Man

Marcela Aurora Low Mansilla

Docente Investigador

Universidad San Sebastián

Valdivia, Chile

Líneas de Investigación


Estudio de compuestos naturales que regulan la diferenciación de células madre mesenquimales en el músculo esquelético, lo que impacta directamente en entender como ocurre la fibrosis luego de un daño, enfermedades o cambios que ocurren con la edad.

Educación

  •  Doctorado en Ciencias Biológicas, área Biología Celular y Molecular, UNIVERSIDAD DE CONCEPCION. Chile, 2011
  •  Bioquímico, UNIVERSIDAD DE CONCEPCION. Chile, 2005

Experiencia Académica

  •   Docente Other

    UNIVERSIDAD SAN SEBASTIAN

    Puerto Montt, Chile

    2018 - 2019

  •   Docente Other

    UNIVERSIDAD AUTONOMA DE CHILE

    Temuco, Chile

    2020 - 2020

  •   Docente Investigadora Full Time

    Universidad San Sebastián

    Medicina y Ciencia

    Valdivia, Chile

    2023 - At present

  •   Investigadora Postdoctoral Full Time

    University of British Columbia

    Vancouver, Canada

    2012 - 2018

  •   Investigadora Postdoctoral Full Time

    UNIVERSIDAD DE CHILE

    Santiago, Chile

    2011 - 2012

Experiencia Profesional

  •   Investigador Full Time

    Centro de Genómica nutricional agroacuícola

    Temuco, Chile

    2021 - 2022

Formación de Capital Humano


-Evaluadora de seminario de título para obtener el título de Químico Farmacéutico.“Eficacia de los fármacos biológicos en pacientes con artritis reumatoide refractaria: revisión bibliográfica”. Srta. Dobra Figueroa, Universidad San Sebastián, sede Patagonia. 1 de marzo 2024.

-Evaluadora de seminario de título para obtener el título de Químico Farmacéutico. “Producción de proteína recombinante Gn de hantavirus andes para evaluar la inmunodominancia de anticuerpos”. Srta. Jeniffer Ojeda, Universidad San Sebastián, sede Patagonia. 19 de abril 2024.


Difusión y Transferencia


PARTICIPACIÓN EN CONGRESOS

POSTER
-Low M, Wu A, Groppa E, Yuan J, Rossi F. 2016. Effects of ?-catenin activation in FAPs on skeletal muscle homeostasis. Till & McCulloch Meetings, Stem cell network. Whistler, BC, Canada.
-Low M, Wu A, Groppa E, Yuan J, Rossi F. 2016. Effects of ?-catenin activation in FAPs on skeletal muscle homeostasis. Molecular mechanisms modulating skeletal muscle development and homeostasis in health and disease. Assilomar, CA, USA.
-Low M, Song Z, Rossi F. 2015. Molecular pathways regulating the fibrogenic differentiation of mesenchymal progenitors. Till & McCulloch Meetings, Stem cell network. Toronto, ON, Canada.
-Low M, Song Z, Rossi F. 2015. Mesenchymal stromal cells as a therapeutic target for fibrotic diseases. Gordon research Conferences: Myogenesis. Barga, Tuscany, Italy.
-Low M, Rossi F. 2014. Looking for anti-fibrotic compounds; a drug screening in skeletal muscle mesenchymal stromal cells. Till & McCulloch Meetings, Stem cell network. Ottawa, ON, Canada.
-Low M, Rossi F. 2014. Fibro adipogenic progenitors as a target of anti fibrotic drugs. 12th Annual Meeting International Society for Stem Cell Research. Vancouver, BC, Canada.
-Low M, Rossi F. 2014. Mesenchymal stromal cells as targets for inhibition of fibrosis in skeletal muscle. Keystone symposia: Fibrosis from bench to Bedside. Keystone, Colorado, USA.
-Low M, Lemos D, Fiore D, Rossi F. 2013. Characterization of collagen expression in Fibro/adipogenic progenitors in vivo and in vitro. Till & McCulloch Meetings, Stem cell network. Banff, Alberta, Canada.
-Low M, Reyes-Jara A, Latorre M, Gárate E, González M. 2011. Zinc metabolism in Enterococcus faecalis. Fourth international workshop on iron and copper homeostasis. Pucón, Chile.
-Low M, Nualart F, Henríquez JP. 2010. Vitamin C up-regulates its SVCT2 transporter and promotes myoblasts fusion via a myogenin-independent mechanism. XXIV Reunión anual sociedad de Biología celular de Chile. Puerto Varas, Chile.
-Low M, Sandoval D, Nualart F, Henríquez JP. 2009. The sodium/ascorbate co-transporter SVCT2 is expressed in chick myotube primary cultures from slow and fast origin. XXIII Reunión anual sociedad de Biología celular de Chile. Pucón, Chile.
-Low M, Sandoval D, Avilés E, Nualart F, Henríquez JP. 2008. Oxidative slow-twitch skeletal muscle fibres express the ascorbic acid transporter SVCT2 during chick myogenesis. 33rd FEBS Congress-11th IUBMB Conference on Biochemistry of Cell Regulation. Athens, Greece.
-Low M, Castro T, Montecinos H, Nualart F. 2004. Apical polarization of SVCT1 in intestinal and kidney proximal tubules epithelial cells. XLVII Reunión anual sociedad de Biología celular de Chile. Pucón, Chile.

