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Sebastian Bernales Odino

Founder

Merken Biotech

Santiago, Chile

Development in the area of Biopharmaceutical, development of new therapies to treat chronic diseases in patients have limited treatment options.

Cell Biology, UNIVERSITY OF CALIFORNIA-SAN FRANCISCO. Estados Unidos, 2006
Science, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1995
Biochemistry, CATHOLIC UNIVERSITY OF AMERICA. Chile, 2000

Doctoral Student Full Time

UNIVERSITY OF CALIFORNIA-SAN FRANCISCO

Peter Walter

San Francisco, CA, Estados Unidos

2001 - 2006
Postdoctoral Fellow Full Time

UNIVERSITY OF CALIFORNIA-SAN FRANCISCO

Marc Shuman

San Francisco CA, Estados Unidos

2007 - 2009
Research Assistant Full Time

Millennium Institute

Santiago, Chile

2001 - 2001
HHMI research student Full Time

UNIVERSITY OF CALIFORNIA-SAN FRANCISCO

Santiago, Estados Unidos

2000 - 2000

Vice presidend of discovery biology Full Time

Medivation inc.

San Francisco, California, Estados Unidos

2015 - 2016
Founder Other

Merken Biotech

Santiago, Chile

2016 - At present
Senior Director of research Full Time

Medivation inc.

San Francisco, California, Chile

2013 - 2015
Director of research Full Time

Medivation Inc.

San Francisco, CA, Estados Unidos

2011 - 2013
Associate Director of research Full Time

Medivation Inc.

San Francisco, CA, Chile

2011 - 2011
Consultant Full Time

Medivation Inc.

San Francisco, CA, Chile

2007 - 2011
Director of International Programs Other

Fundacion Ciencia & Vida

Santiago, Chile

2007 - At present
Scientific Director Other

EcoScience

Santiago, Chile

2007 - At present
CEO Full Time

Praxis Biotech LLC

San Francisco, California, Estados Unidos

2016 - At present

Pregrado,
Jorge Cerda, Estudio de la respuesta a proteinas mal plegadas en la mitocondria (mtUPR)

Postgrado:
Sebastian Belmar, Estudio del Receptor huérfano tipo-receptor tirosina quinasa 2 (Ror2) como blanco farmacológico para la terapia de lesiones osteolíticas.
Gonzalo Ureta, Inhibicion selectiva de la translocacion de proteinas del reticulo endoplasmico como posible tratamiento contra el mieloma multiple.
Luz Delgado, Caracterización del efecto de latrepirdina en modelos de sobreexpresión de alfa-sinucleina.
Daniela Perez, Regulacion citosolica de UPR por Ak.
Marisol Morales, Transactivation of IRE1 and PERK by a small kinase inhibitor molecule.
Carolina Garri,Cell-based high-throughput screening for the discovery of small molecule modulators of the ATF6 branch of the unfolded protein response pathway.

Postdoctoral:
Jennifer Alfaro, Unfolded Protein Response, Drug Discovery for oncology
Ivan Alfaro, Drug Discovery for Neurodegenerative Diseases
Javier Guerrero,Drug discovery for Oncology
Eduardo Riquelme, Drug discovery for metabolic Diseases
Marcelo Chacon, Alzheimer's Disease
Mónica Rodrigo-Breni, Unfolded Protein Responce in disease
Alejandro Amoroso,Unfolded Protein Responce in disease
Erwin De la Fuente,The Unfolded Protein Response and Autophagy During Prostate Cancer Development.
Emma McCullagh,Unfolded Protein Response
Sebastian Belmar, ,Drug discovery for Oncology
Gonzalo Ureta, ,Drug discovery for Oncology
Luz Delgado ,Drug discovery for Oncology

Premio a la Trayectoria Innovadora Anacleto Angelini

Avonni

Chile, 2020

El Premio de Innovación Avonni es el reconocimiento honorífico más importante de Chile, que busca visibilizar los casos de éxito que están creando valor mediante la innovación en distintos rubros y categorías.


Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer’s disease Oliveira, Mauricio M.; Lourenco, Mychael V.; Longo, Francesco; Kasica, Nicole P.; Yang, Wenzhong; Ureta, Gonzalo; Ferreira, Danielle D. P.; Mendonça, Paulo H. J.; Bernales, Sebastian; Ma, Tao; De Felice, Fernanda G.; Klann, Eric; Ferreira, Sergio T. Article SCIENCE SIGNALING (2021)
Integrated Stress Response Inhibitor Reverses Sex-Dependent Behavioral and Cell-Specific Deficits after Mild Repetitive Head Trauma Krukowski, Karen; Nolan, Amber; Frias, Elma S.; Grue, Katherine; Becker, McKenna; Ureta, Gonzalo; Delgado, Luz; Bernales, Sebastian; Sohal, Vikaas S.; Walter, Peter; Rosi, Susanna Article ISI JOURNAL OF NEUROTRAUMA (2020)
Small molecule cognitive enhancer reverses age-related memory decline in mice Krukowski, Karen; Nolan, Amber; Frias, Elma S.; Boone, Morgane; Ureta, Gonzalo; Grue, Katherine; Paladini, Maria-Serena; Elizarraras, Edward; Delgado, Luz; Bernales, Sebastian; Walter, Peter; Rosi, Susanna Article ISI ELIFE (2020)
Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors Ramachandran, Sreekanth A.; Jadhavar, Pradeep S.; Miglani, Sandeep K.; Singh, Manvendra P.; Kalane, Deepak P.; Agarwal, Anil K.; Sathe, Balaji D.; Mukherjee, Kakoli; Gupta, Ashu; Haldar, Srijan; Raja, Mohd; Singh, Siddhartha; Pham, Son M.; Chakravarty, Sarvajit; Quinn, Kevin; Belmar, Sebastian; Alfaro, Ivan E.; Higgs, Christopher; Bernales, Sebastian; Herrera, Francisco J.; Rai, Roopa Article ISI SCOPUS BIOORGANIC MEDICINAL CHEMISTRY LETTERS (2017)
Dual Inhibition of Bruton's Tyrosine Kinase and Phosphoinositide-3-Kinase p110 delta as a Therapeutic Approach to Treat Non-Hodgkin's B Cell Malignanciess Alfaro, Jennifer; Pérez de Arce, Felipe; Belmar, Sebastián; Fuentealba, Glenda; Avila, Patricio; Ureta, Gonzalo; Flores, Camila; Acuña, Claudia; Delgado, Luz; Gaete, Diana; Pujala, Brahmam; Barde, Anup; Nayak, Anjan K.; Upendra, T. V. R.; Patel, Dhananjay; Chauhan, Shailender; Sharma, Vijay K.; Kanno, Stacy; Almirez, Ramona G.; Hung, David T.; Chakravarty, Sarvajit; Rai, Roopa; Bernales, Sebastián; Quinn, Kevin P.; Pham, Son M.; McCullagh, Emma Article ISI JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2017)
Novel 3-methylindoline inhibitors of EZH2: Design, synthesis and SAR Ansari, Amantullah; Satalkar, Sharad; Patil, Varshavekumar; Shete, Amit S.; Kaur, Simranjeet; Gupta, Ashu; Singh, Siddhartha; Raja, Mohd.; Severance, Daniel L.; Bernales, Sebastián; Chakravarty, Sarvajit; Hung, David T.; Pham, Son M.; Herrera, Francisco J.; Rai, Roopa Article Bioorganic and Medicinal Chemistry Letters (2017)
Discovery of Pyrazolopyrimidine Derivatives as Novel Dual Inhibitors of BTK and PI3K delta Pujala, Brahmam; Agarwal, Anil K.; Middya, Sandip; Banerjee, Monali; Surya, Arjun; Nayak, Anjan K.; Gupta, Ashu; Khare, Sweta; Guguloth, Rambabu; Randive, Nitin A.; Shinde, Bharat U.; Thakur, Anamika; Patel, Dhananjay I.; Raja, Mohd.; Green, Michael J.; Alfaro, Jennifer; Avila, Patricio; Pérez de Arce, Felipe; Almirez, Ramona G.; Kanno, Stacy; Bernales, Sebastián; Hung, David T.; Chakravarty, Sarvajit; McCullagh, Emma; Quinn, Kevin P.; Rai, Roopa; Pham, Son M. Article ISI SCOPUS ACS MEDICINAL CHEMISTRY LETTERS (2016)
Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors Jadhavar, Pradeep S. Ramachandran, Sreekanth A. Riquelme, Eduardo. Gupta, Ashu. Quinn, Kevin P. Shivakumar, Devleena. Ray, Soumya. Zende, Dnyaneshwar. Nayak, Anjan K. Miglani, Sandeep K. Sathe, Balaji D. Raja, Mohd. Farias, Olivia. Alfaro, Iva Article ISI SCOPUS BIOORGANIC MEDICINAL CHEMISTRY LETTERS (2016)
Temozolomide analogs with improved brain/plasma ratios - Exploring the possibility of enhancing the therapeutic index of temozolomide Rai, Roopa; Banerjee, Monali; Wong, Darren H.; McCullagh, Emma; Gupta, Ashu; Tripathi, Shailendra; Riquelme, Eduardo; Jangir, Ramnivas; Yadav, Shyamraj; Raja, Mohd.; Melkani, Pankaj; Dixit, Vikas; Patil, Umesh; Shrivastava, Ritesh; Middya, Sandip; Olivares, Felipe; Guerrero, Javier; Surya, Arjun; Pham, Son M.; Bernales, Sebastián; Protter, Andrew A.; Hung, David T.; Chakravarty, Sarvajit Article ISI SCOPUS BIOORGANIC MEDICINAL CHEMISTRY LETTERS (2016)
Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic Mendez, Aaron S; Alfaro, Jennifer; Morales-Soto, Marisol A; Dar, Arvin C; McCullagh, Emma; Gotthardt, Katja; Li, Han; Acosta-Alvear, Diego; Sidrauski, Carmela; Korennykh, Alexei V; Bernales, Sebastian; Shokat, Kevan M; Walter, Peter Article SCOPUS eLife (2015)
Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide Cochrane DR; Bernales S.; Jacobsen BM; Cittelly DM; Howe EN; D'Amato NC; Spoelstra NS; Edgerton SM; Jean A; Guerrero, J; Gomez, F; Medicherla S; alfaro ie; McCullagh E; Jedlicka P.; Torkko KC; Thor AD; Elias AD; Protter AA; Richer, JK Article ISI BREAST CANCER RESEARCH (2014)
Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide. Cochrane, Dawn R; Bernales, Sebastián; Jacobsen, Britta M; Cittelly, Diana M; Howe, Erin N; D'Amato, Nicholas C; Spoelstra, Nicole S; Edgerton, Susan M; Jean, Annie; Guerrero, Javier; Gómez, Francisco; Medicherla, Satyanarayana; Alfaro, Iván E; McCullagh, Emma; Jedlicka, Paul; Torkko, Kathleen C; Thor, Ann D; Elias, Anthony D; Protter, Andrew A; Richer, Jennifer K Article Breast cancer research : BCR (2014)
Dopamine Receptor D3 Expressed on CD4(+) T Cells Favors Neurodegeneration of Dopaminergic Neurons during Parkinson's Disease GONZALEZ, H; Contreras, F; Prado C; Elgueta, D; Franz D.; Bernales S.; Pacheco R. Article ISI SCOPUS JOURNAL OF IMMUNOLOGY (2013)
Enzalutamide, an androgen receptor signaling inhibitor, induces tumor regression in a mouse model of castration-resistant prostate cancer Guerrero, J; alfaro ie; Gomez, F; Protter AA; Bernales S. Article ISI SCOPUS Prostate (2013)
Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model Steele JW; Lachenmayer ML; Ju S; Stock A; Liken J; Kim, SH; Delgado LM; alfaro ie; Bernales S.; Verdile G; Bharadwaj, P; Gupta, V; Barr R; Friss A; Dolios G; Wang, R; Ringe D; Fraser, P; Westaway D; St George-Hyslop, PH; Szabo P; Relkin NR; Buxbaum JD; Glabe CG; Protter AA; Martins RN; Ehrlich ME; Petsko GA; Yue Z; Gandy S. Article ISI SCOPUS MOLECULAR PSYCHIATRY (2013)
Latrepirdine stimulates autophagy and reduces accumulation of alpha-synuclein in cells and in mouse brain Steele JW; Ju S; Lachenmayer ML; Liken J; Stock A; Kim, SH; Delgado LM; alfaro ie; Bernales S.; Verdile G; Bharadwaj, P; Gupta, V; Barr R; Friss A; Dolios G; Wang, R; Ringe D; Protter AA; Martins RN; Ehrlich ME; Yue Z; Petsko GA; Gandy S. Article ISI SCOPUS MOLECULAR PSYCHIATRY (2013)
Modulation of T-cell Mediated Immunity by Dopamine Receptor D5 Prado C; Bernales S.; Pacheco R. Article ISI SCOPUS ENDOCRINE METABOLIC IMMUNE DISORDERS-DRUG TARGETS (2013)
Stimulation of Dopamine Receptor D5 Expressed on Dendritic Cells Potentiates Th17-Mediated Immunity Prado C; Contreras, F; GONZALEZ, H; Díaz P; Elgueta, D; Barrientos M.; Herrada A.A.; Lladser, A; Bernales S.; Pacheco R. Article ISI SCOPUS JOURNAL OF IMMUNOLOGY (2012)
Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration. Bernales, Sebastián; Soto, Marisol Morales; McCullagh, Emma Article Frontiers in aging neuroscience (2012)
Cognition-Enhancing Properties of Dimebon in a Rat Novel Object Recognition Task Are Unlikely to Be Associated with Acetylcholinesterase Inhibition or N-Methyl-D-aspartate Receptor Antagonism Giorgetti M; Gibbons JA; Bernales S.; alfaro ie; La Rochelle, CD; Cremers T; Altar CA; Wronski R; Hutter-Paier, B; Protter AA Article ISI SCOPUS Journal of Pharmacology and Experimental Therapeutics (2010)
Role of dopamine in the physiology of T-cells and dendritic cells. Pacheco, Rodrigo; Prado, Carolina E; Barrientos, Magaly J; Bernales, Sebastián Article Journal of neuroimmunology (2009)
The unfolded protein response during prostate cancer development. So, Alex Yick-Lun; de la Fuente, Erwin; Walter, Peter; Shuman, Marc; Bernales, Sebastián Article Cancer metastasis reviews (2009)
ER-phagy: Selective autophagy of the endoplasmic reticulum Bernales S.; Schuck, S; Walter P. Article SCOPUS AUTOPHAGY (2007)
Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response Bernales, Sebastián; McDonald, Kent L; Walter, Peter; Ploegh, Hidde Article PLoS Biology (2006)
Eisosomes mark static sites of endocytosis Walther, Tobias C.; Brickner, Jason H.; Aguilar, Pablo S.; Bernales, Sebastián; Pantoja, Carlos; Walter, Peter Article Nature Cell Biology (2006)
Intracellular Signaling by the Unfolded Protein Response Bernales, Sebastián; Papa, Feroz R.; Walter, Peter Article Annual Review of Cell and Developmental Biology (2006)
IRE1-Independent Gain Control of the Unfolded Protein Response Leber, Jess H; Bernales, Sebastián; Walter, Peter; Steven McKnight Article PLoS Biology (2004)
The complete sequence of the mitochondrial genome of the Chinook salmon, Oncorhyncus tshawytscha Wilhelm, V; Villegas, J; Engel E.; Bernales S.; Valenzuela P.D.T.; Burzio L.O.; Miquel, A Article SCOPUS BIOLOGICAL RESEARCH (2003)


Compositions containing repair cells and cationic dyes Emma MCCULLAGH; Sebastian Bernales; David Hung Patent Published (2017)
Pellet composition containing repair cells Emma MCCULLAGH; Sebastian Bernales; David Hung Patent Published (2017)
Srebp blockers for use in treating liver fibrosis, elevated cholesterol and insulin resistance Sebastian Bernales; Jeffrey Lindquist; Mausumee Guha Patent Published (2016)
Sterol regulatory element-binding proteins (srebps) inhibitors Brahmam PUJALA; Ramniwas JANGIR; Rambabu GUGULOTH; Bharat Uttam SHINDE; Roopa Rai; Son Minh Pham; Sebastian Bernales; Jeffrey Lindquist; Mausumee Guha; Satyanarayana KALLEM; Bhawana BHATT; Vikas Ramdas BHAGWAT Patent Published (2016)
Compounds and treatment methods Bernales, Sebastian; Andrew A. Protter; David T. Hung; Sarvajit Chakravarty Patent Published (2013)
Treatment methods Andrew A. Protter; David T. Hung; Sarvajit Chakravarty; Sebastian Bernales Patent Published (2013)
Methods and compositions for modulating IRE1, SRC, and ABL activity Bernales, Sebastian; Peter Walter; Alexei Korennykh; Kevan M. Shokat; Chao Zhang; Janet Finer-Moore; Robert Stroud; Pascal Egea; Andrei Korostelev; Arvin Da Patent Published (2011)
Targeted therapeutics David Hung; Sarvajit Chakravarty; Roopa Rai; Sebastian Bernales; Balaji Dashrath SATHE; Gonzalo URETA; Emma MCCULLAGH Patent Published
Treatment methods using diarylthiohydantoin derivatives Andrew A. Protter; David T. Hung; Sarvajit Chakravarty; Sabastian BERNALES, Patent Published


BETA-CARBOLINE MODULATORS OF CHAPERONE MEDIATED AUTOPHAGY FONDECYT (1131137) Proyecto 2013-2016 Inv. Responsable
Beta-Carboline modulators of chaperone mediated autophagy Bernales, Sebastian; Walter, Peter Proyecto (2013)
Deciphering the role of the unfolded protein response in disease Bernales, Sebastian; Walter, Peter Proyecto (2009)
ROLE OF DOPAMINE RECEPTORS ON T-CELL MEDIATED IMMUNITY FONDECYT (1095114) Proyecto 2009-2013 Coinvestigador(a)
Role Of Dopamine Receptors On T-Cell Mediated Immunity Pacheco, Rodrigo; Bernales, Sebastian Proyecto (2009)
AUTOFAGIA Y UPR DURANTE LA PROGRESION DEL CANCER FONDECYT (1080449) Proyecto 2008-2012 Inv. Responsable
Autophagy & UPR during cancer progression Bernales, Sebastian Proyecto (2008)
HIGADO GRASO NO ALCOHOLICO=> ESTUDIOS CLINICOS Y EXPERIMENTALES SOBRE EL ROL DE LOS ACIDOS BILIARES, LAS ADIPOQUINAS Y EL ESTRES DEL RETICULO ENDOPLASMICO FONDECYT (1080170) Proyecto 2008-2011 Coinvestigador(a)
Non-alcoholic fatty liver: clinical and experimental studies about the role of bile acids, adipokines and ER stress Arrese-Jimenez, Marco; Pizarro, Margarita; Bernales, Sebastian; Riquelme, Arnoldo; Miquel, Juan Francisco Proyecto (2008)


Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration Bermales S.; Soto M.M.; McCullagh E Review ISI SCOPUS FRONTIERS IN AGING NEUROSCIENCE (2012)
Role of dopamine in the physiology of T-cells and dendritic cells Pacheco R.; Prado CE; Barrientos MJ; Bernales S. Review ISI SCOPUS Journal of Neuroimmunology (2009)
The unfolded protein response during prostate cancer development So, A; De La Fuente E.; Walter P.; Shuman M; Bernales S. Review ISI SCOPUS Cancer and Metastasis Reviews (2009)