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Francisco Leandro Sepúlveda Valenzuela

Research

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

Estructura funcion de canales ionicos; Sensores de pH; Fisio(pato)logÃa epitelial; Fisiologia Celular; Transporte epitelial; Canales de cloruro y potasio de los epitelios; Transepithelial transport; Ionic channels; Intestinal physiology and pathophysiology

Licenciatura en Ciencias, mención Biología, UNIVERSIDAD DE CHILE. Chile, 1972
Doctor of Science in Biochemistry, Université de Lausanne. Suiza, 1977

Asistente de Investigación Full Time

UNIVERSIDAD DE CHILE

Facultad de Ciencias

Santiago, Chile

1973 - 1977
Maître de confèrences associé Full Time

Université de Nice

Faculté des Sciences

Nice, Francia

1978 - 1978
Senior Scientific Officer Full Time

AFRCInstitute of Animal Physiology and Genetics Research

Cambridge, Reino Unido

1979 - 1981
Principal Scientific Full Time

AFRC Institute of Animal Physiology and Genetics Research

Cambridge, Reino Unido

1981 - 1989
Senior Principal - Scientific Officer Full Time

AFRC Institute of Animal Physiology and Genetics Research

Cambridge, Reino Unido

1990 - 1994
Profesor Full Time

Centro de Estudios Científicos de Santiago

Santiago, Chile

1994 - 1999
Profesor ad Honorem Part Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

1994 - At present
Research Full Time

Centro de Estudios Científicos

Valdivia, Chile

1999 - At present
Postdoctoral Fellow Full Time

AFRC Institute of Animal Physiology and Genetics Research

Cambridge, Reino Unido

1977 - 1979

Supervisor in Physiology Part Time

University of Cambridge

Cambridge, Reino Unido

1985 - 1989
External Lecturer Part Time

Queen Elizabeth College, University de London

London, Reino Unido

1981 - 1986
External Lecturer Part Time

King's College, University de London

London, Reino Unido

1987 - 1994
Visiting Professor Part Time

Université de Paris-6 Pierre et Marie Curie

Paris, Francia

2011 - 2016

Undergraduate Students:
* Pedro Gallardo, "Regulación del Transporte de agua en colon distal, a Canales de agua aquaporina en colon distal de rata y b. canales de agua aquaporina en rodentes de desierto del norte de Chile, absorción de agua co". Ponticificia Universidad Católica de Chile. Finished 2008.
* Francisca Andrea Julio Kalajzic, "Papel de los canales basolaterales de potasio en la secreción intestinal de cloruro". Undergraduate Biochemist. Pontificia Universidad Católica de Valparaiso. Finished 2014.
* Néstor Bastián Corro Acuña. "Mecanismo de acción del bloqueador Tetra-Pentil-Amonio en el canal de potasio TASK-2". Undergraduate Biochemist. Universidad Austral de Chile. Finished in 2014.
* Erwin Leonel Vera Pinilla. "Papel del canal de potasio Kir7.1 en el epitelio intestinal". Undergraduate Medical Technologist. Universidad Austral de Chile. Finished 2017.

PhD Student:
* Leandro Antonio Zúñiga Hormazábal, "Analisis molecular del mecanismo de inhibicion por protones en los canales de potasio pertenecientes a la subfamila TASK", Doctor of Science. Universidad Austral de Chile. Finished 2008.
* Gaspar Peña Münzenmayer. "Mecanismo de Regulación del Canal de Potasio Task-2 por Variaciones del ph Intracelular". Cellular and Molecular Biology PhD. Universidad Austral de Chile. Finished in 2011.
* Viviana Angélica Bustos Salgado. "Regulación del canal de potasio KCNQ1:KCNE3 por 17 beta-estradiol". Cellular and Molecular Biology PhD. Universidad Austral de Chile. Finished in 2012.
* Johana Lisbeth Burgos Vargas. " ". Cellular and Molecular Biology PhD. Universidad Austral de Chile. Ongoing.
* Sandra Paulina Villanueva Subiabre. " Rol del canal de potasio Kir7.1 en el transporte transepitelial de las vías aéreas" Cellular and Molecular Biology PhD. Universidad Austral de Chile. Ongoing.

Membership
* Physiological Society (UK)
* Sociedad de Biología de Chile
* Sociedad Chilena de Ciencias Fisiológicas
* Sociedad Chilena de Bioquímica y Biología Celular
* American Society of Biochemistry and Molecular Biology

Collaborative Activities
* Course Science and Poetry, "Células Madre: Ciencia y P...romesa", Universidad Austral de Chile, 31th May 2016, Valdivia, Chile.
* Course Science and Poetry, "Células Madre: Ciencia y Promesa", Universidad Austral de Chile, 16th May 2017, Valdivia, Chile.

