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José Leonardo Gutiérrez Contreras

Profesor Asociado

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Transcriptional Regulation; Chromatin Remodeling; Chromatin Dynamics.

Biología Celular y Molecular, UNIVERSIDAD DE CONCEPCION. Chile, 2003
Bioquímico, UNIVERSIDAD DE CONCEPCION. Chile, 1997

Profesor Asociado Full Time

UNIVERSIDAD DE CONCEPCION

Ciencias Biológicas

Concepción, Chile

2007 - At present

Postdoc Full Time

Stowers Institute for Medical Research

Kansas City, Estados Unidos

2003 - 2007

Theses directions (only finalized theses):

Direction of Doctoral Theses:

Matías Hepp (2013). Caracterización de la función de las proteínas HMGB sobre la actividad de los complejos remodeladores de cromatina dependientes de ATP, Doctorado en Ciencias Biológicas, área Biología Celular y Molecular, Universidad de Concepción.

Alejandro Maureira (2016). Función de los Factores de Transcripción CREB y C/EBP? en la Actividad Transcripcional del Promotor de RIC-8B humano, Doctorado en Ciencias Biológicas, área Biología Celular y Molecular, Universidad de Concepción.

Direction of Master Theses:

Ximena Steinberg Acuña (2010). Análisis de Interacciones de las isoformas de hC/EBP? con Complejos Remodeladores de Cromatina ATP-Dependientes y Otras Proteínas Nucleares. Magíster en Bioquímica y Bioinformática, Universidad de Concepción.

Yaiza Fernández García (2011). Influencia de Factores de Transcripción Sobre la Actividad “In Vitro” de los Complejos SWI/SNF de Mamíferos. Magíster en Bioquímica y Bioinformática, Universidad de Concepción.

Valentina Alarcón (2013). Influencia de Factores de Transcripción y de Secuencias de ADN Sobre la Remodelación de Cromatina Dependiente de ATP. Magíster en Bioquímica y Bioinformática, Universidad de Concepción.

Nicole Valenzuela (2014). Función de C/EBP? en la regulación transcripcional del gen de albúmina humano. Magíster en Bioquímica y Bioinformática, Universidad de Concepción.

María Francisca Beltrán (2016). Regulación Transcripcional del Gen Dhn2 en Eucalyptus Nitens en Respuesta a la Aclimatación al Frío. Magíster en Bioquímica y Bioinformática, Universidad de Concepción (co-guía).

Cristián Gidi (2016). Efecto de variaciones de distancia entre elementos regulatorios en el ADN sobre la dinámica de remodelación nucleosomal. Magíster en Bioquímica y Bioinformática, Universidad de Concepción.

Roberto Amigo (2017). Interacción diferencial de las isoformas de hC/EBP? con proteínas HMG. Magíster en Bioquímica y Bioinformática, Universidad de Concepción.

Direction of undergraduate theses:

Nicole Valenzuela. Bioingeniería (Universidad de Concepción). Finalizada año 2012.

Verónica Del Rio. Bioquímica (Universidad de Concepción). Finalizada año 2012.

Valentina Alarcón. Bioquímica (Universidad de Concepción). Finalizada año 2013.

Roberto Amigo. Bioingeniería (Universidad de Concepción). Finalizada año 2016.

Participation inInternational Congresses and/or Symposia (last five years):

FEBS-EMBO 2014 Conference (August 30-September 4, 2014, Paris, France). “The yeast HMG proteins Hmo1 and Nhp6 exert a differential stimulatory effect on ATP-dependent nucleosome remodeling activity” (poster).

Symposium of the 2014 “Chromatin Summer School” (December 1st, 2014, Universidad Austral, Valdivia, Chile). “Differential stimulatory effect of HMG proteins on ATP-dependent chromatin remodeling activity” (oral presentation speaker).

Tree Biotechnology 2015 Conference, IUFRO (June 8-12, 2015, Florence, Italy). Hsfa2 transcription factor responds to Cold Acclimatation and Might be related to dehydrin gene in Eucalytus nitens” (poster).

Cold Spring Harbor Laboratory Meeting “Mechanisms of Eukaryotic Transcription” (August 25-29, 2015, Cold Spring Harbor, New York, USA). “SWI/SNF activity on several target genes is affected by the yeast HMG proteins Nhp6A/B and Hmo1” (poster).

International Workshop "Control Epigenético: Mecanismos y Aplicaciones" (July 19-20, 2017, Santiago, Chile). "Influencia de proteínas HMG sobre la actividad remodeladora de nucleosomas del complejo SWI/SNF y sobre su acción en regiones promotoras de genes" (oral presentation speaker).

Workshop for the 25th anniversary of the Workman laboratory: "The Nucleosome: from factor binding and remodeling to cell signaling and disease" (September 22-23, 2017, Kansas City, Missouri, USA). "Influence of the HMG proteins Nhp6 and Hmo1 on SWI/SNF activity" (oral presentation speaker).

Hermann Niemeyer medal

Sociedad de Bioquímica y Biología Molecular de Chile

Chile, 2001

Award given every year to the best student of PhD programs in the field of biochemistry and molecular biology


General regulatory factors exert differential effects on nucleosome sliding activity of the ISW1a complex Oyarzun-Cisterna, Andrea; Gidi, Cristian; Raiqueo, Fernanda; Amigo, Roberto; Rivas, Camila; Torrejon, Marcela; Gutierrez, Jose L. Article ISI BIOLOGICAL RESEARCH (2024)
NUAK1 coordinates growth factor-dependent activation of mTORC2 and Akt signaling Palma, Mario; Riffo, Elizabeth; Farias, Alejandro; Coliboro-Dannich, Viviana; Espinoza-Francine, Luis; Escalona, Emilia; Amigo, Roberto; Gutierrez, Jose L.; Pincheira, Roxana; Castro, Ariel F. Article ISI CELL AND BIOSCIENCE (2023)
Poly(dA:dT) Tracts Differentially Modulate Nucleosome Remodeling Activity of RSC and ISW1a Complexes, Exerting Tract Orientation-Dependent and -Independent Effects Amigo, Roberto; Raiqueo, Fernanda; Tarifeno, Estefania; Farkas, Carlos; Gutierrez, Jose L. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
Global Methylation Analysis Using MSAP Reveals Differences in Chilling-Associated DNA Methylation Changes during Dormancy Release in Contrasting Sweet Cherry Varieties Narvaez, Gabriela; Munoz-Espinoza, Claudia; Soto, Esteban; Rothkegel, Karin; Bastias, Macarena; Gutierrez, Jose; Bravo, Soraya; Hasbun, Rodrigo; Meneses, Claudio; Miyasaka Almeida, Andrea Article ISI HORTICULTURAE (2022)
The linker histone Hho1 modulates the activity of ATP-dependent chromatin remodeling complexes Amigo, Roberto; Farkas, Carlos; Gidi, Cristian; Hepp, Matias, I; Cartes, Natalia; Tarifeno, Estefania; Workman, Jerry L.; Gutierrez, Jose L. Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2022)
The histone variant H3.3 regulates the transcription of the hepatitis B virus Alvarez-Astudillo, Francisca; Garrido, Daniel; Varas-Godoy, Manuel; Leonardo Gutierrez, Jose; Villanueva, Rodrigo A.; Loyola, Alejandra Article ISI ANNALS OF HEPATOLOGY (2021)
Two Distinct Faces of Vitamin C: AA vs. DHA Ferrada, Luciano; Magdalena, Rocio; Barahona, Maria Jose; Ramirez, Eder; Sanzana, Cristian; Gutierrez, Jose; Nualart, Francisco Article ISI ANTIOXIDANTS (2021)
A Trichostatin A (TSA)/Spl-mediated mechanism for the regulation of SALL2 tumor suppressor in Jurkat T cells Hepp, Matias I.; Escobar, David; Farkas, Carlos; Hermosilla, Viviana E.; Alvarez, Claudia; Amigo, Roberto; Gutierrez, Jose L.; Castro, Ariel F.; Pincheira, Roxana; Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2018)
Role of Nhp6 and Hmo1 in SWI/SNF occupancy and nucleosome landscape at gene regulatory regions Hepp, Matías; Smolle, Michaela; Gidi, Cristian; Amigo, Roberto; Valenzuela, Nicole; Arriagada, Axel; Maureira, Alejandro; Gogol, Madelaine; Torrejón, Marcela; Workman, Jerry; Gutiérrez, José Article Biochimica et Biophysica Acta-Gene Regulatory Mechanisms (2017)
The CREB Transcription Factor Controls Transcriptional Activity of the Human RIC8B Gene Maureira A.; Sanchez R.; Valenzuela, N; Torrejón M.; Hinrichs M.V.; Olate, J; Gutiérrez J.L. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2016)
New Face for Chromatin-Related Mesenchymal Modulator: n-CHD9 Localizes to Nucleoli and Interacts With Ribosomal Genes Salomon-Kent, R; Marom, R; John, S; Dundr, M; Schiltz, LR; Gutierrez J.; Workman, J; Benayahu, D; Hager, GL Article ISI JOURNAL OF CELLULAR PHYSIOLOGY (2015)
Sall2 is required for proapoptotic Noxa expression and genotoxic stress-induced apoptosis by doxorubicin Escobar D, Hepp MI, Farkas C, Campos T, Sodir NM, Morales M, Álvarez CI, Swigart L, Evan GI, Gutiérrez JL, Nishinakamura R, Castro AF, Pincheira R. Article Cell Death & Disease (2015)
Nucleosome remodeling by the SWI/SNF complex is enhanced by yeast High Mobility Group Box (HMGB) proteins Hepp, M.I., Alarcon, V., Dutta, A., Workman, J.L., and Gutiérrez, J.L. Article Biochimica et Biophysica Acta-Gene Regulatory Mechanisms (2014)
Wild type p53 transcriptionally represses the SALL2 transcription factor under genotoxic stress Farkas, C.; Martins, C.P.; Escobar, D.; Hepp, M.I.; Donner, D.B.; Castro, A.F.; Evan, G.; Gutiérrez, J.L.; Warren, R.; Pincheira, R. Article PLoS One (2013)
Human CCAAT/Enhancer-Binding Protein beta Interacts with Chromatin Remodeling Complexes of the Imitation Switch Subfamily Steinberg X.P.; Hepp, M., I; Fernandez Garcia Y.; Suganuma T.; Swanson S.K.; Washburn M.; Workman J.L.; Gutiérrez J.L. Article ISI SCOPUS Biochemistry (2012)
ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding Suganuma T.; Gutierrez, JL; Li, B; Florens L.; Swanson, SK; Washburn, MP; Abmayr, SM; Workman, JL Article NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
Activation domains drive nucleosome eviction by SWI/SNF Gutiérrez, J., Chandy, M., Carrozza, M., and Workman, J. Article The EMBO Journal (2007)
Chromatin remodeling by SWI/SNF results in nucleosome mobilization to preferential positions in the rat osteocalcin gene promoter Gutierrez J.; Paredes, R.; Cruzat F.; Hill, DA; van Wijnen, AJ; Lian, JB; Stein, GS; Stein, JL; Imbalzano, AN; Montecino, M. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Nucleosome organization and targeting of SWI/SNF chromatin-remodeling complexes: contributions of the DNA sequence Montecino, M; Stein, JL; Stein, GS; Lian, JB; van Wijnen, AJ; Cruzat, F; GUTIERREZ, S; Olate, J; Marcellini, S; Gutierrez, JL Article BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE (2007)
SWI/SNF displaces SAGA acetylated nucleosomes Chandy, M., Gutiérrez, J., Prochasson, P., and Workman, J. Article Eukaryotic Cell (2006)
A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex Jin, J., Cai, Y., Yao, T., Gottschalk, A., Florens, L.,Swanson, S., Gutiérrez, J., Coleman, M., Workman, J., Mushegian, A., Washburn, M., Conaway, R., and Conaway, J. Article Journal of Biological Chemistry (2005)
Chromatin dynamics rule the genome Pattenden, S., Chandy, M., Gutiérrez, J., and Workman, J. Article Genome Biology (2005)
Preferential occupancy of histone variant H2AZ at inactive promoters influences local histone modifications and chromatin remodeling Li, B., Pattenden, S., Lee, D., Gutiérrez, J., Chen, J., Seidel, C., Gerton, J., and Workman, J. Article Proceedings of the National Academy of Sciences (2005)
Interaction of the 1 alpha,25-dihydroxyvitamin D3 receptor at the distal promoter region of the bone-specific osteocalcin gene requires nucleosomal remodelling Paredes, R.; Gutierrez J.; Gutierrez S. ; Allison, L; Puchi, M; Imschenetzky M.; van Wijnen A.; Lian J.; Stein G.; Stein, J; Montecino, M. Article ISI SCOPUS BIOCHEMICAL JOURNAL (2002)
Reduced CpG methylation is associated with transcriptional activation of the bone-specific rat osteocalcin gene in osteoblasts Villagra, A; Gutierrez J.; Paredes, R.; Sierra, J; Puchi, M; Imschenetzky M.; van Wijnen A.; Lian J.; Stein G.; Stein, J; Montecino, M. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2002)
Cytoplasm of sea urchin unfertilized eggs contains a nucleosome remodeling activity Medina R.; Gutierrez J.; Puchi, M; Imschenetzky M.; Montecino, M. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2001)
Interaction of CBF alpha/AML/PEBP2 alpha transcription factors with nucleosomes containing promoter sequences requires flexibility in the translational positioning of the histone octamer and exposure of the CBF alpha site Gutierrez J.; Sierra, J; Medina R.; Puchi, M; Imschenetzky M.; van Wijnen A.; Lian J.; Stein G.; Stein, J; Montecino, M. Article ISI SCOPUS BIOCHEMISTRY (2000)


