Man

Katina Schinnerling

Profesor Asistente

Universidad Andrés Bello

Santiago, Chile

Líneas de Investigación


Autoinmunidad y tolerancia Rol de microbiota en autoinmunidad Reguladores de tolerogenicidad en células dendríticas Modelo de ratón humanizado para artritis reumatoide (AR) Inmunoterapia para AR basada en células dendríticas tolerogénicas

Educación

  •  Ciencias Naturales (Dr. rer. nat.), especialidad Inmunología, FREIE UNIVERSITAT BERLIN. Alemania, 2013
  •  Biología, TECHNISCHE UNIVERSITAT DRESDEN. Alemania, 2007

Experiencia Académica

  •   Investigadora postdoctoral Other

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Santiago, Chile

    2014 - At present

  •   Profesor Asistente Full Time

    UNIVERSIDAD ANDRES BELLO

    Facultad de Ciencias de la Vida

    Santiago, Chile

    2019 - At present

Experiencia Profesional

  •   Investigadora postdoctoral Full Time

    Universidad de Chile, Facultad de Medicina, Instituto de Ciencias Biomédicas

    Santiago, Chile

    2013 - At present

  •   Asistente científico Part Time

    Charité - hospital clínico de la universidad, Berlín

    Berlín, Alemania

    2007 - 2012

  •   Profesor Investigador Full Time

    Universidad Andrés Bello

    Santiago, Chile

    2019 - At present

Formación de Capital Humano


Tutoría de tesis de pregrado:
3 carrera bioquímica
1 carrera ingeniería en biotecnología
1 carrera biología
2 carrera odontología

Co-tutoría de tesis postgrado:
1 Doctorado en Biotecnología


Premios y Distinciones

  •   Beca de la Fundación Alemana de Becas Académicas (“Studienstiftung des deutschen Volkes”)

    Studienstiftung des deutschen Volkes

    Alemania, 2004

    Beca para estudios universitarios


 

Article (19)

Immune Responses at Host Barriers and Their Importance in Systemic Autoimmune Diseases
Uptake of Tropheryma whipplei by Intestinal Epithelia
Intestinal barrier dysfunction mediates Whipple's disease immune reconstitution inflammatory syndrome (IRIS)
Regulation of Tolerogenic Features on Dexamethasone-Modulated MPLA-Activated Dendritic Cells by MYC
Architectural and functional alterations of the small intestinal mucosa in classical Whipple's disease
Dexamethasone and Monophosphoryl lipid a induce a Distinctive Profile on Monocyte-Derived Dendritic cells through Transcriptional Modulation of genes associated With essential Processes of the immune response
Peripheral T-Cell Reactivity to Heat Shock Protein 70 and Its Cofactor GrpE from Tropheryma whipplei Is Reduced in Patients with Classical Whipple's Disease
Dexamethasone and Monophosphoryl Lipid A-Modulated Dendritic Cells Promote Antigen-Specific Tolerogenic Properties on Naive and Memory CD4(+) T cells
Treatment with Dexamethasone and Monophosphoryl lipid a removes Disease-associated Transcriptional signatures in Monocyte-Derived Dendritic cells from rheumatoid arthritis Patients and confers Tolerogenic Features
Role of Dendritic Cells in the Pathogenesis of Whipple's Disease
Therapeutic potential of hyporesponsive CD4(+) T cells in autoimmunity
Effect of Age on the CD4(+) T-Cell Impairment in HIV-Infected Persons Without and With cART
Macrophages Accumulate in the Gut Mucosa of Untreated HIV-infected Patients
Evaluation of arginine metabolism for the analysis of M1/M2 macrophage activation in human clinical specimens
Immunopathology of Immune Reconstitution Inflammatory Syndrome in Whipple's Disease
Regulatory T Cells in Patients with Whipple's Disease
Impaired Immune Functions of Monocytes and Macrophages in Whipple's Disease
Specific and Nonspecific B-Cell Function in the Small Intestines of Patients with Whipple's Disease
The Immune Reconstitution Inflammatory Syndrome in Whipple Disease A Cohort Study

Abstract (2)

Dexamethasone and MPLA treatment of monocyte-derived dendritic cells from rheumatoid arthritis patients induce transcriptional modulation of genes related to cell recruitment, signaling and metabolism
Treatment with Dexamethasone and Monophosphoryl Lipid a Removes Disease-Associated Transcriptional Signatures in Monocyte-Derived Dendritic Cells from Rheumatoid Arthritis Patients and Confers the Ability to Modulate CD4+T Cell Responses

ConferencePoster (10)

The link between microbiota and autoimmune inflammation in rheumatoid arthritis
Induction of arthritis-like synovial inflammation in NOD-scid Il2rg null mice functionally engrafted withperipheral blood lymphocytes from rheumatoid arthritis patients
Establishment of a chimeric human-mouse model of rheumatoid arthritis for pre-clinical testing
Human peripheral blood lymphocytes maintain polyclonal and antigen-specific reactivity after engraftment into NOD-scid Il2rγnull mice: first steps towards a humanized model of autoimmune arthritis
Human peripheral blood lymphocytes preserve polyclonal and antigen-specific reactivity after engraftment into NOD-scid IL2rγnull mice: first steps towards a “humanized” model of autoimmune arthritis
Human peripheral blood mononuclear cells preserve polyclonal and antigen-specific reactivity after engraftment into NOD-scid IL2rγnull mice: first steps towards a humanized model of autoimmune arthritis
Semi-mature dendritic cells fail to induce a T. whipplei-specific Th1 response in Whipple's disease
Anti-inflammatory milieu induces unspecific T cell regulation in Whipple's disease
Inefficient T cell priming by dendritic cells impairs T. whipplei-specific Th1 response in Whipple's disease
T cell regulation in patients with Whipple's disease

Proyecto (8)

Effect of Prevotella copri on the intestinal epithelial barrier and the activation of inflammatory immune responses by antigen-presenting cells in patients with rheumatoid arthritis
Identificación de especies de la microbiota humana y sus antígenos implicados en la inmunopatogénesis de la artritis reumatoide
Péptidos autoantigénicos presentados por células dendríticas tolerogénicas=> una terapia personalizad a para reinstruir el sistema inmune de pacientes con artritis reumatoide
ESTABLISHMENT OF A HUMANIZED MOUSE MODEL OF ARTHRITIS=> AN APPROACH FOR STUDYING AUTOIMMUNE PROCESSES IN VIVO AND TESTING NOVEL THERAPEUTIC INTERVENTION STRATEGIES
Searching for a validated cell-based therapeutic approach for the treatment of rheumatoid arthritis=> Identification of specific tolerance markers and characterization of monophosphoryl lipid A (MPLA)-activated tolerogenic dendritic cells (MPLA-tDCs)
Migration of T cells in the gut mucosa and importance of mucosal CD4+ regulatory T cells for the immunopathogenesis of SIV/HIV infection
Whipple's disease - Investigation of interactions of T cells and antigen presenting cells
Immunopathogenesis and intervention strategies for mucosal infections

Review (5)

Humanized Mouse Models of Rheumatoid Arthritis for Studies on Immunopathogenesis and Preclinical Testing of Cell-Based Therapies
The role of interleukin-6 signalling and its therapeutic blockage in skewing the T cell balance in rheumatoid arthritis
Tolerogenic dendritic cells for reprogramming of lymphocyte responses in autoimmune diseases
Gene expression profiling of human monocyte-derived dendritic cells - searching for molecular regulators of tolerogenicity
Skewing dendritic cell differentiation towards a tolerogenic state for recovery of tolerance in rheumatoid arthritis
38
Katina Schinnerling

Profesor Asistente

Departamento de Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

9
Diego Catalán

Associate Professor

Programa Disciplinario de Inmunología

Universidad de Chile

Santiago, Chile

3
MARIA MOLINA

Director

Instituto de Ciencias Biomédicas

Universidad de Chile

INDEPENDENCIA, Chile

3
Bárbara Pesce

Profesora Asistente

ICBM

Universidad de Chile

Santiago, Chile

3
Lilian Soto

Rheumatologist

Medicine

CLINICAL HOSPITAL OF UNIVERSIDAD DE CHILE

Santiago, Chile

2
Ricardo Verdugo

Asistant Professor

Facultad de Medicina

UNIVERSIDAD DE CHILE

Santiago, Chile

2
JUAN AGUILLON

PROFESSOR

IMMUNOLOGY PROGRAM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Paulina García

Investigador Postdoctoral

Programa de Inmunologia

Universidad de Chile

Santiago, Chile

1
CARLOS ROSAS

Profesor Asistente

Ciencias Morfológicas

Universidad San Sebastián

Santiago, Chile

1
OCTAVIO ARAVENA

Gestión I+D

I+D+i

Comisión Chilena de Energía Nuclear

Santiago, Chile