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Ana Martinez Gil

Research Professor

Consejo Superior de Investigaciones Científicas (CSIC)

Madrid, Chile

Pharmaceutical Chemistry, Medicinal chemistry, Biological Chemistry, Drug design, anti-neurodegenerative drugs

Organic Chemistry , UNIVERSIDAD COMPLUTENSE DE MADRID. España, 1984
Medicinal Chemistry, UNIVERSIDAD COMPLUTENSE DE MADRID. Chile, 1987
Bussiness Development, UNIVERSIDAD DE NAVARRA. Chile, 2005

Annual Scientic Prize

Royal Spanish Pharmacy Academy

España, 2018

Annual Scientic Prize from the Royal Spanish Pharmacy Academy (RANF)
Award to the best patent.

Madrid+d

Chile, 2015

Madrid+d award to the best patent.
Almirall

Sociedad Española de Química Terapéutica

Chile, 1989

Almirall-SEQT award for young reserachers
PhD Thesis

Caja Madrid

Chile, 1988

Caja Madrid award for PhD Thesis
Extraordinary University award to PhD

UNIVERSIDAD COMPLUTENSE DE MADRID

Chile, 1987

Extraordinary University award to PhD
SEQT award for young researchers in medicinal chemistry

UNIVERSIDAD CENTRAL DE CHILE

Chile, 1985

SEQT award for young researchers in medicinal chemistry


Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate Garcia, Ana M.; Zhao, Wen-Ning; Medina-Menendez, Cristina; Haggarty, Stephen J. Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2020)
Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools Garcia-Rubia, Alfonso; el-Din, Sayed H. Seif; Sabra, Abdel-Nasser A.; El-Lakkany, Naglaa M.; William, Samia; Blundell, Tom L.; Maes, Louis; Botros, Sanaa S. Article ISI JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2020)
From simple quinoxalines to potent oxazolo[5,4-f]quinoxaline inhibitors of glycogen-synthase kinase 3 (GSK3) Lassagne, Frederic; Dugueperoux, Camille; Baratte, Blandine; Robert, Thomas; Ruchaud, Sandrine; Bach, Stephane; Erb, William; Mongin, Florence Article ISI ORGANIC & BIOMOLECULAR CHEMISTRY (2020)
Serum- and glucocorticoid-induced kinase 1, a new therapeutic target for autophagy modulation in chronic diseases Maestro, Ines Article ISI EXPERT OPINION ON THERAPEUTIC TARGETS (2020)
Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3 Martinez de Iturrate, Paula; Sebastian-Perez, Victor; Nacher-Vazquez, Montserrat; Tremper, Catherine S.; Smirlis, Despina; Martin, Julio; Campillo, Nuria E.; Rivas, Luis; Gil, Carmen Article ISI JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2020)
1-Aryl-3-(4-methoxybenzyl)ureas as potentially irreversible glycogen synthase kinase 3 inhibitors: Synthesis and biological evaluation Venter, Jana; van Otterlo, Willem A. L.; Blackie, Margaret A. L. Article ISI BIOORGANIC MEDICINAL CHEMISTRY LETTERS (2019)
A Focused Library of Psychotropic Analogues with Neuroprotective and Neuroregenerative Potential Uliassi, Elisa; Pena-Altamira, Luis Emiliano; Massenzio, Francesca; Rossi, Michele; Roberti, Marinella; Martinez Gonzalez, Loreto Article ISI ACS Chemical Neuroscience (2019)
A Triazolotriazine-Based Dual GSK-3 beta/CK-1 delta Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition Redenti, Sara; Marcovich, Irene; De Vita, Teresa; De Zorzi, Rita; Demitri, Nicola; Bottegoni, Giovanni; Bisignano, Paola; Bissaro, Maicol; Moro, Stefano; Storici, Paola; et al. Article ISI CHEMMEDCHEM (2019)
Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3 Lourdes Sciu, M.; Benitez, Rocio; Laura Moyano, E. Article ISI JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2019)
Correction of Glycogen Synthase Kinase 3 beta in Myotonic Dystrophy 1 Reduces the Mutant RNA and Improves Postnatal Survival of DMSXL Mice Weng, Wen-Chin; Stock, Lauren; Lindquist, Diana; Gourdon, Genevieve; Timchenko, Nikolai; Snape, Mike Article ISI MOLECULAR AND CELLULAR BIOLOGY (2019)
Discovery of novel Schistosoma mansoni PDE4A inhibitors as potential agents against schistosomiasis Schroeder, Susanne; Munday, Jane C.; van der Meer, Tiffany; Zaldivar-Diez, Josefa; Siderius, Marco; de Koning, Harry P.; Brown, Dave; Leurs, Rob Article ISI FUTURE MEDICINAL CHEMISTRY (2019)
GSK-3 Inhibitors: From the Brain to the Retina and Back Again Sanchez-Cruz, Alonso; de la Rosa, Enrique J.; Hernandez-Sanchez, Catalina; Rickman, CB; Grimm, C; Anderson, RE; Ash, JD; LaVail, MM; Hollyfield, JG Article ISI ARTERIAL CHEMORECEPTORS (2019)
Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease de Andrade, Peterson; Mantoani, Susimaire P.; Goncalves Nunes, Paulo Sergio; Magadan, Carlos Roca; Xavier, Danilo Jordao; Sakamoto Hojo, Elza Tiemi; Carvalho, Ivone Article ISI BIOORGANIC & MEDICINAL CHEMISTRY (2019)
Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library Canal-Martin, Andrea; Baldominos, Sara; Pascual, Naiara; Molero, Dolores; Encarnacion Fernandez-Valle, Ma; Blanco-Gabella, Patricia; Gomez-Rubio, Elena; Martin-Santamaria, Sonsoles; Saiz, Almudena; Jimenez-Barbero, Jesus; et al. Article ISI NATURE COMMUNICATIONS (2019)
Potential anti-Alzheimer effects of selected Lamiaceae plants through polypharmacology on glycogen synthase kinase-3 beta, beta-secretase, and casein kinase 1 delta Gurbuz, Perihan; Goger, Fatih; Ayran, Irem Article ISI INDUSTRIAL CROPS AND PRODUCTS (2019)
QSAR Modelling for Drug Discovery: Predicting the Activity of LRRK2 Inhibitors for Parkinson's Disease Using Cheminformatics Approaches FdezRiverola, F; Mohamad, MS; DePaz, JF Article ISI INFORMATION TECHNOLOGY: NEW GENERATIONS (2019)
QSAR Modelling to Identify LRRK2 Inhibitors for Parkinson's Disease Jimena Martinez, Maria Article ISI JOURNAL OF INTEGRATIVE BIOINFORMATICS (2019)
Recapitulation of Pathological TDP-43 Features in Immortalized Lymphocytes from Sporadic ALS Patients Posa, Diana; Porras, Gracia Article ISI MOLECULAR NEUROBIOLOGY (2019)
Tau Tubulin Kinase 1 (TTBK1), a new player in the fight against neurodegenerative diseases Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
TDP-43: A Key Therapeutic Target beyond Amyotrophic Lateral Sclerosis Tosat-Bitrian, Carlota; Nozal, Vanesa; Nagaraj, Siranjeevi Article ISI ACS Chemical Neuroscience (2019)
Theoretical and Experimental Approaches Aimed at Drug Design Targeting Neurodegenerative Diseases Morales-Navarro, Samuel; Rodriguez Nunez, Yeray A.; Sanchez-Aros, Laura; Campilllo, Nuria E. Article ISI SCOPUS PROCESSES (2019)
1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders Benek, Ondrej; Hroch, Lukas; Aitken, Laura; Gunn-Moore, Frank; Vinklarova, Lucie; Kuca, Kamil; Fisar, Zdenek; Musilek, Kamil Article ISI JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2018)
Amyloid beta-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition de la Cueva, Macarena; Pascual, Consuelo; Antequera, Desiree; fernandez, tamara Article ISI ALZHEIMERS RESEARCH & THERAPY (2018)
Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors Chierrito, Talita P. C.; Pedersoli-Mantoani, Susimaire; Canales, Angeles; Javier Canada, F. Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Cyclic Nucleotide-Specific Phosphodiesterases as Potential Drug Targets for Anti-Leishmania Therapy Hendrickx, Sarah; Kalejaiye, Titilola; de Koning, Harry; Caljon, Guy Article ISI ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2018)
Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators Daniel-Mozo, Miguel; Sastre, Javier; Infantes, Lourdes; Mansilla, Alicia; Chaves-Sanjuan, Antonio; Maria Gonzalez-Rubio, Juana; Javier Canada, H. F.; Jose Sanchez-Barrena, Maria Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2018)
High-fructose corn syrup consumption in adolescent rats causes bipolar-like behavioural phenotype with hyperexcitability in hippocampal CA3-CA1 synapses Alten, Baris; Yesiltepe, Metin; Bayraktar, Erva; Tas, Sadik Taskin; Gocmen, Ayse Yesim; Kursungoz, Canan; Sara, Yildirim Article ISI BRITISH JOURNAL OF PHARMACOLOGY (2018)
Identification of new allosteric sites and modulators of AChE through computational and experimental tools Requena, Carlos; Malhotra, Sony; Radoux, Chris; Antonio Paez, Juan Article ISI JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2018)
Modulation of GSK-3 provides cellular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa Villarejo-Zori, Beatriz; Marchena, Miguel; Lizasoain, Ignacio; de la Villa, Pedro Article ISI MOLECULAR NEURODEGENERATION (2018)
Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3 beta and Tau-Aggregation Inhibitors Gandini, Annachiara; Bartolini, Manuela; Tedesco, Daniele; Martinez-Gonzalez, Loreto; Roca, Carlos; Zuccheri, Giampaolo; Miti, Andrea; Feoli, Alessandra; Castellano, Sabrina; Petralla, Sabrina; et al. Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2018)
The adiponectin promoter activator NP-1 induces high levels of circulating TNF alpha and weight loss in obese (fa/fa) Zucker rats Decara, Juan; Serrano, Antonia; Javier Pavon, Francisco; Rivera, Patricia; Arco, Rocio; Gavito, Ana; Vargas, Antonio; Navarro, Juan A.; Tovar, Ruben; Lopez-Gambero, Antonio J.; et al. Article ISI SCIENTIFIC REPORTS (2018)
TNF alpha, disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice Cheng, Yuyan; Desse, Sachi; Worthen, Ryan J.; Jope, Richard S.; Beurel, Eleonore Article ISI BRAIN BEHAVIOR AND IMMUNITY (2018)
A preliminary investigation of phoshodiesterase 7 inhibitor VP3.15 as therapeutic agent for the treatment of experimental autoimmune encephalomyelitis mice Martin-Alvarez, R.; Paul-Fernandez, N.; Palomo, V.; Gil, C.; Mengod, G. Article ISI JOURNAL OF CHEMICAL NEUROANATOMY (2017)
Biological and Pharmacological Characterization of BenzothiazoleBased CK-1 delta Inhibitors in Models of Parkinson's Disease Sanz-San Cristobal, Marina Article ISI ACS OMEGA (2017)
Drugs in clinical development for the treatment of amyotrophic lateral sclerosis Palomo Ruiz, Maria del Valle Article ISI EXPERT OPINION ON INVESTIGATIONAL DRUGS (2017)
From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease Castillo, Willian O.; Moreira, Natalia C. S.; Sakamoto-Hojo, Elza T.; Takahashi, Catarina S. Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015) Article ISI EXPERT OPINION ON THERAPEUTIC PATENTS (2017)
GSK-3 inhibitor TDZD-8 reduces neonatal hypoxic-ischemic brain injury in mice Huang, Sammen; Wang, Haitao; Turlova, Ekaterina; Abussaud, Ahmed; Ji, Xiang; Britto, Luiz R.; Miller, Steven P.; Sun, Hong-Shuo Article ISI CNS NEUROSCIENCE & THERAPEUTICS (2017)
Inhibition of hippocampal long-term potentiation by high-fat diets: is it related to an effect of palmitic acid involving glycogen synthase kinase-3? Contreras, Ana; Del Rio, Danila; Morales, Lidia; Ruiz-Gayo, Mariano; Del Olmo, Nuria Article ISI NEUROREPORT (2017)
Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome Semelidou, Ourania; Conde, Santiago; Ferrus, Alberto Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice Pardo, Marta; Velmeshev, Dmitry; Magistri, Marco; Faghihi, Mohammad A. Article ISI JCI INSIGHT (2017)
Leucine rich repeat kinase 2 (LRRK2) inhibitors based on indolinone scaffold: Potential pro-neurogenic agents Salado, Irene G.; Li, Lingling; Geiger, Larissa; Morales, Aixa V.; Perez, Daniel I. Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Medicinal and Biological Chemistry (MBC) Library: An Efficient Source of New Hits Awale, Mahendra; Reymond, Jean-Louis Article ISI JOURNAL OF CHEMICAL INFORMATION AND MODELING (2017)
Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson's disease Garcia, Ana M.; Cadavid, MariaIsabel; Javier Luque, Francisco Article ISI FUTURE MEDICINAL CHEMISTRY (2017)
Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo Echeverry-Alzate, Victor; Sanz-Sancristobal, Marina; Lopez-Moreno, Jose A.; Santos, Angel Article ISI STEM CELLS (2017)
Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis Maria Medina-Rodriguez, Eva; Bribian, Ana; Boyd, Amanda; Pastor, Jesus; Lagares, Alfonso; Williams, Anna Article ISI SCIENTIFIC REPORTS (2017)
Small molecules targeting glycogen synthase kinase 3 as potential drug candidates for the treatment of retinitis pigmentosa Article ISI JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2017)
Subtly Modulating Glycogen Synthase Kinase 3 beta: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases Palomo, Valle; Anderson, Cara; Morales-Garcia, Jose A.; Reyes, Julio A.; Perez-Castillo, Ana M.; Rubin, Lee L.; Timchenko, Lubov Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2017)
Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects Garcia, Ana M. Article ISI MOLECULES (2017)
The GSK-3-inhibitor VP2.51 produces antidepressant effects associated with adult hippocampal neurogenesis Perez-Domper, Paloma; Gradari, Simona; Luis Trejo, Jose Article ISI NEUROPHARMACOLOGY (2017)
Development of Blood-Brain Barrier Permeable Nitrocatechol-Based Catechol O-Methyltransferase Inhibitors with Reduced Potential for Hepatotoxicity Silva, Tiago; Mohamed, Tarek; Shakeri, Arash; Rao, Praveen P. N.; Valente, Maria Joao; Garrido, Jorge; Serrao, Paula; Soares-da-Silva, Patricio; Remiao, Fernando Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2016)
Enhancing cAMP Levels as Strategy for the Treatment of Neuropsychiatric Disorders Garcia, Ana M. Article ISI CURRENT TOPICS IN MEDICINAL CHEMISTRY (2016)
New applications for known drugs: Human glycogen synthase kinase 3 inhibitors as modulators of Aspergillus fumigatus growth Sebastian, Victor; Manoli, Maria-Tsampika; Mellado, Emilia; Espeso, Eduardo A. Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Novel Triazole-Quinoline Derivatives as Selective Dual Binding Site Acetylcholinesterase Inhibitors Vilela, Adriana F. L.; Cardoso, Carmen L. Article ISI MOLECULES (2016)
Small GSK-3 Inhibitor Shows Efficacy in a Motor Neuron Disease Murine Model Modulating Autophagy de Munck, Estefania; Munoz-Saez, Emma; Gomez-Miguel, Begona; Teresa Solas, M.; Arahuetes, Rosa M. Article ISI PLOS ONE (2016)
Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior Armini, Rubia de Souza; Mouhsine, Hadley; Zagury, Jean-Francois Article ISI BRAIN BEHAVIOR AND IMMUNITY (2016)
Targeting TDP-43 phosphorylation by Casein Kinase-1 delta inhibitors: a novel strategy for the treatment of frontotemporal dementia de la Encarnacion, Ana; Moreno, Fermin; Lopez de Munain, Adolfo Article ISI MOLECULAR NEURODEGENERATION (2016)
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3 beta Inhibitors Di Martino, Rita Maria Concetta; De Simone, Angela; Andrisano, Vincenza; Bisi, Alessandra; Gobbi, Silvia; Rampa, Angela; Fato, Romana; Bergamini, Christian; CavaIli, Andrea; Belluti, Federica Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2016)
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3 beta Fragment Hits against Alzheimer's Disease Prati, Federica; Armirotti, Andrea; Surnma, Maria; Pizzirani, Daniela; Scarpelli, Rita; Bertozzi, Sine Mandrup; Racchi, Marco; Sabatino, Piera; Bolognesi, Maria L. Article ISI ACS Chemical Neuroscience (2015)
Analysis of beta-N-methylamino-L-alanine (L-BMAA) neurotoxicity in rat cerebellum de Munck Garcia, Estefania; Arahuetes Portero, Rosa Ma; Solas Alados, Ma Teresa; Gomez Miguel, Begona Article ISI NEUROTOXICOLOGY (2015)
Biology-oriented development of novel lipophilic antioxidants with neuroprotective activity Summavielle, T. Article ISI RSC ADVANCES (2015)
From Bitopic Inhibitors to Multitarget Drugs for the Future Treatment of Alzheimer's Disease Article ISI CURRENT MEDICINAL CHEMISTRY (2015)
Impairments in cognition and neural precursor cell proliferation in mice expressing constitutively active glycogen synthase kinase-3 King, Margaret K.; Perez-Costae, Emma; Melendez-Ferre, Miguel Article ISI FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2015)
Morphometric and neurochemical alterations found in L-BMAA treated rats Miguel, Begona G.; Teresa Solas, Ma; Ma Arahuetes, Rosa Article ISI ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2015)
Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3 beta Inhibitors Summa, Maria; Favia, Angelo D. Article ISI ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
PDE7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis Mestre, L.; Redondo, M; Carrillo-Salinas, F. J.; Morales-Garcia, J. A.; Alonso-Gil, S.; Perez-Castillo, A.; Guaza, C. Article ISI BRITISH JOURNAL OF PHARMACOLOGY (2015)
Phosphodiesterase 7 Inhibition Induces Dopaminergic Neurogenesis in Hemiparkinsonian Rats Article ISI STEM CELLS TRANSLATIONAL MEDICINE (2015)
Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice Aguilar-Morante, Diana; Hernandez-Encinas, Elena Article ISI NEUROBIOLOGY OF AGING (2015)
Therapeutic approaches for the future treatment of Fragile X Sastre, Ana Article ISI CURRENT OPINION IN BEHAVIORAL SCIENCES (2015)
cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases Article ISI EXPERT OPINION ON THERAPEUTIC PATENTS (2014)
CB1 Blockade Potentiates Down-Regulation of Lipogenic Gene Expression in Perirenal Adipose Tissue in High Carbohydrate Diet-Induced Obesity Vida, Margarita; Luisa Gavito, Ana; Arrabal, Sergio; Romero-Cuevas, Miguel; Bautista, Dolores Article ISI PLOS ONE (2014)