Role of DNA sequences in active processes determining nucleosome positioning at gene regulatory regions Gutierrez, Jose Leonardo Proyecto (2018)
REGULATION AND FUNCTION OF THE SALL2 TRANSCRIPTION FACTOR DURING CELLULAR STRESS FONDECYT (1151031) Proyecto 2015-2019 Coinvestigador(a)
INFLUENCE OF HMG PROTEINS ON THE CATALYTIC ACTIVITY OF THE SWI/SNF CHROMATIN REMODELING COMPLEX AND ON CHROMATIN DYNAMICS OF GENE REGULATORY REGIONS. FONDECYT (1130818) Proyecto 2013-2016 Inv. Responsable
MECANISMOS DE ACCION CATALITICA DE COMPLEJOS REMODELADORES DE CROMATINA ATP-DEPENDIENTES. INFLUENCIA DE FACTORES DE TRANSCRIPCION SOBRE REMODELACION DE CROMATINA Y SU RELACION CON EXPRESION GENICA. FONDECYT (1085092) Proyecto 2008-2011 Inv. Responsable
ROL DE FACTORES INDUCTORES DE TRANSCRIPCION BASAL EN LA REORGANIZACION NUCLEOSOMAL DE LA REGION PROMOTORA PROXIMAL EN EL GEN OSTEOCALCINA FONDECYT (2990066) Proyecto 1999-2002 Inv. Responsable