Man

Andres Alonso Herrada Hidalgo

Principal Investigator

Universidad Autónoma de Chile

Talca, Chile

Líneas de Investigación


Innate immune regulation in homeostatic and inflammatory conditions; dendritic cell/innate immune cell interaction and their effect over function; Innate immune dysfunction and their consequences in autoimmunity

Educación

  •  Bioquimico, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2007
  •  Doctor en Ciencias Biologicas Mencion Genetica Molecular y Microbiologia, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2011
  •  Magister en Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008

Experiencia Académica

  •   Postdoctoral fellow Full Time

    St Jude Children´s Research Hospital

    Memphis, Estados Unidos

    2013 - 2017

  •   Profesor asistente Full Time

    Universidad Autónoma de Chile

    Facultad de Ciencias de la Salud

    Talca, Chile

    2017 - At present

  •   Miembro del claustro académico del Doctorado en Ciencias Biomédicas Full Time

    UNIVERSIDAD AUTONOMA DE CHILE

    Talca, Chile

    2018 - At present

  •   Miembro del claustro académico del Doctorado en Ciencias Biomédicas Other

    UNIVERSIDAD DE TALCA

    Talca, Chile

    2023 - At present

Experiencia Profesional

  •   Postdoctoral training

    Fundacion Ciencia y Vida

    Chile

    2011 - 2012

  •   Postdoctoral Fellow Full Time

    St Jude Chidren´s research Hospital

    Estados Unidos

    2012 - 2017


 

Article (31)

Palbociclib-Induced Cellular Senescence Is Modulated by the mTOR Complex 1 and Autophagy

Cayo, Angel; Venturini, Whitney; Rebolledo-Mira, Danitza; Moore-Carrasco, Rodrigo; Herrada, Andres A.; Nova-Lamperti, Estefania; Valenzuela, Claudio; Brown, Nelson E.

Article ISI
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2023)

Lymph Leakage Promotes Immunosuppression by Enhancing Anti-Inflammatory Macrophage Polarization

Herrada, Andres A.; Olate-Briones, Alexandra; Lazo-Amador, Rodrigo; Liu, Chaohong; Hernandez-Rojas, Bairon; Riadi, Gonzalo; Escobedo, Noelia

Article ISI
FRONTIERS IN IMMUNOLOGY  (2022)

The meningeal lymphatic vasculature in neuroinflammation

Olate-Briones, Alexandra; Escalona, Emilia; Salazar, Celia; Jose Herrada, Maria; Liu, Chaohong; Herrada, Andres A.; Escobedo, Noelia

Article ISI
FASEB JOURNAL  (2022)

Adipose tissue macrophages as a therapeutic target in obesity-associated diseases

Herrada, Andres A.; Olate-Briones, Alexandra; Rojas, Armando; Liu, Chaohong; Escobedo, Noelia; Piesche, Matthias

Article ISI
OBESITY REVIEWS  (2021)

Reduced Naïve T Cell Numbers Correlate with Increased Low-Grade Systemic Inflammation During Ageing and Can be Modulated by Physical Activity

MERELLANO-NAVARRO, Eugenio; Olate-Briones, Alexandra; Leandra Norambuena-Mardones; Vicente Rojas-Ramos; Alexandra Márquez de la Plata-Luna; Jorge Y Faúndez-Acuña; Javiera C Moraga; Escobedo, Noelia; Herrada, AA

Article SCIELO
INTERNATIONAL JOURNAL OF MORPHOLOGY  (2021)

SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism

Jing, Yukai; Luo, Li; Chen, Ying; Westerberg, Lisa S.; Zhou, Peng; Xu, Zhiping; Herrada, Andres A.; Park, Chan-Sik; Kubo, Masato; Mei, Heng; Hu, Yu; Lee, Pamela Pui-Wah; Zheng, Bing; Sui, Zhiwei; Xiao, Wei; Gong, Quan; Lu, Zhongxin; Liu, Chaohong

Article ISI
SIGNAL TRANSDUCTION AND TARGETED THERAPY  (2021)

DOCK2 couples with LEF-1 to regulate B cell metabolism and memory response

Yang, Lu; Jing, Yukai; Wang, Wenjie; Ying, Wenjing; Lin, Li; Chang, Jiang; Luo, Li; Kang, Danqing; Jiang, Panpan; Liu, Ju; Chen, Qiuyue; Miller, Heather; Herrada, Andres A.; Kubo, Masato; Sun, Jinqiao; Liu, Chaohong

