Biotechnology and Systems Biology of pathogen and biomining microorganism.

- March 2021 - current. Master's thesis director.
Professional title: Master in Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
Memory title: non-coding RNA induced by iron in Enterococcus faecalis.
Student: Sebastián Antonio Gómez Contreras.
Current status: Qualifying exam passed.

- March 2021 - current. Director.
Professional title: Biochemist, Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
Memory title: Characterization of ncRNA related to Copper response in Enterococcus faecalis.
Student: Jorge Torres Robles.
Current status: Qualifying exam passed.

- April 2020 - current. Director.
Professional title: Master in Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
Memory title: Transcriptional regulation of NFATc4 / CREB5, and its relationship with the development of cardiac hypertrophy in an in vitro model.
Student: Juan Francisco Silva Agüero.
Current status: Qualifying exam passed.

- June 2020 - current. Associated.
Professional title: Doctor in Pharmacology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
Memory title: Estradiol in the pathogenesis of pulmonary arterial hypertension (HPA): Role of estrogenic activity and hormonal metabolism on smooth arterial muscle cells.
Student: Emanuel Guajardo Correa.
Current status: Qualifying exam passed.

- April 2020 - current. Director.
Professional title: Master in Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
Memory title: Transcriptional regulation of NFATc4 / CREB5, and its relationship with the development of cardiac hypertrophy in an in vitro model.
Student: Juan Francisco Silva Agüero.
Current status: Qualifying exam passed.

- April 2020 - current. Director.
Professional title: Biochemist, Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
Memory title: Transcriptional regulation of NFATc4 / CREB5, and its relationship with the development of cardiac hypertrophy in an in vitro model.
Student: Juan Francisco Silva Agüero.
Current status: Qualifying exam passed.

- August 2018 - March 2019. Director.
Professional title: Biochemist, Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
Memory title: Iron deficiency and subsequent metal reinforcement produces changes in the structure of the intestinal microbiome of Drosophila melanogaster.
Student: Gabriel Gálvez Jiménez.
Current status: Passed, rating 7.0.

- March 2017 - October 2017. Master's thesis director.
Academic degree: Master in Engineering Sciences, mention in Applied Mathematics, Faculty of Physical Sciences and Mathematics, University of Chile.
Thesis title: Mathematical model of copper homeostasis in bacteria.
Student: Martín Ríos Wilson.
Current status: Pass, score 7.0.

- May 2010 - December 2010. Director.
Professional title: Nutritionist, Faculty of Health Sciences, Universidad de Playa Ancha.
Title of the report: Copper Nutrigenomics: Transcriptional study of genes that encode components of the generation of GSH and analysis of viability against changes in the availability of glucose in human lymphocytes exposed to copper.
Former student: Natalia Quiroz Silva.
Current status: Pass, score 7.0.

- May 2010 - December 2010. Director.
Professional title: Nutritionist, Faculty of Health Sciences, Universidad de Playa Ancha.
Title of the report: Copper Nutrigenomics: Transcriptional study of genes that encode components of the generation of GSH and analysis of viability against changes in the availability of glucose in human lymphocytes exposed to copper.
Former student: Nicole Rivas Meneses.
Current status: Pass, score 7.0.

I. Link to the Community

- September 26, 2020. Radio Program. Current situation of the Pandemic in the O'Higgins region.
Institution: Welcome Radio, University of O'Higgins
Location: Rancagua, Chile.
Attendees: Radio program.
Topic: Laboratory of Bioengineering and detection of COVID19 in the region.
Objective: Share the experience of the Laboratory in the context of the pandemic and explain the current detection methods for the diagnosis of COVID-19.

- August 18, 2020. Press release. La Tercera newspaper.
Institution: Diario La Tercera, University of O'Higgins, Seremi de Salud.
Place: National, Chile.
Assistants: Online.
Report: O'Higgins State University stands out in the detection of Covid-19 at the national level
Objective: To highlight the work carried out by the Bioengineering Laboratory in the framework of the pandemic.

- July 04, 2020. Television note. TVN Regional O'Higgins - 24 hours.
Institution: Regional TVN, University of O'Higgins, Seremi de Salud.
Place: Region of the Liberator Bernardo O'Higgins, Chile.
Attendees: Online and live newscast.
Topic: Bioengineering Laboratory - COVID19 Diagnosis at the University of O'Higgins.
Objective: Present at a regional level the SARS-Cov2 detection capabilities of the Bioengineering Laboratory of the University of O'Higgins.

- April 24, 2020. PAR Explora Norte. Chat.
Institution: PAR Explora Norte.
Location: Santiago, Chile.
Attendees: Digital broadcasting medium (200 participants).
Talk entitled: The importance of metals in Chile.
Objective: Disseminate basic and application knowledge on concepts of iron nutrition and copper mining processes in Chile.

- March 2020. Television program. TVN Explorers Capsule.
Institution: National Television of Chile, University of O'Higgins, Center for Mathematical Modeling.
Location: Rancagua, Chile.
Attendees: Open television, cable and web platforms.
Topic: Work in Biomining Center for Mathematical Modeling (CMM) and FIC Project.
Objective: Disseminate the work carried out in Tailings in collaboration with the CMM, the University of O'Higgins, Minera Valle Central and the Regional Government.

- May 2-4, 2019. Mining Table. Member of the central discussion table.
Institution: Rancagua International Fair 2019 (FIRAN2019) and CODELCO.
Location: Rancagua, Chile.
Attendees: 300 people.
Topic: Mining and the participation of the University.
Objective: Disseminate the work in Mining and Biotechnology that is being carried out at the University of O'Higgins.

- December 13-14, 2018. Talk. International Symposium on Integrative Bioinformatics SIBI 2018.
Institution: FONDAP Center for Advanced Studies of Chronic Diseases (ACCDIS) and University of Chile.
Location: Santiago, Chile.
Attendees: 60 people.
Talk entitled: Genome scale networks in Enterococcus faecalis.
Objective: Disseminate my work and current line of research developed at the University of O’Higgins University.

- October 26, 2018. Talk. Cycle of Seminars in Bioinformatics and Computational Biology.
Institution: FONDAP Center for Advanced Studies of Chronic Diseases (ACCDIS)
Place: Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile.
Attendees: 50 people.
Talk titled: Systems Biology in Bacteria.
Objective: Disseminate my work and current line of research developed at the University of O’Higgins University.

- September 2018 - Current. Scientific Advisor Explora
Institution: Bernardo O'Higgins Mining Technological Institute.
Location: Rancagua, 6th region, Chile.
Project title: Copper bioaccumulation in Chlorophytum comosum.
Responsible Professor: Darko Soto.
Objective: Scientific advice to the group of 4 students led by Professor Soto for the development of his research project. The project was presented in the Science week organized by the University of O'Higgins and later selected among the best regional works to be presented at the national level by Explora.

- August 30, 2017. Talk PAR Explora O'Higgins. Rapporteur.
Institution: Liceo Eduardo Charme.
Location: San Fernando, 6th region, Chile.
Attendees: Middle IV students (200 participants).
Talk entitled: The importance of metals in Chile.
Objective: Disseminate basic and application knowledge on concepts of iron nutrition and copper mining processes in Chile.
Current status: The chat is part of the Explore database.

II. International meetings

- Gálvez, G., Latorre, M. Déficit y posterior reforzamiento de hierro afectan la homeostasis de cobre y zinc en Drosophila melanogaster. First International Symposium of Food, Nutrition, Physical Fitness and Health. Santiago, Chile. 29 Marzo 2019.

- Gálvez, G., Latorre, M. Déficit y posterior reforzamiento de hierro afectan la homeostasis de cobre y zinc en Drosophila melanogaster. First International Symposium of Food, Nutrition, Physical Fitness and Health. Santiago, Chile. 29 Marzo 2019.

- Latorre, M., Quenti, D., Singh, K.V., Murray, B.E., Maass, A., Cambiazo, V. The role of Fur in the transcriptional and iron homeostatic response of Enterococcus faecalis. ALAM2018. Santiago, Chile. 13-16 Noviembre 2018.

- Budinich, M., Latorre, M., Mendoza, S., Cortés, M.P., Eveillard, D., Siegel, A., Maass, A. Multi objective metabolic modeling for optimal growth of Acidithiobacillus ferrooxidans Wenelen and Sulfobacillus thermosulfidooxidans Cutipay. ALAM2018. Santiago, Chile. 13-16 Noviembre 2018.

- Ríos, M., Maass, A., Latorre, M. Mathematical modeling of metal homeostasis interplay between copper and iron. ALAM2018. Santiago, Chile. 13-16 Noviembre 2018.

- Aite, M., Belcour, A., Markov, G., Dittami, D., Latorre, M. Siegel, A. Tool for genome comparison at metabolic scale. ALAM2018. Santiago, Chile. 13-16 Noviembre 2018.

