Man

Jimena Cuenca Moreno

Investigador/profesor

Universidad de Los Andes

Santiago, Chile

Líneas de Investigación


Cell Therapy; Immunomodulatory effects of Mesenchymal Stem Cells; Autoimmune Diseases; Mechanisms in Autoimmune Diseases; Inflammation/miRNA; Molecular and Cellular Biology; Bioprocessing and Cellular Manufacturing

Educación

  •  Bioquímica , UNIVERSIDAD DE CHILE. Chile, 2002
  •  Bioquimica y Biologia Molecular, Universidad Complutense de Madrid. España, 2006

Experiencia Académica

  •   Investigador/profesor Full Time

    Universidad de los Andes

    Facultad de Medicina

    Santiago, Chile

    2011 - At present

Experiencia Profesional

  •   Investigador/profesor Full Time

    Universidad de los Andes

    Chile

    2011 - At present

  •   Investigador Full Time

    Instituto Investigaciones Biomédicas Alberto Sols (IIBM), Consejo Superior de Investigaciones Científicas (CSIC) y de la Universidad Autónoma de Madrid (UAM)

    Madrid, España

    2008 - 2010

  •   Investigador Full Time

    Universidad Complutense de Madrid

    Madrid, España

    2007 - 2008

Formación de Capital Humano


2012-present Miembro del cuerpo académico del Programa de Doctorado en Biomedicina, Universidad de los Andes. Miembro claustro académico UAndes
2016-presente Evaluador ANID
2018 Dirección Practica Profesional. Carrera Biología, mención Bioprocesos. Estudiante: Manuel Ramirez Contador (Pontificia Universidad Católica de Chile) Finalizada
2016 Dirección Practica Profesional.Carrera Ingeniería Biológica, Diseño e Innovación de Bioproductos (Université de Technologie (UTC) de Compiègne, Francia)
2017-2023 Carmen Hidalgo (PhDc, Doctorado en Biomedicina, Universidad de los Andes). Co-tutor de Tesis
2022 Tesis pregrado. Juan Ignacio D olivo (Ingeniero civil Bioternologia, PUC). Tutor
2024 Tesis pregrado. Diego Muñoz (Ingenieria Biotecnologia, USACH), Tutor
2024 Tesis pregrado. Francisca Rodriguez (Ingenieria Biotecnologia, USACH), Tutor
2024 Tesis pregrado. Tamara Inostroza (bioquimica, PUCV). Tutor
2025 Tesis pregrado. Matias Sauma (Biotecnología. U Mayor). Tutor


Difusión y Transferencia


Inventor Patente: (EN) METHOD FOR OBTAINING A COMPOSITION CONTAINING A SPECIFIC POPULATION OF UMBILICAL CORD MESENCHYMAL CELLS AND USES THEREOF (WO/2019/051623). Inventores:MAROUN, Khoury; FIGUEROA, Fernando;ESPINOZA, Francisco;BARTOLUCCI, Jorge;CASTRO, Diego;MONTOYA, Paula;GONZÁLEZ, Paz; CUENCA, Jimena


Premios y Distinciones

  •   Beca predoctoral: "Cátedra Severo Ochoa"

    Consejo Superior de Investigaciones Científicas-BSCH

    España, 2002

    Beca para realización de estudios conducentes a obtención de grado de doctor.

  •   Beca predoctoral: “CNIC-BanCaja”

    CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES

    España, 2004

    Beca para realización de estudios conducentes a obtención de grado de doctor.


 

Article (26)

Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritis

Georges-Calderon, Nicolas; Tobar, Hugo E.; Cuenca, Jimena; Varela, Cristobal; Vernal, Rolando; Nardocci, Gino; Adasme-Vidal, Catalina; Kunze-Kullmer, Maximiliano; Hidalgo, Yessia

Article ISI SCOPUS
Journal of Nanobiotechnology  (2025)

Mitochondrial Antiviral Signaling Protein Activation by Retinoic Acid-Inducible Gene I Agonist Triggers Potent Antiviral Defense in Umbilical Cord Mesenchymal Stromal Cells Without Compromising Mitochondrial Function

Castillo-Galan, Sebastian; Grunenwald, Felipe; Hidalgo, Yessia; Cardenas, J. Cesar; Cadiz, Maria Ignacia; Alcayaga-Miranda, Francisca; Khoury, Maroun; Cuenca, Jimena

Article ISI SCOPUS
International Journal of Molecular Sciences  (2025)

Unraveling the pathogenesis of viral-induced pulmonary arterial hypertension: Possible new therapeutic avenues with mesenchymal stromal cells and their derivatives

Castillo-Galan, Sebastian; Parra, Valentina; Cuenca, Jimena

Article ISI SCOPUS
Biochimica et Biophysica Acta - Molecular Basis of Disease  (2025)