Visit in Chile
* Working meetings, Dr. Dominique Eladari, Centre de Recherche des Cordeliers Unité INSERM U872, Equipe 3 Escalier E-RDC, Paris, 22th January to 01st Febraury 2013.
* Working meetings, Dra. Andrea González, MedImmune, Cambridge, 22 th January 2013.
* Working meetings, Dra. Gloria Riquelme, Facultad de Medicina y Jefa de gabinete del Rector, Universidad de Chile, 05th Febraury 2013.
* Working meetings, Michael Janta, Universidad Würzburg, Alemania, 23th January 2013.
* Working meetings, Wendy González, Universidad de Talca, 24th January 2013.
* Working meetings, Andrea Peruffo, Tecniplast, 24th - 26th January 2013.
* Working meetings, Graciela Gigola, Universidad Nacional del Sur, 24th - 26th January 2013.
* Working meetings, Dasha Fuentes, Centro Nacional para la Producción de Animales de Laboratorio (CENPALAB), 24th - 26th January 2013.
* Colloquium, Dr. Yaroslav Ispolatov, Departamento de Física, Facultad de Ciencia Universidad de Santiago de Chile, 07th november 2013
* Working meetings, Dr. Jacques Teulon, Universite Pierre et Marie Curie-Paris 6, Paris, 25th - 30th November 2013.
* Collaborative scientific meeting with Dr. Jacques Teulon, Universidad Pierre et marie Curie, Paris, 09th - 31th January 2017.

Visit Abroad
* Collaborative scientific meeting with Dr. Dominique Eladari y Dra. Regine Chambrey, Institut national de la santé et de la recherche médicale, Paris, May 2013.
* Collaborative scientific meeting of Sandra Villanueva with Dr. Jacques Teulon to learn new techniques, Université Pierre et Marie Curie, Paris, 01st May to 01st June 2013.
* Collaborative scientific meeting with Dr. Jacques Teulon, Institut national de la santé et de la recherche médicale, Paris, 19th May to 13th June 2014.
* Collaborative scientific meeting with Dra. Olga Andrini and Dr. Marc Paulais, Universidad Pierre et marie Curie, Paris, 19th May to 13th June 2014.
* Collaborative scientific meeting with Dr. Jacques Teulon, Universidad Pierre et marie Curie, Paris, 01st - 28th July 2015.
* Collaborative scientific meeting with Dr. Jacques Teulon, Universidad Pierre et marie Curie, Paris, 09th - 31th January 2017.

Zyma, Nyon Studentship

Nyon University

Suiza, 1974

Scholarship obtained to study PhD in science at the University of Lausanne, Switzerland
Fellowship del Fonds National suisse de la recherche scientifique y la Royal Society

Royal Society

Reino Unido, 1977

Fellowship del Fonds National suisse de la recherche scientifique y la Royal Society, Suiza-UK.
Individual Merit promotion

AFRC Institute of Animal Physiology and Genetics Research

Reino Unido, 1990

.
Cátedra Presidencial en Ciencia

.

Chile, 1996

.
Medalla Rectoral

UNIVERSIDAD DE CHILE

Chile, 1996

.
Howard Hughes Medical Institute International Scholarhip

Howard Hughes Medical Institute International

Estados Unidos, 1997

.
John Simon Guggenheim Memorial Foundation Fellowship

John Simon Guggenheim Memorial Foundation

Estados Unidos, 2001

.
Senior Editor

The Journal of Physiology

Reino Unido, 2016

.


Chloride goes through TMEM16A channels with permission from Ca2+ and encouragement from protons Sepúlveda, Francisco V. Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2017)
Phosphatidylinositol (4,5)bisphosphate dynamically regulates the K-2P background K+ channel TASK-2 Niemeyer, María Isabel; Cid, L. Pablo; Paulais, Marc; Teulon, Jacques; Sepúlveda, Francisco V. Article ISI SCOPUS SCIENTIFIC REPORTS (2017)
Side Fenestrations Provide an "Anchor" for a Stable Binding of A1899 to the Pore of TASK-1 Potassium Channels Ramírez, David; Arévalo, Bárbara; Martínez, Gonzalo; Rinné, Susanne; Sepúlveda, Francisco V.; Decher, Niels; González, Wendy Article ISI SCOPUS MOLECULAR PHARMACEUTICS (2017)
Gating, Regulation, and Structure in K-2P K+ Channels: In Varietate Concordia? Niemeyer, M. I.; Cid, L. P.; Gonzalez, W.; Sepulveda, F. V. Article ISI SCOPUS Molecular Pharmacology (2016)
Channel-Mediated Lactate Release by K+-Stimulated Astrocytes Sotelo-Hitschfeld, T; Niemeyer, MI; Machler, P; Ruminot, I; Lerchundi R.; Wyss, MT; Stobart J.; Fernandez-Moncada, I; Valdebenito, R; Garrido-Gerter, P; Contreras-Baeza, Y; Schneider, BL; Aebischer, P; Lengacher, S; San Martin, A; Le Douce, J; Bonvento, G; Magistretti, PJ; Sepulveda, FV; Weber, B.; Barros, LF Article ISI SCOPUS Journal of Neuroscience (2015)
Cleft Palate, Moderate Lung Developmental Retardation and Early Postnatal Lethality in Mice Deficient in the Kir7.1 Inwardly Rectifying K+ Channel Villanueva, Sandra; Burgos, Johanna; Lpez-Cayuqueo, Karen I.; Lai, Ka-Man Venus; Valenzuela, David M.; Cid, L. Pablo; Seplveda, Francisco V.; Zhang, Zhe Article ISI SCOPUS PLOS ONE (2015)
CLCNKB mutations causing mild Bartter syndrome profoundly alter the pH and Ca2+ dependence of ClC-Kb channels Andrini O.; Keck, M; L'Hoste, S; Briones, R; Mansour-Hendili, L; Grand, T; Sepulveda, FV; Blanchard, A.; Lourdel S.; Vargas-Poussou, R; Teulon, J Article ISI SCOPUS PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2014)
Zebrafish and mouse TASK-2 K+ channels are inhibited by increased CO2 and intracellular acidification Pena-Munzenmayer, G; Niemeyer, MI; Sepulveda, FV; Cid, LP Article ISI SCOPUS PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2014)
An Extracellular Ion Pathway Plays a Central Role in the Cooperative Gating of a K-2P K+ Channel by Extracellular pH Gonzalez, W; Zuniga, L.; Cid, LP; Arevalo, B.; Niemeyer, MI; Sepulveda, FV Article ISI SCOPUS Journal of Biological Chemistry (2013)
Electrophysiological evidence for the presence of cystic fibrosis transmembrane conductance regulator (CFTR) in mouse sperm Figueiras-Fierro, D; Acevedo, JJ; Martinez-Lopez, P; Escoffier, J; Sepulveda, FV; Balderas, E; Orta, G; Visconti, PE; Darszon, A Article ISI SCOPUS Journal of Cellular Physiology (2013)
G protein modulation of K-2P potassium channel TASK-2 Añazco C.; Pena-Munzenmayer, G; Araya C.; Cid, LP; Sepulveda, FV; Niemeyer, MI Article ISI SCOPUS Pflugers Archiv European Journal of Physiology (2013)
Novel CLCNKB Mutations Causing Bartter Syndrome Affect Channel Surface Expression Keck, M; Andrini O.; Lahuna, O; Burgos, J; Cid, LP; Sepulveda, FV; L'Hoste, S; Blanchard, A.; Vargas-Poussou, R; Lourdel S.; Teulon, J Article ISI SCOPUS Human Mutation (2013)
Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium Rapetti-Mauss, R; O'Mahony, F; Sepulveda, FV; Urbach, V; Harvey, BJ Article ISI SCOPUS Journal of Physiology (2013)
Severe Defects in Absorptive Ion Transport in Distal Colons of Mice That Lack ClC-2 Channels Catalan, M. A.; Flores C.A.; Gonzalezbegne M.; Zhang, Y.; Sepulveda, F. V.; Melvin, J. E. Article ISI SCOPUS Gastroenterology (2012)
Extracellular pH in Restricted Domains as a Gating Signal for Ion Channels Involved in Transepithelial Transport Sandoval M.; Burgos, J; Sepulveda, FV; Cid, LP Article ISI BIOLOGICAL & PHARMACEUTICAL BULLETIN (2011)
Gating of a pH-Sensitive K-2P Potassium Channel by an Electrostatic Effect of Basic Sensor Residues on the Selectivity Filter Zuniga, L.; Cid, L. P.; Sepulveda, F. V.; Niemeyer M.I.; Marquez, V; Gonzalez-Nilo F.D.; Chipot, C Article ISI PLOS ONE (2011)
Sexual dimorphism and oestrogen regulation of KCNE3 expression modulates the functional properties of KCNQ1 K+ channels Alzamora, R; O'Mahony, F; Bustos, V; Rapetti-Mauss, R; Urbach, V; Cid, LP; Sepulveda, FV; Harvey, BJ Article ISI SCOPUS Journal of Physiology (2011)
Isolation of the Atlantic salmon beta-actin promoter and its use to drive expression in salmon cells in culture and in transgenic zebrafish Cornejo I.; Sepulveda, FV; Kibenge FSB; Young, JI Article ISI SCOPUS Aquaculture (2010)
Separate Gating Mechanisms Mediate the Regulation of K-2P Potassium Channel TASK-2 by Intra- and Extracellular pH Niemeyer, MI; Cid, LP; Pena-Munzenmayer, G; Sepulveda, FV Article ISI SCOPUS Journal of Biological Chemistry (2010)
Strain-dependent differences in electrogenic secretion of electrolytes across mouse colon epithelium Flores, CA; Cid, LP; Sepulveda, FV Article ISI SCOPUS Experimental Physiology (2010)
Rapid Recycling of ClC-2 Chloride Channels Between Plasma Membrane and Endosomes: Role of a Tyrosine Endocytosis Motif in Surface Retrieval Cornejo I.; Niemeyer, MI; Zuniga, L.; Yusef, YR; Sepulveda, FV; Cid, LP Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Voltage-dependent and -independent titration of specific residues accounts for complex gating of a ClC chloride channel by extracellular protons Niemeyer, MI; Cid, LP; Yusef, YR; Briones, R; Sepulveda, FV Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2009)
