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Sylvain Marcellini Liotaud

Associate Professor

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Control of gene expression and regulation during organogenesis. Skeletal development EvoDevo

Genetics and Cell Biology, UNIVERSITE DE LA MEDITERRANEE : AIX-MARSEILLE II. Francia, 2002

Post-Doc Full Time

University of Cambridge

Cambridge, Reino Unido

2003 - 2005
Post-Doc Full Time

Universidad de Concepcion

Facultad de Ciencias Biologicas

Concepcion, Chile

2006 - 2007
Associate Professor Full Time

Universidad de Concepcion

Facultad de Ciencias Biologicas

Concepcion, Chile

2008 - At present

Evaluador Becas CHILE Part Time

CONICYT

Chile

2010 - At present
Coordinador Comité de Biología Celular y Molecular (Formación de Capital Humano Avanzado) Part Time

CONICYT

Chile

2011 - 2014
Par Evaluador Part Time

CNA

Chile

2014 - 2018
Miembro del Grupo de Estudio Biologia 2 Part Time

CONICYT - FONDECYT

Chile

2015 - 2017
Tesorero Part Time

Latin American Society for Developmental Biology (LASDB)

Chile

2017 - At present

PhD THESES
Adrian ROMERO (PhD thesis, TUTOR) “Regulatory architecture of the SCPP gene cluster”, Ongoing
David MUÑOZ (PhD thesis, TUTOR) “Evolutionary origin of the osteogenic role of the Osterix transcription factor”, Ongoing
Fret CERVANTES (PhD thesis, TUTOR) “Rewiring of the Sox9-dependent osteogenic regulatory network”, Ongoing
Gabriela Torro (PhD thesis, CO-TUTOR) “Role of Ric8 during neural crest formation”. Co-directed with the Dr. Marcela Torrejon, University of Concepcion. Finished in 2016.
Patricia HANNA (PhD thesis, TUTOR) “Transcriptional control of osteoblast and osteocyte-specific genes in Xenopus tropicalis”, Finished in 2014.
Ariana BERTIN (PhD thesis, CO-TUTOR) “Signaling pathways driving the propagation of the mineralization front in intramembraneous bone”, Co-directed with the Dr. Juan Pablo Henriquez, University of Concepcion. Finished in 2014.

MASTER THESES
Pedro CONTRERAS (Master thesis, TUTOR) “Role of repeated sequences embedded within osteoblastic transcriptional enhancers”, Finished in 2017
Hector CASTILLO (Master thesis, TUTOR), “An improved fluorescent in vivo bioassay to detect contamination of Chilean drinkable waters resources”, Finished in 2017
David MUNOZ (Master thesis, TUTOR) “Expression and regulation of the collagen genes in Xenopus tropicalis developing bones”, Finished in 2015
Gastón OTAROLA (Master thesis, TUTOR) “A novel biosensor system to detect contamination of Chilean drinkable waters resources”, Finished in 2014

UNDERGRADUATE THESES
Rodrigo MENDEZ (Undergraduate thesis, TUTOR) “Tissue-specific response to dioxins”, Ongoing
Francisca BERMEDO (Undergraduate thesis, CO-TUTOR), “Neuromuscular junction formation in Xenopus”. Finished in 2016
Pedro CONTRERAS (Undergraduate thesis, TUTOR) “Transcriptional regulation in skeletal cells”, Finished in 2016
David NAVARRO (Undergraduate thesis, TUTOR) “Evolution of the expression and function of the btg family members”, Finished in 2014
Alan FRITZ (Undergraduate thesis, TUTOR) “Morphological description of osteocytogenesis in the developing Xenopus tropicalis calvaria”, Finished in 2014
Gastón OTAROLA (Undergraduate thesis, TUTOR) “Generation of inducible transgenesis vector to study biological processes in Xenopus tropicalis”, Finished in 2012
Daniel ALDEA (Undergraduate thesis, TUTOR) “Evolution of the network forming collagen family”, Finished in 2012
Federico JARA (Undergraduate thesis, TUTOR) “Anatomical comparison of skeletal development between Xenopus tropicalis and Chilean endemic frog species”, Finished in 2011
Javier ESPINOZA (Undergraduate thesis, TUTOR) “An histological and molecular analysis of bone development in Xenopus tropicalis”, Finished in 2010
Mario SANCHEZ (Undergraduate thesis, TUTOR) “Molecular characterization of the Xenopus tropicalis osteocalcin promoter”, Finished in 2009

