The enzymes involved in the catabolism of agmatine in mammals brain, agmatine is a molecule with neuromodulatory, neurotransmitter functions and a potential drug .

Since 2014:

PARTICIPATION AS A PROFESSOR UNDERGRADUATE THESIS GUIDE

2014
Tutor of the thesis titled "Enzymatic characterization of the variants of agmatinase like protein (ALP) H65A and H394A", of the student Matías Quiñones San Martin, Biology degree supported on January 29, 2014.

Tutor of the thesis titled "Cloning, expression and functional analysis of mouse agmatinase", of the student of the Bioengineering career Nicol Natalia Romero Carrera, supported on April 4, 2014.

2015
Tutor of the thesis titled "Isolation of proteins that interact with the Agmatinase like protein (ALP)", of the student of Biochemistry career Arlette Denise González San Martin, supported on April 30, 2015.

2017
Tutor of the thesis entitled "Characterization of Tosocarolpyruvate carboxylase of Lupinus albus, student of the career of Biology Luis Arriagada, supported on April 26, 2017.

 PARTICIPATION AS A PROFESSOR GRADUATE THESIS GUIDE

2013
Tutor of the thesis of the Master in Biochemistry and Bioinformatics titled: "Functional and structural analysis of LIM domain mutants in rat brain Agmatinasa", by the student Paola Montes, supported on August 20, 2013.

Tutor of the thesis of the Master in Biochemistry and Bioinformatics entitled: "Characterization of the interaction ALP-Mn2 +", by the student Jaime Cofré, supported on May 29, 2013.

Co-tutor of the thesis of the Master in Biochemistry and Bioinformatics entitled: "Glicemia-dependent modulation of the GK-GKRP interaction in hypothalamic glia", by the student Magdiel Salgado, supported on November 8, 2013.

2015
Tutor of the PhD thesis in Biological Science, mention Cellular and Molecular Biology entitled "Functional Characterization of LIMCH1", by David García Labraña, student, supported on June 23, 2015.

2016
Tutor of the thesis of the Master in Biochemistry and Bioinformatics entitled: "Cloning and Functional Characterization of Mouse Agmatinase", by the student Nicol Romero Carrera, supported on August 5, 2016.

2018
Tutor of the thesis of the Master in Biochemistry and Bioinformatics entitled: "Functional analysis of the CH domain of LIMCH1", by the student Arlette Gonzalez San Martin, supported on November 8, 2018.

CONFERENCES, TALKS OR EQUIVALENTS

a) Presentations in international congress

2013
1. E. Uribe, J. Cofre, P. García, J. Benítez, D. García, J. Martínez-Oyanedel and N. Carvajal. Insights into the interaction of an agmatinase-like protein with Mn2 + and Zn2 + ions. FEBS-Congress 2013, St. Petersburg, July 6-11, 2013.

2014
2. V. Morin, O. Riquelme, C. Reyes, S. Bustamante, E. Uribe, S. Gutierrez, A. Castro. Effect of a cathepsin L variant on colorectal cancer HCT 116 cell proliferation. FEBS-EMBO 2014. August 30 - September 4, 2014, Paris, France.
3. E. Uribe, M. Quiñones, J. Cofre, D. Garcia, J. Benitez, N. Romero, A. Gonzalez, N. Carvajal. Insight on the interaction of an agmatinase-like protein with Mn2 + and evidence for the agmatinase activity of the protein Limch 1. FEBS-EMBO 2014. August 30 - September 4, 2014, Paris, France.
4. M García-Robles, M. Salgado, E. Tarifeño, P. Ordenes, M, Villagra, R. Elizondo-Vega, A. Uribe. Hexokinase IV and its regulatory protein in the hypothalamus. FEBS-EMBO 2014. August 30 - September 4, 2014, Paris, France.

2015
5. Garcia-Robles MA., Barahona MJ., Llanos P., Millán C., Salgado M., Elizondo-Vega R., Uribe EA. Glucose transporter 2 inhibition in tanycytes affects feeding behavior. American Society for Neurochemistry (ASN) 47th Annual Meeting, March 19-23, 2016, Denver, USA.

b) Presentations in national congress.