A genetically encoded ratiometric sensor to measure extracellular pH in microdomains bounded by basolateral membranes of epithelial cells Urra, J; Sandoval M.; Cornejo I.; Barros, LF; Sepulveda, FV; Cid, LP Article ISI SCOPUS PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2008)
Clcn2 encodes the hyperpolarization-activated chloride channel in the ducts of mouse salivary glands Romanenko, VG; Nakamoto, T.; Catalan, MA; Gonzalez-Begne, M; Schwartz, GJ; Jaramillo, Y.; Sepulveda, FV; Figueroa, CD; Melvin, JE Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)
Abolition of Ca2+-mediated intestinal anion secretion and increased stool dehydration in mice lacking the intermediate conductance Ca2+-dependent K+ channel Kcnn4 Flores, CA; Melvin, JE; Figueroa, CD; Sepulveda, FV Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2007)
Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K+ channel Niemeyer, MI; Gonzalez-Nilo, FD; Zuniga, L.; Gonzalez, W; Cid, LP; Sepulveda, FV Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Gating of two-pore domain K+ channels by extracellular pH Niemeyer, MI; Gonzalez-Nilo, FD; Zuniga, L.; Gonzalez, W; Cid, LP; Sepulveda, FV Article ISI SCOPUS BIOCHEMICAL SOCIETY TRANSACTIONS (2006)
Removal of gating in voltage-dependent ClC-2 chloride channel by point mutations affecting the pore and C-terminus CBS-2 domain Yusef, YR; Zuniga, L.; Catalán M.; Niemeyer, MI; Cid, LP; Sepulveda, FV Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2006)
Two splice variants derived from a Drosophila melanogaster candidate ClC gene generate ClC-2-type Cl(-) channels Flores, CA; Niemeyer, MI; Sepulveda, FV; Cid, LP Article ISI SCOPUS MOLECULAR MEMBRANE BIOLOGY (2006)
Basolateral localization of native ClC-2 chloride channels in absorptive intestinal epithelial cells and basolateral sorting encoded by a CBS-2 domain di-leucine motif Pena-Muzenmayer, G; Catalán M.; Cornejo I.; Figueroa, CD; Melvin, JE; Niemeyer, MI; Cid, LP; Sepulveda, FV Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2005)
Functional evaluation of human ClC-2 chloride channel mutations associated with idiopathic generalized epilepsies Niemeyer, MI; Yusef, YR; Cornejo I.; Flores, CA; Sepulveda, FV; Cid, LP Article ISI PHYSIOLOGICAL GENOMICS (2004)
The voltage-dependent CIC-2 chloride channel has a dual gating mechanism Zuniga, L.; Niemeyer, MI; Varela D.; Catalán M.; Cid, LP; Sepulveda, FV Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2004)
A conserved pore-lining glutamate as a voltage- and chloride-dependent gate in the CIC-2 chloride channel Niemeyer, MI; Cid, LP; Zuniga, L.; Catalán M.; Sepulveda, FV Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2003)
Extracellular conserved cysteine forms an intersubunit disulphide bridge in the KCNK5 (TASK-2) K+ channel without having an essential effect upon activity Niemeyer, MI; Cid, LP; Valenzuela, X; Sepulveda, FV Article ISI SCOPUS MOLECULAR MEMBRANE BIOLOGY (2003)
A voltage-independent K+ conductance activated by cell swelling in Ehrlich cells is modulated by a G-protein-mediated process Niemeyer, MI; Stutzin A.; Sepulveda, FV Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2002)
ClC-2 in guinea pig colon: mRNA, immunolabeling, and functional evidence for surface epithelium localization Catalán M.; Cornejo I.; Figueroa, CD; Niemeyer, MI; Sepulveda, FV; Cid, LP Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2002)
Distribution of aquaporins in the colon of Octodon degus, a South American desert rodent Gallardo, P; Olea, N.; Sepulveda, FV Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2002)
Effect of an N-terminus deletion on voltage-dependent gating of the ClC-2 chloride channel Varela D.; Niemeyer, MI; Cid, LP; Sepulveda, FV Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2002)
Aquaporin-2, a regulated water channel, is expressed in apical membranes of rat distal colon epithelium Gallardo, P; Cid, LP; Vio, CP; Sepulveda, FV Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2001)
Cloning, cellular distribution and functional expression of small intestinal epithelium guinea pig C1C-5 chloride channel Cornejo I.; Niemeyer, MI; Sepulveda, FV; Cid, LP Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2001)
K+ conductance activated during regulatory volume decrease. The channels in Ehrlich cells and their possible molecular counterpart Niemeyer, MI; Cid, LP; Sepulveda, FV Article ISI COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY (2001)
Modulation of the two-pore domain acid-sensitive K+ channel TASK-2 (KCNK5) by changes in cell volume Niemeyer, MI; Cid, LP; Barros, LF; Sepulveda, FV Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Characterisation of a cell swelling-activated K+-selective conductance of Ehrlich mouse ascites tumour cells Niemeyer, MI; Hougaard, C; Hoffmann, EK; Jorgensen, F; Stutzin A.; Sepulveda, FV Article ISI JOURNAL OF PHYSIOLOGY-LONDON (2000)
K+ currents activated by leukotriene D-4 or osmotic swelling in Ehrlich ascites tumour cells Hougaard, C; Niemeyer, MI; Hoffmann, EK; Sepulveda, FV Article ISI PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2000)
Splice variants of a ClC-2 chloride channel with differing functional characteristics Cid, LP; Niemeyer, MI; Ramirez A.; Sepulveda, FV Article ISI AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2000)
Swelling-induced taurine efflux from hela cells: Cell volume regulation Lambert I.H.; Sepulveda, F. V. Article SCOPUS GLIAL CELLS IN HEALTH AND DISEASE OF THE CNS (2000)


Side Fenestrations Provide an “Anchor” for a Stable Binding of A1899 to the Pore of TASK-1 Potassium Channels David Ramírez; Bárbara Arévalo; Gonzalo Martínez; Susanne Rinné; Francisco V. Sepúlveda; Niels Decher; Wendy González ConferencePoster (2017)
Phosphatidylinositol (4,5)-bisphosphate dynamically regulates the K2P background K+ channel TASK-2 Niemeyer, Maria Isabel; Cid, Luis P.; Marc Paulais; Jacques Teulon; Francisco Sepúlveda ConferencePoster (2016)


“ TASK%2 two%pore%domain K + channel: thoughts about gating and its fitness to physiological function. ” Sepúlveda, Francisco V. ConferenceProceedingWhole ION CHANNELS IN THE VALLEY III (2015)
Gating and function of TASK-2 channels Sepúlveda, Francisco V. ConferenceProceedingWhole K -channels - from molecules to Physiology and Pathophysiology (2015)
Ion channels in intestinal secretion: Physiological insights from mutagenesis Sepúlveda, Francisco V. ConferenceProceedingWhole Epithelia and Smooth Muscle Interactions in Health and Disease (2013)
“TASK-2 K2P channel: multiple gating regulators in search of physiological functions.” Sepúlveda, Francisco V. ConferenceProceedingWhole Open Seminars in Basic Science (2013)


B lymphocytes taken to task: a role for a background conductance K-2P K+ channel in B cells. Focus on "Expression of TASK-2 and its upregulation by B cell receptor stimulation in WEHI-231 mouse immature B cells" Flores, CA; Cid, LP; Niemeyer, MI; Sepulveda, FV EditorialMaterial ISI SCOPUS American Journal of Physiology - Cell Physiology (2011)
A tale from the Crypt: splice variants of BK channels in colonic potassium secretion Flores, CA; Cid, LP; Sepulveda, FV EditorialMaterial ISI SCOPUS Journal of Physiology (2010)