Crosstalk between Phosphodiesterase 7 and Glycogen Synthase Kinase-3: Two Relevant Therapeutic Targets for Neurological Disorders Article ISI ACS Chemical Neuroscience (2014)
Glycogen Synthase Kinase-3 Inhibitors Reverse Deficits in Long-term Potentiation and Cognition in Fragile X Mice Franklin, Aimee V.; McMahon, Lori L. Article ISI BIOLOGICAL PSYCHIATRY (2014)
Modulation of cAMP-Specific PDE without Emetogenic Activity: New Sulfide-Like PDE7 Inhibitors Garcia, Ana M.; Gracia-Rubio, Irene; Ros-Simo, Clara; Valverde, Olga Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2014)
Protein Kinase CK-1 Inhibitors As New Potential Drugs for Amyotrophic Lateral Sclerosis Bello, Murilo L.; Liachko, Nicole F.; Kraemer, Brian C.; Miguel, Laetitia; Lecourtois, Magalie Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2014)
A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases Staderini, Matteo; Aulic, Suzana; Hoang Ngoc Ai Tran; Gonzalez-Ruiz, Victor; Cabezas, Nieves; Antonia Martin, M.; Carlos Menendez, J. Article ISI ACS MEDICINAL CHEMISTRY LETTERS (2013)
beta-N-methylamino-L-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): The first step towards an experimental model for sporadic ALS Ojeda, Irene Article ISI ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2013)
Comparative assessment of PDE 4 and 7 inhibitors as therapeutic agents in experimental autoimmune encephalomyelitis Gonzalez-Garcia, C.; Ballester, A.; Gomez-Perez, R.; Eguiluz, C.; Redondo, M; Ballester, S. Article ISI BRITISH JOURNAL OF PHARMACOLOGY (2013)
Dual inhibitor of PDE7 and GSK-3-VP1.15 acts as antipsychotic and cognitive enhancer in C57BL/6J mice Lipina, Tatiana V.; Roder, John C. Article ISI NEUROPHARMACOLOGY (2013)
Emerging Drugs and Targets for Parkinson's Disease Article ISI EMERGING DRUGS AND TARGETS FOR ALZHEIMER'S DISEASE, VOL 2: NEURONAL PLASTICITY, NEURONAL PROTECTION AND OTHER MISCELLANEOUS STRATEGIES (2013)
Evidence for a new binding mode to GSK-3: Allosteric regulation by the marine compound palinurin Bidon-Chanal, Axel; Fuertes, Ana; Alonso, Diana Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
Glycogen Synthase Kinase-3 Inhibitors as Potent Therapeutic Agents for the Treatment of Parkinson Disease. Susin, C.; Perez, D. I. Article ISI ACS Chemical Neuroscience (2013)
Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival Medina-Rodriguez, E. M.; Arenzana, F. J.; Redondo, M; Garcia de Sola, R.; Bribian, A. Article ISI CELLULAR AND MOLECULAR LIFE SCIENCES (2013)
Lessons Learnt from Glycogen Synthase Kinase 3 Inhibitors Development for Alzheimer's Disease Article ISI CURRENT TOPICS IN MEDICINAL CHEMISTRY (2013)
Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease Perez-Gonzalez, Rocio; Bolos, Marta; Perez-Grijalba, Virginia; Krzyzanowska, Agnieszka; Sarasa, Manuel Article ISI NEUROBIOLOGY OF AGING (2013)
Regulation of Th1 Cells and Experimental Autoimmune Encephalomyelitis by Glycogen Synthase Kinase-3 Kaidanovich-Beilin, Oksana; Yeh, Wen-I; Song, Ling; Michalek, Suzanne M.; Woodgett, James R.; Harrington, Laurie E. Article ISI JOURNAL OF IMMUNOLOGY (2013)
Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities Redondo, Miriam; Soteras, Ignacio; Brea, Jose; Gonzalez-Garcia, Alejandro; Isabel Cadavid, Maria; Isabel Loza, Maria Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
5-Imino-1,2,4-Thiadiazoles: First Small Molecules As Substrate Competitive Inhibitors of Glycogen Synthase Kinase 3 Encinas, Arantxa; Castro, Ana Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2012)
5-Imino-1,2-4-thiadiazoles and quinazolines derivatives as glycogen synthase kinase 3 beta (GSK-3 beta) and phosphodiesterase 7 (PDE7) inhibitors: Determination of blood-brain barrier penetration and binding to human serum albumin Pistolozzi, Marco; Fortugno, Cecilia; Felix, Guy; Bertucci, Carlo Article ISI EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2012)
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation Chiriano, Gianpaolo; Mancini, Francesca; Carloni, Paolo Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2012)
Adiponectin promoter activator NP-1 reduces body weight and hepatic steatosis in high-fat diet-fed animals Pavon, Francisco J.; Bermudez-Silva, Francisco J.; Alonso, Monica; Lopez-Ogalla, Javier; Alonso-Gascon, Mercedes; Santamaria, Gema; Perez-Valero, Vidal Article ISI AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2012)
Effect of Phosphodiesterase 7 (PDE7) Inhibitors in Experimental Autoimmune Encephalomyelitis Mice. Discovery of a New Chemically Diverse Family of Compounds Val, Cristina; Alonso-Gil, Sandra; Paul-Fernandez, Nuria; Martin-Alvarez, Rocio; Perez-Castillo, Ana; Mengod, Guadalupe Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2012)
Glycogen Synthase Kinase 3 Inhibition Promotes Adult Hippocampal Neurogenesis in Vitro and in Vivo Luna-Medina, Rosario Article ISI ACS Chemical Neuroscience (2012)
Identification in Silico and Experimental Validation of Novel Phosphodiesterase 7 Inhibitors with Efficacy in Experimental Autoimmune Encephalomyelitis Mice Article ISI ACS Chemical Neuroscience (2012)
Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model Zarruk, Juan G.; Ceballos, Placido; Moro, Maria A.; Cadavid, Maria I.; Loza, Maria I. Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2012)
The new iminothiadiazole derivative VP1.14 ameliorates hippocampal damage after an excitotoxic injury Susin, Cristina Article ISI JOURNAL OF NEUROCHEMISTRY (2012)
An application of two MIFs-based tools (Volsurf plus and Pentacle) to binary QSAR: The case of a palinurin-related data set of non-ATP competitive Glycogen Synthase Kinase 3 beta (GSK-3 beta) inhibitors Ermondi, Giuseppe; Caron, Giulia; Garcia Pintos, Isela; Gerbaldo, Michela; Gandara, Zoila; Gomez, Generosa; Fall, Yagamare Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