Article ISI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  (2020)

Development of New Serum Biomarkers for Early Lymphedema Detection

Herrada, Andres A.; Mejias, Camila; Lazo-Amador, Rodrigo; Olate-Briones, Alexandra; Lara, Danitza; Escobedo, Noelia

Article ISI
LYMPHATIC RESEARCH AND BIOLOGY  (2019)

Innate Immune Cells' Contribution to Systemic Lupus Erythematosus

Herrada, Andres A.; Escobedo, Noelia; Iruretagoyena, Mirentxu; Valenzuela, Rodrigo A.; Burgos, Paula, I; Cuitino, Loreto; Llanos, Carolina

Article ISI SCOPUS
FRONTIERS IN IMMUNOLOGY  (2019)

Innate Immune Cells' Contribution to Systemic Lupus Erythematosus.

Herrada, Andrés A; Escobedo, Noelia; Iruretagoyena, Mirentxu; Valenzuela, Rodrigo A; Burgos, Paula I; Cuitino, Loreto; Llanos, Carolina

Article
Frontiers in immunology  (2019)

Metabolic heterogeneity underlies reciprocal fates of T17 cell stemness and plasticity.

Karmaus, Peer W F; Chen, Xiang; Lim, Seon Ah; Herrada, Andrés A; Nguyen, Thanh-Long M; Xu, Beisi; Dhungana, Yogesh; Rankin, Sherri; Chen, Wenan; Rosencrance, Celeste; Yang, Kai; Fan, Yiping; Cheng, Yong; Easton, John; Neale, Geoffrey; Vogel, Peter; Chi, Hongbo

Article
Nature  (2019)

TASK-3 Gene Knockdown Dampens Invasion and Migration and Promotes Apoptosis in KATO III and MKN-45 Human Gastric Adenocarcinoma Cell Lines

Cikutovic-Molina, Rocio; Herrada, Andres A.; Gonzalez, Wendy; Brown, Nelson; Zuniga, Leandro

Article ISI SCOPUS
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2019)

A filamentous bacteriophage targeted to carcinoembryonic antigen induces tumor regression in mouse models of colorectal cancer.

Murgas, Paola; Bustamante, Nicolás; Araya, Nicole; Cruz-Gómez, Sebastián; Durán, Eduardo; Gaete, Diana; Oyarce, César; López, Ernesto; Herrada, Andrés Alonso; Ferreira, Nicolás; Pieringer, Hans; Lladser, Alvaro

Article
Cancer immunology, immunotherapy => CII  (2018)

Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis.

Karmaus, Peer W F; Herrada, Andrés A; Guy, Cliff; Neale, Geoffrey; Dhungana, Yogesh; Long, Lingyun; Vogel, Peter; Avila, Julian; Clish, Clary B; Chi, Hongbo

Article
The Journal of experimental medicine  (2017)

Disease Prevention=> An Opportunity to Expand Edible Plant-Based Vaccines?

Concha C, Cañas R; Macuer J, Torres MJ; Herrada AA, Jamett F

Article
Vaccines (Basel)  (2017)

Disease Prevention=> An Opportunity to Expand Edible Plant-Based Vaccines?

Concha, Christopher; Cañas, Raúl; Macuer, Johan; Torres, María José; Herrada, Andrés A; Jamett, Fabiola; Ibáñez, Cristian

Article
Vaccines  (2017)

Spironolactone Decreases DOCA-Salt-Induced Organ Damage by Blocking the Activation of T Helper 17 and the Downregulation of Regulatory T Lymphocytes

Amador, Cristian A; Barrientos, Victor; Peña, Juan; Herrada, Andres A.; Gonzalez, Magdalena; Valdes, Solange; Carrasco, Loreto; Alzamora, Rodrigo; Figueroa, Fernando; Kalergis, Alexis M; Michea, Luis

Article ISI SCOPUS
HYPERTENSION  (2014)

Spironolactone Decreases DOCA-Salt-Induced Organ Damage by Blocking the Activation of T Helper 17 and the Downregulation of Regulatory T Lymphocytes