No evidence for a role of CLCN2 variants in idiopathic generalized epilepsy Niemeyer, MI; Cid, LP; Sepulveda, FV; Blanz, J; Auberson, M; Jentsch, TJ Letter ISI SCOPUS Nature Genetics (2010)


CLONAMIENTO Y EXPRESION FUNCIONAL DE CANALES DE CLORURO CLC DEL EPITELIO INTESTINAL Cid, Luis P.; Sepulveda, Francisco V.; Del Castillo-Salomon, Jesus; Jentsch, Thomas Proyecto (1996)
CANALES DE CLORURO ACTIVADOS POR CALCIO EN EL EPITELIO INTESTINAL COMO MEDIADORES DE LA SECRECION DE FLUIDO: POTENCIALES MEDIADORES DE LA DIARREA ROTAVIRAL Y MODIFICADORES DEL DEFECTO INTESTINAL EN LA FIBROSIS QUISTICA Niemeyer, Maria Isabel; Cid, Luis P.; Sepulveda, Francisco V. Proyecto (0)
DESARROLLO DE UN MODELO CELULAR EXPERIMENTAL PARA LA FIBROSIS QUISTICA (FQ). ESTUDIOS GENETICOS-MOLECULARES Y ELECTROFISIOPATOLOGICOS STUTZIN, ANDRES J.; EGUIGUREN OSSA, ANA LUISA; RIVEROS KELLER, NORA MARIA; WOLFF FERNANDEZ, JOSE DANIEL; SEPULVEDA VALENZUELA, FRANCISCO LEANDRO Proyecto (0)
EPILEPSIA IDIOPATICA GENERALIZADA: ESTUDIO FUNCIONAL DE MUTACIONES EN EL GEN CLCN2. Cid, Luis P.; Sepulveda, Francisco V. Proyecto (0)
ESTUDIO CELULAR Y MOLECULAR D LA VIA BASOLATERAL DE SALIDA DE CLORURO EN EL EPITELIO INTESTINAL Sepúlveda, Francisco V.; Cid, Luis P.; Niemeyer, Maria Isabel Proyecto (0)
EXPLORING THE POSSIBLE ROLE OF THE INWARDLY RECTIFYING K+ CHANNEL KIR7.1 IN THE CILIATED EPITHELIA OF THE CHOROID PLEXUS AND THE CILIARY BODY OF THE EYE Sepúlveda, Francisco V.; Cid, Luis P.; Niemeyer, Maria Isabel; TEULON , JACQUES Proyecto (0)
EXTRACELLULAR AND INTRACELLULAR SENSORS IN THE GATING OF TASK-2, A TWO-PORE-DOMAIN POTASSIUM CHANNEL. Niemeyer, Maria Isabel; Cid, Luis P.; Sepulveda, Francisco V. Proyecto (0)
GENERACION DE UN RATON QUE EXPRESE EL CANAL CIC-2 UNIDO A LA PROTEINA FLUORESCENTE VERDE. ESTUDIO DE LOCALIZACION E IMPLICACIONES FUNCIONALES. Sepúlveda, Francisco V.; CORNEJO ARANEDA, ISABEL MARGARITA; SANDOVAL CONCHA, MOISES GERARDO Proyecto (0)
IDENTIFICACION MOLECULAR Y CARACTERIZACION FUNCIONAL DEL CANAL DE K EPITELLIAL ACTIVADO POR AUMENTO DEL VOLUMEN CELULAR. STUTZIN SCHOTTLANDER, ANDRES JOAQUIN; Cid, Luis P.; Niemeyer, Maria Isabel; Riquelme, Gloria H.; Sepulveda, Francisco V. Proyecto (0)
IDENTIFICATION OF POTASSIUM CHANNELS INVOLVED IN SODIUM-COUPLED ABSORPTION NUTRIENTS AND IN THE SECRETION OF ELECTROLYTES AND FLUID IN INTESTINAL EPITHELIUM Sepúlveda, Francisco V.; Cid, Luis P. Proyecto (0)
MECANISMO DE REGULACION Y ESTRUCTURA OLIGOMERICA DE UN CANAL DE CLORURO EXPRESADO EN EPITELIOS Sepúlveda, Francisco V.; Cid, Luis P.; Niemeyer, Maria Isabel Proyecto (0)
MECANISMOS MOLECULARES DEL EFECTO DUAL DE LOS PROTONES EXTRACELULARES SOBRE EL GATING DEL CANAL DE CLORURO CLC-2. Sepúlveda, Francisco V.; Burgos, Johanna; Olave, Andrea Paz Proyecto (0)
MICRODOMINIOS TISULARES DE PH EXTRACELULAR ESTUDIADOS IN SITU CON SU SENSOR CODIFICADO GENETICAMENTE EN RATONES. Cid, Luis P.; Sepulveda, Francisco V. Proyecto (0)
MOLECULAR DISSECTION TO STUDY THE CONTRIBUTION OF THE INTRA AND EXTRACELLULAR PH SENSORS OF TASK-2 CHANNELS ON ITS RENAL FUNCTION. AN EXPERIMENTAL APPROACH USING TRANSGENIC MICE TO RESCUE THE TASK-2-NULL PHENOTYPE. Cid, Luis P.; Sepulveda, Francisco V. Proyecto (0)
MOLECULAR MECHANISM OF REGULATION OF KCNQ1/KCNE3 POTASSIUM CHANNEL BY 17BETA-OESTRADIOL Sepúlveda, Francisco V.; Cid, Luis P.; HARVEY , BRIAN J.P. Proyecto (0)
PAPEL DE LOS CANALES EPITELIALES DE LA FAMILIA C1C EN LA FUNCION INTESTINAL. Cid, Luis P.; Sepulveda, Francisco V. Proyecto (0)
PAPEL DEL CANAL HCLC-2 EN LA GENERACION DE LAS CORRIENTES DE CLORURO RESPONSABLES DE LA REGULACION DEL VOLUMEN EN CELULAS DE MAMIFERO HERMOSO RAMELLO, MARCELA ALEJANDRA; SEPULVEDA VALENZUELA, FRANCISCO LEANDRO Proyecto (0)
PARTICIPACION DE TASK-2, UN CANAL DE K+ SENSIBLE A PH EXTRACELULAR, EN LA DISMINUCION DE VOLUMEN CELULAR HOMEOSTATICO Y APOPTOTICO. Niemeyer, Maria Isabel; Barros, Luis F.; Sepulveda, Francisco V. Proyecto (0)
PH INDUCED CONFORMATIONAL CHANGES OF CLC CHLORIDE CHANNELS BRIONES JEREZ, RODOLFO CESAR; Sepulveda, Francisco V. Proyecto (0)
REGULACION DEL TRANSPORTE DE AGUA EN EL COLON GALLARDO MUNIZAGA, PEDRO ALBERTO; Sepulveda, Francisco V. Proyecto (0)
REGULACION DEL VOLUMEN CELULAR EN CELULAS HELA. PAPEL DE LOS CANALES DE POTASIO Y DEL CALCIO INTRACELULAR Sepúlveda, Francisco V.; EGUIGUREN OSSA, ANA LUISA; MCNAUGHTON , PETER; RIQUELME PINO, GLORIA HENA; STUTZIN SCHOTTLANDER, ANDRES JOAQUIN Proyecto (0)
VIAS DE PERMEACION REGULADAS POR EL VOLUMEN CELULAR PARA EL CLORURO Y OSMOLITOS ORGANICOS EN CELULAS HELA. MODULACION POR EL ANION PERMEANTE Sepúlveda, Francisco V.; EGUIGUREN OSSA, ANA LUISA; STUTZIN SCHOTTLANDER, ANDRES JOAQUIN; TORRES DIAZ, RUBEN JOSE Proyecto (0)


