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Maria Francisca Sabugo Siraqyan

Medico Reumatologo

UNIVERSIDAD DE CHILE HOSPITAL CLÍNICO

Santiago, Chile

1.- ModulaciÃ³n de la artritis murina por cÃ©lulas dendrÃticas reguladoras pulsadas con pÃ©ptidos autoantigÃ©nicos.; 2.- ExpresiÃ³n de citoquinas pro-inflamatorias y polimorfismos de sus genes y su asociaciÃ³n a enfermedades auto-inmunes e inflamatorias.; 3.- IngenierÃa de anticuerpos para terapia de enfermedades autoinmunes.; Patogenia de la artritis reumatoide; Terapias biolÃ³gicas en reumatologÃa; Uveitis; Artritis Reumatoide; Lupus Eritematoso SistÃ©mico; Autoinmunidad; InmunologÃa Celular

Médico Cirujano, universidad de Chile. Chile, 2000

Instructor en Medicina. 33 horas semanales

Hospital Clínico de la Univesidad de Chile

Santiago, Chile

Not Available - Not Available
Profesor asistente Full Time

Hospital Clinico Universidad de Chile

Medicina

Santiago, Chile

2007 - At present

Diseño de un ramo de 3 año de medicina de curriculum innovado: "Casos integradores II". Además del diseño de este ramo, que incorpora temas y estrategias innovadoras en nuestra carrera, he sido profesor encargado del ramo por 3 años consecutivos

Adjudicación concurso de Extension facultad de Medicina Universidad de Chile con el proyecto: "Empoderando al paciente reumatológico: implementación de estrategias de autocuidado, apoyo familiar e intervenciones comunitarias". Dirigido a pacientes con Lupus eritematoso sistémico, Artritris reumatoide y Espondiloartritis anquilosante. Se encuentra en ejecución actualmente

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Illness Experiences in Women with Oral Dryness as a Result of Sjögren's Syndrome: The Patient Point of View Rojas-Alcayaga, Gonzalo; Herrera Ronda, Andrea; Bustos Reydet, Claudia; Geenen, Rinie Article SCOPUS Musculoskeletal Care (2016)
Acute Herpes Simplex Virus 1 Pneumonitis in a Patient With Systemic Lupus Erythematosus Sabugo, F; Espinoza-Araya R.; Meneses M.F.; Cuchacovich M. Article ISI JCR-JOURNAL OF CLINICAL RHEUMATOLOGY (2014)
Aortitis. Report of three cases Wurmann, P; Sabugo, F; CRUZ J.; Diaz G.; Sanchez, F; Pino, S; Pezo, N; Diaz, JC; Fernandez, C. Article ISI REVISTA MEDICA DE CHILE (2014)
Effect of interleukin-6 receptor blockade on the balance between regulatory T cells and T helper type 17 cells in rheumatoid arthritis patients Pesce B,; Soto L.; Sabugo, F; Wurmann, P; Cuchacovich M.; López MN; Sotelo, PH; Molina, MC; Catalan, D Article ISI SCOPUS Clinical and Experimental Immunology (2013)
Weak CD4+ T-cell responses to citrullinated vimentin in rheumatoid arthritis patients carrying HLA-DR9 alleles Catalan, D; Aravena, O; Zúñiga R.; Silva N.; Escobar A.; Sabugo, F; Wurmann, P; Soto L.; González R.; Alfaro, J; et al. Article ISI SCOPUS Rheumatology International (2012)
Anti-TNF therapy in patients with rheumatoid arthritis decreases Th1 and Th17 cell populations and expands IFN-gamma-producing NK cell and regulatory T cell subsets Aravena, O; Pesce B,; Soto L.; Orrego, N.; Sabugo, F; Wurmann, P; Molina, MC; Alfaro, J; Cuchacovich M.; Catalan, D Article ISI SCOPUS Immunobiology (2011)
The presence of anti-citrullinated protein antibodies (ACPA) does not affect the clinical response to adalimumab in a group of RA patients with the tumor necrosis factor (TNF) alpha-308 G/G promoter polymorphism Soto L.; Sabugo, F; Catalan, D; Wurmann, P; Cermenatti T.; Gatica H.; Aravena, O; Salazar, L; Cuchacovich M. Article ISI SCOPUS Clinical Rheumatology (2011)
B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and Fc gamma RIIb, which are modulated by anti-tumor necrosis factor therapy Catalan, D; Aravena, O; Sabugo, F; Wurmann, P; Soto L.; Cuchacovich M. Article ISI SCOPUS Arthritis Research and Therapy (2010)
Comparison of the Clinical Efficacy of Two Different Immunosuppressive Regimens in Patients with Chronic Vogt-Koyanagi-Harada Disease Cuchacovich M.; Solanes F.; Diaz G.; Cermenati, T; Avila, S; Verdaguer J.; Verdaguer, JI; Carpentier, C; Stopel, J; Rojas, B; et al. Article ISI SCOPUS Ocular Immunology and Inflammation (2010)
Enfermedad de Behçet en Chile: Análisis clínico de 44 casos Wurmann, Pamela; Diaz, Gonzalo; Sabugo, Francisca; Soto, Lilian; Solanes, Federica; Pino, Sandra; Merino, Guillermo; Verdaguer, Juan Ignacio; Villarroel, Francisco; Cuchacovich, Miguel Article SCIELO REVISTA MEDICA DE CHILE (2009)
Retrospective review of Chilean patients with Behcet disease Wurmann, P; Diaz G.; Sabugo, F; Soto L.; Solanes F.; Pino, S; Merino, G; Verdaguer, JI; Villarroel F.; Cuchacovich M. Article ISI REVISTA MEDICA DE CHILE (2009)
Basal anti-cyclic citrullinated peptide (anti-CCP) antibody levels and a decrease in anti-CCP titres are associated with clinical response to adalimumab in rheumatoid arthritis Cuchacovich M.; Catalan, D; Wainstein E.; Gatica H.; Soto L.; Aravena, O; Pesce B,; Sabugo, F Article ISI SCOPUS CLINICAL AND EXPERIMENTAL RHEUMATOLOGY (2008)
Infliximab can induce a prolonged clinical remission and a decrease in thyroid hormonal requirements in a patient with SAPHO syndrome and hypothyroidism Sabugo, F; Liberman C.; Niedmann, JP; Soto L.; Cuchacovich M. Article ISI SCOPUS CLINICAL RHEUMATOLOGY (2008)
Systemic vasculitis associated with Fasciola hepatica infection Llanos, C.; Soto L.; Sabugo, F; Gallegos, I.; Valenzuela O.; Verdaguer J.; Cuchacovich M. Article ISI SCOPUS SCANDINAVIAN JOURNAL OF RHEUMATOLOGY (2006)
Tumour necrosis factor (TNF)alpha-308 G/G promoter polymorphism and TNF alpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis Cuchacovich M.; Soto L.; Edwardes, M; Gutiérrez M; Llanos, C.; Pacheco, D. ; Sabugo, F; Alamo, M; Fuentealba, C.; Villanueva, L; et al. Article ISI SCOPUS SCANDINAVIAN JOURNAL OF RHEUMATOLOGY (2006)
Rituximab (anti-CD20 monoclonal antibody) for refractory systemic lupus erythematosus. Report of one case Sabugo, F; Llanos, C.; Soto L.; Gutierrez J.; Cuchacovich M. Article ISI REVISTA MEDICA DE CHILE (2005)
Frequency of unwanted children after birth Vargas, NA; Valdés M.; Sabugo, F; Diaz-Valdes, M; Arce, MI Article ISI REVISTA MEDICA DE CHILE (2002)

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ANTI-TNF THERAPY INDUCES CHANGES ON T CELLS AND NK CELLS SUB-POPULATIONS IN RHEUMATOID ARTHRITIS PATIENTS Catalán DF; Pesce B,; Aravena, O; Orrego, N.; Soto L.; Sabugo, F; Wurmann, P; Cuchacovich M. Abstract ISI CLINICAL AND EXPERIMENTAL RHEUMATOLOGY (2011)
Adalimumab, a Tumor Necrosis Factor Blockade Therapy, Decreases Th1 and Th17 Populations in Rheumatoid Arthritis Patients Pesce B,; Catalan, D; Orrego, N.; Aravena, O; Soto L.; Wurman, P; Sabugo, F; Cuchacovich M.; Aguillon, J. Abstract ISI CLINICAL IMMUNOLOGY (2010)
Basal anti-cyclic citrullinated peptide (anti-ccp) antibodies levels and a decrease in anti-CCP titres are associated with clinical response to adalimumab therapy in rheumatoid arthritis patients Cuchacovich M.; Catalan, D; Wainstein E.; Gatica H.; Soto L.; Aravena, O; Pesce B,; Sabugo, F; Aguillon, J. Abstract ISI ANNALS OF THE RHEUMATIC DISEASES (2007)
Anti-TNF-alpha therapy augments DPP IV activity and decreases autoantibodies to GRP78/BIP and phosphoglucose isomerase in the circulation of rheumatoid arthritis patients Cuchacovich M.; Mavropoulos, J; Carolina, L.; Carlos, AJ; Gatica H.; Pizzo, S; Sabugo, F; Gonzalez-Gronow, M Abstract ISI ANNALS OF THE RHEUMATIC DISEASES (2005)
The role of aspirin and heparin in pregnant patients with anti-phospholipid antibodies Tincani, A; Sabugo, F; Rebaioli, CB; Lojacono, A; Faden, D Abstract ISI ANNALS OF THE RHEUMATIC DISEASES (2005)

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Aortitis, causas infrecuentes en Reumatología: presentación de casos Pamela Wurmann; Francisca Sabugo; Julio Cruz; Gonzalo Díaz; Felipe Sánchez; Sandra Pino; Ninette Pezo; Juan Carlos Díaz; Cristina Fernández CaseReport SCIELO SCOPUS REVISTA MEDICA DE CHILE (2014)