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HUGO ARNALDO GONZALEZ VELOZO

Associated Investigator

Universidad San Sebastián

Santiago, Chile

Cancer Biology, Metastasis, tumor-immune crosstalk, Bioinformatics, Cancer System Biology.

Tecnologia Medica, UNIVERSIDAD DE TALCA. Chile, 2005
Tecnologo Medico, UNIVERSIDAD DE TALCA. Chile, 2005
Molecular Biology, UNIVERSIDAD ANDRES BELLO. Chile, 2013

PhD Candidate and Professor Full Time

UNIVERSIDAD ANDRES BELLO

Biological Sciences

Santiago, Chile

2008 - 2010
PhD Candidate Full Time

FUNDACION CIENCIA PARA LA VIDA

Santiago, Chile

2009 - 2014
POSTDOCTORAL FELLOW Full Time

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

SAN FRANCISCO, Estados Unidos

2015 - 2022
Assistant Adjunct Professor Full Time

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

San Francisco, Estados Unidos

2022 - At present
Associate Professor Full Time

Fundacion Ciencia y Vida

Santiago, Chile

2023 - At present
Investigador Asociado Full Time

UNIVERSIDAD SAN SEBASTIAN

Centro Basal Ciencia y Vida

Santiago, Chile

2025 - At present

Postdoctoral Fellow Full Time

University of California San Francisco

San Francisco, Estados Unidos

2015 - 2022
PhD candidate and postdoctoral researcher Full Time

Fundacion Ciencia y Vida

Santiago, Chile

2009 - 2014
Teaching assistant Full Time

Universidad Andres Bello

Santiago, Chile

2008 - 2010
Assistant Adjunct Professor Full Time

University of California San Francisco

San Franciso, Estados Unidos

2022 - At present
Associate Professor Full Time

Fundacion Ciencia y vida

Santiago, Chile

2023 - At present
Investigador Asociado Centro Basal Ciencia y Vida Full Time

Universidad San Sebastian

Santiago, Chile

2025 - At present

MENTORING AND TEACHING EXPERIENCE
Mentoring (Alumni)

• Master program mentor for Merel van Gogh, University of Utrecht, Netherlands. Current appointment: PhD candidate at University of Zurich.

• Master program Mentor for Tamara Verbeek, University of Utrecht, Netherlands. Current appointment: PhD student at University of Utrecht.

• Mentor for Wenbin Mei, Peking University, China (intern). Current appointment: PhD candidate at Rockefeller University.

• Mentor for Isabella Robles, University of California Berkeley (intern). Current appointment: Stanford University.

• Mentor for Sandhya Kalavacherla, Massachusetts Institute of Technology (MIT) (intern). Current appointment: University of California San Diego.

• Mentor for Stephen Georgiou, University of California Berkeley (intern). Current appointment: University of California San Francisco.

• Mentor for Ankitha Nanjaraj, University of California San Francisco (Research Associated). Current appointment: Sangamo Therapeutics Inc.

Collaborations with biopharmaceutical companies in the USA.

• Company: 3T BIOSCIENCES INC.
Location: South San Francisco, CA, USA.
Dates of collaboration: (12/2020-12/2021).
Role: Scientific advisor in developing new ex-vivo systems for testing next-generation T cell therapies against solid cancers.

• Company: SENTI BIOSCIENCES, INC.
Location: South San Francisco, CA, USA.
Dates of collaboration: (08/2021-Present).
Role: Scientific advisor and collaborator in developing next-generation NK cell therapies for carcinomas.

BECA DE POSTDOCTORADO EN EL EXTRANJERO BECAS CHILE

CONICYT

Chile, 2015

Scholarship to perform postdoctoral training in an international institution.
BECA DE DOCTORADO EN CHILE

CONICYT

Chile, 2010

Scholarship for Ph.D. studies in Chile.
BECAS DE TÉRMINO DE TESIS DOCTORAL

CONICYT

Chile, 2012

Scholarship to fund the completion of doctoral dissertation.
Summa Cum Laude Distinction for doctoral dissertation.

UNIVERSIDAD ANDRES BELLO

Chile, 2013

Doctoral dissertation evaluated with the highest distinction.
Elected Member of the UCSF Hellen Diller Family Comprehensive Cancer Center

University of California San Francisco

Estados Unidos, 2023

Elected member of the Breast Oncology Program at the UCSF Hellen Diller Family Comprehensive Cancer Center since July 2023
Elected member of the UCSF ImmunoX faculty team

University of California San Francisco

Chile, 2024

Elected member of the UCSF ImmunoX faculty team since August 2024.
Fondecyt number 1230021