K-2P channels in plants and animals González, Wendy; Valdebenito, Braulio; Caballero, Julio; Riadi, Gonzalo; Riedelsberger, Janin; Martínez, Gonzalo; Ramirez, David; Zúñiga, Leandro; Sepúlveda, Francisco V.; Dreyer, Ingo; Janta, Michael; Becker, Dirk Review ISI SCOPUS Pflugers Archiv European Journal of Physiology (2015)
MOLECULAR ASPECTS OF STRUCTURE, GATING, AND PHYSIOLOGY OF pH-SENSITIVE BACKGROUND K-2P AND Kir K+-TRANSPORT CHANNELS Sepulveda, F. V.; Cid, L. P.; Teulon, J; Niemeyer M.I. Review ISI SCOPUS PHYSIOLOGICAL REVIEWS (2015)
TASK-2 K-2P K+ channel: thoughts about gating and its fitness to physiological function Lopez-Cayuqueo, KI; Pena-Munzenmayer, G; Niemeyer, MI; Sepulveda, FV; Cid, LP Review ISI SCOPUS Pflugers Archiv European Journal of Physiology (2015)
TASK-2: a K-2p K+ channel with complex regulation and diverse physiological functions Cid, L. Pablo; Roa-Rojas, Hugo A.; Niemeyer, María I.; González, Wendy; Araki, Masatake; Araki, Kimi; Sepúlveda, Francisco V. Review ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2013)
ClC-5 mutations associated with Dent's disease: a major role of the dimer interface Lourdel S.; Grand, T; Burgos, J; Gonzalez, W; Sepulveda, F. V.; Teulon, J Review ISI SCOPUS Pflugers Archiv European Journal of Physiology (2012)
TMEM16 proteins: the long awaited calcium-activated chloride channels? Flores, CA; Cid, LP; Sepulveda, FV; Niemeyer, MI Review ISI SCOPUS Brazilian Journal of Medical and Biological Research (2009)

Francisco Sepúlveda

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

Luis Cid

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTIFICOS CECs

Valdivia, Chile

Maria Niemeyer

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTIFICOS CECS

Valdivia, Chile

Leandro Zuñiga

Profesor Asociado

Medicine

Universidad de Talca

Talca, Chile

Carlos Flores

Researcher

Biology Lab

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

Marcelo Catalan

Profesor Auxiliar

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

Carlos Figueroa

Head

Anatomy, Histology and Pathology

Universidad Austral de Chile

Valdivia, Chile

Isabel Cornejo

Investigadora

Biología

Centro de Estudios Científicos

Valdivia, Chile

Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

Johanna Burgos

Postdoctoral

Biología

Centro de Estudios Científicos

Valdivia, Chile

Andres Stutzin

Full Professor

ICBM

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

Bárbara Arévalo

Investigador

Investigación

Centro de Estudios de Alimentos Procesados

Talca, Chile

Diego Varela

Profesor Asociado

Fisiología y Biofísica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

David Ramirez

Profesor Asistente

Facultad de Ciencias Biológicas

Universidad de Concepción

Concepcion, Chile

Moisés Sandoval

Co-Investigador

Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

Alejandro San Martin

Senior Reseacher

Biología

CENTRO DE ESTUDIOS CIENTIFICOS

Valdivia, Chile

Janin Riedelsberger

Profesora Asistente

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

Ingo Dreyer

Professor Titular

Bioinformatica

Universidad de Talca

Talca, Chile

Carolina Añazco

Profesora Asociada

Universidad San Sebastián

Valdivia, Chile

Ximena Valenzuela

Académico

Campus Patagonia

Universidad Austral de Chile

Coyhaique, Chile

VALERIA MARQUEZ

Profesor Asistente

Centro de Nanotecnologia Aplicada

Universidad Mayor de Chile

SANTIAGO, Chile

Dulce Figueiras

Investigador responsable

Medicina

Universidad de La Frontera

Temuco, Chile

Braulio Valdebenito

TALCA, Chile

Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Rodrigo Alzamora

ASSISTANT PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD DE CHILE

Santiago, Chile

Gaspar Peña

Profesor Asistente

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

Sandra Villanueva

Tesista

Biología

Centro de Estudios Científicos

Valdivia, Chile

Gonzalo Riadi

Assistant Professor

Bioinformatics

Universidad de Talca

Talca, Chile

Viviana Bustos

Researcher

Universidad de Los Lagos

Valdivia, Chile

Francisco Leandro Sepúlveda Valenzuela

Líneas de Investigación

Educación

Licenciatura en Ciencias, mención Biología, UNIVERSIDAD DE CHILE. Chile, 1972

Doctor of Science in Biochemistry, Université de Lausanne. Suiza, 1977

Experiencia Académica

Asistente de Investigación Full Time

Maître de confèrences associé Full Time

Senior Scientific Officer Full Time

Principal Scientific Full Time

Senior Principal - Scientific Officer Full Time

Profesor Full Time

Profesor ad Honorem Part Time

Research Full Time

Postdoctoral Fellow Full Time

Experiencia Profesional

Supervisor in Physiology Part Time

External Lecturer Part Time

External Lecturer Part Time

Visiting Professor Part Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

Zyma, Nyon Studentship

Fellowship del Fonds National suisse de la recherche scientifique y la Royal Society

Individual Merit promotion

Cátedra Presidencial en Ciencia

Medalla Rectoral

Howard Hughes Medical Institute International Scholarhip

John Simon Guggenheim Memorial Foundation Fellowship

Senior Editor

Article (46)

ConferencePoster (2)

ConferenceProceedingWhole (4)

EditorialMaterial (2)

Letter (1)

Proyecto (22)

Review (6)