Identification of Cellular Stress Responses as Key Regulators of Immunity Role of the Unfolded Protein Response in the coordination of the immune response Molecular Immunology, Biology of antigen presenting cells

• Master Co-supervisor, Master in de Biomedische Wetenschappen. Faculteit Geneeskunde en Gezondheidwetenschappen, Universiteit Gent : Elisabeth Gilis. Thesis entitled “Role of the unfolded protein response and ER stress in the activation of dendritic cells”. Director: Prof Dr Bart Lambrecht, Co-Director : Dra Fabiola Osorio. Academiejaar 2011-2012. Winter-Spring 2012. Ghent, Belgium.

• Thesis director conducing to the degree of Molecular Biotechnology Engineer. Cristobal Javier Costoya Tolosa. Thesis entitled: Thesis entitled “Role of the endoplasmic reticulum stress in dendritic cell function under inflammatory contexts”. September 2014- March 2016.
• Thesis director conducing to the degree of Molecular Biotechnology Engineer. Bernardita Medel. Thesis entitled: “Role of the unfolded protein response sensor IRE1a in cross-presentation of antigens by CD8a+ like DCs”. September 2015- September 2016
• Thesis director conducing to the degree of Molecular Biotechnology Engineer. Antonia Geisse. Thesis entitled: “Role of the unfolded protein response sensor IRE1a in the differentiation of dendritic cells”. July 2017- April 2019.
• Thesis director conducing to the degree of Molecular Biotechnology Engineer. Maria Francisca Gutierrez. Thesis entitled: "Determination of IRE1a activation in secretory and non-secretory organs immune cells from reporter mice for IRE1a RNase activity". October 2018 -Jan 2021
• Thesis director conducing to the degree of Molecular Biotechnology Engineer. Jose Ignacio Bernales. Thesis entitled: "Role of the IRE1a/XBP1 pathway in the regulation of the antigenic presentation machinery in activated dendritic cells". October 2018- Dec 2021
• Thesis director conducing to the degree of Molecular Biotechnology Engineer. Alonso Lira. Thesis entitled: ""Characterization of the constitutive activation of the IRE1a-XBP1 axis and its physiological role in cDC1 generated in vitro". March 2019- March 2021.
• Thesis director conducing to the degree of Molecular Biotechnology Engineer. Maria Jose Vasquez. Thesis entitled: "Transcriptomic study of the activation of the IRE1/XBP1 axis in dendritic cells activated with influenza virus". March 2021- March 2022.
• Thesis director conducing to the degree of Molecular Biotechnology Engineer. Amada Arcaya. Thesis entitled: "Analysis of unfolded protein response genes in metabolic organs". Sept 2022- 2023.
• Thesis director conducing to the degree of Molecular Biotechnology Engineer. Javier Lopez. Thesis entitled: "Regulation of dendritic cell function by the RNase domain of IRE1". Sept 2022- 2023.
• Thesis director conducing to the degree of Molecular Biotechnology Engineer. Paula Lisboa. Thesis entitled: "Metabolic roles of the unfolded protein response sensors XBP1 y ATF6 in dendritic cells". Sept 2024- 2025.
• Thesis director conducing to the degree of Molecular Biotechnology Engineer. Ailin Tapia. Thesis entitled: "Regulation of intestinal innate lymphoid cells by IRE1 expression in myeloid cells". Sept 2024- 2025.
• Thesis director conducing to the degree of Molecular Biotechnology Engineer. Juan Pablo Gonzalez. Thesis entitled: "Control or organelle architecture by the unfolded protein response sensors XBP1 y ATF6 in dendritic cells ". Sept 2025- Present.