Visiting Professor

University of Paris 6

Francia, 2013

Visiting Professorship position from the University of Paris6, France, for one month during October 2013, at the UMR 7232 – Biologie Intégrative des Organismes Marins (BIOM), Observatoire Océanologique de Banyuls/Mer: -Collaboration with Dr. Hector Escriva (supervising of Daniel Aldea, a PhD student we are co-supervising, planning experiments, writing scientific articles together). -Collaboration with Dr. Laurent Sachs (scientific meetings, planning experiments, writing scientific articles togeher). -Seminar at the University of Paris 6 -Lectures for Master students (Genomics, Genetics)
Visiting Professor

University of Paris 6

Chile, 2014

Visiting Professorship position from the University of Paris6, France, for one month during October 2014, at the UMR 7232 – Biologie Intégrative des Organismes Marins (BIOM), Observatoire Océanologique de Banyuls/Mer: -Collaboration with Dr. Hector Escriva (supervising of Daniel Aldea, a PhD student we are co-supervising, planning experiments, writing scientific articles together). -Collaboration with Dr. Laurent Sachs (scientific meetings, planning experiments, writing scientific articles togeher). -Seminar at the University of Paris 6 -Lectures for Master students (Genomics, Genetics)


Genetic regulation of amphioxus somitogenesis informs the evolution of the vertebrate head mesoderm Aldea, Daniel; Subirana, Lucie; Keime, Celine; Meister, Lydvina; Maeso, Ignacio; Marcellini, Sylvain; Gomez-Skarmeta, Jose Luis; Bertrand, Stephanie; Escriva, Hector Article ISI SCOPUS NATURE ECOLOGY & EVOLUTION (2019)
Skeletal Mineralization in Association with Type X Collagen Expression Is an Ancestral Feature for Jawed Vertebrates Debiais-Thibaud, Mélanie; Simion, Paul; Ventéo, Stéphanie; Muñoz, David; Marcellini, Sylvain; Mazan, Sylvie; Haitina, Tatjana Article ISI SCOPUS MOLECULAR BIOLOGY AND EVOLUTION (2019)
Bone regeneration after traumatic skull injury in Xenopus tropicalis Muñoz, David; Castillo, Héctor; Henríquez, Juan Pablo; Marcellini, Sylvain Article ISI SCOPUS Mechanisms of Development (2018)
Evolution of dental tissue mineralization: an analysis of the jawed vertebrate SPARC and SPARC-L families Enault, S; Munoz, D; Simion, P; Venteo, S; Sire, JY; Marcellini, S; Debiais-Thibaud, M Article ISI SCOPUS BMC EVOLUTIONARY BIOLOGY (2018)
The neuromuscular junction of Xenopus tadpoles: Revisiting a classical model of early synaptogenesis and regeneration Bermedo-García, Francisca; Ojeda, Jorge; Méndez-Olivos, Emilio E.; Marcellini, Sylvain; Larraín, Juan; Henríquez, Juan Pablo Article ISI SCOPUS Mechanisms of Development (2018)
The Ric-8A/G?13/FAK signalling cascade controls focal adhesion formation during neural crest cell migration in xenopus Toro-Tapia G.; Villaseca S.; Beyer A.; Roycroft A.; Marcellini S.; Mayor, R; Torrejo? M. Article ISI SCOPUS Development (Cambridge) (2018)
A Single Chance to Contact Multiple Targets: Distinct Osteocyte Morphotypes Shed Light on the Cellular Mechanism Ensuring the Robust Formation of Osteocytic Networks Fritz, A; Bertin, A; Hanna, P; Nualart, F; Marcellini, S Article ISI SCOPUS JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION (2016)
Molecular footprinting of skeletal tissues in the catshark Scyliorhinus canicula and the clawed frog Xenopus tropicalis identifies conserved and derived features of vertebrate calcification Enault, S; Muñoz D.N.; Silva W.T.A.F.; Borday-Birraux V.; Bonade M.; Oulion S.; Ventéo S.; Marcellini, S; Debiais-Thibaud, M Article SCOPUS FRONTIERS IN GENETICS (2015)
Cellular and molecular characterization of a novel primary osteoblast culture from the vertebrate model organism Xenopus tropicalis Bertin, Ariana; Hanna, Patricia; Otarola, Gaston; Fritz, Alan; Henriquez, Juan Pablo; Marcellini, Sylvain Article ISI HISTOCHEMISTRY AND CELL BIOLOGY (2014)
