Lebowitz, Jonathan; Li, Hui; Alzamora, Rodrigo; Wang, Huamin; Johnson, John P.; Hallows, Kenneth R. Article JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Genomic Priming of the Antisecretory Response to Estrogen in Rat Distal Colon throughout the Estrous Cycle O'Mahony, Fiona; Alzamora, Rodrigo; Chung, Ho-Lam; Thomas, Warren; Harvey, Brian J. Article Molecular Endocrinology (2009)
Direct binding and activation of protein kinase C isoforms by steroid hormones. Alzamora, Rodrigo; Harvey, Brian J. Article ISI STEROIDS (2008)
Rapid responses to aldosterone in the kidney and colon. Harvey, Brian J.; Alzamora, Rodrigo; Stubbs, Adam K.; Irnaten, Mustapha; McEneaney, Victoria; Thomas, Warren Article ISI JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2008)
Direct binding and activation of protein kinase C isoforms by aldosterone and 17beta-estradiol. Alzamora, Rodrigo; Brown, Laura R.; Harvey, Brian J. Article MOLECULAR ENDOCRINOLOGY (2007)
Female gender-specific inhibition of KCNQ1 channels and chloride secretion by 17beta-estradiol in rat distal colonic crypts. O´Mahony, Fiona; Alzamora, Rodrigo; Betts, Vicki; LaPaix, Franck; Carter, Derek; Irnaten, Mustapha; Harvey, Brian J. Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Nongenomic effect of aldosterone on Na+,K+-adenosine triphosphatase in arterial vessels Alzamora, R; Marusic, ET; Gonzalez, M.; Michea, L. Article ISI SCOPUS ENDOCRINOLOGY (2003)
Non-genomic convergent and divergent signalling of rapid responses to aldosterone and estradiol in mammalian colon. Harvey, Brian J.; Doolan, Christine M.; Condliffe, Steven B.; Renard, Celine; Alzamora, Rodrigo; Urbach, Valerie Article ISI STEROIDS (2002)
Rapid responses to steroid hormones: from frog skin to human colon. A homage to Hans Ussing. Harvey, Brian J.; Alzamora, Rodrigo; Healy, Vincent; Renard, Celine; Doolan, Christine M. Article ISI BIOCHIMICA ET BIOPHYSICA ACTA (2002)
Role of 11beta-hydroxysteroid dehydrogenase in nongenomic aldosterone effects in human arteries. Alzamora, Rodrigo; Michea, Luis; Marusic, Elisa T. Article ISI HYPERTENSION (2000)


CFTR Regulation by Phosphorylation. Alzamora, Rodrigo; King, J Darwing Jr; Hallows, Kenneth R.; Amaral, MD; Kunzelmann, Karl BookSection (2011)


Molecular determinants and physiological role of steroid hormone-induced PKC activation in distal colon. Alzamora, Rodrigo; Harvey, Brian J. Proyecto Postgraduate Studentship Prize. Mount awarded 91,803 UK Pounds (2001)
Dietary chloride in the development of hypertension: a new player regulating intrarenal renin-angiotensin system and dendritic cell activity? Michea, Luis; Alzamora, Rodrigo Proyecto (0)
Regulation of Ion Channels by AMP-Activated Kinase in Kidney Cells Alzamora, Rodrigo; Hallows, Kenneth R. Proyecto Postdoctoral Fellowship. Mount awarded US$ 88,000 (0)
Regulation of renal tubular sodium reabsorption by AMP-activated protein kinase in angiotensin II-induced hypertension Alzamora, Rodrigo; Michea, Luis Proyecto (0)
Role in sodium homeostasis and hypertension of a novel molecular mechanism that mediates the action of aldosterone in target tissues: regulation of the beta-3 subunit of the sodium pump Michea, Luis; Alzamora, Rodrigo Proyecto (0)