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Soraya Elisa Gutierrez Gallegos

Profesor Titular

UNIVERSIDAD DE CONCEPCIÓN

Concepcion, Chile

Ciclo celuar; cathepsin L; Cancer; 1. Molecular characterization of an adenilyl cyclase from Xenopus laevis. Function-Structure studies. ((Torrejon y cols. 1997, Torrejon y cols. 1998, Echeverria y cols. 2000).; 2. Screening of genes that participate during neural development by insertional mutagenesis using the gene-trap approach. Postdoctoral position with Dr Sigrid Reinsch.; 3. Function and localization of XtRIC-8 during Xenopus tropicalis embryogenesis; Translocaciones cromosomales; Estructura de cromatina; Regulacion transcripcional

Cell and Molecular Biology, UNIVERSITY OF MASSACHUSETTS. Estados Unidos, 2003
Biochemistry, UNIVERSIDAD DE CONCEPCION. Chile, 1994
Bioquímico, UNIVERSIDAD DE CONCEPCION. Chile, 1987

Profesor Titular Full Time

UNIVERSIDAD DE CONCEPCION

Ciencias Biológicas

Concepción, Chile

2019 - At present
Profesor Asociado Full Time

UNIVERSIDAD DE CONCEPCION

Ciencias Biológicas

Concepción, Chile

2007 - 2018
Profesor Asistente Full Time

UNIVERSIDAD DE CHILE

Ciencias Biológicas

Concepción, Chile

2003 - 2006
Instructor Full Time

UNIVERSIDAD DE CHILE

Ciencias Biológicas

Concepción, Chile

1991 - 2002
Profesor Part Time

UNIVERSIDAD ADVENTISTA DE CHILE

Ingeniería y Negocios

Chillán, Chile

1991 - 1995

Profesor Titular Full Time

Universidad de Concepcion

Concepcion, Chile

2019 - At present
Profesor Asociado Full Time

Universidad de Concepcion

Concepcion, Chile

2007 - 2018
Profesor Asistente Full Time

Universidad de Concepcion

Concepcion, Chile

2003 - 2006
Instructor Full Time

Universidad de Concepcion

Concepcion, Chile

1991 - 2002
Profesor Part Time

Universidad Adventista de Chile

Chillán, Chile

1991 - 1995


Etoposide-induced DNA damage in a chromosomal breakpoint of RUNX1 gene is independent of RUNX1 expression Schnake N.; GutiÃ©rrez S. Article SCOPUS Leukemia Research Reports (2019)
Identification of a novel long non-coding RNA within RUNX1 intron 5 Schnake N.; Hinojosa M.; GutiÃ©rrez S. Article ISI SCOPUS HUMAN GENOMICS (2019)
Alternative RUNX1 Promoter Regulation by Wnt/beta-Catenin Signaling in Leukemia Cells and Human Hematopoietic Progenitors Medina M.A.; Ugarte G.D.; Vargas M.F.; Avila M.E.; Necuñir D.; Elorza, A.A.; Gutiérrez S.E.; De Ferrari G.V. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2016)
Transcriptional Auto-Regulation of RUNX1 P1 Promoter Martínez M; Hinojosa M.; Trombly, D; Morin, V; Stein, J; Stein G.; Javed, A; Gutierrez, SE Article ISI SCOPUS PLOS ONE (2016)
“Wnt signaling induces transcription, spatial proximity, and translocation of fusion gene partners in human hematopoietic cells” Ugarte G, Vargas M; Medina M, León P; Necuñir D, Elorza A; Gutiérrez S, Moon R; Loyola A, De Ferrari G . Article BLOOD (2015)
“Specificity protein 7 is not essential for tooth morphogenesis” Clarke JC, Bae JM; Adhami M, Rashid H; Chen H, Napierala D; Gutierrez SE, Sinha K; Crombrugghe B, Javed A. Article Connect Tissue Res. (2014)
Cis-regulatory elements are harbored in Intron5 of the RUNX1 gene. Rebolledo-Jaramillo, Boris; Alarcon, Ricardo A; Fernandez, Valentina I; Gutierrez, Soraya E Article BMC genomics (2014)
Runx2 Regulates Endochondral Ossification Through Control of Chondrocyte Proliferation and Differentiation Chen H.; Ghori-Javed F.Y.; Rashid, H; Adhami M.D.; Serra R.; Gutiérrez S.E.; Javed, A Article ISI SCOPUS JOURNAL OF BONE AND MINERAL RESEARCH (2014)
Breakpoint Regions of ETO Gene Involved in (8;21) Leukemic Translocations Are Enriched in Acetylated Histone H3 Stuardo, M.; Nicovani, S.; Javed, A; Gutierrez S. Article ISI SCOPUS Journal of Cellular Biochemistry (2013)
Epigenetic changes: a common theme in acute myelogenous leukemogenesis. Gutierrez, Soraya E; Romero-Oliva, Francisco A Article Journal of hematology & oncology (2013)
Runx2 regulates the gene network associated with insulin signaling and energy homeostasis. Adhami, Mitra; Ghori-Javed, Farah Y; Chen, Haiyan; Gutierrez, Soraya E; Javed, Amjad Article Cells, tissues, organs (2011)