A dynamic history of gene duplications and losses characterizes the evolution of the SPARC family in eumetazoans Bertrand, S; Fuentealba, J; Aze A.; Hudson C.; Yasuo, H; Torrejón M.; Escriva, H; Marcellini, S Article ISI SCOPUS Proceedings of the Royal Society B: Biological Sciences (2013)
Evolution of the vertebrate bone matrix: An expression analysis of the network forming collagen paralogues in amphibian osteoblasts Aldea, D; Hanna, P.; Muñoz D; Espinoza J.; Torrejón M.; Sachs, L; Buisine, N; Oulion S.; Escriva, H; Marcellini, S Article ISI SCOPUS Journal of Experimental Zoology Part B: Molecular and Developmental Evolution (2013)
Ric-8A, a guanine nucleotide exchange factor for heterotrimeric G proteins, is critical for cranial neural crest cell migration Fuentealba, J; Toro-Tapia, G; Arriagada C.; Riquelme, L.; Beyer A.; Henriquez, JP; Caprile T.; Mayor, R; Marcellini, S; Hinrichs, MV; Olate, J; Torrejón M. Article ISI SCOPUS Developmental Biology (2013)
SCO-spondin from embryonic cerebrospinal fluid is required for neurogenesis during early brain development Vera A.; Stanic K.; Montecinos, H.; Torrejón M.; Marcellini, S; Caprile T. Article ISI SCOPUS Frontiers in Cellular Neuroscience (2013)
The vitamin C transporter SVCT2 is down-regulated during postnatal development of slow skeletal muscles Sandoval, D; Ojeda J.; Low M; Nualart, F.; Marcellini, S; Osses N.; Henriquez, JP Article ISI SCOPUS HISTOCHEMISTRY AND CELL BIOLOGY (2013)
Evolution of the interaction between Runx2 and VDR, two transcription factors involved in osteoblasto]genesis Marcellini, S; Bruna, C; Henriquez, JP; Albistur, M; Reyes, AE; Barriga, EH; Henriquez, B; Montecino, M. Article ISI SCOPUS BMC EVOLUTIONARY BIOLOGY (2010)
Two families of Xenopus tropicalis skeletal genes display well-conserved expression patterns with mammals in spite of their highly divergent regulatory regions Espinoza J.; Sánchez, M; Sanchez A.; Hanna, P.; Torrejón M.; Buisine, N; Sachs, L; Marcellini, S Article ISI SCOPUS Evolution & Development (2010)
Vitamin D control of gene expression: Temporal and spatial parameters for organization of the regulatory machinery Montecino, M.; Stein, GS; Stein, JL; Lian, JB; van Wijnen, AJ; Carvallo L; Marcellini, S; Cruzat F.; Arriagada, G Article ISI CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION (2008)
An architectural perspective of vitamin D responsiveness Montecino, M.; Stein, GS; Cruzat F.; Marcellini, S; Stein, JL; Lian, JB; van Wijnen, AJ; Arriagada, G Article ISI SCOPUS ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2007)
Divergent functions of two ancient Hydra Brachyury paralogues suggest specific roles for their C-terminal domains in tissue fate induction Bielen, H; Oberleitner, S; Marcellini, S; Gee, L; Lemaire, P; Bode, HR; Rupp, R; Technau, U Article ISI SCOPUS DEVELOPMENT (2007)
Nucleosome organization and targeting of SWI/SNF chromatin-remodeling complexes: contributions of the DNA sequence Montecino, M.; Stein, JL; Stein, GS; Lian, JB; van Wijnen, AJ; Cruzat F.; Gutierrez S. ; Olate, J; Marcellini, S; Gutierrez, JL Article ISI Biochemistry and Cell Biology (2007)
Two or four bristles: Functional evolution of an enhancer of scute in Drosophilidae Marcellini, S; Simpson, P Article ISI SCOPUS PLoS Biology (2006)
When Brachyury meets Smad1: the evolution of bilateral symmetry during gastrulation Marcellini, Sylvain Article WOS BIOESSAYS (2006)
A major bristle QTL from a selected population of Drosophila uncovers the zinc-finger transcription factor Poils-au-dos, a repressor of achaete-scute Gibert, JM; Marcellini, S; David, JR; Schlotterer, C; Simpson, P Article ISI DEVELOPMENTAL BIOLOGY (2005)
achaete, but not scute, is dispensable for the peripheral nervous system of Drosophila Marcellini, Sylvain; Gibert, Jean-Michel; Simpson, Pat Article Developmental Biology (2005)
Evolution of Brachyury proteins: identification of a novel regulatory domain conserved within Bilateria Marcellini, Sylvain; Technau, Ulrich; Smith J.C.; Lemaire, Patrick Article Developmental Biology (2003)


Editorial: Evolution of Organismal Form: From Regulatory Interactions to Developmental Processes and Biological Patterns Marcellini, S; Escriva, H EditorialMaterial ISI SCOPUS FRONTIERS IN GENETICS (2016)


A bioassay based on the exogenous expressio of a highly sensitive AhR isoform for the detection of dioxins and similar compounds Sylvain, Marcellini; Gaston, Otarola Patent Geographical region: CHILE (2016)


A Sox2/Sox9/FosL1 transcriptional code drives developmental and regenerative skull ossification Sylvain, Marcellini; Felipe Aguilera; Salvatore Spicuglia Proyecto (2019)
The evolution of the vertebrate head and the co-option of myogenic enhancers by the osteogenic regulatory network Sylvain, Marcellini; Hector Escriva (CNRS, France) Proyecto (2016)
Transcriptional enhancers invaded by highly repeated sequences: turning “junk DNA” into biologically relevant regulatory information Sylvain, Marcellini; Marcela Torrejon; Laureny Sachs; Nicolas Buisine Proyecto (2015)
NEW ROLES OF RIC-8A: A PLEIOTROPIC REGULATOR OF CELL POLARITY AND MIGRATION DURING NEURAL CREST DEVELOPMENT Marcela Torrejon; Marcellini, Sylvain Proyecto (2014)
A fluorescence-based bioassay for the efficient detection of water ressources contaminated by toxic compunds Gaston, Otarola; Sylvain, Marcellini Proyecto Original title: Bioensayo basado en emisión de fluorescencia para la detección eficiente de aguas contaminadas por compuestos tóxicos (0)
BIOCOP: A fast, sensitive and efficient detection of persistent organic pollutants Sylvain, Marcellini; Gaston, Otarola; Hector, Castillo Proyecto https://www.innbio.cl/2015/11/25/jovenes-investigadores-de-facultad-de-ciencias-biologicas-ganan-premio-concurso-desafio-high-tech/ (0)


Aryl hydrocarbon receptor-based bioassays for dioxin detection: Thinking outside the box Otarola, G; CASTILLO H.; Marcellini, S Review ISI SCOPUS JOURNAL OF APPLIED TOXICOLOGY (2018)
Evolutionary Developmental Biology (Evo-Devo) Research in Latin America Marcellini S.; González F.; Sarrazin A.F.; Pabón-Mora N.; Benítez M.; Piñeyro-Nelson A.; Rezende G.L.; Maldonado E.; Schneider P.N.; Grizante M.B.; Da Fonseca R.N.; Vergara-Silva F.; Suaza-Gaviria V.; Zumajo-Cardona C.; Zattara E.E.; Casasa S.; Suárez-Baron H.; Brown F.D. Review ISI SCOPUS JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION (2017)
Evolutionary origin of endochondral ossification: the transdifferentiation hypothesis Cervantes-Diaz F.; Contreras P.; Marcellini S. Review ISI SCOPUS DEVELOPMENT GENES AND EVOLUTION (2017)
Control of osteogenesis by the canonical Wnt and BMP pathways in vivo Marcellini, Sylvain; Henriquez, Juan Pablo; Bertin, Ariana Review ISI SCOPUS BioEssays (2012)