Man

Yessia Hidalgo Fadic

Researcher

Corporación IMPACT

Santiago, Chile

Líneas de Investigación


Autoimmunity, aging and inflammation process, and how inducing functional changes in the immune cells. Mitochondria, intracellular and extracellular in autoimmunity. Extracellular vesicles. Flow Cytometry expert.

Educación

  •  Doctorado en Ciencias con mención en Biología Molecular, Celular y Neurociencias, UNIVERSIDAD DE CHILE. Chile, 2018
  •  Ingeniero en Biotecnología Molecular, UNIVERSIDAD DE CHILE. Chile, 2012
  •  Licenciado en Biotecnología Molecular, UNIVERSIDAD DE CHILE. Chile, 2011

Experiencia Profesional

  •   PhD student Full Time

    Universidad de Chile

    Santiago, Chile

    2013 - 2017

  •   Research Assistant Full Time

    Universidad de Chile

    Santiago, Chile

    2011 - 2012

  •   Undergraduate student Full Time

    Universidad de Chile

    Santiago, Chile

    2010 - 2011

  •   Research Assistant Full Time

    Fundacion Ciencia y Vida

    Santiago, Chile

    2017 - 2018

  •   Insternship Other

    Curie Institute

    Paris, Francia

    2015 - 2015

  •   Postdoctoral researcher Part Time

    Cells for Cells

    Santiago, Chile

    2018 - 2020

  •   Flow facility manager Part Time

    Consorcio Regenero

    Santiago, Chile

    2019 - At present

  •   Young researcher Part Time

    Cells for Cells

    Santiago, Chile

    2021 - 2020

  •   Researcher Part Time

    Universidad de Los Andes

    Santiago, Chile

    2022 - 2024

  •   Flow Cytometry Facility Manager Part Time

    Universidad de Los Andes

    Santiago, Chile

    2022 - 2024

  •   Researcher and flow cytometry manager Full Time

    Corporación IMPACT

    Santiago, Chile

    2024 - At present

Formación de Capital Humano


Flow Cytometry expert.
During my researcher career, I acquired strong knowledge in the flow cytometry technique, mainly in the Maria Rosa Bono's lab. This knowledge allowed me to found work as Flow Cytometry Facility Manager of Cells for Cells/Regenero institution. Currently, this experience help me in the design, performing and analysis of the experiments. Currently I work as Flow Cytometry Facility Manager of Centro de Investigación e Innovación Biomédica (CIIB), Universidad de Los Andes, Santiago, Chile.

Supervision undergraduate students.
I had a student in charge. This student was María José Fuenzalida, an undergraduate student of the engineer in molecular biotechnology Career of University of Chile. During the years 2014 to 2016, She developed an internship and her Title Seminar in the laboratory. I trained her in terms related to design the experimental proposal and taught her the experimental techniques to perform her proposal. The work that developed María José Fuenzalida is titled “Estudio de las subpoblaciones de linfocitos B y T presentes en el timo de ratones que desarrollan lupus”

Currently, I am a tutor of Lucas Cereceda, that he performs its undergraduate thesis to Biotechnology career from Universidad Mayor. Lucas characterizes circulating mitochondria in plasma physically and functionally in healthy donors and lupus patients. He will finish his thesis in the next two months.

Also I have a student Gabriela Maita from Biology Career of Pontificia Universidad Católica de Santiago. She performs her professional practice to finish his career.

Teaching activities.
I perform classroom lessons in the field of immunology. At the University of Chile, Faculty of Sciences is taught the course the Basic Immunology to the Engineer of Molecular Biotechnology career, led by Ph.D. Maria Rosa Bono. In this course, the main foundations of immunology are taught. I am part of teaching the item how the immune system behaves when it responds in an exaggerated manner, such as in hypersensitivity reactions: allergies and autoimmunity. I have taught this knowledge since 2014.

I perform class lessons in the Doctoral Biomedicine Program of Universidad de Los Andes, Santiago, Chile. These classes are related to the flow cytometry technique and its applications. Also I perform practical activities in flow cytometry with the students.


Premios y Distinciones

  •   Yessia Hidalgo

    UNIVERSIDAD DE CHILE

    Chile, 2013

    CONICYT Doctoral Scholarship Beca Doctorado Nacional CONICYT # 21130598


 

Article (17)

A Phase I Dose-Escalation Clinical Trial to Assess the Safety and Efficacy of Umbilical Cord-Derived Mesenchymal Stromal Cells in Knee Osteoarthritis
Impact of platelet-derived mitochondria transfer in the metabolic profiling and progression of metastatic MDA-MB-231 human triple-negative breast cancer cells
Levels of Small Extracellular Vesicles Containing hERG-1 and Hsp47 as Potential Biomarkers for Cardiovascular Diseases
Lactate: an alternative pathway for the immunosuppressive properties of mesenchymal stem/stromal cells
Safety and efficacy of clinical-grade, cryopreserved menstrual blood mesenchymal stromal cells in experimental acute respiratory distress syndrome
Mesenchymal stem cell-mediated transfer of mitochondria: mechanisms and functional impact
A Chemically Defined, Xeno- and Blood-Free Culture Medium Sustains Increased Production of Small Extracellular Vesicles From Mesenchymal Stem Cells
The Multifaceted Roles of B Cells in the Thymus: From Immune Tolerance to Autoimmunity
Cells from discarded dressings differentiate chronic from acute wounds in patients with Epidermolysis Bullosa
Thymic B Cells Promote Germinal Center-Like Structures and the Expansion of Follicular Helper T Cells in Lupus-Prone Mice
Adoptive transfer of autoimmune splenic dendritic cells to lupus-prone mice triggers a B lymphocyte humoral response
Purinergic Signaling as a Regulator of Th17 Cell Plasticity
The human thymus perivascular space is a functional niche for viral-specific plasma cells
Alloreactive Regulatory T Cells Allow the Generation of Mixed Chimerism and Transplant Tolerance
Alloreactive regulatory T cells generated with retinoic acid prevent skin allograft rejection
Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation
T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour

Abstract (2)

Accumulation of autoreactive antibody-producing cells in the thymus of lupus-prone BWF1 mice
Allogeneic inducible regulatory T cells allow the generation of mixed chimerism via nonmyeloablative conditioning in mice models

BookSection (1)

A Spontaneous Mouse Model of Lupus: Physiology and Therapy

Proyecto (3)

REVEALING THE CONTRIBUTION OF MELANOMA-DERIVED CIRCULATING CELL-FREE MITOCHONDRIA IN THE FORMATION OF PREMETASTATIC NICHE IN LYMPH NODES AND THEIR IMPACT IN THE EARLY DEVELOPMENT OF METASTASIS
INVESTIGATING THE IMMUNOREGULATORY EFFECT OF CIRCULATING CELL-FREE MITOCHONDRIA FROM HEALTHY DONORS AND SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS ON MEMORY CD4+ T CELLS.
INVESTIGATING THE EFFECT OF MAVS-ENRICHED MITOCHONDRIAL TRANSPLANTATION ON INTRACELLULAR ANTIVIRAL IMMUNITY AND THEIR RESTORATIVE AND IMMUNOMODULATORY EFFECTS IN A VIRAL-INDUCED ACUTE LUNG INJURY MODEL.

Review (1)

Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance
23
Yessia Hidalgo

Researcher

Centro de Investigación e Innovación Biomédica

Corporación IMPACT

Santiago, Chile

9
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

8
Mario Rosemblatt

Executive Director

-

Fundacion Ciencia & Vida

Santiago, Chile

6
Daniela Sauma

Academic and researcher

Biologia

Universidad de Chile

Santiago, Chile

5
Sarah Nuñez

Académico Investigador

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

4
Paulina Ruiz

Profesor Asistente

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Gabriela Tejon

Investigador Postdoctoral

Biología

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
María Gleisner

INVESTIGADORA

ICBM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Jimena Cuenca

Investigador/profesor

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

1
Claudia Altamirano

Profesor Titular

Facultad de Ingeniería

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaíso, Chile

1
Jaime De Calisto

Director Docente

Escuela de Biotecnología

Universidad Mayor

Santiago, Chile

1
Francisca Alcayaga

Profesor Asociado

Facultad de Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Aliosha Figueroa

Asistente de Investigación

Consorcio Regenero S.A.

Santiago, Chile

1
Boris Rebolledo

Researcher

Center for Genetics and Genomics

Universidad del Desarrollo

Santiago, Chile

1
Ricardo Fernandez

Profesor Asociado A

Salud

Universidad de Los Lagos

Osorno, Chile

1
Charlotte Hill

Postdoctoral Fellow

CIIB

Universidad de Los Andes

Santiago, Chile

1
Ricardo Fernández

Associate Professor

Salud

Universidad de Los Lagos

Osorno, Chile

1
Roberto Elizondo

Profesor Asistente

Departamento de Biología Celular

Universidad de Concepción

CONCEPCION, Chile

1
Felipe Galvez

Estudiante Doctorado

Universidad de La Frontera

Temuco, Chile