Amador, Cristian A.; Barrientos, Victor; Pena, Juan; Herrada, Andres A.; Gonzalez, Magdalena; Valdes, Solange; Carrasco, Loreto; Alzamora, Rodrigo; Figueroa, Fernando; Kalergis, Alexis M.; Michea, Luis

Article
Hypertension  (2014)

Haem oxygenase 1 expression is altered in monocytes from patients with systemic lupus erythematosus

Herrada A.A.; Llanos, C.; Mackern-Oberti J.P.; Carreño L.J.; Henriquez, C; Gómez R.S.; Gutiérrez M.A.; Anegon, I; Jacobelli S.H.; Kalergis, A.M.

Article ISI SCOPUS
Immunology  (2012)

Haem oxygenase 1 expression is altered in monocytes from patients with systemic lupus erythematosus

Herrada A.A.; Llanos, C; Mackern-Oberti J.P.; Carreno L.J.; Henriquez, C; Gómez R.S.; Gutierrez M.A.; Anegon, I; Jacobelli S.H.; Kalergis A. M.

Article
Immunology  (2012)

Harnessing DNA-induced immune responses for improving cancer vaccines.

Herrada, Andrés A; Rojas-Colonelli, Nicole; González-Figueroa, Paula; Roco, Jonathan; Oyarce, César; Ligtenberg, Maarten A; Lladser, Alvaro

Article
Human vaccines & immunotherapeutics  (2012)

Stimulation of Dopamine Receptor D5 Expressed on Dendritic Cells Potentiates Th17-Mediated Immunity

Prado C; Contreras, F; GONZALEZ, H; Díaz P; Elgueta, D; Barrientos M.; Herrada A.A.; Lladser, A; Bernales S.; Pacheco R.

Article ISI SCOPUS
JOURNAL OF IMMUNOLOGY  (2012)

Stimulation of dopamine receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity.

Prado, Carolina; Contreras, Francisco; González, Hugo; Díaz, Pablo; Elgueta, Daniela; Barrientos, Magaly; Herrada, Andrés A; Lladser, Álvaro; Bernales, Sebastián; Pacheco, Rodrigo

Article
Journal of immunology (Baltimore, Md. : 1950)  (2012)

Aldosterone as a modulator of immunity. Implications in the organ damage

Herrada AA, Campino C; Amador C.A, Michea L.F; Fardella C.E, and Kalergis. A.M

Article
The Journal of Hypertension  (2011)

Aldosterone Promotes Autoimmune Damage by Enhancing Th17-Mediated Immunity

Herrada, AA; Contreras, FJ; Marini, NP; Amador, CA; Gonzalez, PA; Cortes, CM; Riedel, CA; Carvajal, CA; Figueroa F; Michea, LF; Fardella CE; Kalergis, AM

Article
JOURNAL OF IMMUNOLOGY  (2010)

Modulation of nuclear factor-kappa B activity can influence the susceptibility to systemic lupus erythematosus

Kalergis, AM; Iruretagoyena, MI; Barrientos MJ; Gonzalez, PA; Herrada, AA; Leiva, ED; Gutierrez MA; Riedel, CA; Bueno, SM; Jacobelli, SH

Article
Immunology  (2009)

Primary aldosteronism can alter peripheral levels of transforming growth factor beta and tumor necrosis factor alpha

Carvajal, CA; Herrada, AA; Castillo, CR; Contreras, FJ; Stehr, CB; Mosso, LM; Kalergis, AM; Fardella CE

Article
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION  (2009)

Primary aldosteronism can alter peripheral levels of transforming growth factor beta and tumor necrosis factor alpha.

Carvajal, C A; Herrada, A A; Castillo, C R; Contreras, F J; Stehr, C B; Mosso, L M; Kalergis, A M; Fardella, C E

Article
Journal of endocrinological investigation  (2009)

Immune complex-induced enhancement of bacterial antigen presentation requires Fc gamma Receptor III expression on dendritic cells

Herrada, AA; Contreras, FJ; Tobar, JA; Pacheco R.; Kalergis, AM

Article
Proceedings of the National Academy of Sciences of the United States of America  (2007)

Immune complex-induced enhancement of bacterial antigen presentation requires Fcgamma receptor III expression on dendritic cells.

