Man

Diego Francisco Catalán Martina

Associate Professor

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Linfocitos B reguladores en autoinmunidad Búsqueda de epitopos T inmunodominantes en artritis reumatoide

Educación

  •  Licenciado en Medicina, UNIVERSIDAD DE CHILE. Chile, 2004
  •  Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2010

Experiencia Académica

  •   Associate Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2022 - At present

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Santiago, Chile

    2010 - 2022

Experiencia Profesional

  •   Assistant Professor Full Time

    Universidad de Chile

    Chile

    2010 - 2022

  •   Associate Professor Full Time

    Universidad de Chile

    Santiago, Chile

    2022 - At present


 

Article (39)

B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity
Isolation of HLA-DR-naturally presented peptides identifies T-cell epitopes for rheumatoid arthritis
Response to: Correspondence on "HLA-DR 'naturally' presented peptides: you will find what you have pulsed with" by Maggi et al
TNF-alpha Affects Signature Cytokines of Th1 and Th17 T Cell Subsets through Differential Actions on TNFR1 and TNFR2
Immunosuppressive Mechanisms of Regulatory B Cells
Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells
Regulation of Tolerogenic Features on Dexamethasone-Modulated MPLA-Activated Dendritic Cells by MYC
Analysis of the HLA-DR peptidome from human dendritic cells reveals high affinity repertoires and nonconventional pathways of peptide generation
Dexamethasone and Monophosphoryl lipid a induce a Distinctive Profile on Monocyte-Derived Dendritic cells through Transcriptional Modulation of genes associated With essential Processes of the immune response
STAT3 inhibition by STA21 increases cell surface expression of MICB and the release of soluble MICB by gastric adenocarcinoma cells
TIM-1 defines a human regulatory B cell population that is altered in frequency and function in systemic sclerosis patients
Clinical significance of tumor expression of major histocompatibility complex class I-related chains A and B (MICA/B) in gastric cancer patients
Dexamethasone and Monophosphoryl Lipid A-Modulated Dendritic Cells Promote Antigen-Specific Tolerogenic Properties on Naive and Memory CD4(+) T cells
Treatment with Dexamethasone and Monophosphoryl lipid a removes Disease-associated Transcriptional signatures in Monocyte-Derived Dendritic cells from rheumatoid arthritis Patients and confers Tolerogenic Features
Neuropilin-1(+) regulatory T cells promote skin allograft survival and modulate effector CD4(+) T cells phenotypic signature
Rapamycin-conditioned dendritic cells activated with monophosphoryl lipid A promote allograft acceptance in vivo
Systemic sclerosis patients present alterations in the expression of molecules involved in B-cell regulation
Therapeutic potential of hyporesponsive CD4(+) T cells in autoimmunity
Tolerogenic Dendritic Cells Derived from Donors with Natural Rubber Latex Allergy Modulate Allergen-Specific T-Cell Responses and IgE Production
A short protocol using dexamethasone and monophosphoryl lipid A generates tolerogenic dendritic cells that display a potent migratory capacity to lymphoid chemokines
Blocking of p38 and transforming growth factor ss receptor pathways impairs the ability of tolerogenic dendritic cells to suppress murine arthritis
Dexamethasone Preconditioning Improves the Response of Collagen-Induced Arthritis to Treatment with Short-Term Lipopolysaccharide-Stimulated Collagen-Loaded Dendritic Cells
Effect of interleukin-6 receptor blockade on the balance between regulatory T cells and T helper type 17 cells in rheumatoid arthritis patients
The immunological response and post-treatment survival of DC-vaccinated melanoma patients are associated with increased Th1/Th17 and reduced Th3 cytokine responses
An efficient method for variable region assembly in the construction of scFv phage display libraries using independent strand amplification
Weak CD4+ T-cell responses to citrullinated vimentin in rheumatoid arthritis patients carrying HLA-DR9 alleles
Anti-TNF therapy in patients with rheumatoid arthritis decreases Th1 and Th17 cell populations and expands IFN-gamma-producing NK cell and regulatory T cell subsets
The presence of anti-citrullinated protein antibodies (ACPA) does not affect the clinical response to adalimumab in a group of RA patients with the tumor necrosis factor (TNF) alpha-308 G/G promoter polymorphism
B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and Fc gamma RIIb, which are modulated by anti-tumor necrosis factor therapy
Perfil de producción de citoquinas en linfocitos T de sangre periférica de pacientes con poliposis nasal y asma bronquial en respuesta a la estimulación con enterotoxina estafilocócica B
Basal anti-cyclic citrullinated peptide (anti-CCP) antibody levels and a decrease in anti-CCP titres are associated with clinical response to adalimumab in rheumatoid arthritis
Modulation of established murine collagen-induced arthritis by a single inoculation of short-term lipopolysaccharide-stimulated dendritic cells
Inflammation, synovial angiogenesis and chondroid apoptosis in the evolution of type II collagen-induced arthritis
Short-term lipopolysaccharide stimulation indeces differentiation of murine bone marrow-derived dentritic cells into tolerogenic phenotype
Tumour necrosis factor (TNF)alpha-308 G/G promoter polymorphism and TNF alpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis
Multiple imputation procedures allow the rescue of missing data: An application to determine serum tumor necrosis factor (TNF) concentration values during the treatment of rheumatoid arthritis patients with anti-TNF therapy
The -308 polymorphism in the promoter region of the tumor necrosis factor-alpha (TNF-?) gene and ex vivo lipopolysaccharide-induced TNF-? expression in patients with aggressive periodontitis and/or type 1 diabetes mellitus
The -308 polymorphism in the promotor region of the tumor necrosis factor-alpha (TNF-alpha) gene and ex vivo lipopolysaccharide-induced TNF-alpha expression in patients with aggresive peridontitis and/or type 1 diabetes mellitus
Nuevas armas inmunológicas para la medicina del siglo XXI: Terapia biológica basada en el uso de anticuerpos monoclonales de última generación