“Chondrocyte-specific regulatory activity of runx2 is essential for survival and skeletal development” Chen H, Ghori-Javed FY; Rashid H, Serra R; Gutierrez SE, Javed A. . Cells Tissues Organs. 2011 Article Epub (2011)
Altered chromatin modifications in AML1/RUNX1 breakpoint regions involved in (8;21) translocation. Stuardo, Marcela; Martinez, Milka; Hidalgo, Karla; Montecino, Martin; Javed, Amjad; Lian, Jane B; Stein, Gary S; Stein, Janet L; Gutiérrez, Soraya E Article Journal of cellular physiology (2009)
Specific Residues of RUNX2 Are Obligatory for Formation of BMP2-Induced RUNX2-SMAD Complex to Promote Osteoblast Differentiation Javed, A; Afzal, F; Bae, JS; Gutierrez S. ; Zaidi, K; Pratap, J; van Wijnen, AJ; Stein, JL; Stein, GS; Lian, JB Article ISI SCOPUS Cells Tissues Organs (2009)
Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal Javed, A; Bae J.-S.; Afza F.; Gutierrez S. ; Pratap, J; Zaidi S.K.; Lou Y.; van Wijnen A.J.; Stein J.L.; Stein G.S.; Lian J.B. Article SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Nucleosome organization and targeting of SWI/SNF chromatin-remodeling complexes: contributions of the DNA sequence Montecino, M.; Stein, JL; Stein, GS; Lian, JB; van Wijnen, AJ; Cruzat F.; Gutierrez S. ; Olate, J; Marcellini, S; Gutierrez, JL Article ISI Biochemistry and Cell Biology (2007)
Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation Bae J.-S.; Gutierrez S. ; Narla R.; Pratap, J; Devados R.; van Wijnen A.J.; Stein J.L.; Stein G.S.; Lian J.B.; Javed, A Article SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2007)
Subnuclear targeting of Runx1 is required for synergistic activation of the myeloid specific M-CSF receptor promoter by PU.1 Li, XG; Vradii, D; Gutierrez S. ; Lian, JB; van Wijnen, AJ; Stein, JL; Stein, GS; Javed, A Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2005)
The vitamin D response element in the distal osteocalcin promoter contributes to chromatin organization of the proximal regulatory domain Gutierrez S. ; Liu, JL; Javed, A; Montecino, M.; Stein, GS; Lian, JB; Stein, JL Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Conservative segregation of maternally inherited CS histone variants in larval stages of sea urchin development Oliver, MI; Rodriguez, C; Bustos, P; Morin, V; Gutierrez S. ; Montecino, M.; Geneviere, AM; Puchi, M; Imschenetzky M. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2003)
Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer Stein, GS; Lian, JB; Stein, JL; van Wijnen, AJ; Montecino, M.; Pratap, J; Choi J.; Zaidi, SK; Javed, A; Gutierrez S. ; Harrington, K; Shen, JL; Young D. Article ISI SCOPUS BLOOD CELLS MOLECULES AND DISEASES (2003)
Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D-3 receptor but not p300 intrinsic histone acetyltransferase activity Sierra, J; Villagra, A; Paredes, R.; Cruzat F.; Gutierrez S. ; Javed, A; Arriagada, G; Olate, J; Imschenetzky M.; van Wijnen, AJ; Lian, JB; Stein, GS; Stein, JL; Montecino, M. Article ISI SCOPUS MOLECULAR AND CELLULAR BIOLOGY (2003)
Runx2/Cbfa1 functions: Diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions Lian, JB; Stein, JL; Stein, GS; van Wijnen, AJ; Montecino, M.; Javed, A; Gutierrez S. ; Shen, J; Zaidi, SK; Drissi, H Article ISI CONNECTIVE TISSUE RESEARCH (2003)
CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression Gutierrez S. ; Javed, A; Tennant, DK; van Rees, M; Montecino, M.; Stein, GS; Stein, JL; Lian, JB Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Interaction of the 1 alpha,25-dihydroxyvitamin D3 receptor at the distal promoter region of the bone-specific osteocalcin gene requires nucleosomal remodelling Paredes, R.; Gutierrez J.; Gutierrez S. ; Allison, L; Puchi, M; Imschenetzky M.; van Wijnen A.; Lian J.; Stein G.; Stein, J; Montecino, M. Article ISI SCOPUS BIOCHEMICAL JOURNAL (2002)
Remodeling of sperm chromatin after fertilization involves nucleosomes formed by sperm histones H2A and H2B and two CS histone variants Oliver, MI; Concha, C; Gutierrez S. ; Bustos, A.; Montecino, M.; Puchi, M; Imschenetzky M. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2002)


Effect of a cathepsin L variant on colorectal cancer HCT116 cell proliferation Morin, V; Riquelme O.; Reyes, C.; Bustamante S.; Uribe, E; Gutierrez S. ; Castro A. Abstract ISI FEBS JOURNAL (2014)
Identification of a putative promoter element in intron5 of the RUNX1 gene Gutierrez S. ; Hinojosa M. Abstract ISI FASEB JOURNAL (2014)
SCL and RUNX1 regulate RUNX1 gene expression by association to RUNX1-P1 promoter Gutierrez S. ; Martínez M Abstract ISI FEBS JOURNAL (2014)
Effect of Cathepsin L variant gen silencing over proliferation, viability and organization of mitotic spindle in cell lines of colorectal cancer (Caco-2) and uterine cervical cancer (HeLa) Morin, V; Rivas F.; Riquelme O.; Reyes, C.; Gutierrez S. ; Leonardi M.; Romo, X. Abstract ISI FEBS JOURNAL (2013)
The breakpoint cluster regions of ETO gene involved in (8;21) leukemic translocations are enriched in acetylated histone H3 Stuardo, M.; Schnake N.; Javed, A; Gutierrez S. Abstract ISI FEBS JOURNAL (2013)
Epigenetic regulation of bone-phenotypic genes Henriquez, B; Cruzat F.; Hepp, M.; Olate, J; Gutierrez S. ; Montecino, M. Abstract ISI FEBS JOURNAL (2008)
Chromatin remodeling of the proximal rat osteocalcin promoter is dependent on vitamin D receptor binding at the distal promoter element Gutierrez S. ; Javed, A; Montecino, M.; van Wijnen, AJ; Stein, GS; Lian, JB; Stein, JL Abstract ISI JOURNAL OF BONE AND MINERAL RESEARCH (2003)


Lox-1 Receptor Activation By Oxldl Is A Fundamental Molecular Switch Among Obesity, Pro-inflammatory Milieu And Colorectal Cancer Development And Progression. Toledo, Jorge Roberto Proyecto (2020)
IDENTIFICATION AND CHARACTERIZATION OF A NOVEL ANTISENSE RNA ENCODED IN INTRON5 OF THE RUNX1 GENE FONDECYT (1130697) Proyecto 2013-2017 Inv. Responsable
DEVELOPMENTAL PROGRAMMING OF CHRONIC DISEASES IN ADULT AND AGING INDIVIDUALS=> THE ROLE OF MATERNAL MELATONIN IN THE REGULATION OF FETAL TRANSCRIPTIONAL AND GENE PROMOTER ACTIVITY. FONDECYT (1110220) Proyecto 2011-2015 Coinvestigador(a)
ROLE OF HISTONE ACETYLATION IN FORMATION OF LEUKEMIA CAUSING (8;21) TRANSLOCATION FONDECYT (1100670) Proyecto 2010-2013 Inv. Responsable
CISTEIN-PROTEASA QUE PARTICIPA EN REMODELACION DEL PRONUCLEO MASCULINO POSTFECUNDACION=> CONSOLIDACION DE UN MODELO Y PERSPECTIVAS FUTURAS. FONDECYT (1050100) Proyecto 2005-2008 Coinvestigador(a)
ROL DE LA ESTRUCTURA DE CROMATINA EN LA GENERACION DE TRANSLOCACIONES CROMOSOMICAS. FONDECYT (1040481) Proyecto 2004-2008 Inv. Responsable
ROL DE LA ESTRUCTURA DE CROMATINA EN LA GENERACION DE TRANSLOCACIONES CROMOSOMICAS. FONDECYT (7040013) Proyecto 2004-2005 Inv. Responsable


Nuclear microenvironments support assembly and organization of the transcriptional regulatory machinery for cell proliferation and differentiation Stein, GS; Lian, JB; van Wijnen, AJ; Stein, JL; Javed, A; Montecino, M.; Zaidi, SK; Young D.; Choi, JY; Gutierrez S. ; Pockwinse, S Review ISI JOURNAL OF CELLULAR BIOCHEMISTRY (2004)
Nuclear microenvironments support physiological control of gene expression Stein, GS; Lian, JB; Montecino, M.; Stein, JL; van Wijnen, AJ; Javed, A; Pratap, J; Choi J.; Zaidi, SK; Gutierrez S. ; Harrington, K; Shen, JL; Young D.; Pockwinse, S Review ISI SCOPUS CHROMOSOME RESEARCH (2003)