2013
1. García, D., Benítez, J., Romero, N., González, A., Carvajal, N., Uribe, E. The Limch1protein has agmatinase activity. XII Panamerican Association for Biochemistry and Molecular Biology Congress, Puerto Varas 9-14 November 2013.
2. Benítez, J., Cofre, J., Montes, P., Vallejos, A., García, D., Martínez-Oyanedel, J., Carvajal, N., Uribe, E. Interaction of agmatinase-like protein with Mn2 + and Zn2 + ions. XII Panamerican Association for Biochemistry and Molecular Biology Congress, Puerto Varas 9-14 November 2013.
3. Quiñones, M., Castro, V., Guzman, B., Garcia, D., Guixé, V., Carvajal, N., Uribe, E. Reconstruction of the last common ancestor of arginases and agmatinases. XII Panamerican Association for Biochemistry and Molecular Biology Congress, Puerto Varas 9-14 November 2013.
4. Romero, N., García, D. Quiñones, M., Benítez, J. Carvajal, N, Uribe, E. Cloning and expression of mouse liver agmatinase. XII Panamerican Association for Biochemistry and Molecular Biology Congress, Puerto Varas 9-14 November 2013.
5. Salgado, M., Tarifeño, E., Ordenes, P., Yañez, M., Elizondo, R, Uribe, E., Garcia, M. Dynamic localization of glucokinase and its regulatory protein in hypothalamic tanycytes. XII Panamerican Association for Biochemistry and Molecular Biology Congress, Puerto Varas 9-14 November 2013.

2014
6. Garcia, D., Torrealba, N., Ordenes, P., Benitez, J., Garcia, M., Carvajal, N., Uribe E. LIMCH1 isoforms I and II: characterization of novel proteins with agmatinase activity. XXXVII Annual Meeting of the Society of Biochemistry and Molecular Biology of Chile. Puerto Varas, September 30 - October 4, 2014
7. González D., Quiñones M., Benitez J., Cofré J., Carvajal N., Uribe E. Determination of LIM-domain interaction proteins and analysis of possible Mn2 + coordinating residues in ALP. XXXVII Annual Meeting of the Society of Biochemistry and Molecular Biology of Chile. Puerto Varas, September 30 - October 4, 2014.
8. Romero N., Moreira C., Benitez J., Carvajal N., Uribe E. Mouse liver agmatinase support polyamine biosynthesis in vivo. XXXVII Annual Meeting of the Society of Biochemistry and Molecular Biology of Chile. Puerto Varas, September 30 - October 4, 2014.

2015
9. Gonzalez, A., Garcia, D., Ordenes, P., Benitez, J., Barbara, A., Rivas, B., Garcia, M., Carvajal, N., Uribe, E. Cloning of two LIMCH1 isoforms: Characterization of their distribution in mouse brain and their agmatinase activity. XXXVIII Annual Meeting of the Society of Biochemistry and Molecular Biology of Chile. Puerto Varas, September 22-25, 2015.

2016
10.González, A., Romero, N., Benítez, J., García, D., Reyes, M., Arancibia, B., Mella, K., Uribe, E. Cloning and functional characterization of mouse agmatinase. XXXIX Annual Meeting of the Society of Biochemistry and Molecular Biology of Chile. Puerto Varas, September 27-30, 2016.

2017
11. Characterization of Mn2 + binding site in agmatinase like protein (ALP).
Ma Belen Reyes, Camila Navarrete, Erika Mardones, David Garcia, Kelly Mella, Luis Arriagada, José Martínez, Nelson Carvajal, Elena Uribe. XL Annual Meeting SBBMCH 26-29 September 2017, Puerto Varas

c) Invited to participate in conferences.

Presentation of the talk entitled "Analyzing the gene and the function of an enzyme", on April 18, 1013 in the Fraternity College of the Masonic Educational Corporation in Lomas Coloradas, Coronel.
Presentation of the talk entitled "Analyzing the gene and function of an enzyme", on May 13, 1013 at the 2nd National Meeting of Science and Technology of the Adventist Educational System, held at the Adventist School of Tacahuano.
Presentation in the Symposium entitled: "Biotechnology Applied to Mining", On Wednesday, June 29, 2016 at the Jaime Baeza Auditorium of the EmpreUdeC Building, the title of the paper was Regulation of agmatine levels in mammals.
Presentation of the Master Class "Science and Faith in Biochemical Research", within the framework of the 110th anniversary of Adventist Education in Chile and the 25th anniversary of the Adventist University of Chile, held on October 12 of the current year (2016)