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Ivan Marcelo Ruminot Moraga

INVESTIGADOR

CENTRO DE ESTUDIOS CIENTIFICOS

VALDIVIA, Chile

Líneas de Investigación


Metabolismo energético cerebral; Interacción neurona-astrocito Mecanismos de regulación de pH y su relación con el metabolsmo celular Rol del glicogeno en la energización celular Rol de los astrocitos en la dinámica energética posterior a la isquemia

Educación

  •  DOCTORADO EN CIENCIAS MENCION BIOLOGÍA CELULAR Y MOLECULAR, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2012
  •  LICENCIATURA EN BIOQUÍMICA, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2005
  •  BIOQUÍMICO, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2005

Experiencia Académica

  •   Profesor Asistente Part Time

    UNIVERSIDAD SANTO TOMAS

    2009 - 2012

  •   Postdoctoral fellow Full Time

    UNIVERSITY OF KAISERSLAUTERN

    Kaiserslautern, Alemania

    2012 - 2015

  •   INVESTIGADOR POSTDOCTORAL Full Time

    CENTRO DE ESTUDIOS CIENTIFICOS

    VALDIVIA, Chile

    2015 - 2018

  •   INVESTIGADOR Full Time

    CENTRO DE ESTUDIOS CIENTIFICOS

    VALDIIVIA, Chile

    2018 - At present

  •   INVESTIGADOR Full Time

    CENTRO DE ESTUDIOS CIENTIFICOS

    VALDIVIA, Chile

    2018 - At present

  •   INVESTIGADOR Full Time

    UNIVERSIDAD SAN SEBASTIAN

    CIENCIAS PARA EL CUIDADO DE LA SALUD

    VALDIVIA, Chile

    2022 - At present

Experiencia Profesional

  •   Asistente de investigación

    Centro de Estudios Científicos

    Chile

    2005 - 2007

Formación de Capital Humano


Jana Schmälzle, Bachelor in Science, TU Kaiserslautern, Germany
Dominik Appel, Master in Science, TU Kaiserslautern, Germany
Belén Leyton, Tecnología Médica, Universidad Austral de Chile, Valdivia
Hector Oyarzún, Tecnología Médica, Universidad Austral de Chile, Valdivia
Pablo Castro, Escuela de Tecnología Médica, Universidad Austral de Chile, Valdivia
Matias Ditzel, Escuela de Tecnología Médica, Universidad Austral de Chile, Valdivia
Paloma Soto, Escuela de Tecnología Médica, Universidad Austral de Chile, Valdivia
Sebastián Holtheuer, Escuela de Bioquímica, Universidad Austral de Chile, Valdivia


Difusión y Transferencia


Participación continua en el programa de difusión científica "Científicos por un mes", dirigido a estudiantes secundarios quienes desarrollan un proyecto científico en los laboratorios del Centro de Estudios Científicos.



 

Article (26)

Single-Fluorophore Indicator to Explore Cellular and Sub-cellular Lactate Dynamics
Bidirectional astrocytic GLUT1 activation by elevated extracellular K+
Aerobic Glycolysis in the Brain: Warburg and Crabtree Contra Pasteur
Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle
Fluid Brain Glycolysis: Limits, Speed, Location, Moonlighting, and the Fates of Glycogen and Lactate
Tight coupling of astrocyte energy metabolism to synaptic activity revealed by genetically encoded FRET nanosensors in hippocampal tissue
Tight coupling of astrocyte energy metabolism to synaptic activity revealed by genetically encoded FRET nanosensors in hippocampal tissue
Neuronal control of astrocytic respiration through a variant of the Crabtree effect.
Near-critical GLUT1 and Neurodegeneration
Near-critical GLUT1 and Neurodegeneration.
Proton Fall or Bicarbonate Rise GLYCOLYTIC RATE IN MOUSE ASTROCYTES IS PAVED BY INTRACELLULAR ALKALINIZATION
Targeting of astrocytic glucose metabolism by beta-hydroxybutyrate.
Channel-Mediated Lactate Release by K+-Stimulated Astrocytes
Inhibition of monocarboxylate transporter by N-cyanosulphonamide S0859
The role of membrane acid/base transporters and carbonic anhydrases for cellular pH and metabolic processes
Higher Transport and Metabolism of Glucose in Astrocytes Compared with Neurons: A Multiphoton Study of Hippocampal and Cerebellar Tissue Slices
Higher Transport and Metabolism of Glucose in Astrocytes Compared with Neurons=> A Multiphoton Study of Hippocampal and Cerebellar Tissue Slices
The Electrogenic Sodium Bicarbonate Cotransporter NBCe1 Is a High-Affinity Bicarbonate Carrier in Cortical Astrocytes
A Genetically Encoded FRET Lactate Sensor and Its Use To Detect the Warburg Effect in Single Cancer Cells
Small is fast=> astrocytic glucose and lactate metabolism at cellular resolution
Small is fast=> astrocytic glucose and lactate metabolism at cellular resolution.
Fast and Reversible Stimulation of Astrocytic Glycolysis by K+ and a Delayed and Persistent Effect of Glutamate
NBCe1 Mediates the Acute Stimulation of Astrocytic Glycolysis by Extracellular K+
Kinetic validation of 6-NBDG as a probe for the glucose transporter GLUT1 in astrocytes.
Na+-Ca2+ cosignaling in the stimulation of the glucose transporter GLUT1 in cultured Astrocytes
ATP steal between cation pumps: a mechanism linking Na+ influx to the onset of necrotic Ca2+ overload

Abstract (1)

Imaging dynamics of energy metabolites in hippocampal astrocytes during neuronal activity

Proyecto (13)

Astrocytic metabolism after ischemic stress
Synergic metabolic signaling by noradrenaline and K+ in astrocytes
IMPACTO DE LA DELECIÓN GLIO-ESPECIFICA DEL NBCE1 EN LA DINÁMICA DE METABOLITOS ENERGÉTICOS EN CÉLULAS NERVIOSAS Y EN LA ACTIVIDAD CEREBRAL DEL RATÓN ADULTO.
ESTUDIO DE LA DINÁMICA INTRACELULAR DE LACTATO Y PIRUVATO EN ASTROCITOS IN VITRO E IN SITU DURANTE ACTIVIDAD NEURONAL EXCITATORIA
AN IMAGING STUDY ON THE CONTRIBUTION OF GLIAL ENERGY METABOLISM TO THE NEUROPROTECTIVE EFFECT OF KETONE BODIES
SHORT TERM REGULATION OF ASTROCYTIC GLYCOLYSIS
DYNAMICS OF GLUCOSE TRANSPORT AS MODULATED BY NEURONAL ACTIVITY IN THE MAMMALIAN BRAIN
DINAMICA DE LA GLUCOSA EN ASTROCITOS=> ESTUDIOS EN CULTIVO E IN SITU.
DEVELOPMENT AND APPLICATION OF SCALING INDEX METHODS FOR THE AUTOMATED QUANTIFICATION OF COLOCALIZATION IN FLUORESCENCE MICROSCOPY.
MECANISMOS CELULARES DEL TRANSPORTE CEREBRAL DE GLUCOSA
PARTICIPACION DE TASK-2, UN CANAL DE K+ SENSIBLE A PH EXTRACELULAR, EN LA DISMINUCION DE VOLUMEN CELULAR HOMEOSTATICO Y APOPTOTICO.
PATOGENIA DE LA MUERTE NECROTICA EN CELULAS HEPATICAS=> DISECCION DE MECANISMOS MOLECULARES EFECTOS.
PATOGENIA DE LA MUERTE NECROTICA EN CELULAS HEPATICAS=> DISECCION DE MECANISMOS MOLECULARES EFECTOS.

Review (1)

Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis
17
Ivan Ruminot

INVESTIGADOR

BIOLOGIA

CENTRO DE ESTUDIOS CIENTIFICOS

VALDIVIA, Chile

7
Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

3
Alejandro San Martin

Senior Reseacher

Biología

CENTRO DE ESTUDIOS CIENTIFICOS

Valdivia, Chile

1
Sharin Valdivia

Profesor Adjunto Adhonorem

Facultad de Ciencias

Universidad Austral de Chile

Valdivia, Chile

1
GONZALO MARDONES

Associate Professor

Medicine

Universidad San Sebastián

Valdivia, Chile

1
ALEX GALAZ

COFOUNDER (Co-CEO)

INFOOD PROTEIN AND BIOTECHNOLOGY

VALDIVIA, Chile

1
Pamela Sandoval

Postdoctoral Researcher

Biología

Centro de Estudios Científicos -CECs-

Valdivia, Chile

1
Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

1
Angelo Bernier

Tesista de Magíster

Biología

Centro de Estudios Científicos de Valdivia

Valdivia, Chile

1
Carla Bittner

Profesor Asociado

Departamento de Salud

Universidad de Los Lagos

Puerto Montt, Chile

1
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile