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Ivan Marcelo Ruminot Moraga

INVESTIGADOR

CENTRO DE ESTUDIOS CIENTIFICOS

VALDIVIA, Chile

Metabolismo energético cerebral; Interacción neurona-astrocito Mecanismos de regulación de pH y su relación con el metabolsmo celular Rol del glicogeno en la energización celular Rol de los astrocitos en la dinámica energética posterior a la isquemia

DOCTORADO EN CIENCIAS MENCION BIOLOGÍA CELULAR Y MOLECULAR, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2012
LICENCIATURA EN BIOQUÍMICA, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2005
BIOQUÍMICO, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2005

Profesor Asistente Part Time

UNIVERSIDAD SANTO TOMAS

2009 - 2012
Postdoctoral fellow Full Time

UNIVERSITY OF KAISERSLAUTERN

Kaiserslautern, Alemania

2012 - 2015
INVESTIGADOR POSTDOCTORAL Full Time

CENTRO DE ESTUDIOS CIENTIFICOS

VALDIVIA, Chile

2015 - 2018
INVESTIGADOR Full Time

CENTRO DE ESTUDIOS CIENTIFICOS

VALDIIVIA, Chile

2018 - At present
INVESTIGADOR Full Time

CENTRO DE ESTUDIOS CIENTIFICOS

VALDIVIA, Chile

2018 - At present
INVESTIGADOR Full Time

UNIVERSIDAD SAN SEBASTIAN

CIENCIAS PARA EL CUIDADO DE LA SALUD

VALDIVIA, Chile

2022 - At present

Asistente de investigación

Centro de Estudios Científicos

Chile

2005 - 2007

Jana Schmälzle, Bachelor in Science, TU Kaiserslautern, Germany
Dominik Appel, Master in Science, TU Kaiserslautern, Germany
Belén Leyton, Tecnología Médica, Universidad Austral de Chile, Valdivia
Hector Oyarzún, Tecnología Médica, Universidad Austral de Chile, Valdivia
Pablo Castro, Escuela de Tecnología Médica, Universidad Austral de Chile, Valdivia
Matias Ditzel, Escuela de Tecnología Médica, Universidad Austral de Chile, Valdivia
Paloma Soto, Escuela de Tecnología Médica, Universidad Austral de Chile, Valdivia
Sebastián Holtheuer, Escuela de Bioquímica, Universidad Austral de Chile, Valdivia

Participación continua en el programa de difusión científica "Científicos por un mes", dirigido a estudiantes secundarios quienes desarrollan un proyecto científico en los laboratorios del Centro de Estudios Científicos.