PRESENTACIONES ORALES

-Low M, Wu A, Rossi F. 2016. Fibro/adipogenic progenitors in skeletal muscle and regeneration. XXX Reunión Anual Sociedad de Biología Celular de Chile, Puerto Varas, Chile.
-Low M, Lemos D, Chang ChK, Paylor B, Rossi F. 2013. Modulation of regeneration versus fibrosis in skeletal muscle fibro/adipogenic progenitors. Stem Cell Network Meeting, Toronto, Ontario, Canada.
-Low M, Morales B, Avilés E, Sandoval D, Nualart F, Henríquez JP. 2007. Sodium vitamin C co-transporter 2 (SVCT2) is expressed in slow-twitch muscle fibres during chick myogenesis. XXI Reunión anual sociedad de Biología celular de Chile. Pucón, Chile.
- Low M, Nualart F, Henríquez JP. 2006. Expression and function of sodium/ascorbate transporter SVCT2 in muscle cells. XX Reunión anual sociedad de Biología celular de Chile. Pucón, Chile.


Premios y Distinciones

  •   Beca Conicyt Doctorado

    UNIVERSIDAD DE CONCEPCION

    Chile, 2005

    Beca para realizar estudios de Doctorado en Ciencias Biológicas

  •   Beca Conicyt Extensión

    UNIVERSIDAD DE CONCEPCION

    Chile, 2009

    Beca para termino de estudios de doctorado

  •   Beca Chile

    UNIVERSITY OF BRITISH COLUMBIA

    Chile, 2011

    Beca para realizar estudios de Postdoctorado en el extranjero

  •   Becas Till and McCulloch

    UNIVERSITY OF BRITISH COLUMBIA

    Canada, 2012

    Beca para asistencia a congreso de Células madre otorgada entre los años 2012-2015


 

Article (12)

Activation of β-catenin in mesenchymal progenitors leads to muscle mass loss
In vitro assessment of anti-fibrotic drug activity does not predict in vivo efficacy in murine models of Duchenne muscular dystrophy
Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential.
Pharmacological blockage of fibro/adipogenic progenitor expansion and suppression of regenerative fibrogenesis is associated with impaired skeletal muscle regeneration
Interplay between copper and zinc homeostasis through the transcriptional regulator Zur in Enterococcus faecalis
Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors.
Dynamic expression of the sodium-vitamin C co-transporters, SVCT1 and SVCT2, during perinatal kidney development
The vitamin C transporter SVCT2 is down-regulated during postnatal development of slow skeletal muscles
Up-regulation of the vitamin C transporter SVCT2 upon differentiation and depolarization of myotubes
The ascorbic acid transporter SVCT2 is expressed in slow-twitch skeletal muscle fibres
Differential distribution of the Sodium-vitamin C cotransporter-1 along the proximal tubule of the mouse and human kidney
Vitamin C uptake and recycling among normal and tumor cells from the central nervous system

Abstract (2)

Oxidative slow-twitch skeletal muscle fibres express the ascorbic acid transporter SVCT2 during chick myogenesis
SVCT1 is expressed in the apical brush border membrane of kidney proximal tubule epithelial cells (segment S3) during post-natal kidney development.

BookSection (3)

Fibro/Adipogenic Progenitors (FAPs): Isolation by FACS and Culture.
Isolation, Culture, and Differentiation of Fibro/Adipogenic Progenitors (FAPs) from Skeletal Muscle
Vitamin C in skeletal muscles: the importance of transport.
17
Marcela Low

Docente Investigador

Facultad de Medicina y Ciencia

Universidad San Sebastián

Valdivia, Chile

6
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

6
JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

4
Daniel Sandoval

Co-investigador

Ciencia Animal

UNIVERSIDAD DE CONCEPCIÓN

Chillán, Chile

4
Katterine Salazar

Associate Professor

Cell Biology

University of Concepcion

Concepción, Chile

3
María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

3
Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

3
Teresa Caprile

Associate profesor

DPTO. BIOLOGIA CELULAR,

UNIVERSIDAD DE CONCEPCIÓN

Concepcion, Chile

3
Allisson Astuya

profesor asociado

Departamento de Oceanografia de la Universidad de Concepción

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

2
Alejandro Yanez

Full professor

Faculty of Science

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Veronica Cambiazo

Profesora titular

Unidad de Nutrición Básica

UNIVERSIDAD DE CHILE - INTA

Santiago, Chile

1
Sylvain Marcellini

Associate Professor

Department of Cell biology

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Viviana Montecinos

Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Romina Bertinat

Technician

Farmacología

Universidad de Concepcion

Concepción, Chile

1
Fernando Martinez

Assistant Professor

Cell Biology

Universidad de Concepción

Concepción, Chile

1
Carlos Figueroa

Head

Anatomy, Histology and Pathology

Universidad Austral de Chile

Valdivia, Chile

1
Mauricio Gonzalez

Profesor Titular

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

1
Viviana Ulloa

Profesional Superior

Dirección de Estudios Estratégicos

Universidad de Concepción

Concepción, Chile

1
Angelica Reyes

Profesor Asociado

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Carola Millan

Profesor

de Ciencias

UNIVERSIDAD ADOLFO IBAÑEZ FACULTAD DE ARTES LIBERALES

Viña del Mar, Chile

1
Jorge Ojeda

Académico investigador

Ciencias Básicas y Morfología

Universidad Católica de la Santisima Concepción

Concepción, Chile

1
Nelson Osses

Associated Professor

Institute of Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile