Neurobiology of Alzheimer´s disease; Glutamatergic signaling; Synapse dysfunction and excitotoxicity; Biological and molecular bases of neurodegeneration.

PhD Thesis:

1. "EXPERIMENTAL PERIODONTITIS INDUCED BY PORPHYROMONAS GINGIVALIS OR AGGREGATIBACTER ACTINOMYCETEMCOMITANS AND ITS ASSOCIATION WITH ALZHEIMER'S DISEASE"
Thesis to qualify for the degree of PhD in Dental Sciences, Faculty of Dentistry, University of Chile
Principal Tutor: Dr. Andrea Paula Lima.
Candidate: Mr. Jaime Díaz Zúñiga
Year: 2019

2. "MODIFICATION OF FUNCTIONAL CONNECTIVITY AS AN EARLY ALTERATION MECHANISM, OF SPACE MEMORY IN PATIENTS WITH COGNITIVE DETERIORATION"
Thesis to qualify for the degree of PhD in Biomedical Sciencess; Faculty of Medicine, University of Chile
Principal Tutor: Dr. Andrea Paula Lima.
Candidate: Iván Plaza Rosales
Year: 2020

3. "PARTICIPATION OF OXYGEN REAGENT SPECIES AND NUCLEAR SIGNALS OF Ca2 + IN GENE EXPRESSION DEPENDENT ON HIPOCAMPAL NEURAL ACTIVITY AND SINAPTOTOXICITY OF BETA AMYLOID PEPTIDE".
Thesis to qualify for the degree of PhD in Pharmacology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile
Co-Tutor: Dr. Andrea Paula Lima.
Candidate: Pedro Lobos Zambrano
2018-present

4. "PARTICIPATION OF PSERSTAT3 IN THE MITOCHONDRIAL FUNCTION AND NEURITOGENESIS OF NEURONS TREATED WITH PEGETY OLIGOMETERS? -AMILOID".
PhD in Sciences with mention in Molecular, Cellular and Neuroscience Biology, University of Chile
Student: Yorka Muñoz
Co-Tutor: Dr. Andrea Paula Lima.
Year: 2018

5. "Ca2+ SIGNALS EVOKED IN DENDRITES OF PRIMARY RAT HIPPOCAMPAL NEURONS ENGAGE RyR2-MEDIATED Ca2 + RELEASE FOR PROPAGATION TO THE NUCLEUS".
PhD in Biomedical Sciences; Faculty of Medicine, University of Chile
Student: Alex Córdova
Year 2016

6. "ROLE OF THE SIGNALING ROUTE IRE1? / XBP1 AS REGULATOR OF THE SECRETION OF THE PEPTIDE A? IN THE MURINE MODEL OF ALZHEIMER'S DISEASE (AD) ".
PhD in Biomedical Sciences, Faculty of Medicine, University of Chile
Student: Víctor Hugo Cornejo Corona
Co-tutor: Dr. Andrea Paula Lima.
Year: 2015

7. "THE CONSUMPTION OF ANTIOXIDANT N-ACETYLCISTEIN (NAC) MODULATES THE STATE REDOX CEREBRAL AND PREVENTS COGNITIVE DETERIORATION IN AN EXPERIMENTAL MODEL OF ALZHEIMER'S DISEASE"
PhD in Biomedical Sciences, Faculty of Medicine, University of Chile
Student: Jamileth Y. More de la Cruz
Principal Tutor: Dr. Andrea Paula Lima.
2019

Master Thesis:

1. "EFFECTS OF BETA-AMYLOID PEPTIDE OLIGOMETERS ON THE TRANSLOCATION OF Nrf2 TO THE NUCLEO AND EXPRESSION OF ANTIOXIDANT ZIMS, INDUCED BY BDNF IN PRIMARY CROPS OF HYPOCAMPAL NEURONS"
Thesis to qualify for the degree of Master in Biological Chemistry from Bernardo O'Higgins University
Candidate: Marilyn Solányela Fonseca Díaz
Principal Tutor: Dr. Andrea Paula Lima.
2018-present