- Frioux, C., Fremy. E., Trottier, C., Latorre, M., Siegel, A. Scalable and exhaustive screening of metabolic functions carried out by microbial consortia. ALAM2018. Santiago, Chile. 13-16 Noviembre 2018.

- Latorre, M. Transcriptional and metabolic regulatory network in Enterococcus faecalis. II Workshop on Systems Biology Chile-France. Valparaíso, Chile. 7-9 Noviembre 2018.

- Panesso, D., Latorre, M., Rincon, S., Miller, W., Diaz, L., Reyes, J., Rios, R., Ardila, J., Carvajal, L.P., Arias, C.A. The LiaR regulon of Daptomycin-resistant Enterococcus faecium. IDSA 2017. San Diego, Estados Unidos. 4-8 Octubre 2017.

- Latorre, M. A System Biology approach to identify putative new targets involved in antibiotic resistance in Enterococcus faecalis. Molecular Basis of Infectious Diseases (MBID) Retreat. Houston, Estados Unidos. 31 Marzo 2017.

- Rojas, C., Mandakovic, D., Maldonado, J., Latorre, M., Cabrera, P., Cambiazo, V., González, M. Structure and interaction patterns of soil microbial communities along an altitudinal pH gradient in the Atacama Desert. ISME. Montreal, Canada. 21-25 Agosto 2016.

- Rincon, S., Panesso, D., Latorre, M., Appel, T., Reyes, J., Tran, T.T., Arias, C.A. Transcriptional Analysis of the liaFSR cluster in Daptomycin resistant Enterococcus faecalis. ASM Microbe 2016-ICAAC 2016. Boston, Estados Unidos. 16 - 20 Junio 2016.

- Diaz, L., Reyes, J., Narechania, A., Rios, R., Munita, J.M., Tran, T.T., Panesso, D., Deikus, G., Sebra, C., Planet, P.J., Bhardwaj, P., Ryan, C., Latorre, M., Palmer, K., Arias, C.A. Genome-Wide Transcriptional Analysis of LiaFSR-mediated Daptomycin Resistance (DAP-R) in Enterococcus faecalis (Efs). ICC2015. Londres, Inglaterra. 8-12 Junio 2015.

- Latorre, M., Cortés, M.P, Travisany, D., Budinich, M., Aravena, A., Parada, P., González, M., Maass, A. Global transcriptional responses of Acidithiobacillus ferrooxidans Wenelen under different sulfide minerals. IBS2015. Bali, Indonesia. 5 - 9 Octubre 2015.

- Latorre, M., González, M., Maass, A. Identification of common and specific cellular processes transcriptionally activated during copper treatments in four biological models. IBS2015. Bali, Indonesia. 5 - 9 Octubre 2015.

- Travisany, D., Cortés, M.P., Latorre, M., Di Genova, A., Budinich, M., Parada, P., González, M., Maass, A. Three genomes of Acidithiobacillus thiooxidans provide insights into adaptation and evolution. IBS2013. 7 - 11. Antofagasta, Chile. Octubre 2013.

- Latorre, M., González, M., Maass, A. Identification of common and specific cellular processes transcriptionally activated during copper treatments in four biological models. 9th International Copper Meeting. Vico Equense, Chile. 5 - 10 Octubre 2014.

- Latorre, M., Arias, C.A., González, M., Maass, A. A System Biology approach to identify putative new targets involved in antibiotic resistance in Enterococcus faecalis. 4th ASM Conference on Enterococci. Cartagena, Colombia. 5-7 Marzo 2014.

- Latorre, M., Budinich, M.., Maturana, D., Maass, A., González, M. Conserved transcriptional regulatory networks in Lactobacillales order species. Plant & Animal Genome XX (PAGXX). San Diego, Estados Unidos. 14-18 Enero 2012.

- Latorre, M., Galloway-Peña, J., Rho, J., Murray, B.E., Maass, A., González, M. Conserved transcriptional regulatory mechanism involved in copper and iron homeostasis in Lactobacillales order species. Fourth International Workshop on Iron and Copper. Pucón, Chile. 30 Noviembre – 3 Diciembre 2011.

- Latorre, M., Rho, J.H., Murray, B.E., Maass, A., González, M. Identification and verification of transcriptional networks involved in iron homeostasis and oxidative stress damage activated by copper in Enterococcus faecalis. TEMA-14: Trace Elements in Man and Animals. Enshi, China. 19 - 24 Septiembre 2011.

- González, M., Latorre, M., Maass, A., Transcriptional regulatory network activated by copper and iron in Enterococcus faecalis. International Workshop on Genomics of Health and Diseases. Natal, Brasil. 12-15 Marzo 2011.

- Latorre, M., Moreno, P., Aravena, A., Cambiazo, V., Maass, A., González, M. In-silico identification and characterization of efflux heavy metals resistance proteins in Acidithiobacillus ferroxidans. Tema 13-Trace Elements in Man and Animals. Pucón, Chile. 9 - 13 Noviembre 2008.

- Zúñiga, A., Latorre, M., Hanna, P., Cambiazo, V. Molecular and functional characterization of RhoGEF3, a regulator of RhoGTPases in Drosophila melanogaster embryos. 4th International Meeting of the Latin American Society of Developmental Biology. Buenos Aires, Argentina. 23-25 Octubre 2006.

- Reyes, A., Latorre, M., Bourgogne, A., Murray, B., González, M. Functional Analysis of a cop-like operon from Enterococcus faecalis. 5th International Copper Meeting: Copper and Related Metals in Biology, Alghero, Italia. 14 - 18 Octubre 2006.

III. International collaborations

- Université de Picardie Jules Verne (Amien, France): Laboratory directed by Dr. Irina Korichneva (MILEAGE project Nº734931).

- CNRS-IRISA-INRIA (Rennes, France): Dyliss Group led by Dr. Anne Siegel (3 articles published together, 2 projects).

- University of Nantes (Nantes, France): Computational Biology Group of Dr. Damien Eveillard (2 articles published together, 2 projects).

- The University of Texas (Houston, USA): Group of "Infectious Diseases" led by Dr. Barbara E. Murray and Dr. Danielle Garsin (6 articles published during the project, 3 projects).

- MD Anderson (Houston, USA): Dra. Sruti DebRoy Group (2 articles published together).

- The University of Alaska Anchorage (Alaska, USA): Dr. Jason Burkhead Group (3 articles published together, 2 projects).

- Federal University of Santa Catarina (Florianópolis, Brazil). Laboratory directed by Dr. Alexandra Latini (COVID19 project N ° COVID0620).

IV. Scientific Societies.

- Active member. Chilean Cell Biology Society (SBCCH), Chile. March 2017-current.

- Founding Partner. Chilean Society of Bioinformatics (SCB), Chile. October 2020 - current.

V. International Journal Reviewer

- Journal: Metallomics (ISI / Wos).
Function: Reviewer of scientific articles.
Year: 2017 - current.

- Journal:: Biological Research (ISI / Wos).
Function: Reviewer of scientific articles.
Year: 2016 - current.

- Journal: Frontiers in Microbiology (ISI / Wos).
Function: Reviewer of scientific articles.
Year: 2018 - current.

- Journal: Plos One (ISI / Wos).
Function: Reviewer of scientific articles.
Year: 2017 - current.

- Journal: Journal of Applied Microbiology (ISI / Wos).
Function: Reviewer of scientific articles.
Year: 2018 - current.

VI. International meeting organizer

- Event: III International Symposium on Integrative Bioinformatics SIBI 2019.
Location: Pucón, Chile.
Dates: December 11-13, 2019
Organizers: Universidad de Chile, Universidad de O'Higgins, Regional Government, Universidad Mayor, Universidad de la Frontera, BIOINFO, METROPOLE Digital, CAPES, ACCDiS, Biome.
Attendees: 100 attendees, 15 Universities.
Character: International
Role played: Event organizer. Financing of the FIC2018 project and the University of O'Higgins.
Others: https://es.bioinformaticaintegrativa.cl/

- Event: II Workshop on Systems Biology Chile-France.
Location: Valparaíso, Chile.
Dates: 7-9 November 2018
Organizers: University of O'Higgins, Center for Mathematical Modeling, CNRS-Inria.
Attendees: 30 assistant, 7 Universities.
Character: International
Role played: Event organizer. Financing project PCI 2017-REDESI170193.
Others: http://eventos.cmm.uchile.cl/sysbio2018/

- Event: CRG: 1st Doctoral and Post Doctoral meeting.
Location: Santiago, Chile.
Dates: 7-9 November 2018
Organizers: Universidad de Chile, Pontificia Universidad Católica de Chile, Universidad Andrés Bello.
Attendees: 50 attendees, 5 Universities.
National character.
Role played: Event organizer. Financing Fondap project No. 15090007.