ANID

Chile, 2023

Title: Molecular determinants of tumor cell fitness in human brain metastases: connecting transcriptional regulators with metastatic phenotypes Role: Principal Investigator Years: 2023-2027 Total Direct Cost per year: $71,250.00 Description: This study is focused on understanding the gene regulatory networks, and identifying the cis-regulatory elements and transcription factors that mediate the fitness of human metastatic tumor cells.
Conque Cancer Now

CONCERN FOUNDATION

Estados Unidos, 2024

The Concern Foundation (USA) Title: Reprogramming of the Metastatic Niche by Tumor Cell-Derived Factors Role: Principal Investigator Years: 2024-2026 Total Direct Cost per year: $75,000.00 Description: This study aims to validate mechanistically how specific factors secreted by metastatic tumor cells reprogram the composition and activation state of non-malignant cells at the metastatic site. Here we combine high dimensional flow cytometry analyses and molecular cancer biology, with syngeneic system of breast cancer metastasis.
Grant number BCRF-23-183 (USA).

The Breast Cancer Research Foundation.

Estados Unidos, 2024

Title: Eradicating metastatic disease by enhancing breast cancer treatment and anti-tumor immunity Role: Co-Investigator with Professor Valerie Weaver (lead PI) Years: 2023-2024 (renewable annually) Total Direct Cost per year: $187,500.00 Description: This study led by Professor Valerie Weaver aims to study the interface between innate immunity, extracellular matrix and metastatic progression in breast cancer metastasis, my contribution in on studies related to brain metastasis colonization.


Tissue mechanics in tumor heterogeneity and aggression Finger, Anna-Marie; Hendley, Audrey Marie; Figueroa, Diego; Gonzalez, Hugo; Weaver, Valerie Marie Article TRENDS IN CANCER (2025)
Spatial Multiomics Reveals Intratumoral Immune Heterogeneity with Distinct Cytokine Networks in Lung Cancer Brain Metastases Christensson, Gustav; Bocci, Matteo; Kazi, Julhash U.; Durand, Geoffroy; Lanzing, Gustav; Pietras, Kristian; Velozo, Hugo Gonzalez; Hagerling, Catharina Article ISI CANCER RESEARCH COMMUNICATIONS (2024)
Cellular architecture of human brain metastases Allen, Breanna M.; Okholm, Trine Line Hauge; Verbeek, Tamara; Phillips, Joanna J.; Spitzer, Matthew H.; Roose, Jeroen P. Article ISI CELL (2022)
Visualizing Spatial and Stoichiometric Barriers to Bispecific T-Cell Engager Efficacy You, Ran; Artichoker, Jordan; Ray, Arja; Velozo, Hugo Gonzalez; Rock, Dan A.; Conner, Kip P.; Krummel, Matthew F. Article ISI CANCER IMMUNOLOGY RESEARCH (2022)
Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression Timothy Marsh; Candia M Kenific; Deepthisri Suresh; Eliah R Shamir; Alexandra Tankka; Andrew M Leidal; Sandhya Kalavacherla; Kimberly Woo; Jayanta Debnath Article DEVELOPMENTAL CELL (2020)
Immune effector monocyte-neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer Salari, Kiarash; Wang, Chih-Yang; Lin, Charlene; Dejmek, Annika; Jirstrom, Karin Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Immune effector monocyte–neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer Kiarash Salari; Chih-Yang Wang; Charlene Lin; Isabella Robles; Merel van Gogh; Annika Dejmek; Karin Jirström Article PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
STAT3 Activation in combination with NF-KappaB inhibition induces tolerogenic dendritic cells with High therapeutic potential to attenuate collagen-induced arthritis Carolina Prado; Valentina Ugalde; Alicia Figueroa; Alvaro Lladser; Rodrigo Pacheco Article JOURNAL OF IMMUNOLOGY RESEARCH (2019)
Dopaminergic Stimulation of Myeloid Antigen-Presenting Cells Attenuates Signal Transducer and Activator of Transcription 3-Activation Favouring the Development of Experimental Autoimmune Encephalomyelitis Carolina Prado; Michela Gaiazzi; Valentina Ugalde; Alicia Figueroa; Francisco J Osorio-Barrios; Alvaro Lladser; Emanuela Rasini; Franca Marino; Mauro Zaffaroni; Marco Cosentino; et al. Article FRONTIERS IN IMMUNOLOGY (2018)
Innate and acquired immune surveillance in the postdissemination phase of metastasis Isabella Robles Article FEBS (2018)
Roles of the immune system in cancer: from tumor initiation to metastatic progression Article GENES AND DEVELOPMENT (2018)
GATA3 targets semaphorin 3B in mammary epithelial cells to suppress breast cancer progression and metastasis Payam Shahi,; Chih-Yang Wang; Jonathan Chou; H Gonzalez Velozo; Aline Ruderisch; Ying Yu; Ming-Derg Lai Article ONCOGENE (2017)
ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression Payam Shahi,; Chih-Yang Wang; Devon A Lawson; Euan M Slorach; Angela Lu; Ying Yu; Ming-Derg Lai; Hugo Gonzalez Velozo Article PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Dopamine Receptor D3 Signaling on CD4(+) T Cells Favors Th1-and Th17-Mediated Immunity Contreras F.; Prado, C; Gonzalez, H; Franz D.; Osorio-Barrios, F; Osorio, F; Ugalde, V.; Lopez, E.; Elgueta, D; Figueroa, A; et al. Article ISI SCOPUS JOURNAL OF IMMUNOLOGY (2016)
Dopamine receptor D5 deficiency results in a selective reduction of hippocampal NMDA receptor subunit NR2B expression and impaired memory Moraga-Amaro, R.; Gonzalez, H; Ugalde, V.; Donoso-Ramos, JP; Quintana-Donoso, D; Lara, M; Morales, B; Rojas, P; Pacheco R.; Stehberg, J Article ISI SCOPUS NEUROPHARMACOLOGY (2016)
Dopamine receptors D3 and D5 regulate CD4(+) T-cell activation and differentiation by modulating ERK activation and cAMP production Franz D.; Contreras F.; Gonzalez, H; Prado, C; Elgueta, D; Figueroa C; Pacheco R. Article ISI SCOPUS Journal of Neuroimmunology (2015)
Dopamine receptor D3 deficiency results in chronic depression and anxiety Moraga-Amaro, R.; Gonzalez, H; Pacheco R.; Stehberg, J Article ISI SCOPUS BEHAVIOURAL BRAIN RESEARCH (2014)
Neuroprotective effect of the monoacylglycerol lipase inhibitor JZL184 in the chronic MPTP mouse model Fernandez D, Celorrio M; Riezu-Boj J, Ugarte A; Pacheco R, Gonzalez H; Oyarzabal J, Hillard C Article Neurobiology of Aging (2014)
The monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model Fernández-Suárez, Diana; Celorrio, Marta; Riezu-Boj, Jose, I; Pacheco, Rodrigo; Gonzalez, Hugo; Oyarzabal, Julen; Hillard, Cecilia J.; Franco, Rafael; Aymerich, María S. Article ISI SCOPUS NEUROBIOLOGY OF AGING (2014)
Dopamine Receptor D3 Expressed on CD4(+) T Cells Favors Neurodegeneration of Dopaminergic Neurons during Parkinson's Disease Gonzalez, H; Contreras F.; Prado, C; Elgueta, D; Franz D.; Bernales S.; Pacheco R. Article ISI SCOPUS JOURNAL OF IMMUNOLOGY (2013)
Stimulation of Dopamine Receptor D5 Expressed on Dendritic Cells Potentiates Th17-Mediated Immunity Prado, C; Contreras F.; Gonzalez, H; Diaz, P; Elgueta, D; Barrientos M.; Lladser, A; Bernales S.; Pacheco R. Article ISI SCOPUS JOURNAL OF IMMUNOLOGY (2012)