2. "PARTICIPATION OF REACTIVE OXYGEN SPECIES AND THE NRF2 TRANSCRIPTION FACTOR IN INTRACELLULAR SIGNALING INDUCED BY BDNF IN PRIMARY CULTURE OF HYPOCAMPAL NEURONS."
Master in Biochemistry at the University of Chile.
Student: Bárbara Bruna Jara
Principal Tutor: Dr. Andrea Paula Lima.
Year: 2017

3. "DO RYANODINE RECEPTORS MODULATE ENDOPLASMIC RETICULUM-MITOCHONDRIA INTERFACE IN AN ALZHEIMER'S DISEASE MODEL?"
Student: Nadja Galusso
Principal Tutor: Dr. Andrea Paula Lima.
45 ECTS Master Thesis Degree Project, Department of Neurochemistry. Stockholm University
Year: 2016

4. "DETERIORATION IN LEARNING AND HIPOCAMPO DEPENDENT SPACE MEMORY AS A RESULT OF THE DECREASE IN THE EXPRESSION OF THE CALCIUM CHANNEL RECEIVER OF RYANODINE TYPE 2 (RYR2) IN THE HIPOCAMPO".
Student: Jamileth Y. More de la Cruz
Principal Tutor: Dr. Andrea Paula Lima.
Master's Program in Neurosciences, Faculty of Medicine, U. de Chile
Year: 2015

5. "ROLE OF REACTIVE OXYGEN SPECIES IN THE MODIFICATION OF THE MITOCHONDRIAL NETWORK AND THE EXPRESSION OF THE RYANODINE RECEIVER INDUCED BY THE PEPTIDE A OLIGOMETERS?"
Student: Pablo G. Barattini Matta
Principal Tutor: Dr. Andrea Paula Lima.
Master in Biochemistry, Faculty of Chemistry and Pharmacy, U. Chile.
Year: 2015

6. "ELECTROPHISIOLOGICAL FEATURES OF LEARNING AND SPACE MEMORY IN PATIENTS WITH ALZHEIMER'S DISEASE IN THE INITIAL PHASE".
Candidate: Rodrigo Félix Manrique Häfelin
Principal Tutor: Dr. Andrea Paula Lima.
Master in Medical and Biological Sciences, Mention Neurosciences, Faculty of Medicine, U. Chile
Start: 2013. Tutor. Conclusion: 06/10/2015

1. Interview for the newspaper El Mercurio: Women are gaining ground in science and increasingly faster. https://digital.elmercurio.com/2019/03/08/A/DG3IE41T#zoom=page-width

2. Andrea Paula Lima, doctor in biochemistry. Future looks. Futuro 360. CNN Chile. https://www.futuro360.com/opinion/andrea-paula-lima-doctora-en-bioquimica-vamos-a-tener-la-capacidad-de-usar-la-mente-sin-estar-presente_20190206/

3. Alzheimer's Nerd Night https://youtu.be/fWKvxgKecp4 1770172019

4. New Woman Magazine News: Learn about the story of Andrea Paula Lima, the researcher who struggles to advance in the treatment of Alzheimer's. 6/18/2018.

5. ADN Radio Chile Woman STEM Interview: Andrea Paula Lima 6/18/2018

6. Conicyt Report: Andrea paula lima: "For women, science is not an easy path, but it is changing". 6/11/2018

7. News Chilean Society of Neurosciences. Dr. Andrea Paula Lima investigates treatment to reverse the cognitive deterioration of Alzheimer's. https://socneurociencia.cl/2018/05/31/la-dra-andrea-paula-lima-investiga-tratamiento-para-revertir-el-deterioro-cognitivo-del-alzheimer/

8. Interview for the newspaper El Mostrador: Alzheimer, An unresolved challenge. May 30, 2018. Highlighted for receiving the Award of Excellence for Young Researcher Adelina Gutiérrez.