Single-Fluorophore Indicator to Explore Cellular and Sub-cellular Lactate Dynamics Aburto, Camila; Galaz, Alex; Bernier, Angelo; Yohana Sandoval, Pamela; Holtheuer-Gallardo, Sebastian; Ruminot, Ivan; Soto-Ojeda, Ignacio; Hertenstein, Helen; Aurelia Schweizer, Johanna; Schirmeier, Stefanie; Paulina Pastor, Tammy; Antonio Mardones, Gonzalo; Felipe Barros, Luis; San Martin, Alejandro Article ISI ACS SENSORS (2022)
Bidirectional astrocytic GLUT1 activation by elevated extracellular K+ Fernandez-Moncada, Ignacio; Robles-Maldonado, Daniel; Castro, Pablo; Alegria, Karin; Epp, Robert; Ruminot, Ivan; Barros, Luis Felipe Article ISI GLIA (2021)
Aerobic Glycolysis in the Brain: Warburg and Crabtree Contra Pasteur Barros L.F.; Ruminot I.; San MartÃn A.; Lerchundi R.; FernÃ¡ndez-Moncada I.; Baeza-Lehnert F. Article ISI SCOPUS Neurochemical Research (2020)
Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle Theparambil, Shefeeq M.; Hosford, Patrick S.; Ruminot, Ivan; Kopach, Olga; Reynolds, James R.; Sandoval, Pamela Y.; Rusakov, Dmitri A.; Barros, L. Felipe; Gourine, Alexander V. Article ISI NATURE COMMUNICATIONS (2020)
Fluid Brain Glycolysis: Limits, Speed, Location, Moonlighting, and the Fates of Glycogen and Lactate Barros, L. Felipe; San Martin, Alejandro; Ruminot, Ivan; Sandoval, Pamela Y.; Baeza-Lehnert, Felipe; Arce-Molina, Robinson; Rauseo, Daniela; Contreras-Baeza, Yasna; Galaz, Alex; Valdivia, Sharin. Article ISI SCOPUS NEUROCHEMICAL RESEARCH (2020)
Tight coupling of astrocyte energy metabolism to synaptic activity revealed by genetically encoded FRET nanosensors in hippocampal tissue Ruminot, I; Schmalzle, J; Leyton, B; Barros, LF; Deitmer JW Article ISI SCOPUS JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2019)
Tight coupling of astrocyte energy metabolism to synaptic activity revealed by genetically encoded FRET nanosensors in hippocampal tissue Ruminot, I; Schmalzle, J; Leyton, B; Barros, LF; Deitmer, JW Article JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2019)
Neuronal control of astrocytic respiration through a variant of the Crabtree effect. Fernández-Moncada, Ignacio; Ruminot, Iván; Robles-Maldonado, Daniel; Alegría, Karin; Deitmer, Joachim W; Barros, L Felipe Article Proceedings of the National Academy of Sciences of the United States of America (2018)
Near-critical GLUT1 and Neurodegeneration Barros, L. Felipe; San Martín, Alejandro; Ruminot, Ivan; Sandoval, Pamela Y.; Fernández-Moncada, Ignacio; Baeza-Lehnert, Felipe; Arce-Molina, Robinson; Contreras-Baeza, Yasna; Cortés-Molina, Francisca; Galaz, Alex; Alegría, Karin Article Journal of Neuroscience Research (2017)
Near-critical GLUT1 and Neurodegeneration. Barros, L Felipe; San Martín, Alejandro; Ruminot, Ivan; Sandoval, Pamela Y; Fernández-Moncada, Ignacio; Baeza-Lehnert, Felipe; Arce-Molina, Robinson; Contreras-Baeza, Yasna; Cortés-Molina, Francisca; Galaz, Alex; Alegría, Karin Article Journal of neuroscience research (2017)
Proton Fall or Bicarbonate Rise GLYCOLYTIC RATE IN MOUSE ASTROCYTES IS PAVED BY INTRACELLULAR ALKALINIZATION Theparambil, Shefeeq M.; Weber, Tobias; Schmälzle, Jana; Ruminot, Ivàn; Deitmer, Joachim W. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Targeting of astrocytic glucose metabolism by beta-hydroxybutyrate. Valdebenito, Rocío; Ruminot, Iván; Garrido-Gerter, Pamela; Fernández-Moncada, Ignacio; Forero-Quintero, Linda; Alegría, Karin; Becker, Holger M; Deitmer, Joachim W; Barros, L Felipe Article Journal of cerebral blood flow and metabolism => official journal of the International Society of Cerebral Blood Flow and Metabolism (2016)