Abstract (11)

Identification of T-cell autoantigenic peptides in rheumatoid arthritis as new targets for an antigen-specific dendritic cell-based therapy
Dexamethasone and MPLA treatment of monocyte-derived dendritic cells from rheumatoid arthritis patients induce transcriptional modulation of genes related to cell recruitment, signaling and metabolism
Treatment with Dexamethasone and Monophosphoryl Lipid a Removes Disease-Associated Transcriptional Signatures in Monocyte-Derived Dendritic Cells from Rheumatoid Arthritis Patients and Confers the Ability to Modulate CD4+T Cell Responses
Adalimumab, a Tumor Necrosis Factor Blockade Therapy, Decreases Th1 and Th17 Populations in Rheumatoid Arthritis Patients
Dexamethasone Pretreatment Followed by an Inoculation of Short-term Lipopolysaccharide-stimulated Dendritic Cells Improves the Response of Murine Collagen-induced Arthritis
Basal anti-cyclic citrullinated peptide (anti-ccp) antibodies levels and a decrease in anti-CCP titres are associated with clinical response to adalimumab therapy in rheumatoid arthritis patients
Tumor necrosis factor-alpha levels gurrelate with a better response to adalimumab in patients with rheumatoid arthritis
Dendritic cells pulsed with type II bovine collagen modulate the murine collagen induced arthritis.
Ex vivo pro-inflammatory cytokines expression in patients with aggressive periodontitis.
Rapid protocol to generate tolerogenic dendritic cells using microbial lipopeptide (BLP).
Tumor necrosis factor-alpha-308 G/G promoter polymorphism correlates with a better response to adalimumab in patients with rheumatoid arthritis.

Actualizacion (1)

Terapias emergentes en artritis reumatoide

Editorial (1)

How we can improve the predictive value of prognostic biomarkers in rheumatoid arthritis

EditorialMaterial (1)

Editorial: Searching for immune tolerance Manipulating New Molecules and Exploiting New Concepts on lymphocyte Biology

Proyecto (9)

Perfil de sialilación en linfocitos T CD4+ como factor de resistencia a la supresión por linfocitos B reguladores Siglec-5hi en artritis reumatoide
Plataforma de área limpia y equipamiento para la producción de prototipos basados en proteínas recombinantes, productos celulares y farmacéuticos estériles bajo buenas prácticas de manufactura para investigación en seres humanos
Unveiling naturally presented epitopes targeted by CD8+ T cells from rheumatoid arthritis patients: One step forward to understand the immunopathogenesis of the disease
Understanding the influence of the inflamed synovial environment on Siglec-5-expressing regulatory B cells in rheumatoid arthritis patients
Dissecting the interplay between commensal microbiota and regulatory B cells in SLE
Exploring the interplay between gut flora and immune system in rheumatologic patients from Chile and UK
Identifying immunodominant T–cell antigen–peptides and T–cell responses in rheumatoid arthritis: A further step in the development of an antigen–specific dendritic cell–based therapy to restore self–tolerance
International research network on characterization of new therapeutic targets for rheumatoid arthritis
Pre-clinical evaluation and registration of tolerogenic dendritic cells pulsed with autoantigenic peptides (TOLDeC-AP) for antigen-specific immunotherapy of rheumatoid arthritis

Review (7)

The role of interleukin-6 signalling and its therapeutic blockage in skewing the T cell balance in rheumatoid arthritis
Tolerogenic dendritic cells for reprogramming of lymphocyte responses in autoimmune diseases
Skewing dendritic cell differentiation towards a tolerogenic state for recovery of tolerance in rheumatoid arthritis
Clinical parameters and biomarkers for anti-TNF treatment prognosis in rheumatoid arthritis patients
Neuropilin-1 in transplantation tolerance
Emergent therapies for rheumatoid arthritis
Biological therapy based on the use of last generation monoclonal antibodies
69
Diego Catalán