Dopamine receptor D5 expressed on dendritic cells promotes CD4+T-cell-mediated autoinununity Prado, C; Contreras F.; Gonzalez, H; Pacheco R. Abstract ISI JOURNAL OF NEUROIMMUNOLOGY (2012)
Stimulation of dopamine receptor D3 expressed on CD4(+) T-cells favours Th1 immunity Pacheco R.; Contreras F.; Prado, C; Gonzalez, H; Elgueta, D; Franz D. Abstract ISI IMMUNOLOGY (2012)


Role of dopamine receptors expressed on CD4+ T-cell and on dendritic cells in the development of autoimmune response and in cellular mechanisms involved in the physiopathology of multiple sclerosis FONDECYT (1130271.) Proyecto 2013-2017 Tesista
Proyecto de inicio a la investigación para estudiantes de doctorado=> "Papel de los receptores de dopamina expresados en células T CD4+ en el desarrollo de la enfermedad de Parkinson". UNIVERSIDAD NACIONAL ANDRÉS BELLO (DI-133-12/I) Proyecto 2012-2012 Inv. Responsable
Role of dopamine receptors on the T-cell mediated immunity FONDECYT (1095114) Proyecto 2009-2013 Tesista
Financiamiento Basal para Centros Científicos y Tecnológicos de Excelencia FONDEF (PFB-16) Proyecto 2008-2013 Tesista


Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases Gonzalez, Hugo; Elgueta, Daniela; Montoya, Andro; Pacheco, Rodrigo Review ISI SCOPUS JOURNAL OF NEUROIMMUNOLOGY (2014)
T-cell-mediated regulation of neuroinflammation involved in neurodegenerative diseases Gonzalez, H; Pacheco R. Review ISI SCOPUS JOURNAL OF NEUROINFLAMMATION (2014)