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Lilian Soto Saez

Rheumatologist

CLINICAL HOSPITAL OF UNIVERSIDAD DE CHILE

Santiago, Chile

Rheumatoid arthritis (RA) pathogenesis; Action mechanisms and effects of biologic drugs for RA; Biological therapies in rheumatology; B cell alterations in autoimmunity; Biology of tolerogenic dendritic cells; Tolerance induction; Antigen discovery.

Medical Surgeon, UNIVERSIDAD DE CHILE. Chile, 1997
Medical Internist, UNIVERSIDAD DE CHILE. Chile, 2000
Subspecialist in Rheumatology, UNIVERSIDAD DE CHILE. Chile, 2003

Assistant Professor Part Time

UNIVERSIDAD DE CHILE

Faculty of Medicine

SANTIAGO, Chile

2002 - At present

RHEUMATOLOGIST Part Time

CLINICAL HOSPITAL OF UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2003 - At present
TECHNICAL DIRECTOR Part Time

INTERIN LTDA

SANTIAGO, Chile

2012 - At present
RHEUMATOLOGIST / CLINICAL RESEARCHER Part Time

DERMACROSS

SANTIAGO, Chile

2014 - At present

Award “Dr. Antonio Reginato” to the Best Scientific Work – Basic Category

Chilean Society of Rheumatology

Chile, 2011

Award “Dr. Antonio Reginato” to the Best Scientific Work – Basic Category “Adalimumab promotes changes on T- and NK cells in rheumatoid arthritis patients” XXVIII Chilean Congress of Rheumatology, Antofagasta, CHILE.


TIM-1 defines a human regulatory B cell population that is altered in frequency and function in systemic sclerosis patients Aravena O.; Ferrier A.; Menon M.; Mauri C.; Aguillón J.C.; Soto L.; Catalán D. Article ISI SCOPUS ARTHRITIS RESEARCH & THERAPY (2017)
Treatment with Dexamethasone and Monophosphoryl lipid a removes Disease-associated Transcriptional signatures in Monocyte-Derived Dendritic cells from rheumatoid arthritis Patients and confers Tolerogenic Features Garcia-Gonzalez, PA; Schinnerling, K; Sepulveda-Gutierrez, A; Maggi, J; Hoyos, L; Morales, RA; Mehdi, AM; Nel, HJ; Soto, L; Pesce, B; Molina, MC; Cuchacovich, M; Larrondo, ML; Neira, O; Catalan, DF; Hilkens, CM; Thomas, R; Verdugo, RA; Aguillón, JC Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2016)
Systemic sclerosis patients present alterations in the expression of molecules involved in B-cell regulation Soto L.; Ferrier, A; Aravena, O; Fonseca, E; Berendsen, J; Biere, A; Bueno, D.; Ramos, V; Aguillón JC; Catalan, D Article ISI SCOPUS Frontiers in immunology (2015)
A short protocol using dexamethasone and monophosphoryl lipid A generates tolerogenic dendritic cells that display a potent migratory capacity to lymphoid chemokines Garcia-Gonzalez, P; Morales R.; Hoyos L; Maggi, J; Campos J.; Pesce B,; Garate, D; Larrondo M.; González R.; Soto L.; Ramos, V; Tobar, P.; Molina, MC; Pino-Lagos, K; Catalan, D; Aguillón JC Article ISI SCOPUS Journal of Translational Medicine (2013)
Effect of interleukin-6 receptor blockade on the balance between regulatory T cells and T helper type 17 cells in rheumatoid arthritis patients Pesce B,; Soto L.; Sabugo, F; Wurmann, P; Cuchacovich M.; López MN; Sotelo, PH; Molina, MC; Aguillón JC; Catalan, D Article ISI SCOPUS Clinical and Experimental Immunology (2013)
Weak CD4+ T-cell responses to citrullinated vimentin in rheumatoid arthritis patients carrying HLA-DR9 alleles Catalan, D; Aravena, O; Zúñiga R.; Silva N.; Escobar A.; Sabugo, F; Wurmann, P; Soto L.; González R.; Alfaro, J; Larrondo M.; Cuchacovich M.; Aguillon, J.C. Article ISI SCOPUS Rheumatology International (2012)
Anti-TNF therapy in patients with rheumatoid arthritis decreases Th1 and Th17 cell populations and expands IFN-gamma-producing NK cell and regulatory T cell subsets Aravena, O; Pesce B,; Soto L.; Orrego, N.; Sabugo, F; Wurmann, P; Molina, MC; Alfaro, J; Cuchacovich M.; Aguillón JC; Catalan, D Article ISI SCOPUS Immunobiology (2011)
The presence of anti-citrullinated protein antibodies (ACPA) does not affect the clinical response to adalimumab in a group of RA patients with the tumor necrosis factor (TNF) alpha-308 G/G promoter polymorphism Soto L.; Sabugo, F; Catalan, D; Wurmann, P; Cermenatti T.; Gatica H.; Aravena, O; Salazar, L; Aguillón JC; Cuchacovich M. Article ISI SCOPUS Clinical Rheumatology (2011)
B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and Fc gamma RIIb, which are modulated by anti-tumor necrosis factor therapy Catalan, D; Aravena, O; Sabugo, F; Wurmann, P; Soto L.; Kalergis, AM; Cuchacovich M.; Aguillón JC Article ISI SCOPUS Arthritis Research and Therapy (2010)
Basal anti-cyclic citrullinated peptide (anti-CCP) antibody levels and a decrease in anti-CCP titres are associated with clinical response to adalimumab in rheumatoid arthritis Cuchacovich M.; Catalan, D; Wainstein E.; Gatica H.; Soto L.; Aravena, O; Pesce B,; Sabugo, F; Aguillón JC Article ISI SCOPUS CLINICAL AND EXPERIMENTAL RHEUMATOLOGY (2008)
Tumour necrosis factor (TNF)alpha-308 G/G promoter polymorphism and TNF alpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis Cuchacovich M.; Soto L.; Edwardes, M; Gutiérrez M; Llanos, C.; Pacheco, D. ; Sabugo, F; Alamo, M; Fuentealba, C; Villanueva, L; Gatica H.; Schiattino, I; Salazar, L; Catalan, D; Valenzuela O. Article ISI SCOPUS SCANDINAVIAN JOURNAL OF RHEUMATOLOGY (2006)
Tumour necrosis factor-alpha (TNF-alpha) levels and influence of 2308 TNF-alpha promoter polymorphism on the responsiveness to infliximab in patients with rheumatoid arthritis Cuchacovich M.; Ferreira L.; Aliste, M; Soto L.; Cuenca J.; Cruzat, A; Gatica H.; Schiattino, I; Pérez, C.; Aguirre A.; SALAZAR ONFRAY F; Aguillón JC Article ISI SCOPUS SCANDINAVIAN JOURNAL OF RHEUMATOLOGY (2004)
The -308 polymorphism in the tumour necrosis factor (TNF) gene promoter region and ex vivo lipopolysaccharide-induced TNF expression and cytotoxic activity in Chilean patients with rheumatoid arthritis Cuenca J.; Cuchacovich M.; Pérez, C.; Ferreira L.; Aguirre A.; Schiattino, I; Soto L.; Cruzat, A; SALAZAR ONFRAY F; Aguillón JC Article ISI SCOPUS RHEUMATOLOGY (2003)


ANTI-TNF THERAPY INDUCES CHANGES ON T CELLS AND NK CELLS SUB-POPULATIONS IN RHEUMATOID ARTHRITIS PATIENTS Catalán DF; Pesce B,; Aravena, O; Orrego, N.; Soto L.; Sabugo, F; Wurmann, P; Cuchacovich M.; Aguillón JC Abstract ISI CLINICAL AND EXPERIMENTAL RHEUMATOLOGY (2011)
Adalimumab, a Tumor Necrosis Factor Blockade Therapy, Decreases Th1 and Th17 Populations in Rheumatoid Arthritis Patients Pesce B,; Catalan, D; Orrego, N.; Aravena, O; Soto L.; Wurman, P; Sabugo, F; Cuchacovich M.; Aguillon, J. Abstract ISI CLINICAL IMMUNOLOGY (2010)
Basal anti-cyclic citrullinated peptide (anti-ccp) antibodies levels and a decrease in anti-CCP titres are associated with clinical response to adalimumab therapy in rheumatoid arthritis patients Cuchacovich M.; Catalan, D; Wainstein E.; Gatica H.; Soto L.; Aravena, O; Pesce B,; Sabugo, F; Aguillon, J. Abstract ISI ANNALS OF THE RHEUMATIC DISEASES (2007)
Tumor necrosis factor-alpha levels gurrelate with a better response to adalimumab in patients with rheumatoid arthritis Cuchacovich M.; Soto L.; Gutiérrez M; Llanos, C.; Sabugo, F; Pacheco, D. ; Alamos, M.; Fuentealba, C; Villanueva, L; Gatica H.; Schiattino, I; Salazar, L; Catalan, D; Valenzuela O.; SALAZAR ONFRAY F; Aguillon, J. Abstract ISI ANNALS OF THE RHEUMATIC DISEASES (2006)
TNF-alpha-308 G/G promoter polymorphism correlates with a better response to adalimumab in patients with rheumatoid arthritis Cuchacovich M.; Soto L.; Edwardes, M; Suissa, S; Gutiérrez M; Llanos, C.; Sabugo, F; Pacheco, D. ; Alamo, M; Fuentealba, C; Villanueva, L; Gatica H.; Salazar, L; Valenzuela O.; Salazar F.; Aguillon, J. Abstract ISI ANNALS OF THE RHEUMATIC DISEASES (2005)
Tumor necrosis factor-alpha-308 G/G promoter polymorphism correlates with a better response to adalimumab in patients with rheumatoid arthritis. Cuchacovich M.; Soto L.; Edwardes, M; Gutiérrez M; Llanos, C.; Pacheco, D. ; Sabugo, F; Alamo, M; Fuentealba, C; Villanueva, L; Gatica H.; Schiattino, I; Salazar, L; Catalan, D; Valenzuela O.; SALAZAR ONFRAY F; Aguillón JC Abstract ISI ARTHRITIS AND RHEUMATISM (2005)


How we can improve the predictive value of prognostic biomarkers in rheumatoid arthritis Soto L.; Catalan, D; Aguillon, J.C.; Cuchacovich M. Editorial SCOPUS International Journal of Clinical Rheumatology (2015)


Identifying immunodominant T-cell antigen-peptides and T-cell responses in rheumatoid arthritis: A further step in the development of an antigen-specific dendritic cell-based therapy to restore self-tolerance Aguillón, Juan Carlos Proyecto (2018)
A Multicenter Double-Blind, Randomized Controlled Study of Etanercept and Methotrexate in Combination or as Monotherapy in Subjects With Psoriatic Arthritis Soto, Lilian Proyecto (2016)
Péptidos autoantigénicos presentados por células dendríticas tolerogénicas: Una terapia personalizada para reinstruir el sistema inmune de pacientes con artritis reumatoide Aguillón, Juan Carlos Proyecto (2016)
ESTUDIO ALEATORIZADO, DOBLE CIEGO, CONTROLADO CON PLACEBO Y PRINCIPIO ACTIVO, DE DS-5565 EN PACIENTES CON DOLOR ASOCIADO A FIBROMIALGIA Soto, Lilian Proyecto (2015)
Búsqueda de un enfoque terapéutico validado basado en células para el tratamiento de la artritis reumatoide: Identificación de marcadores específicos de tolerancia y caracterización de células dendríticas tolerogénicas activadas con monofosforil lípido A (MPLA-tDCs) Aguillón, Juan Carlos Proyecto (2014)
Indagando mecanismos inflamatorios y su relación con el stress oxidativo en pacientes con Fibromialgia Soto, Lilian Proyecto (2014)
Randomized, controlled, doble-blind, crossover study with placebo for 52 weeks, for the evaluation of adverse effects of special interest in active systemic lupus erythematosus adults patients with positive autoantibodies and Belimumab Soto, Lilian Proyecto (2014)
A clinical outcomes study to evaluate the effects of IL-6 receptor blockade with tocilizumab (TCZ) in comparison with etanercept (ETA) on the rate of cardiovascular events in patients with moderate to severe rheumatoid arthritis (RA) Soto, Lilian Proyecto (2013)
Efficacy, pharmacokinesis and security of BI 695500 to rituximab in active RA patients moderate and severe: randomized study, doble-blind, of parallel groups, multiple dosis and active comparator Soto, Lilian Proyecto (2013)
Fcgamma receptors and regulatory B cells: A novel network behind the immune response governing systemic sclerosis Soto, Lilian Proyecto (2012)
Effects of the therapy with an anti-IL-6 receptor antibody on Th17 and Tregs cell populations in rheumatoid arthritis patients Soto, Lilian Proyecto (2011)
Phase II randomized, double-blind, controlled study to evaluate the immunity responses, security and clinical efficacy of three Neovac's TNF-Kinoid dosis in RA adult patients that have presented recurrence. Soto, Lilian Proyecto (2011)
Applying the knowledge on murine tolerogenic dendritic cells to the development of tolerogenic monocyte-derived dendritic cells from rheumatoid arthritis (RA) patients aimed at providing a therapeutic strategy for RA treatment Aguillón, Juan Carlos Proyecto (2010)
Tumor necrosis factor (TNF) in the balance of Th1/Th17 axes: Lessons from anti-TNF therapy in rheumatoid arthritis Cuchacovich-Turteltaub, Miguel Proyecto (2009)
Desarrollo de tecnologías de generación de anticuerpos monoclonales completamente humanos: producción de un prototipo contra receptores tirosina quinasa Erb B para uso de terapia selectiva en cáncer gástrico Molina, María Carmen Proyecto (2007)
Factores predictores de respuesta clinica al tratamiento con anticuerpos monoclonales anti-TNF-a en pacientes con artritis reumatoide Cuchacovich-Turteltaub, Miguel Proyecto (2004)


The role of interleukin-6 signalling and its therapeutic blockage in skewing the T cell balance in rheumatoid arthritis Schinnerling K.; Aguillón J.C.; Catalán D.; Soto L. Review ISI SCOPUS CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2017)
Skewing dendritic cell differentiation towards a tolerogenic state for recovery of tolerance in rheumatoid arthritis Schinnerling, K; Soto L.; Garcia-Gonzalez, P; Catalan, D; Aguillón JC Review ISI SCOPUS Autoimmunity Reviews (2015)
Clinical parameters and biomarkers for anti-TNF treatment prognosis in rheumatoid arthritis patients Cuchacovich M.; Bueno, D.; Carvajal R.; Bravo N.; Aguillón JC; Catalan, D; Soto L. Review ISI SCOPUS CLINICAL RHEUMATOLOGY (2014)
Biological therapy based on the use of last generation monoclonal antibodies Aguillón JC; Contreras, J.; Dotte, A; Cruzat, A; Catalan, D; Salazar, L; Molina, MC; Guerrero, J; Lopez M.; Soto L.; SALAZAR ONFRAY F; Cuchacovich M. Review ISI REVISTA MEDICA DE CHILE (2003)

Lilian Soto

Rheumatologist

Medicine

CLINICAL HOSPITAL OF UNIVERSIDAD DE CHILE

Santiago, Chile

Diego Catalán

Associate Professor

Programa Disciplinario de Inmunología

Universidad de Chile

Santiago, Chile

JUAN AGUILLON

PROFESSOR

IMMUNOLOGY PROGRAM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Maria Sabugo

Medico Reumatologo

Medicina

UNIVERSIDAD DE CHILE HOSPITAL CLÍNICO

Santiago, Chile

OCTAVIO ARAVENA

Gestión I+D

I+D+i

Comisión Chilena de Energía Nuclear

Santiago, Chile

Bárbara Pesce

Profesora Asistente

ICBM

Universidad de Chile

Santiago, Chile

Pamela Wurmann

reumatologa

medicina

universidad de chile

santiago, Chile

Lorena Salazar

Profesora Asistente

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Lampa, Chile

MARIA MOLINA

Director

Instituto de Ciencias Biomédicas

Universidad de Chile

INDEPENDENCIA, Chile

Carolina Llanos

Associate Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

Lorena Salazar

Academico

Instituto Cs Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

Katina Schinnerling

Profesor Asistente

Departamento de Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

Veronica Ramos

Bioquímico

Inmunologia, VIH y Alergias

Hospital Clínico Universidad de Chile

Santiago, Chile

Jimena Cuenca

Investigador/profesor

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

Daniel Bueno

Médico

Servicio de Salud metropolitano Sur

Santiago, Chile

Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

Mercedes López

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

Julia Guerrero

académico

Programa Disciplinario Fisiologia y Biofisica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Alejandro Escobar

assistant professor

Institute for Research in Dental Sciences

UNIVERSIDAD DE CHILE

Santiago, Chile

Karina Pino

Group Leader/Associate Professor

Centro de Investigación Biomédica

Universidad de los Andes

Santiago, Chile

Alexis Kalergis

Full Professor

Microbiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Ricardo Verdugo

Asistant Professor

Facultad de Medicina

UNIVERSIDAD DE CHILE

Santiago, Chile

Roberto Zúñiga

Investigador Asociado a Proyectos

Programa Disciplinario de Inmunologia

Universidad de Chile/ Facultad de Medicina

Santiago, Chile

Paulina García

Investigador Postdoctoral

Programa de Inmunologia

Universidad de Chile

Santiago, Chile

Rodrigo Morales

Postdoctoral researcher

Dept. of Medicine Solna (MedS)

Karolinska Institutet

Stockholm, Suecia

Javier Campos

Gestor de Propiedad Intelectual

Universidad Tecnológica Metropolitana

Santiago, Chile

Lilian Soto Saez

Líneas de Investigación

Educación

Medical Surgeon, UNIVERSIDAD DE CHILE. Chile, 1997

Medical Internist, UNIVERSIDAD DE CHILE. Chile, 2000

Subspecialist in Rheumatology, UNIVERSIDAD DE CHILE. Chile, 2003

Experiencia Académica

Assistant Professor Part Time

Experiencia Profesional

RHEUMATOLOGIST Part Time

TECHNICAL DIRECTOR Part Time

RHEUMATOLOGIST / CLINICAL RESEARCHER Part Time

Premios y Distinciones

Award “Dr. Antonio Reginato” to the Best Scientific Work – Basic Category

Article (13)

Abstract (6)

Editorial (1)

Proyecto (16)

Review (4)