Channel-Mediated Lactate Release by K+-Stimulated Astrocytes Sotelo-Hitschfeld, T; Niemeyer, MI; Machler, P; Ruminot I, Lerchundi; R, Wyss; MT, Stobart J.; Fernandez-Moncada, I; Valdebenito R, Garrido-Gerter; P, Contreras-Baeza; Y, Schneider; BL, Aebischer; P, Lengacher; S, San-Martin; A, Le Douce; J, Bonvento; G, Magistretti; PJ, Sepulveda; FV, Weber B. Article Journal of Neuroscience (2015)
Inhibition of monocarboxylate transporter by N-cyanosulphonamide S0859 Heidtmann, Hella; Ruminot, Ivan; Becker, Holger M.; Deitmer, Joachim W. Article ISI EUROPEAN JOURNAL OF PHARMACOLOGY (2015)
The role of membrane acid/base transporters and carbonic anhydrases for cellular pH and metabolic processes Deitmer, Joachim W.; Theparambil, Shefeeq M.; Ruminot, Ivan; Becker, Holger M. Article ISI FRONTIERS IN NEUROSCIENCE (2015)
Higher Transport and Metabolism of Glucose in Astrocytes Compared with Neurons: A Multiphoton Study of Hippocampal and Cerebellar Tissue Slices Jakoby, P; Schmidt, E.; Ruminot, I; Gutiérrez R.; Barros, LF; Deitmer JW Article ISI CEREBRAL CORTEX (2014)
Higher Transport and Metabolism of Glucose in Astrocytes Compared with Neurons=> A Multiphoton Study of Hippocampal and Cerebellar Tissue Slices Jakoby, P; Schmidt E., Ruminot I; Gutiérrez R., Barros LF; Deitmer, JW Article CEREBRAL CORTEX (2014)
The Electrogenic Sodium Bicarbonate Cotransporter NBCe1 Is a High-Affinity Bicarbonate Carrier in Cortical Astrocytes Theparambil, Shefeeq M.; Ruminot, Ivan; Schneider, Hans-Peter; Shull, Gary E.; Deitmer, Joachim W. Article ISI JOURNAL OF NEUROSCIENCE (2014)
A Genetically Encoded FRET Lactate Sensor and Its Use To Detect the Warburg Effect in Single Cancer Cells San-Martin, A; Ceballo, S; Ruminot I, Lerchundi; R, Frommer; WB, Barros LF Article PLOS ONE (2013)
Small is fast=> astrocytic glucose and lactate metabolism at cellular resolution Barros LF, San-Martin; A, Sotelo-Hitschfeld; T, Lerchundi; R, Fernandez-Moncada; I, Ruminot I; Gutiérrez R., Valdebenito R; Ceballo, S; Alegria, K; Baeza-Lehnert, F Article Frontiers in Cellular Neuroscience (2013)
Small is fast=> astrocytic glucose and lactate metabolism at cellular resolution. Barros, L F; San Martín, A; Sotelo-Hitschfeld, T; Lerchundi, R; Fernández-Moncada, I; Ruminot, I; Gutiérrez, R; Valdebenito, R; Ceballo, S; Alegría, K; Baeza-Lehnert, F; Espinoza, D Article Frontiers in cellular neuroscience (2013)
Fast and Reversible Stimulation of Astrocytic Glycolysis by K+ and a Delayed and Persistent Effect of Glutamate bittner cx; Valdebenito, R; Ruminot, I; Loaiza A.; Larenas V; Sotelo-Hitschfeld, T; Moldenhauer, H; San Martin, A; Gutiérrez R.; Zambrano M.; Barros, LF Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2011)
NBCe1 Mediates the Acute Stimulation of Astrocytic Glycolysis by Extracellular K+ Ruminot I, Gutiérrez R.; Pena-Munzenmayer, G; Añazco C., Sotelo-Hitschfeld; T, Lerchundi; R, Niemeyer; MI, Shull; GE, Barros LF Article Journal of Neuroscience (2011)
Kinetic validation of 6-NBDG as a probe for the glucose transporter GLUT1 in astrocytes. Barros, Luis Felipe; Bittner, Carla X; Loaiza, Anitsi; Ruminot, Iván; Larenas, Valeria; Moldenhauer, Hans; Oyarzún, Carolina; Alvarez, Mauro Article Journal of neurochemistry (2009)
Na+-Ca2+ cosignaling in the stimulation of the glucose transporter GLUT1 in cultured Astrocytes Porras, OH; Ruminot I, Loaiza A Article Glia (2008)
ATP steal between cation pumps: a mechanism linking Na+ influx to the onset of necrotic Ca2+ overload Castro J.; Ruminot, I; Porras, OH; Flores, CM; Hermosilla T.; Verdugo E.; Venegas, F; Hartel, S; Michea, L.; Barros, LF Article ISI SCOPUS CELL DEATH AND DIFFERENTIATION (2006)