Exploring the Binding Sites of Glycogen Synthase Kinase 3. Identification and Characterization of Allosteric Modulation Cavities Eugenia Campillo, Nuria Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2011)
GSK-3 inhibitors: preclinical and clinical focus on CNS Article ISI Frontiers in Molecular Neuroscience (2011)
PDE 7 Inhibitors: New Potential Drugs for the Therapy of Spinal Cord Injury Paterniti, Irene; Mazzon, Emanuela; Impellizzeri, Daniela; Redondo, Myriam; Esposito, Emanuela; Cuzzocrea, Salvatore Article ISI PLOS ONE (2011)
Phosphodiesterase 7 Inhibition Preserves Dopaminergic Neurons in Cellular and Rodent Models of Parkinson Disease Article ISI PLOS ONE (2011)
Protein Kinases CK1 and CK2 as New Targets for Neurodegenerative Diseases Article ISI MEDICINAL RESEARCH REVIEWS (2011)
Reduction of body weight, liver steatosis and expression of stearoyl-CoA desaturase 1 by the isoflavone daidzein in diet-induced obesity Crespillo, A.; Vida, M.; Pavon, F. J.; Romero-Zerbo, Y.; Perez-Valero, V.; Bermudez-Silva, F. J.; de Fonseca, F. R. Article ISI BRITISH JOURNAL OF PHARMACOLOGY (2011)
Switching Reversibility to Irreversibility in Glycogen Synthase Kinase 3 Inhibitors: Clues for Specific Design of New Compounds Dans, Pablo D.; Javier Luque, F. Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2011)
Emerging Drugs and Targets for Alzheimer's Disease, Vol 2: Neuronal Plasticity, Neuronal Protection and Other Miscellaneous Strategies Article ISI EMERGING DRUGS AND TARGETS FOR ALZHEIMER'S DISEASE, VOL 2: NEURONAL PLASTICITY, NEURONAL PROTECTION AND OTHER MISCELLANEOUS STRATEGIES (2010)
Anticonvulsant and Neuroprotective Effects of the Novel Calcium Antagonist NP04634 on Kainic Acid-Induced Seizures in Rats Article ISI JOURNAL OF NEUROSCIENCE RESEARCH (2009)
NP04634 prevents cell damage caused by calcium overload and mitochondrial disruption in bovine chromaffin cells Valero, Teresa; del Barrio, Laura; Egea, Javier; Canas, Noelia; Garcia, Antonio G.; Villarroya, Mercedes Article ISI EUROPEAN JOURNAL OF PHARMACOLOGY (2009)
Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors Castano, Tania; Wang, Huanchen; Ballester, Sara; Gonzalez-Garcia, Coral; Cuenca, Jimena; Huertas, Oscar; Luis Gelpi, Jose; Ke, Hengming Article ISI CHEMMEDCHEM (2009)
Tacrine-Melatonin Hybrids as Multifunctional Agents for Alzheimer's Disease, with Cholinergic, Antioxidant, and Neuroprotective Properties Isabel Fernandez-Bachiller, Maria; Cristina Gonzalez-Munoz, Gema; Usan, Paola; Garcia-Palomero, Esther; Garcia, Antonio G.; Isabel Rodriguez-Franco, Maria Article ISI CHEMMEDCHEM (2009)
The first enantioselective synthesis of palinurin Castro, Ana Article ISI CHEMICAL COMMUNICATIONS (2009)
Thienylhalomethylketones: Irreversible glycogen synthase kinase 3 inhibitors as useful pharmacological tools Simon, Diana; Wandosell, Francisco; Moreno, Francisco J.; Gelpi, Jose L.; Luque, Francisco J. Article ISI BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice Rosa, Angelo O.; Kaster, Manuella P.; Binfare, Ricardo W.; Morales, Susana; Martin-Aparicio, Ester; Luisa Navarro-Rico, Maria; Garcia, Antonio G.; Rodrigues, Ana Lucia S. Article ISI PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2008)
CODES, a novel procedure for ligand-based virtual screening: PDE7 inhibitors as an application example Castro, Ana; Jose Jerez, Maria; Calderson, Felix; Domenech, Teresa; Nueda, Arsenio Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2008)
Neuroprotective effect of the new thiadiazolidinone NP00111 against oxygen-glucose deprivation in rat hippocampal slices: Implication of ERK1/2 and PPAR gamma receptors Garcia, Antonio G. Article ISI EXPERIMENTAL NEUROLOGY (2008)
Non-ATP competitive glycogen synthase kinase 3 beta (GSK-3 beta) inhibitors: Study of structural requirements for thiadiazolidinone derivatives Castro, Ana; Braese, Stefan; Porcal, Williams; Perez, Concepcio Article ISI BIOORGANIC & MEDICINAL CHEMISTRY (2008)
PDE7 inhibitors as new drugs for neurological and inflammatory disorders Article ISI EXPERT OPINION ON THERAPEUTIC PATENTS (2008)
Polyaniline-based microelectrodes for sensing ascorbic acid in beverages Kilmartin, Paul A.; Bartlett, P. N. Article ISI CURRENT APPLIED PHYSICS (2008)
Potent beta-amyloid modulators Usan, P.; Delgado, E.; De Austria, C. Article ISI NEURODEGENERATIVE DISEASES (2008)
Preclinical efficacy on GSK-3 inhibitors: Towards a future generation of powerful drugs Article ISI MEDICINAL RESEARCH REVIEWS (2008)
Electron Correlated Ab Initio Study of Amino Group Flexibility for Improvement of Molecular Mechanics Simulations on Nucleic Acid Conformations and Interactions Poltev, V. I.; Deriabina, A.; Furmanchuk, A.; Gorb, L.; Leszczynski, J. Article ISI JOURNAL OF BIOLOGICAL PHYSICS (2007)
Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease Hamann, Mark; Perez-Puerto, M. Jose; Castro, Ana; Morales, Susana; Navarro, Maria Luisa; del Monte-Millan, Maria; Pennaka, Hari; Balaiah, Akula; Peng, Jiangnan; Cook, Jennifer; et al. Article ISI JOURNAL OF NATURAL PRODUCTS (2007)
NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: Potential therapeutic role in brain disorders Cortes-Canteli, Marta; Sanchez-Galiano, Susana Article ISI JOURNAL OF NEUROSCIENCE (2007)
Dual binding site acetylcholinesterase inhibitors - Potential new disease-modifying agents for AD Valenzuela, Rita; de Austria, Celia; Munoz-Ruiz, Pilar; Dorronsoro, Isabel Article ISI JOURNAL OF MOLECULAR NEUROSCIENCE (2006)
Enantioselective LC/MS method for the determination of an antimalarial agent fenozan B07 in dog plasma Maraschiello, C; Vilageliu, J; Dorronsoro, I; Floriano, P; Gomez-Acebo, E Article ISI CHIRALITY (2006)
Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases Rao, Karumanchi V.; Donia, Marwa S.; Franzblau, Scott G.; Tekwani, Babu L.; Khan, Shabana I.; Willett, Kristine L.; Hamann, Mark T. Article ISI JOURNAL OF NATURAL PRODUCTS (2006)
Novel cholinesterase inhibitors as future effective drugs for the treatment of Alzheimer's disease Article ISI EXPERT OPINION ON INVESTIGATIONAL DRUGS (2006)
Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors Castro, Ana Article ISI CURRENT PHARMACEUTICAL DESIGN (2006)
Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: Advances in the development of specific phosphodiesterase inhibitors Jerez, MJ Article ISI MEDICINAL RESEARCH REVIEWS (2005)
Design and synthesis of N-benzylpiperidine-purine derivatives as new dual inhibitors of acetyl- and butyryleholinesterase Rodriguez-Franco, MI; Fernandez-Bachiller, MI Article ISI BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: New disease-modifying agents for Alzheimer's disease Munoz-Ruiz, P; del Monte-Millan, M; Bartolini, M; Andrisano, V; Orozco, M; Luque, FJ Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2005)
Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE Alonso, D; del Monte, M; Orozco, M Article ISI BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Good oral absorption prediction on non-nucleoside benzothiadiazine dioxide human cytomegalovirus inhibitors using combined chromatographic and neuronal network techniques Article ISI BIOORGANIC MEDICINAL CHEMISTRY LETTERS (2005)
Marine compounds for the therapeutic treatment of neurological disorders Alonso, D Article ISI EXPERT OPINION ON THERAPEUTIC PATENTS (2005)
Molecular mechanics description of cytosine energy and geometry using preliminary ab initio results Poltev, VI; Deriabina, AS; Lozano, L Article ISI JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM (2005)
Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation Luna-Medina, R; Cortes-Canteli, M Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
SAR and 3D-QSAR studies on thiadiazolidinone derivatives: Exploration of structural requirements for glycogen synthase kinase 3 inhibitors Gelpi, JL; Moreno, FJ Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2005)
Synthesis and biological evaluation of tacrine-thiadiazolidinone hybrids as dual acetyl-cholinesterase inhibitors Alonso, D; del Monte, M Article ISI ARCHIV DER PHARMAZIE (2005)
CODES/Neural network model: a useful tool for in silico prediction of oral absorption and blood-brain barrier permeability of structurally diverse drugs Chana, A; Stud, M Article ISI QSAR COMBINATORIAL SCIENCE (2004)
GSK-3 inhibitors: Discoveries and developments Article ISI CURRENT MEDICINAL CHEMISTRY (2004)
Nitric oxide in the cerebral cortex of amyloid-precursor protein (SW) Tg2576 transgenic mice Rodrigo, J; Castro-Blanco, S; Bentura, ML; Nieto, M; Gomez-Isla, T; Fernandez, AP Article ISI NEUROSCIENCE (2004)
AMPA Glutamate Receptors and Neuropathic Pain Morales-Alcelay, Susana Article ISI MINI-REVIEWS IN MEDICINAL CHEMISTRY (2003)
Benzothiadiazine dioxides (BTD) derivatives as non-nucleoside human cytomegalovirus (HCMV) inhibitors. Study of structural requirements for biological activity Article ISI BIOORGANIC & MEDICINAL CHEMISTRY (2003)
Synthesis and muscarinic activities of O-[benzyl- or benzoylpyrazolyl)propynyl]-oximes of N-methylpiperidinone, 3-tropinone, and 3-quinuclidinone Rodriguez-Franco, MI; Badia, A; Banos, JE Article ISI BIOORGANIC & MEDICINAL CHEMISTRY (2003)
Thienyl and phenyl alpha-halomethyl ketones: New inhibitors of glycogen synthase kinase (GSK-3 beta) from a library of compound searching Perez, DI Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2003)
First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3 beta) inhibitors: Thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2002)
Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation Article ISI MEDICINAL RESEARCH REVIEWS (2002)
Inhibitors of glycogen synthase kinase-3: future therapy for unmet medical needs? Article ISI EXPERT OPINION ON THERAPEUTIC PATENTS (2002)
Non-Cholinergic Pharmacotherapy Approaches to the Future Treatment of Alzheimer's Disease Castro, Ana; Isabel Rodriguez-Franco, M. Article ISI MINI-REVIEWS IN MEDICINAL CHEMISTRY (2002)
Anti-HIV-1 activity of benzothiadiazine dioxide Witvrouw, M; Pannecouque, C; Balzarini, J; De Clercq, E Article ISI ANTIVIRAL CHEMISTRY CHEMOTHERAPY (2001)
CoMFA of benzyl derivatives of 2,1,3-benzo and benzothieno[3,2-a]thiadiazine 2,2-dioxides: clues for the design of phosphodiesterase 7 inhibitors Abasolo, MI; Segarra, V Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2001)
Peripheral and Dual Binding Site Acetylcholinesterase Inhibitors: Implications in treatment of Alzheimer's Disease Castro, Ana Article ISI MINI-REVIEWS IN MEDICINAL CHEMISTRY (2001)
Recent strategies in the development of new human cytomegalovirus inhibitors Article ISI MEDICINAL RESEARCH REVIEWS (2001)
Benzothiadiazine dioxide dibenzyl derivatives as potent human cytomegalovirus inhibitors: Synthesis and comparative molecular field analysis Bruno, AM Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2000)
Benzyl derivatives of 2,1,3-benzo- and benzothieno[3,2-a]thiadiazine 2,2-dioxides: First phosphodiesterase 7 inhibitors Miralpeix, M; Domenech, T; Beleta, J; Palacios, JM; Ryder, H; Miro, X; Casacuberta, JM; Azorin, F; Pina, B Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2000)
Hindered inversion/rotation in diheteroaryl alkyl amines with a N-(1-pyrazolyl) group: Dynamic NMR and molecular modelling studies Rodriguez-Franco, MI Article ISI TETRAHEDRON (2000)
Inhibition of tau phosphorylation: a new therapeutic strategy for the treatment of Alzheimer's disease and other neurodegenerative disorders Article ISI EXPERT OPINION ON THERAPEUTIC PATENTS (2000)
Lipase-catalysed synthesis of new acetylcholinesterase inhibitors: N-benzylpiperidine aminoacid derivatives Lanot, C Article ISI BIOORGANIC & MEDICINAL CHEMISTRY (2000)
N-benzylpiperidine derivatives of 1,2,4-thiadiazolidinone as new acetylcholinesterase inhibitors Rodriguez-Franco, I; Banos, JE; Badia, A Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2000)
Nonnucleoside human cytomegalovirus inhibitors: Synthesis and antiviral evaluation of (chlorophenylmethyl)benzothiadiazine dioxide derivatives Andrei, G; Snoeck, R; De Clercq, E Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2000)
Novel agents for the treatment of human cytomegalovirus infection Article ISI EXPERT OPINION ON THERAPEUTIC PATENTS (2000)
Prediction of drug half-life values of antihistamines based on the CODES/neural network model Caceres J. Article ISI QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS (2000)
Regioselective lipase-catalysed gamma-monoamidation of D-glutamic acid diesters: effect of the N-protecting group Article ISI TETRAHEDRON-ASYMMETRY (2000)
Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties Rodriguez-Franco, MI; Badia, A; Banos, JE Article ISI ARCHIV DER PHARMAZIE (2000)
Thienothiadiazine 2,2-dioxide acyclonucleosides: synthesis and antiviral activity De Clercq, E Article ISI ANTIVIRAL CHEMISTRY CHEMOTHERAPY (2000)
Candida antarctica lipase B catalysed amidation of pyroglutamic acid derivatives. A reaction survey Article ISI JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC (1999)
Chlorophenylmethyl benzothiadiazine dioxides derivatives: Potent human cytomegalovirus inhibitors Article ISI BIOORGANIC MEDICINAL CHEMISTRY LETTERS (1999)
Imidazothiadiazine dioxides: Synthesis and antiviral activity Esteban, AI; De Clercq, E Article ISI BIOORGANIC & MEDICINAL CHEMISTRY (1999)
Intramolecular oxidative cyclizations in heteroarylthioureas: A versatile pathway to bridgehead heterocyclic systems Article ISI JOURNAL OF HETEROCYCLIC CHEMISTRY (1999)
Novel potential agents for human cytomegalovirus infection: Synthesis and antiviral activity evaluation of benzothiadiazine dioxide acyclonucleosides De Clercq, E Article ISI JOURNAL OF MEDICINAL CHEMISTRY (1999)
On the tautomerism of 2,1,3-benzothiadiazinone S,S-dioxide and related compounds Article ISI TETRAHEDRON (1999)
Selective dopamine receptors: Synthesis, complexing properties, and molecular modelling studies of new podands derived from 4-hydroxy-1H-pyrazole Rodriguez-Franco, MI; San Lorenzo, P Article ISI TETRAHEDRON (1999)
Synthesis and potential muscarinic receptor binding and antioxidant properties of 3-(thiadiazolyl)pyridine 1-oxide compounds Alonso, D; Aran, VJ; Cardelus, I; Banos, JE; Badia, A Article ISI ARCHIV DER PHARMAZIE (1999)
Enzymatic alcoholysis of SO2-uracil analog diacyclonucleosides. Long-distance effect of the substituents on the regioselectivity Alonso, D Article ISI JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC (1998)
Lipase catalysed amidation of diethyl glutamate derivatives: peculiarities of ethyl S- and R-pyroglutamate Article ISI BIOTECHNOLOGY LETTERS (1998)
Phosphodiesterase inhibitory properties of losartan. Design and synthesis of new lead compounds Crespo, MI; Pujol, F; Palacios, JM Article ISI BIOORGANIC MEDICINAL CHEMISTRY LETTERS (1998)
Resolution of 1-(4-amino-3-chloro-5-cyanophenyl)-2-bromo-1-ethanol by lipase mediated enantioselective alcoholysis, hydrolysis and acylation Fierros, M; Rodriguez-Franco, MI; Puig, C Article ISI TETRAHEDRON-ASYMMETRY (1998)
Synthesis of nonsymmetrically 3,4-disubstituted 1,2,5-thiadiazole dioxides Aran, VJ; Llenas, J; Palacios, JM Article ISI JOURNAL OF HETEROCYCLIC CHEMISTRY (1998)
Towards lipophilic derivatives of S-adenosyl-L-methionine Juanes, O; Goya, P Article ISI JOURNAL OF HETEROCYCLIC CHEMISTRY (1998)
Applications of a statistical model to the analysis of the kinetic parameters in isothermal and non-isothermal crystallization of polymer blends based on PVDF Acosta, JL; GarciaLaureiro, JI Article ISI POLYMER (1997)
Arylimino-1,2,4-thiadiazolidinones: A new family of potassium channel openers Palacios, JM Article ISI BIOORGANIC & MEDICINAL CHEMISTRY (1997)
Base promoted transformation on thiadiazolopyridinium chlorides Fayet, JP Article ISI JOURNAL OF HETEROCYCLIC CHEMISTRY (1997)
Benzothiadiazine dioxide acyclonucleosides as lead compounds for the development of new agents against human cytomegalovirus and varicella-zoster virus infections DeClercq, E Article ISI BIOORGANIC MEDICINAL CHEMISTRY LETTERS (1997)
Comparative molecular field analysis (CoMFA) on [6]+[6] fused pyrazines with nematocide properties Martinez, MM Article ISI QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS (1997)
Molecular modeling of (E)-1-Alkyl-4(3)-[2-(1H-azolyl)vinyl]-pyridinium salts and evaluation of their behavior towards choline acetyltransferase Barat, A; Roca, T; ROZAS, I Article ISI BIOORGANIC & MEDICINAL CHEMISTRY (1997)
Regioselective lipase catalyzed synthesis of diester crowns. New asymmetric macrocycles containing a 1,3-bis(1H-pyrazol-1-yl)propane unit Jimeno, ML Article ISI TETRAHEDRON (1997)
Regioselective lipase-catalyzed synthesis of L-glutamic alpha-monoamide derivatives. Effect of the N-blocking group Biezma, MI Article ISI TETRAHEDRON (1997)
Selective carriers of norepinephrine and ammonium ions: Ionophoric properties and molecular modelling studies of diester crown compounds containing a 1,3-bis(1H-pyrazol-1-yl)propane unit Article ISI BIOORGANIC & MEDICINAL CHEMISTRY (1997)
Synthesis and antiviral activity of modified 1,2,6-thiadiazine dioxide acyclonucleosides Article ISI NUCLEOSIDES NUCLEOTIDES NUCLEIC ACIDS (1997)
Conformation and ortho steric effects in a series of 2-(pyrazol-1-yl)quinolines SINGH, SP; ELGUERO, J Article ISI JOURNAL OF HETEROCYCLIC CHEMISTRY (1996)
New synthetic route to 1,2,4-thiadiazolines and 1,3-thiazolines via thiadiazolopyridinium salts MartinezRipoll, M; Cano, FH Article ISI HETEROCYCLES (1996)
DIOXIDES OF BICYCLIC THIADIAZINES - A NEW FAMILY OF SMOOTH-MUSCLE RELAXANTS Article ISI BIOORGANIC & MEDICINAL CHEMISTRY (1995)
NEW 1,2,6-THIADIAZINE DIOXIDE ACYCLONUCLEOSIDES - SYNTHESIS AND ANTIVIRAL EVALUATION Article ISI BIOORGANIC & MEDICINAL CHEMISTRY (1995)
REGIOSELECTIVE MUCOR-MIEHEI LIPASE-CATALYZED SYNTHESIS OF PODANDS CONTAINING A 1,3-BIS(1H-PYRAZOL-1-YL)PROPANE UNIT Article ISI TETRAHEDRON (1995)
SEMIEMPIRICAL (AM1, PM3 AND SAM1) CALCULATIONS OF THE PROTONATION ENTHALPIES OF PROTON SPONGES RELATED TO 1,8-DIAMINONAPHTHALENE - ESTIMATION OF THE AQUEOUS BASICITY OF NEW DESIGNED SUPERBASES LLAMASSAIZ, AL; FOCESFOCES, C; ELGUERO, J Article ISI JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 (1995)
THE REGIOCONTROLLED AND STEREOCONTROLLED RING-OPENING OF HETEROARYLGLYCIDATES WITH NITROGEN NUCLEOPHILES ALCAIDE, B; BIURRUN, C; PLUMET, J Article ISI TETRAHEDRON LETTERS (1995)
THE STRUCTURE OF THE COMPOUNDS RESULTING FROM THE REACTION OF ARYLHYDRAZINES WITH DEHYDROACETIC ACID - AN NMR AND CRYSTALLOGRAPHIC STUDY SINGH, SP; FRUCHIER, A; CARRIO, JS; VIRGILI, A Article ISI TETRAHEDRON (1995)
REGIOSELECTIVE LIPASE-MEDIATED ACYLATION-DEACYLATION IN THIADIAZINE DIACYCLONUCLEOSIDES Article ISI TETRAHEDRON (1994)
TAUTOMERISM OF BENZOPENTA AND CYCLOPENTA-[1,2,6]THIADIAZINE S,S-DIOXIDES Article ISI JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 (1994)
APPLICATION OF ULTRASONIC NEBULIZATION FOR THE DETERMINATION OF RARE-EARTH ELEMENTS IN PHOSPHATES AND RELATED SEDIMENTARY-ROCKS USING INDUCTIVELY-COUPLED PLASMA-ATOMIC EMISSION-SPECTROMETRY WITH COMMENTS ON DISSOLUTION PROCEDURES BRENNER, IB; DORFMAN, E Article ISI JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY (1993)
SO2 EXTRUSION IN 1,2,6-THIADIAZINE 1,1-DIOXIDES - A NOVEL SYNTHESIS OF PYRAZOLES KLEIN, JF; POMMELET, JC; CHUCHE, J Article ISI CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE (1993)
SYNTHESIS AND BIOLOGICAL EVALUATION OF 4-QUINOLONE RIBOSIDES DELACRUZ, A Article ISI JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 (1993)
THE MOLECULAR-STRUCTURE OF 3(5)-METHYL-4,5(3)-TRIMETHYLENEPYRAZOLE HYDROCHLORIDE AND ITS C-13 AND N-15 NMR-SPECTROSCOPY THOZET, A; LECOCQ, S Article ISI JOURNAL OF CRYSTALLOGRAPHIC AND SPECTROSCOPIC RESEARCH (1993)
THE PROBLEM OF THE EXISTENCE OF C(AR)-H...N INTRAMOLECULAR HYDROGEN-BONDS IN A FAMILY OF 9-AZAPHENYL-9H-CARBAZOLES ESPADA, M; OCANA, B; TEJERINA, B; GOMEZBELTRAN, F Article ISI JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 (1993)
(E)-1-ALKYL-[2-(1H-AZOL-2-YL)VINYL]PYRIDINIUM SALTS - THEORETICAL-ANALYSIS, SYNTHESIS AND EVALUATION OF THEIR INTERACTION WITH CHOLINE-ACETYLTRANSFERASE Article ISI BIOORGANIC MEDICINAL CHEMISTRY LETTERS (1992)
TAUTOMERISM AND ACIDITY IN 4-QUINOLONE-3-CARBOXYLIC ACID-DERIVATIVES PFLEIDERER, W Article ISI TETRAHEDRON (1992)
LIPASE-MEDIATED ACYLATION OF ACYCLONUCLEOSIDES - APPLICATION TO NOVEL FLUOROQUINOLONE DERIVATIVES GOTOR, V; MORIS, F Article ISI SYNTHETIC COMMUNICATIONS (1991)
SYNTHESIS AND NMR-SPECTROSCOPY (H-1, C-13) OF 1-(2'-BENZOTHIAZOLYL)-3(5),4-POLYMETHYLENEPYRAZOLES AND RELATED-COMPOUNDS Article ISI JOURNAL OF HETEROCYCLIC CHEMISTRY (1991)
SYNTHESIS OF PSI-[CH(CN)NH] PSEUDOPEPTIDES - A NEW PEPTIDE-BOND SURROGATE HERRANZ, R; SUAREZGEA, ML; VINUESA, S; GARCIALOPEZ, MT Article ISI TETRAHEDRON LETTERS (1991)
A H-1 AND C-13 NMR-STUDY OF THE STRUCTURE AND TAUTOMERISM OF 4-PYRAZOLYLPYRAZOLINONES GROVER, M; TARAR, LS Article ISI JOURNAL OF HETEROCYCLIC CHEMISTRY (1990)
GLYCOSIDES OF PYRIDO[2,3-C]-1,2,6-THIADIAZINE 2,2-DIOXIDES PAEZ, JA Article ISI NUCLEOSIDES NUCLEOTIDES (1990)
ROTATIONAL-ISOMERISM IN 6-BETA-D-GLUCOPYRANOSIDES OF METHYL-1,2,6-THIADIAZIN-3(2H)-ONE 1,1-DIOXIDES Article ISI JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 (1990)
STRUCTURE OF 1,2,6-THIADIAZINE 1,1-DIOXIDES ROZAS, I; DEPAZ, JLG Article ISI JOURNAL OF PHYSICAL ORGANIC CHEMISTRY (1990)
ON THE TAUTOMERISM OF 2-PHENACYL-4-PYRIMIDINONES AND RELATED-COMPOUNDS Article ISI CHEMISCHE BERICHTE (1989)
REACTION OF 4-HYDRAZINOQUINOLINES WITH BETA-DIKETONES - SYNTHESIS AND SPECTROSCOPY (H-1, C-13 NMR, MS) OF SOME PYRAZOLYLQUINOLINES VAID, RK Article ISI JOURNAL OF HETEROCYCLIC CHEMISTRY (1989)
SYNTHESIS AND CYTOSTATIC SCREENING OF AN SO2 ANALOG OF DORIDOSINE Article ISI ARCHIV DER PHARMAZIE (1988)
SYNTHESIS AND SPECTROSCOPIC PROPERTIES OF N-AZOLYLPROPANAMIDES Article ISI JOURNAL OF HETEROCYCLIC CHEMISTRY (1988)
SYNTHESIS OF 2S-DIOXO ISOSTERES OF PURINE AND PYRIMIDINE NUCLEOSIDES .4. SELECTIVE GLYCOSYLATION OF 4-AMINO-5H-IMIDAZO [4,5-C]-1,2,6-THIADIAZINE 2,2-DIOXIDE Article ISI NUCLEOSIDES NUCLEOTIDES (1987)
N-GLUCOSYL-5-AMINO-4-CARBAMOYLIMIDAZOLES AND 4-ETHOXYCARBONYLIMIDAZOLES AS POTENTIAL PRECURSORS OF 4-OXOIMIDAZO[4,5-C]-1,2,6-THIADIAZINE 2,2-DIOXIDES Article ISI HETEROCYCLES (1986)
SYNTHESIS AND INTRAMOLECULAR CYCLIZATION OF BISTHIADIAZINYLMETHANE DERIVATIVES Article ISI TETRAHEDRON (1985)


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