Associate Professor

Programa Disciplinario de Inmunología

Universidad de Chile

Santiago, Chile

30
JUAN AGUILLON

PROFESSOR

IMMUNOLOGY PROGRAM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

23
OCTAVIO ARAVENA

Gestión I+D

I+D+i

Comisión Chilena de Energía Nuclear

Santiago, Chile

20
Lilian Soto

Rheumatologist

Medicine

CLINICAL HOSPITAL OF UNIVERSIDAD DE CHILE

Santiago, Chile

18
Bárbara Pesce

Profesora Asistente

ICBM

Universidad de Chile

Santiago, Chile

15
Lorena Salazar

Profesora Asistente

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Lampa, Chile

14
MARIA MOLINA

Director

Instituto de Ciencias Biomédicas

Universidad de Chile

INDEPENDENCIA, Chile

12
Lorena Salazar

Academico

Instituto Cs Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

10
Katina Schinnerling

Profesor Asistente

Departamento de Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

9
Maria Sabugo

Medico Reumatologo

Medicina

UNIVERSIDAD DE CHILE HOSPITAL CLÍNICO

Santiago, Chile

6
Carolina Llanos

Associate Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

6
Roberto Zúñiga

Investigador Asociado a Proyectos

Programa Disciplinario de Inmunologia

Universidad de Chile/ Facultad de Medicina

Santiago, Chile

5
Pamela Wurmann

reumatologa

medicina

universidad de chile

santiago, Chile

4
Karina Pino

Group Leader/Associate Professor

Centro de Investigación Biomédica

Universidad de los Andes

Santiago, Chile

3
Jimena Cuenca

Investigador/profesor

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

3
Ricardo Verdugo

Asistant Professor

Facultad de Medicina

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Mauricio Campos Mora

Ph.D student

Universidad de Chile

Santiago, Chile

3
Mercedes López

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

3
Rodrigo Morales

Postdoctoral researcher

Dept. of Medicine Solna (MedS)

Karolinska Institutet

Stockholm, Suecia

3
Alejandro Escobar

assistant professor

Institute for Research in Dental Sciences

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Paulina García

Investigador Postdoctoral

Programa de Inmunologia

Universidad de Chile

Santiago, Chile

3
Javier Campos

Gestor de Propiedad Intelectual

Universidad Tecnológica Metropolitana

Santiago, Chile

2
Fermín González

Profesor Asociado

Odontología Conservadora

Universidad de Chile

Santiago, Chile

2
Norberto Collazo

Business Developer

Center for Sustainable Biotechnology

Fraunhofer Chile Research

Santiago, Chile

2
Veronica Ramos

Bioquímico

Inmunologia, VIH y Alergias

Hospital Clínico Universidad de Chile

Santiago, Chile

2
Daniel Bueno

Médico

Servicio de Salud metropolitano Sur

Santiago, Chile

1
Matias Gutiérrez

Investigador

Programa Disciplinario de Inmunología

Universidad de Chile

Santiago, Chile

1
Andrés Tittarelli

Profesor Asociado

Instituto Universitario de Investigación y Desarrollo Tecnológico (IDT)

Universidad Tecnológica Metropolitana

Santiago, Chile

1
Rodrigo Villegas

Jefe Programa de Bioestadística

Bioestadística

Universidad de Chile - Facultad de Medicina

Santiago, Chile

1
Luis Mercado

Profesor Titular

Instituto de Biología

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Marcela Hermoso

Full Professor

School of Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Julia Guerrero

académico

Programa Disciplinario Fisiologia y Biofisica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Claudio Acuña

Profesosr Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
ARTURO FERREIRA

FULL PROFESSOR, CHAIR IMMUNOLOGY DISCIPLINARY PROGRAM

IMMUNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Hector Contreras

Academico

Oncologia Basico Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA

Santiago, Chile

1
Bruno Nervi

Associated Professor

Hematology - Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Fabian Tempio

Asistente de Investigación

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
Carolina Ribeiro

Assistant Professor

Immunology Program

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

1
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Cristian Falcón

Urólogo

Hospital San Juan de Dios

Santiago, Chile

1
Mirentxu Iruretagoyena

Jefe Seccion Inmunologia

Laboratorio Clinico

Clinica Alemana de Santiago

Santiago, Chile

1
Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

1
Raquel Aguilera

PROFESOR ASISTENTE

INMUNOLOGÍA CLÍNICA Y REUMATOLOGÍA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Claudia Duran-Aniotz

Profesor Asociado

Escuela de Psicología

Universidad Adolfo Ibánez

Santiago, Chile