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Nelson Enrique Brown Vega

Associate Professor

University of Talca

Talca, Chile

- Role of cyclin D-CDK4/6 enzymatic complexes in senescence and autophagy, using in vitro models of breast and gastric cancer. - Role of the senescence-associated secretory phenotype (SASP) in gastric tumorigenesis and platelet activity.

Doctorado en Medicina, UNIVERSITY OF HEIDELBERG. Alemania, 2004
Medicina, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1997
Medico Cirujano, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1998

Profesor Asistente Full Time

UNIVERSIDAD DE TALCA

Talca, Chile

2012 - 2014
Profesor Asociado Full Time

UNIVERSIDAD DE TALCA

Talca, Chile

2015 - At present
Research Associate Full Time

TUFTS UNIVERSITY

Health Sciences

Boston, Estados Unidos

2004 - 2009
Intructor in Medicine Full Time

TUFTS UNIVERSITY

Health Sciences

Boston, Estados Unidos

2009 - 2012

Research Associate Full Time

Tufts Medical Center / Tufts University

Boston, Estados Unidos

2004 - 2009
Instructor in Medicine Full Time

Tufts University

Boston, Estados Unidos

2009 - 2012
Assistant Professor Full Time

University of Talca

Talca, Chile

2012 - 2015
Associate Professor Full Time

University of Talca

Talca, Chile

2015 - At present


mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership Cayo, Angel; Brown, Nelson Article INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Endothelial transmigration of platelets depends on soluble factors released by activated endothelial cells and monocytes Huilcaman, Ricardo; Veliz-Olivos, Natalia; Venturini, Whitney; Olate-briones, Alexandra; Treuer, Adriana; Valenzuela, Claudio; Brown, Nelson; Moore-Carrasco, Rodrigo Article ISI PLATELETS (2021)
Platelet Activation Is Triggered by Factors Secreted by Senescent Endothelial HMEC-1 Cells In Vitro Venturini, Whitney; Olate-Briones, Alexandra; Valenzuela, Claudio; Mendez, Diego; FUENTES, EDUARDO; Cayo, Angel; Mancilla, Daniel; Segovia, Raul; Brown, Nelson E.; Moore-Carrasco, Rodrigo Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Adenosine Derivates as Antioxidant Agents: Synthesis, Characterization, in Vitro Activity, and Theoretical Insights Valdes F.; Brown N.; Morales-Bayuelo A.; Prent-PeÃ±aloza L.; Gutierrez M. Article ISI SCOPUS ANTIOXIDANTS (2019)
SASP-Dependent Interactions between Senescent Cells and Platelets Modulate Migration and Invasion of Cancer Cells Valenzuela C.A.; Quintanilla R.; Olate-Briones A.; Venturini W.; Mancilla, D; Cayo A.; Moore-Carrasco R.; Brown N.E. Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
TASK-3 Gene Knockdown Dampens Invasion and Migration and Promotes Apoptosis in KATO III and MKN-45 Human Gastric Adenocarcinoma Cell Lines Cikutovic-Molina, Rocio; Herrada, Andres A.; Gonzalez, Wendy; Brown, Nelson; Zuniga, Leandro Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Semisynthesis, Characterization and Evaluation of New Adenosine Derivatives as Antiproliferative Agents Zurita, FV; Vega, NB; Gutierrez Cabrera, M Article ISI SCOPUS MOLECULES (2018)
TASK-3 Downregulation Triggers Cellular Senescence and Growth Inhibition in Breast Cancer Cell Lines Zuniga, R; Valenzuela, C; Concha, G; Brown, N; Zuniga, L. Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Palbociclib-induced autophagy and senescence in gastric cancer cells Valenzuela, Claudio A.; Vargas, Leandro; Martinez, Valentina; Bravo, Sindy; Brown, Nelson E. Article ISI SCOPUS Experimental Cell Research (2017)
The Potential Role of Senescence As a Modulator of Platelets and Tumorigenesis Valenzuela, Claudio A.; Quintanilla, Ricardo; Moore-Carrasco, Rodrigo; Brown, Nelson E. Article ISI SCOPUS FRONTIERS IN ONCOLOGY (2017)
CDK6-mediated repression of CD25 is required for induction and maintenance of Notch1-induced T-cell acute lymphoblastic leukemia Jena, N.; Sheng, J.; Hu, J. K.; Li, W.; Zhou, W.; Lee, G.; Tsichlis, N.; Pathak, A.; Brown, N.; Deshpande, A.; Luo, C.; Hu, G. F.; Hinds, P. W.; Van Etten, R. A.; Hu, M. G. Article ISI LEUKEMIA (2016)
Expression and cellular localization of HCN channels in rat cerebellar granule neurons Zúñiga, Rafael;; González, Daniela; Valenzuela, Claudio; Brown, Nelson; Zúñiga, Leandro Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)
Docking‘S Study Of 6-Substituted Adenosine-5'-N-Ethyluronamide Analogs As Selective Agonists At A3 Adenosine Receptor And Selection Of Compounds For To Be Synthesized Later Valdés, Francisco; Luna, Victor; Arévalo, Barbara; Brown, Nelson; Gutiérrez, Margarita Article DER PHARMA CHEMICA (2015)
Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence Sedic, Maja; Skibinski, Adam; Brown, Nelson; Gallardo, Mercedes; Mulligan, Peter; Martinez, Paula; Keller, Patricia J.; Glover, Eugene; Richardson, Andrea L.; Cowan, Janet; Toland, Amanda E.; Ravichandran, Krithika; Riethman, Harold; Naber, Stephen P.; Naeaer, Anders M.; Blasco, Maria A.; Hinds, Philip W.; Kuperwasser, Charlotte Article ISI NATURE COMMUNICATIONS (2015)
}The selective cytotoxicity elicited by phytochemical extract from Senecio graveolens ( Asteraceae) on breast cancer cells is enhanced by hypoxia Echiburu-Chau, C; Alfaro-Lira, S; Brown, N; Salas, CO; Cuellar, M; Santander, J; Ogalde, JP; ROTHHAMMER, F. Article ISI INTERNATIONAL JOURNAL OF ONCOLOGY (2014)
Cyclin D1 Activity Regulates Autophagy and Senescence in the Mammary Epithelium Brown, Nelson E.; Jeselsohn, Rinath; Bihani, Teeru; Hu, Miaofen G.; Foltopoulou, Parthena; Kuperwasser, Charlotte; Hinds, Philip W. Article ISI CANCER RESEARCH (2012)
Cyclin D1 Kinase Activity Is Required for the Self-Renewal of Mammary Stem and Progenitor Cells that Are Targets of MMTV-ErbB2 Tumorigenesis Jeselsohn, Rinath; Brown, Nelson E.; Arendt, Lisa; Klebba, Ina; Hu, Miaofen G.; Kuperwasser, Charlotte; Hinds, Philip W. Article ISI CANCER CELL (2010)
Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1(-/-) mice Gutierrez, Gabriel M.; Kong, Elizabeth; Sabbagh, Yves; Brown, Nelson E.; Lee, Jong-Seo; Demay, Marie B.; Thomas, David M.; Hind, Philip W. Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The LxCxE pRb interaction domain of cyclin D1 is dispensable for murine development Landis, Mark W.; Brown, Nelson E.; Baker, Gregory L.; Shifrin, Anna; Das, Manjusri; Geng, Yan; Sicinski, Piotr; Hinds, Philip W. Article ISI CANCER RESEARCH (2007)
A truncated polycystin-2 protein causes polycystic kidney disease and retinal degeneration in transgenic rats Gallagher, Anna Rachel; Hoffmann, Sigrid; Brown, Nelson; Cedzich, Anna; Meruvu, Sujatha; Podlich, Dirk; Feng, Yuxi; Koenecke, Vera; de Vries, Uwe; Hammes, Hans-Peter; Gretz, Norbert; Witzgall, Ralph Article ISI JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)
Use of the tetracycline system for inducible protein synthesis in the kidney Gallagher, AR; Schonig, K; Brown, N; Bujard, H; Witzgall, R Article ISI JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2003)
Stimulation of the Sympathetic Perimesenteric Arterial Nerves Releases Neuropeptide Y Potentiating the Vasomotor Activity of Noradrenaline: Involvement of Neuropeptide Y-Y1 Receptors Donoso, M. V.; Brown, N.; Carrasco, C.; Cortes, V.; Fournier, A.; Huidobro-Toro, J. P. Article Journal of Neurochemistry (1997)


Phytochemical extract from Senecio graveolens (Chachacoma): Searching new candidates for anti-cancer drugs Echiburu-Chau, C; Salas C.; Cuellar, M; Santander, J; Ogalde, JP; Brown, N; Alfaro-Lira, S; López N.; ROTHHAMMER, F. Abstract ISI EUROPEAN JOURNAL OF CANCER (2014)


Cyclin D1, metabolism and the autophagy-senescence balance Valenzuela, Claudio A.; Brown, Nelson E.; Brown, Nelson; Hinds, Philip BookSection (2017)
Tumor Suppressor Genes Brown, Nelson; Hinds, Philip BookSection (2014)


Caracterización y validación de marcadores de autofagia como determinantes terapéuticos y de pronóstico en lesiones tempranas de cáncer gástrico en la población de Molina Gobierno Regional del Maule (4369) Proyecto 2015-2017 Director(a)
THE ROLE OF CYCLIN D 1 ACTIVITY IN THE REGULATION OF AUTOPHAGY AND SENESCENCE IN MAMMARY AND GASTRIC EPHITELIAL CELLS FONDECYT (1140389) Proyecto 2014-2017 Inv. Responsable
Desarrollo y evaluación funcional de moléculas sintéticas inhibidoras de los canales de potasio task-3 para el tratamiento de tumores sólidos FONDEF (CA13I10223) Proyecto 2013-2015 Coinvestigador(a)


Adenosine: Synthetic methods of its derivatives and antitumor activity ValdÃ©s F.Z.; Luna V.Z.; ArÃ©valo B.R.; Brown N.V.; GutiÃ©rrez M.C. Review ISI SCOPUS (2018)