Herrada, Andrés A; Contreras, Francisco J; Tobar, Jaime A; Pacheco, Rodrigo; Kalergis, Alexis M

Article
Proceedings of the National Academy of Sciences of the United States of America  (2007)

Molecular mechanisms used by Salmonella to interfere with Dendritic Cell function

Bueno S, Herrada AA and Kalergis A.M.

Article
INMUNOLOGIA  (2005)

Abstract (1)

Heme oxygenase-1 expression were decreased in monocytes from Systemic Lupus Erithematosus patients

Mackern, J; Llanos, C.; Herrada, A; Leandro, C; Gomez, R; Anegon, I; Jacobelli, S.; Kalergis, A

Abstract ISI
JOURNAL OF IMMUNOLOGY  (2012)

Proyecto (17)

Estudio intervencional, aleatorizado, controlado y simple ciego para evaluar efectividad de Yerba Mate como nutracéutico complementario a tratamiento de primera línea en pacientes con EMRR en el control inflamatorio clínico y subclínico de la enfermedad

Escobedo N; Lorna Galleguillos Goiry; Herrada, AA; PRADO, CAROLINA ELIZABETH

Proyecto
 (2023)

Role of meningeal lymphatic endothelial cell-secreted Reelin in the modulation of meningeal macrophage polarization and neuroinflammation during sialidosis

Andrés A Herrada; Noelia Escobedo

Proyecto
 (2023)

Role of lysosomal sialidase Neu1 in meningeal lymphatic vasculature dysfunction and neuroinflammation

Escobedo N; Herrada, AA

Proyecto
 (2020)

Evaluación de poblaciones de linfocitos T vírgenes y citoquinas proinflamatorias en sangre de poblaciones de adultos mayores autovalentes o dependientes de la Región del Maule

Universidad Autónoma de Chile (UA-EN2018-20)

Proyecto
2019-2020
Inv. Principal

Role of lymphatic vasculature in the development of brain and kidney damage during Systemic Lupus Erythematosus

Herrada, AA

Proyecto
 (2019)

Role of Lymphatic Vasculature in the development of Multiple Sclerosis

National Multiple Sclerosis Society (PP-1805-30965)

Proyecto
2018-2019
Inv. Responsable

Validación de biomarcadores para la generación de un test de detección temprana de linfedema primario y secundario

Universidad Autónoma de Chile (UA17-04)

Proyecto
2018-2019
Coinvestigador(a)

International collaboration Chile-Mayo Clinic for genetic evaluation of naive T cells from chilean and american SLE patients and controls

PCI (REDI170651)

Proyecto
2017-2019
Inv. Responsable

The MKP-1/p38 axis=> coordinating innate and adaptive immunity National

National Institute of Health (R01NS064599)

Proyecto
2015-2017
Postdoctorado

Role of NRP-1 expressed on Tregs in the Onset and Development of Diabetes

PEW (PEW-FELLOW2013)

Proyecto
2013-2015
Inv. Principal

Modulation of dendritic cell function by HO-1 and MR=> implications on autoimmune and cardiovascular disease

PFCHA (AT24100215)

Proyecto
2009-2010
Inv. Responsable

Estudio de la expression y regulación diferencial de los receptores Fcgamma activadores e inhibidores en la célula dendrítica en lupus erimatoso sistémico=> impacto en la activación de linfocitos autorreactivos

FONDECYT (1085281)

Proyecto
2008-2011
Tesista

Millennium institute of Immunology and Immunotherapy

Ministerio de economía, fomento y turismo (P09-016-F)

Proyecto
2007-2010
Tesista

MODULATION OF DENDRITIC CELL FUNCTION BY HO-1 AND MR=> IMPLICATIONS ON AUTOIMMUNE AND CARDIOVASCULAR DISEASE

PFCHA (21070429)

Proyecto
2007-2010
Inv. Responsable

Novel Therapeutic and Prophylactic Strategies to Control Mucosal Infections by South American bacterial strains

European union (INCO-2006-CT-032296)

Proyecto
2006-2008
Tesista

Estudio de las interacciones moleculares necesarias para la sinapsis inmunológica entre la célula dendrítica y el linfocito Y=> implicaciones en la inmunidad anti-bacteriana

FONDECYT (1030557)

Proyecto
2005-2008
Tesista

Generacion de una vacuna recombinante contra el virus respiratorio sincicial

FONDEF (D04I1075)

Proyecto
2005-2007
Tesista

Review (4)

The role of regulatory T cells and follicular T helper cells in HBV infection

Lin, Nengqi; Yin, Wei; Miller, Heather; Byazrova, Maria G.; Herrada, Andres A.; Benlagha, Kamel; Lee, Pamela; Guan, Fei; Lei, Jiahui; Gong, Quan; Yan, Youqing; Filatov, Alexander; Liu, Chaohong

Review ISI
FRONTIERS IN IMMUNOLOGY  (2023)

The regulation of DOCK family proteins on T and B cells

Chen, Yuanyuan; Chen, Yan; Yin, Wei; Han, Hong; Miller, Heather; Li, Jianrong; Herrada, Andres A.; Kubo, Masato; Sui, Zhiwei; Gong, Quan; Liu, Chaohong

Review ISI
JOURNAL OF LEUKOCYTE BIOLOGY  (2021)

The role of ubiquitinase in B cell development and function

Zhang, Tong; Sun, Jianxuan; Cheng, Jiali; Yin, Wei; Li, Jingwen; Miller, Heather; Herrada, Andres A.; Gu, Heng; Song, Hongmei; Chen, Yan; Gong, Quan; Liu, Chaohong

Review ISI
JOURNAL OF LEUKOCYTE BIOLOGY  (2021)

Molecular mechanisms used by Salmonella to interfere with dendritic cell function

Bueno, S. M.; Herrada A.A.; Kalergis, A.M.

Review SCOPUS
Inmunologia  (2005)

22
Andres Herrada

Principal Investigator

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Talca, Chile

5
Noelia Escobedo

Profesor Asistente

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Talca, Chile

4
Alexis Kalergis

Full Professor

Microbiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

3
Carolina Llanos

Associate Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

1
HUGO GONZALEZ

Associate Professor

Fundación Ciencia y Vida

Santiago, Chile

1
Armando Rojas

Profesor Titular, Director de Laboratorio Investigaciones Biomédicas

Ciencias Preclínicas

FACULTAD DE MEDICINA, UNIVERSIDAD CATOLICA DEL MAULE

Talca, Chile

1
Loreto Cuitiño

Investigador Asociado

Oftalmología

Hospital Clínico Universidad de Chile

229788866, Chile

1
Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

1
Alexandra Olate

1
Mirentxu Iruretagoyena

Jefe Seccion Inmunologia

Laboratorio Clinico

Clinica Alemana de Santiago

Santiago, Chile

1
Rodrigo Valenzuela

Postdoctorado

Oftalmología

Universidad de Chile

Santiago, Chile

1
Leandro Zuñiga

Profesor Asociado

Medicine

Universidad de Talca

Talca, Chile

1
Nelson Brown

Associate Professor

University of Talca

Talca, Chile

1
Emilia Escalona

Investigador postdoctoral

Universidad Autónoma de Chile

Talca , Chile

1
Juan Peña

Director Medico

Servicios Veterinarios especializados VETCO

santiago, Chile

1
Susan Bueno

Profesor Asociado

Genética Molecular y Microbiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Cristián Amador

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

1
Francisco Contreras

Investigador en área de Investigación y Desarrollo de productos biológicos

Centrovet Ltda.

Santiago, Chile

1
Carolina Prado

Investigador Joven

Fundacion Ciencia y Vida

Santiago, Chile

1
Fernando Figueroa

Director

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago de Chile, Chile

1
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Patricia Diaz

Academic

University of Connecticut Health Center

Farmington, CT, Estados Unidos

1
Rodrigo Alzamora

ASSISTANT PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

1
Gonzalo Riadi

Assistant Professor

Bioinformatics

Universidad de Talca

Talca, Chile

1
Pablo Díaz

Professional/Scientific advisor

Scientific Affairs

Instituto de Salud Públida de Chile

santiago, Chile

1
Leandro Carreño

Profesor Asistente

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
Sebastian Bernales

Founder

Merken Biotech

Santiago, Chile

1
Angel Cayo

ACADÉMICO INVESTIGADOR

MEDICINA TRASLACIONAL

Universidad Católica del Maule

TALCA, Chile