A Phase I Dose-Escalation Clinical Trial to Assess the Safety and Efficacy of Umbilical Cord-Derived Mesenchymal Stromal Cells in Knee Osteoarthritis

Vernal, Rolando; Hidalgo, Yessia; Cuenca, Jimena

Article ISI
Stem Cells Translational Medicine  (2024)

A novel porous hydrogel based on hybrid gelation for injectable and tough scaffold implantation and tissue engineering applications

Hidalgo, Carmen; Viafara-Garcia, Sergio; Cuenca, Jimena

Article ISI
Biomedical Materials (Bristol)  (2023)

A Psychrophilic GelMA: Breaking Technical and Immunological Barriers for Multimaterial High-Resolution 3D Bioprinting

Cuenca, Jimena; Hidalgo, Carmen; Viafara-Garcia, Sergio M.; Wolf, Bettina; Rumbak, Mayan; Enrione, Javier

Article ISI
Biomacromolecules  (2023)

Safety and efficacy of clinical-grade, cryopreserved menstrual blood mesenchymal stromal cells in experimental acute respiratory distress syndrome

Silva, Johnatas Dutra; da Silva, Luisa Helena Andrade; Cruz, Fernanda Ferreira; Utreras, Yildy; Hidalgo, Yessia; Cadiz, Maria Ignacia; Limonchi, Rafael Tapia; Cuenca, Jimena

Article ISI
Frontiers in Cell and Developmental Biology  (2023)

Delivery of affordable and scalable encapsulated allogenic/autologous mesenchymal stem cells in coagulated platelet poor plasma for dental pulp regeneration

Trigo, Cesar; Ortuzar, Maria-Ignacia; Cuenca, Jimena

Article ISI SCOPUS
Scientific Reports  (2022)

Current Status of Cell-Based Therapies for Respiratory Virus Infections: Applicability to COVID-19

Cuenca, Jimena

Article ISI SCOPUS
European Respiratory Journal  (2020)

Exosomes on the border of species and kingdom intercommunication

Cuenca, Jimena

Article ISI SCOPUS
TRANSLATIONAL RESEARCH  (2019)

Stem cell exosomes inhibit angiogenesis and tumor growth of oral squamous cell carcinoma

Rosenberger, Leonie; Lillo-Vera, Fernando; Pedraza, Paulina L.; Ignacia Ortuzar, Maria; Figueroa-Valdes, Aliosha I.; Cuenca, Jimena

Article ISI SCOPUS
SCIENTIFIC REPORTS  (2019)

The Reparative Abilities of Menstrual Stem Cells Modulate the Wound Matrix Signals and Improve Cutaneous Regeneration

Cuenca, Jimena; Le-Gatt, Alice; Castillo, Valentina; Belletti, Jose; Monica Kurte, G.; Schuh, Christina M. A. P.; Khoury, Maroun

Article ISI SCOPUS
Frontiers in Physiology  (2018)

Antimicrobial Activity of Mesenchymal Stem Cells: Current Status and New Perspectives of Antimicrobial Peptide-Based Therapies

Alcayaga-Miranda, Francisca

Article ISI SCOPUS
Frontiers in Immunology  (2017)

Safety and Efficacy of the Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Patients With Heart Failure A Phase 1/2 Randomized Controlled Trial (RIMECARD Trial [Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy])

Bartolucci, Jorge G; Verdugo, Fernando J.; González, Paz L; Larrea, Ricardo E; Lopez, Valentina M; Brobeck, Matthew J; Patel, Amit N

Article ISI SCOPUS
Circulation Research  (2017)

Characterization of menstrual stem cells: angiogenic effect, migration and hematopoietic stem cell support in comparison with bone marrow mesenchymal stem cells

Alcayaga-Miranda F.; Cuenca J.; Luz-Crawford P.; Aguila-Diaz, C; Fernandez A.; Figueroa F.E.; Khoury M.

Article ISI SCOPUS
Stem Cell Research and Therapy  (2015)

Chorion Mesenchymal Stem Cells Show Superior Differentiation, Immunosuppressive, and Angiogenic Potentials in Comparison With Haploidentical Maternal Placental Cells

Carvajal C.; Cuenca J.; Alcayaga-Miranda F.; Figueroa F.E.; Bartolucci J.; Salazar-Aravena, L; Khoury M.

Article ISI SCOPUS
Stem Cells Translational Medicine  (2015)

Combination therapy of menstrual derived mesenchymal stem cells and antibiotics ameliorates survival in sepsis

Alcayaga-Miranda F.; Cuenca J.; Martin A.; Contreras L.; Figueroa F.E.; Khoury M.

Article ISI SCOPUS
Stem Cell Research and Therapy  (2015)

MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers

Duroux-Richard I.; Cuenca J.; Ponsolles, C; Badilla Pineiro, A; González F.; Roubert, C; Areny R.; Chea, R; Pefaur J.; Pers Y.M.; et al.

Article ISI SCOPUS
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2015)

Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors

Castano, Tania; Wang, Huanchen; Ballester, Sara; Gonzalez-Garcia, Coral; Cuenca, Jimena; Huertas, Oscar; Luis Gelpi, Jose; Ke, Hengming

Article ISI
CHEMMEDCHEM  (2009)

Multiple imputation procedures allow the rescue of missing data: An application to determine serum tumor necrosis factor (TNF) concentration values during the treatment of rheumatoid arthritis patients with anti-TNF therapy

Schiattino, I; Villegas R.; Cruzat A.; Cuenca J.; Salazar L.; Aravena O.; Pesce B.; Catalan D.; Llanos C.; Cuchacovich M.

Article ISI SCIELO SCOPUS
BIOLOGICAL RESEARCH  (2005)

The -308 polymorphism in the promoter region of the tumor necrosis factor-alpha (TNF-?) gene and ex vivo lipopolysaccharide-induced TNF-? expression in patients with aggressive periodontitis and/or type 1 diabetes mellitus

Perez C.; González F.E.; Aguirre Á.; Cruzat A.; Contreras-Levicoy, J; Dotte, A; Aravena O.; Salazar L.; Catalan D.; Cuenca J.; et al.

Article SCOPUS
European Cytokine Network  (2004)

The -308 polymorphism in the promotor region of the tumor necrosis factor-alpha (TNF-alpha) gene and ex vivo lipopolysaccharide-induced TNF-alpha expression in patients with aggresive peridontitis and/or type 1 diabetes mellitus

Perez C.; Pavez V.; Aguirre Á.; Cruzat A.; Contreras-Levicoy, J; Dotte, A; Aravena O.; Salazar L.; Catalan D.; Cuenca J.; et al.

Article ISI
European Cytokine Network  (2004)

Tumour necrosis factor-alpha (TNF-alpha) levels and influence of 2308 TNF-alpha promoter polymorphism on the responsiveness to infliximab in patients with rheumatoid arthritis

Cuchacovich M.; Ferreira L.; Aliste, M; Soto L.; Cuenca J.; Cruzat A.; Gatica H.; Schiattino, I; Perez C.; Aguirre Á.; et al.

Article ISI SCOPUS
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY  (2004)

The -308 polymorphism in the tumour necrosis factor (TNF) gene promoter region and ex vivo lipopolysaccharide-induced TNF expression and cytotoxic activity in Chilean patients with rheumatoid arthritis

Cuenca J.; Cuchacovich M.; Perez C.; Ferreira L.; Aguirre Á.; Schiattino, I; Soto L.; Cruzat A.; SALAZAR ONFRAY F

Article ISI SCOPUS
RHEUMATOLOGY  (2003)

Tumor necrosis factor alpha genetic polymorphism as a risk factor in disease

Cruzat A.; Cuenca J.; Cuchacovich M.

Article ISI
REVISTA MEDICA DE CHILE  (2002)

Genetic polymorphism at position-308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population

Cuenca J.; Aguirre, AJ; Schiattino, I

Article ISI SCIELO
BIOLOGICAL RESEARCH  (2001)

ConferencePoster (3)

A phase I clinical trial for safety determination of the intra-articular administration of umbilical cord mesenchymal stromal cells-derived small extracellular vesicles in patients with knee osteoarthrosis

José Matas1 ; Eliseo Parra2; Aliosha I. Figueroa-Valdés2; Jimena Cuenca3; Yessia Hidalgo4; María Ignacia Cádiz5; Celeny Figuera5; Dario Donoso Meneses3; Fernando Figueroa3; Maroun Khoury4; Francisca Alcayaga-Miranda3; Francisco Espinoza1

ConferencePoster
 (2022)

Cryopreserved Mesenchymal Stem Cells: Are they Safe and Effective for Treatment of Acute Respiratory Distress Syndrome?,

Rocco, P

ConferencePoster
 (2019)

SAFETY AND EFFICACY PROFILE OF CRYOPRESERVED MESENCHYMAL STEM CELLS FOR THE TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME

Alcayaga, F; Rocco P P.

ConferencePoster
 (2019)

Patent (1)

METHOD FOR OBTAINING A COMPOSITION CONTAINING A SPECIFIC POPULATION OF UMBILICAL CORD MESENCHYMAL CELLS AND USES THEREOF

Castro, Diego; Cuenca, Jimena

Patent patent pending
 

Proyecto (5)

Desarrollo de un producto alogénico basado en un hidrogel bioactivo con nanovesículas extracelulares y su validación como tratamiento endodóntico regenerativo

Cuenca, Jimena

Proyecto
 (2023)

Center of Interventional Medicine for Precision and Advanced Cellular Therapy (IMPACT)

Universidad de Chile; Universidad de La Frontera; UNIVERSIDAD DE LOS ANDES

Proyecto
 (2021)

Investigating the effect of MAVs-enriched mitochondrial transplantation on intracellular antiviral immunity and their restorative and immunomodulatory effects in a viral-induced acute lung injury model

Cuenca, Jimena; Hidalgo, Yessia

Proyecto
 (2021)

REGENERO THE CHILEAN STEM CELL CONSORTIUM



Proyecto
 (2013)

Investigating the anti-angiogenic effect of exosome-mediated delivery of functionally active miRNA-149-3p,145-5p and 6131 to tumor tissue.

Alcayaga, Francisca; Cuenca, Jimena

Proyecto
 (0)

19
Maroun Khoury

Professor

Faculty of Medicine

Universidad de Los Andes

santiago, Chile

2
Lilian Soto

Rheumatologist

Medicine

CLINICAL HOSPITAL OF UNIVERSIDAD DE CHILE

Santiago, Chile

6
Fernando Figueroa

Director

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago de Chile, Chile

4
Lorena Salazar

Profesora Asistente

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Lampa, Chile

6
JUAN AGUILLON

PROFESSOR

IMMUNOLOGY PROGRAM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

3
OCTAVIO ARAVENA

Gestión I+D

I+D+i

Comisión Chilena de Energía Nuclear

Santiago, Chile

2
Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

1
Javier Enrione

Profesor Titular

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

1
Rolando Vernal

Profesor Titular

Departamento de Odontología Conservadora

UNIVERSIDAD DE CHILE

Santiago, Chile

36
Jimena Cuenca

Investigador/profesor

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

1
Alejandro Bruhn

Profesor Titular. Director de Investigación y Postgrado, Facultad de Medicina

Departamento de Medicina Intensiva

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

7
Francisca Alcayaga

Profesor Asociado

Facultad de Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
ARTURO FERREIRA

FULL PROFESSOR, CHAIR IMMUNOLOGY DISCIPLINARY PROGRAM

IMMUNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Carolina Llanos

Associate Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Hugo Tobar

GLP Unit Manager

IMPACT

IMPACT Center, Universidad de los Andes

Santiago, Chile

2
gabriela zavala

Investigador post-doctoral

Cells for Cells

Universidad de los Andes

Santiago, Chile

3
Patricia Luz

Profesor asistente

Universidad de los Andes

Santiago , Chile

3
Lorena Salazar

Academico

Instituto Cs Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Jacqueline Péfaur

1
Rodrigo Villegas

Académico

Instituto de Salud Poblacional

Universidad de Chile

Santiago, Chile

1
Monica Kurte

Investigador

Ninguna

Santiago, Chile

1
Fermín González

Profesor Asociado

Odontología Conservadora

Universidad de Chile

Santiago, Chile

2
Aliosha Figueroa

Asistente de Investigación Senior

Centro de Medicina Intervencional de Precisión y Terapia Celular Avanzada (IMPACT)

Santiago, Chile

4
Yessia Hidalgo

Flow cytometry unit manager / Researcher

Centro de Investigación e Innovación Biomédica

Corporación IMPACT / Universidad de Los Andes

Santiago, Chile

1
Ana Martinez

Research Professor

Centro Investigaciones Biológicas (CIB)

Consejo Superior de Investigaciones Científicas (CSIC)

Madrid, Chile

1
Nuria Campillo

Científico titular

Biología Físico-Química

Centro de Investigaciones Biológicas (CIB-CSIC)

Madrid, España

1
Carmen Gil

4
Claudia Brizuela

Research professor

Endodontic

Universidad de Los Andes

Santiago, Chile

1
Christina Schuh

Associate Professor

Centre for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

1
Fernando Verdugo

Cardiologo

Cardiologia

Hospital del Salvador

Santiago, Chile

3
Diego Catalán

Associate Professor

Programa Disciplinario de Inmunología

Universidad de Chile

Santiago, Chile

1
Valentina Castillo

Investigadora Postdoctoral

Instituto de Ingeniería Biológica y Médica

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Bárbara Pesce

Profesora Asistente

ICBM

Universidad de Chile

Santiago, Chile

2
Sergio Viafara

Asistant Researcher

CiiB

Universidad de Los Andes

Santiago, Chile

2
Maria Ortúzar

Gerente de producto

Nalca Biotech SpA

Puerto Varas, Chile

1
Sebastian Castillo

Postdoc

Medicina

Universidad de Los Andes

Santiago, Chile