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Fernando Javier Sepúlveda Briceño

Representante Legal

NeuroLabs

Talcahuano, Chile

Endocannabinoids system involvement in the communication tanycyte-neuron to regulate food intake Role of amyloid aggregates during brain aging

Bioquimico, UNIVERSIDAD DE CONCEPCION. Chile, 2007
Biologia Celular y Molecular, UNIVERSIDAD DE CONCEPCION. Chile, 2014

Profesor asistente Part Time

UNIVERSIDAD ANDRES BELLO

Chile

2012 - At present
Profesor Asistente Full Time

UNIVERSIDAD DE CONCEPCION

Ciencias Biologicas

Concepcion, Chile

2017 - At present

Academico Part Time

Universidad Andres Bello

Chile

2012 - At present
Representante Legal

Servicios Agroquimicos Neurolab LTDA

Chile

2013 - At present

FORMACIO?N DE ESTUDIANTES DE PREGRADO Y POSTGRADO
2017 - 2018 Tutor. Macarena Konar Nie. Development of thesis to get a degree in Bioengineer. University of Concepcion. Role of endocannabinoid system signaling in the glia-neuron communication and its effects on eating behavior
2016 - 2017 Co-Tutor. Alejandra Palma. Development of thesis to obtain the degree of Master in Biochemistry and Bioinformatics. University of Concepcion. Study of the role of the receptor of Ghrelin and CB1 in the hypothalamic arcuate nucleus and its relation with the food intake
2016 - 2017 Co-Tutor. Rodrigo Matamala. Development of thesis to get a degree in Biochemistry. University of Concepcion. Expression of components of the endocannabinoid system under conditions of hypoglycemia and hyperglycemia.

Presentador oficial en Charla TEDx

UNIVERSIDAD DEL DESARROLLO

Chile, 2015

Selected as main presenter TEDx Talk. “El valor de pensar”. Universidad del Desarrollo, Concepcio?n. Chile
Medalla Hermann Niemeyer

SOCIEDAD DE BIOQUIMICA DE CHILE

Chile, 2014

Reconocimiento al mejor alumno de doctorado 2014 en Chile. Sociedad de Bioqui?mica y Biologi?a Molecular de Chile
Premio Fermelo

SOCIEDAD DE BIOQUIMICA DE CHILE

Chile, 2010

Fermelo Prize to the Best presentation of incorporation to Society of Biochemistry and Molecular Biology of Chile. XXXIII Reunio?n anual de la SBBMCh, Chillan, Chile
Mejor Tesis en Biologia Celular

Sociedad de Biología Celular

Chile, 2008

Best Cellular Biology Thesis Award in Chile. Reconocimiento a la mejor tesis de pregrado en Chile, Fundacio?n para la Biologi?a Celular y la Sociedad de Biologi?a Celular de Chile.
Premio Colegio Qui?mico Farmace?utico y Bioqui?mico

COLEGIO DE QUIMICO FARMACEUTICO DE CHILE A.G.

Chile, 2007

Prize of Colegio Qui?mico Farmace?utico y Bioqui?mico de Chile 2007. Recognition to the best exam in Biochemistry in the 2007. Concepcio?n, Chile.

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Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior Uranga, Romina María; Barahona, María José Article ISI SCOPUS Scientific Reports (2017)
NMDA receptor modulates Aβ association and membrane perforation Sepulveda FJ; Peters C; Fernandez-Perez EJ, Article J Alzheimers Dis (2016)
Copper-uptake is critical for the down regulation of synapsin and dynamin induced by neocuproine: modulation of synaptic activity in hippocampal neurons Castro PA; Ramirez A.; Sepulveda, FJ; Peters, C; Fierro H; Waldron, J; Luza, S; Fuentealba, J; De Ferrari, GV; Bush, AI; et al. Article ISI SCOPUS FRONTIERS IN AGING NEUROSCIENCE (2014)
Copper-uptake is critical for the down regulation of synapsin and dynamin induced by neocuproine: modulation of synaptic activity in hippocampal neurons. Castro, Patricio A; Ramirez, Alejandra; Sepúlveda, Fernando J; Peters, Christian; Fierro, Humberto; Waldron, Javier; Luza, Sandra; Fuentealba, Jorge; Muñoz, Francisco J; De Ferrari, Giancarlo V; Bush, Ashley I; Aguayo, Luis G; Opazo, Carlos M Article Frontiers in aging neuroscience (2014)
Nature of the neurotoxic membrane actions of amyloid-beta on hippocampal neurons in Alzheimer's disease Sepulveda, FJ; Fierro H; Fernandez, E.; Castillo, C.; Peoples, RW; Opazo C.; Aguayo, LG Article ISI NEUROBIOLOGY OF AGING (2014)
Ibuprofen Inhibits the Synaptic Failure Induced by the Amyloid-beta Peptide in Hippocampal Neurons Zurita, MP; Muñoz G.; Sepulveda, FJ; Gómez, P; Castillo, C.; Burgos, CF; Fuentealba, J; Opazo C.; Aguayo, LG Article ISI SCOPUS Journal of Alzheimer's Disease (2013)
Ibuprofen inhibits the synaptic failure induced by the amyloid-Î² peptide in hippocampal neurons. Zurita, Maria Paz; Muñoz, Gonzalo; Sepúlveda, Fernando J; Gómez, Paulina; Castillo, Carolina; Burgos, Carlos F; Fuentealba, Jorge; Opazo, Carlos; Aguayo, Luis G Article Journal of Alzheimer's disease : JAD (2013)
A beta Oligomers Induce Glutamate Release from Hippocampal Neurons Brito-Moreira, J.; Paula-Lima, AC; Bomfim, TR; Oliveira, FF; Sepulveda, FJ; de Mello, FG; Aguayo, LG; Panizzutti R. Article ISI CURRENT ALZHEIMER RESEARCH (2011)
AÎ² oligomers induce glutamate release from hippocampal neurons. Brito-Moreira, J; Paula-Lima, A C; Bomfim, T R; Oliveira, F B; Sepúlveda, F J; De Mello, F G; Aguayo, L G; Panizzutti, R; Ferreira, S T Article Current Alzheimer research (2011)
Biphasic effects of copper on neurotransmission in rat hippocampal neurons Peters, C; Muñoz B.; Sepulveda, FJ; Urrutia, J; Quiroz M.; Luza, S; De Ferrari, GV; Aguayo, LG; Opazo C. Article ISI SCOPUS Journal of Neurochemistry (2011)
Biphasic effects of copper on neurotransmission in rat hippocampal neurons. Peters, Christian; Muñoz, Braulio; Sepúlveda, Fernando J; Urrutia, Juan; Quiroz, Mauricio; Luza, Sandra; De Ferrari, Giancarlo V; Aguayo, Luis G; Opazo, Carlos Article Journal of neurochemistry (2011)
Soluble A beta(1-40) Peptide Increases Excitatory Neurotransmission and Induces Epileptiform Activity in Hippocampal Neurons Cuevas ME; Haensgen, H; Sepulveda, FJ; Zegers G.; Roa, J; Opazo C.; Aguayo, LG Article ISI SCOPUS Journal of Alzheimer's Disease (2011)
Soluble AÎ²(1-40) peptide increases excitatory neurotransmission and induces epileptiform activity in hippocampal neurons. Cuevas, Magdalena E; Haensgen, Henny; Sepúlveda, Fernando J; Zegers, Gabriela; Roa, Jorge; Opazo, Carlos; Aguayo, Luis G Article Journal of Alzheimer's disease : JAD (2011)
beta-Amyloid Causes Depletion of Synaptic Vesicles Leading to Neurotransmission Failure Parodi, J; Sepulveda, FJ; Roa, J; Opazo C.; Inestrosa, NC; Aguayo, LG Article ISI SCOPUS Journal of Biological Chemistry (2010)
Beta-amyloid causes depletion of synaptic vesicles leading to neurotransmission failure. Parodi, Jorge; Sepúlveda, Fernando J; Roa, Jorge; Opazo, Carlos; Inestrosa, Nibaldo C; Aguayo, Luis G Article The Journal of biological chemistry (2010)
Canonical Wnt3a Modulates Intracellular Calcium and Enhances Excitatory Neurotransmission in Hippocampal Neurons Avila, ME; Sepulveda, FJ; Burgos, CF; Moraga-Cid, G; Parodi, J; Moon RT.; Aguayo, LG; Opazo C.; De Ferrari, GV Article ISI SCOPUS Journal of Biological Chemistry (2010)
Canonical Wnt3a modulates intracellular calcium and enhances excitatory neurotransmission in hippocampal neurons. Avila, Miguel E; Sepúlveda, Fernando J; Burgos, Carlos F; Moraga-Cid, Gustavo; Parodi, Jorge; Moon, Randall T; Aguayo, Luis G; Opazo, Carlos; De Ferrari, Giancarlo V Article The Journal of biological chemistry (2010)
Differential Roles of NMDA Receptor Subtypes NR2A and NR2B in Dendritic Branch Development and Requirement of RasGRF1 Sepulveda, FJ; Bustos, FJ; Inostroza, E; Neve, RL; Montecino, M.; van Zundert, B Article ISI SCOPUS JOURNAL OF NEUROPHYSIOLOGY (2010)
Differential roles of NMDA Receptor Subtypes NR2A and NR2B in dendritic branch development and requirement of RasGRF1. Sepulveda, Fernando J; Bustos, Fernando J; Inostroza, Eveling; Zúñiga, Felipe A; Neve, Rachael L; Montecino, Martin; van Zundert, Brigitte Article Journal of neurophysiology (2010)
Synaptotoxicity of Alzheimer Beta Amyloid Can Be Explained by Its Membrane Perforating Property Sepulveda, FJ; Parodi, J; Peoples, RW; Opazo C.; Aguayo, LG Article ISI SCOPUS PLOS ONE (2010)
Synaptotoxicity of Alzheimer beta amyloid can be explained by its membrane perforating property. Sepulveda, Fernando J; Parodi, Jorge; Peoples, Robert W; Opazo, Carlos; Aguayo, Luis G Article PloS one (2010)
Alzheimer beta-amyloid blocks epileptiform activity in hippocampal neurons Sepulveda, FJ; Opazo C.; Aguayo, LG Article ISI SCOPUS MOLECULAR AND CELLULAR NEUROSCIENCE (2009)
Alzheimer beta-amyloid blocks epileptiform activity in hippocampal neurons. Sepúlveda, Fernando J; Opazo, Carlos; Aguayo, Luis G Article Molecular and cellular neurosciences (2009)
Sustained increase of Ca+2 oscillations after chronic TRPV1 receptor activation with capsaicin in cultured spinal neurons Larrucea, C; Castro P. ; Sepulveda, FJ; Wandersleben G.; Roa, J; Aguayo, LG Article ISI SCOPUS BRAIN RESEARCH (2008)
Sustained increase of Ca+2 oscillations after chronic TRPV1 receptor activation with capsaicin in cultured spinal neurons. Larrucea, Carlos; Castro, Patricio; Sepulveda, Fernando J; Wandersleben, Gretchen; Roa, Jorge; Aguayo, Luis G Article Brain research (2008)
Anti-homeostatic synaptic plasticity of glycine receptor function after chronic strychnine in developing cultured mouse spinal neurons Castro PA; Sepulveda, FJ; Cuevas, M.; Izaurieta, P; van Zundert, B; Aguayo, LG Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2007)
Anti-homeostatic synaptic plasticity of glycine receptor function after chronic strychnine in developing cultured mouse spinal neurons. Carrasco, M A; Castro, P A; Sepulveda, F J; Cuevas, M; Tapia, J C; Izaurieta, P; van Zundert, B; Aguayo, L G Article Journal of neurochemistry (2007)
Regulation of glycinergic and GABAergic synaptogenesis by brain-derived neurotrophic factor in developing spinal neurons Castro P. ; Sepulveda, FJ; Gatica K.; Davis, MI; Aguayo, LG Article ISI SCOPUS NEUROSCIENCE (2007)
Regulation of glycinergic and GABAergic synaptogenesis by brain-derived neurotrophic factor in developing spinal neurons. Carrasco, M A; Castro, P; Sepulveda, F J; Tapia, J C; Gatica, K; Davis, M I; Aguayo, L G Article Neuroscience (2007)

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Pore-Forming Neurotoxin-Like Mechanism for A beta Oligomer-Induced Synaptic Failure Aguayo, LG; Parodi, J; Sepulveda, FJ; Opazo C. ConferencePaper ISI SCOPUS CURRENT HYPOTHESES AND RESEARCH MILESTONES IN ALZHEIMER'S DISEASE (2009)