• Thesis director conducing to the degree of Master in Biological Sciences. Cristobal Javier Costoya Tolosa. Thesis entitled: Role of the signalling axis IRE1a/XBP1s in dendritic cells during cancer immunotherapy in murine models”. August 2015- September 2017.
• Thesis director conducing to the degree of Master in Biological Sciences. Sandra Gaete. Thesis entitled: “Activation of the sensor of the unfolded protein response sensor IRE1a in intratumoral dendritic cells”. March 2017- March 2019
• Thesis director conducing to the degree of Master in Biological Sciences. Antonia Geisse Thesis entitled: “Regulation of conventional type 1 dendritic cell function in the intestinal tract through the activation of the IRE1a/XBP1s axis”. March 2019- June 2022.
• Thesis director conducing to the degree of Master in Biological Sciences. Maria Francisca Gutierrez. Thesis entitled: " Control of immunity by ATF6 signaling in dendritic cells". November 2020- Present
• Thesis director conducing to the degree of Master in Biological Sciences. Jose Ignacio Bernales. Thesis entitled: "Regulation of phago-lysosomal maturation by IRE1 in dendritic cells". November 2020- August 2022.
• Thesis director conducing to the degree of Master in Biological Sciences. Amada Arcaya. Thesis entitled: "Control of lysosomal function in dendritic cells". 2023-present.
• Thesis director conducing to the degree of Master in Biological Sciences. Javier Lopez. Thesis entitled: "Metabolic regulation of dendritic cells by the unfolded protein response". March 2024- Present.
• Thesis director conducing to the degree of Master in Biological Sciences. Paula Lisboa. Thesis entitled: "Metabolic control of UPR sensors in adaptive immunity by dendritic cells". March 2026- present.

• Thesis director conducing to the degree of PhD in Biotechnology. Bernardita Medel, PhD program in Biotechnology, Universidad Andres Bello. Thesis project entitled: “Regulation of dendritic cell activation by the unfolded protein response sensor IRE1a”. June 2017-July 2022.
• Thesis director conducing to the degree of PhD in Cellular and Molecular Biology and Neurosciences. Felipe Flores, PhD program of Cellular and Molecular Biology and Neurosciences, Faculty of Sciences, Universidad de Chile. Thesis project entitled: “Regulation of antitumor immunity by the unfolded protein response sensor IRE1a”. 2017-2022.
• Thesis director conducing to the degree of PhD in Biomedical Sciences. Jonathan Morales. PhD program in Biomedical Sciences, Faculty of Medicine, Universidad de Chile. Thesis project entitled: “Regulation of dendritic cell activation by the unfolded protein response sensor ATF6” July 2018-2024
• Thesis director conducing to the degree of PhD in Biomedical Sciences. Monica Guzman. PhD program in Biomedical Sciences. Faculty of Medicine, Universidad de Chile. Thesis project entitled: "control of antiviral immunity by the IRE1/XBP1 axis in dendritic cells". June 2021- 2025
• Thesis director conducing to the degree of PhD in Biomedical Sciences. Alonso Lira PhD program in Biomedical Sciences. Faculty of Medicine, Universidad de Chile. Thesis project entitled: "Regulation of miRNA biology by IRE1 RNase in dendritic cells". June 2022- Present.

• Postdoctoral Supervisor. Dr Paulina Garcia-Gonzalez. Postdoctoral Project entitled: “Regulation of Human Dendritic Cell Function by the Unfolded Protein Response Sensor IRE1a”. March 2018-March 2022. Funded by HHMI international research scholar grant and FONDECYT postdoctoral fellowships.

2021 Director of the Chilean Association of Immunology ASOCHIN
2019 President of the Chilean Association of Immunologists (ASOCHIN)
2019 Member of the American Association of Immunologists (AAI)
2018 Member of the Chilean Society of Cell Biology SBCCh
2018 Organizer of the “II meeting of the Chilean Association of Immunology”, in conjunction with the XXIV Latinoamerican Association of
Microbiology ALAM . 13-16th November 2018, Santiago, Chile.
2018 Member of the Scientific Committee of Latin American Association of Immunology (ALAI) meeting 2018, held in Cancun, Mexico.
2018 Editor in Frontiers in Immunology journal for the Research Topic entitled: “Looking Beyond Pattern Recognition: Perturbations in Cellular
Homeostasis and Metabolism as Emerging Regulators of Dendritic Cell Function”
2017 Scientific Reviewer of the scientific and technological research projects (PICT), Argentinean National Scientific and Technical Research Council
(CONICET)
2017 Organizer of the “I meeting of the Chilean Association of Immunology”. 28th April 2017, Valparaiso, Chile
2017 Member of the Academic Committee of the PhD program in Biomedical Sciences, Faculty of Medicine, Universidad de Chile
2016 Member of the Faculty Board of the PhD program in Biomedical Sciences, Faculty of Medicine, Universidad de Chile
2016 Guest Associate Editor in Antigen Presenting Cell Biology journal Frontiers in Immunology
2016 Member of the Chilean Society of Biology
2016 Director of the Chilean Association of Immunology ASOCHIN
2016 Member of the Chilean Association of Immunology ASOCHIN
2016 Founder member of the Chilean Association of Immunology ASOCHIN
2016 Organizer of the Symposium “Bright Present and Future of Cancer Immunotherapy”. Faculty of Medicine, University of Chile, Santiago, Chile.
15-16th December 2016.
2016 Organizer of the “I Immunology Week 2016”. Faculty of Medicine, University of Chile, Santiago, Chile. 20, 21-24,25th October 2016
2014 Organizer of II Symposium on Immune Regulation SIREG 2014. Faculty of Medicine, University of Chile, Santiago, Chile. October 2014.
2011 Member of the Federation of European Biochemical Societies, (FEBS)

Expositora invitada a congresos internacionales
1. 2026 Expositora invitada, 18th International Symposium on Dendritic Cells (DC2026), 11-14 octubre, San Diego, USA.
2. 2026 Expositora invitada 8th Advanced Course on Tissue Immunity 2026, an Institut Curie initiative. 20-23 enero, Fundación Ciencia & Vida, Chile
3. 2025 Expositora invitada Chile-EMBO Life Science Forum. Santiago, 10-12 octubre. https://meetings.embo.org/event/esf-chile.
4. 2024 Expositora invitada 7th Advanced Course on Immunity & Cancer Immunotherapy 2024, an Institut Curie advanced international course. Charla titulada: ‘Regulation of dendritic cell function by cellular stress’. 12-15 noviembre, Fundación Ciencia & Vida, Chile
5. 2024 Expositora invitada 39th Annual Meeting of the Society of Immunotherapy of Cancer (SITC), simposio ‘Focus on Latin America Immuno Oncology’. Charla titulada: ‘Nuanced role for IRE1 RNase in dendritic cells in the regulation of antitumor immunity’. 8-10 noviembre, Houston, USA.
6. 2024 Expositora invitada 14th Latin American and Caribbean Congress of Immunology (ALACI). Charla titulada: ‘Regulation of intestinal Th17 responses by the unfolded protein response sensor IRE1 in dendritic cells’. 4-8 noviembre, Buenos Aires, Argentina.
7. 2022 Expositora invitada 13th Latin American and Caribbean Congress of Immunology (ALACI). Charla titulada: ‘Control of antitumor immunity by the unfolded protein response sensor IRE1 in dendritic cells’. 5-10 junio, Varadero, Cuba.
8. 2022 Keynote speaker- 5th Annual Meeting ASOCHIN- Charla plenaria titulada: Regulation of dendritic cell function by the unfolded protein response sensor IRE1. 20-21 noviembre. Pirque, Chile.
9. 2018 Investigadora Invitada inauguración del programa de investigadores internacionales organizado por Howard Hughes Medical Insitute (HHMI), Wellcome Trust, Bill & Melinda Gates Foundation y el Gulbenkian Institute. 18-21 febrero 2018, Lisboa, Portugal. Charla titulada: ‘Control of dendritic cell function by the unfolded protein response sensor IRE1 in dendritic cells’.
10. 2017 Expositora invitada I Reunión Anual Asociación Chilena de Inmunología -ASOCHIN. Universidad Católica de Valparaíso, Curauma, Chile. “The Unfolded Protein Sensor IRE1? regulates function and survival of dendritic cells”. abril 2017.