Imaging dynamics of energy metabolites in hippocampal astrocytes during neuronal activity Ruminot, I; Schmalzle, J; Heidtmann, H; Barros, LF; Deitmer JW Abstract ISI GLIA (2015)


Astrocytic metabolism after ischemic stress Barros, Luis Felipe; Ruminot, Iván Proyecto (2019)
Synergic metabolic signaling by noradrenaline and K+ in astrocytes Ruminot, Iván Proyecto Development of an optical method to estimate acute glycogen mobilization in single astrocytes. Investigate the impact of fast glycogen mobilization on glucose consumption in astrocytes stimulated with noradrenaline and increases of extracellular K+. (2019)
IMPACTO DE LA DELECIÓN GLIO-ESPECIFICA DEL NBCE1 EN LA DINÁMICA DE METABOLITOS ENERGÉTICOS EN CÉLULAS NERVIOSAS Y EN LA ACTIVIDAD CEREBRAL DEL RATÓN ADULTO. FONDECYT (3160131) Proyecto 2015-2018 Inv. Responsable
ESTUDIO DE LA DINÁMICA INTRACELULAR DE LACTATO Y PIRUVATO EN ASTROCITOS IN VITRO E IN SITU DURANTE ACTIVIDAD NEURONAL EXCITATORIA PFCHA (74140076) Proyecto 2013-2015 Inv. Responsable
AN IMAGING STUDY ON THE CONTRIBUTION OF GLIAL ENERGY METABOLISM TO THE NEUROPROTECTIVE EFFECT OF KETONE BODIES CONICYT/DFG (ALEMANIA) (DFG- 12, DE 231/25-1) Proyecto 2012-2014 Postdoctorado
SHORT TERM REGULATION OF ASTROCYTIC GLYCOLYSIS FONDECYT (1100936) Proyecto 2010-2013 Personal técnico y/o de apoyo
DYNAMICS OF GLUCOSE TRANSPORT AS MODULATED BY NEURONAL ACTIVITY IN THE MAMMALIAN BRAIN PCI (444CHL-113) Proyecto 2008-2009 Tesista
DINAMICA DE LA GLUCOSA EN ASTROCITOS=> ESTUDIOS EN CULTIVO E IN SITU. FONDECYT (1070046) Proyecto 2007-2010 Personal técnico y/o de apoyo
DEVELOPMENT AND APPLICATION OF SCALING INDEX METHODS FOR THE AUTOMATED QUANTIFICATION OF COLOCALIZATION IN FLUORESCENCE MICROSCOPY. FONDECYT (1060890) Proyecto 2006-2009 Personal técnico y/o de apoyo
MECANISMOS CELULARES DEL TRANSPORTE CEREBRAL DE GLUCOSA FONDECYT (1051082) Proyecto 2005-2007 Personal técnico y/o de apoyo
PARTICIPACION DE TASK-2, UN CANAL DE K+ SENSIBLE A PH EXTRACELULAR, EN LA DISMINUCION DE VOLUMEN CELULAR HOMEOSTATICO Y APOPTOTICO. FONDECYT (1030838) Proyecto 2003-2006 Personal técnico y/o de apoyo
PATOGENIA DE LA MUERTE NECROTICA EN CELULAS HEPATICAS=> DISECCION DE MECANISMOS MOLECULARES EFECTOS. FONDECYT (1020648) Proyecto 2002-2005 Tesista
PATOGENIA DE LA MUERTE NECROTICA EN CELULAS HEPATICAS=> DISECCION DE MECANISMOS MOLECULARES EFECTOS. FONDECYT (1020648) Proyecto 2002-2005 Tesista


Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis Deitmer J.W.; Theparambil S.M.; Ruminot I.; Noor S.I.; Becker H.M. Review ISI SCOPUS FRONTIERS IN NEUROSCIENCE (2019)