Expositora en congresos nacionales e internacionales
1. 2025 Expositora 38th European Macrophage and Dendritic Cell Society Meeting (EMDS 2025). Charla titulada: Control of intestinal type 3 immunity by IRE1 RNase in CD11c+ cells. 16-18 septiembre 2025, Edimburgo, Escocia.
2. 2024 Expositora VII Annual Meeting of the Chilean Association of Immunology (ASOCHIN). Charla titulada: ‘Intestinal immunity unfolded: How IRE1 shapes defense programs through gut dendritic cells’. 27-29 noviembre. Concón, Chile.
3. 2023 Expositora CFCD - Club Francophone des Cellules Dendritiques (French DC society). "Control of intestinal Th17 cell homeostasis by the unfolded protein response sensor IRE1 in dendritic cells". Bordeaux, Francia. 7-8 diciembre.
4. 2023 Expositora Keystone Symposia meeting on Myeloid Cells: Diversity and Distinct Biological Roles. "Control of intestinal Th17 cell homeostasis by the unfolded protein response sensor IRE1 in dendritic cells". Salt Lake City, USA.16-23 abril.
5. 2022 Expositora HHMI Meeting-Cellular and Organismal Physiology. “Deciphering the Role of the Unfolded Protein Response Sensor IRE1 in Dendritic Cell Biology”. Online. 8-9 marzo.
6. 2019 Expositora EMBO Meeting in Antigen Presentation Talk entitled: “IRE1? activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8+ T Cell Priming”. Paris, Francia. 30 mayo- 2 junio.
7. 2018 Expositora Inaugural Meeting International Research Scholar Program Howard Hughes Medical Institute (HHMI), Wellcome Trust, Bill & Melinda Gates Fundation, Gulbenkian Institute. Calouste Gulbekian Fundation. “Regulation of dendritic cell function by the unfolded protein response”. Lisboa, Portugal. 22 de febrero.
8. 2018 Expositora II Reunión Anual de la Asociación Chilena de Inmunología – ASOCHIN, en conjunto con la XXIV Reunión de la Sociedad Latinoamericana de Microbiología –ALAM. “Regulation of dendritic cell function by the unfolded protein response” Santiago, Chile. 13-16 noviembre.
9. 2018 Expositora XXXII Reunión Anual de la Sociedad Chilena de Biología Celular. “Understanding IRE1a function in Antitumor Immunity”. Puerto Varas.
10. 2018 Expositora XXII Congreso de la Sociedad Chilena de Cancerologia “Understanding IRE1a function in Antitumor Immunity”. 19-20 noviembre. Viña del Mar, Chile.
11. 2018 Expositora Tercer Simposio Internacional “Cancer and Inflammation” Universidad Austral de Chile, Valdivia, Chile. “Regulation of antitumor immunity by the unfolded protein response”. 11-12 enero.
12. 2018 Expositora ER proteostasis International Symposium, BNI, Facultad de Medicina, UChile. “Understanding IRE1? function in antitumor immunity”.10 septiembre.
13. 2015 Expositora XI Congress of the Latin-American Association of Immunology (ALAI) . 13-16 octubre 2015 Medellín, Colombia. “The unfolded-protein response sensor IRE-1? regulates the function of CD8?+ dendritic cells”.
14. 2014 Expositora International Symposium on Cancer Immunology and Immunotherapy. “Regulation of Dendritic Cell function by the Unfolded Protein Response”. Santiago, Chile. 18 de diciembre.
15. 2011 Expositora XXVI Annual Meeting of the Sociedad de Biología Celular de Chile. “XBP-1 controls the homeostasis of tissue-resident dendritic cells”. Puerto Varas, Chile. Speaker.