9. News Faculty of Medicine. Dr. Andrea Paula Lima, best young scientist 2017. May 22, 2018.

10. Portfolio Health publication. Scientists analyze early signs of Alzheimer's with virtual reality. Diario Financiero - Health Portfolio. 05/08/2017.

11. Video Report of Chilevisión News about Alzheimer's, with research carried out by scientists from the Instituto Milenio de Neurociencia Biomédica, BNI, by doctors Andrea Paula Lima and Enzo Brunetti. www.youtube.com/watch?v=NoIcwqIk2uo 04/03/2017

12. Publication of El Mostrador - With virtual reality exercise scientists study early signs of Alzheimer 13/03/2017
Scientists of the University of Chile Pose Preventive Techniques against Alzheimer's - OdontoNews
http://webdental.cl/odontologia/?p=6889 04/04/2017

13. Report Portal Universidad de la Frontera: Researchers from the U. de Chile and UFRO share experiences in project formulation. July 1, 2016
Outstanding cooperation program to contribute to the development of its extension, teaching and research activities.

14. Reuters Agency Video: Eye Movement link to Alzheimer's disease. https://stock.adobe.com/ee/editorial/eye-movement-link-to-alzheimer-s/157771553

15. University of Chile Radio Program - To your health. Dr. Andréa Paula Lima Alzheimer's Disease and Music.

16. Publication of El Mostrador with his research on the detection of diseases such as Alzheimer's, through the study of eye movements. In this is mentioned his membership in BNI. https://www.elmostrador.cl/cultura/2015/10/29/neurocientificos-chilenos-detectan-enfermedades-psiquiatricas-por-el-movimiento-de-los-ojos/?php%20bloginfo(%27url%27) ;% 20?% 3E / culture

17. Radio Mentalized Program. Radio University of Chile. 3/31/2015 http://radio.uchile.cl/programas/mentalizados/en-esta-edicion-conversamos-con-la-doctora-andrea-paula-lima-sobre-el-cerebro-la-memoria-y -Alzheimer's disease/

18. Diario La Tercera Trends: Chilean scientists detect Schizophrenia and Alzheimer by eye movements http://www2.latercera.com/noticia/cientificos-chilenos- detectn- schizophrenia-y-alzheimer-by-eye-movements / # 29/10 / 2015.

19. News Cecilia Espinosa Cortes - Dr. Paula Lima is honored by the Royal Society. Meeting Frontiers UK-Brazil-Chile. 2014

20. El Mercurio Daily Report: Study of the Millennium Institute of Neurosciences Biomedical: Analysis of eye movements gives clues about Alzheimer's. December 16, 2013.
Outstanding study through the way in which patients explore and extract visual information and associated brain activity is aimed at improving diagnosis.

21. News "Young researcher of BNI wins international award" Pagina Web Biomedical Neuroscience Institute, University of Chile. 01/28/2013.
http://www.bni.cl/nv_detailed.php?did=75

22. Interview on research on findings about Alzheimer's. Radio Universidad de Chile, Milenio Program 08/04 / 201http: //radio.uchile.cl/programas/milenio/vicky-quevedo-entrevisto-al-academico-de-la-u-de-chile-daniel-espinoza-sobre -the-optimization-in-networks-and-with-andrea-paulalima-on-your-research-in-findings-on-the-alzheimer /

23. News "Andrea Paula-Lima: The cellular search in Alzheimer's" 04/09/2013. Website Faculty of Dentistry, University of Chile. 04/09/2013. http://www.odontologia.uchile.cl/noticias/90092/la-busqueda-celular-en-el-alzheimer

24. News "Prevent Alzheimer's" Regional Journal Arica Hoy. 03/19/2013 http://www.aricahoy.cl/?p=942

25. News "The scientist who studies a new possibility for Alzheimer's." 03/19/2013. Enciclope
News "Alzheimer: Andrea Paula-Lima investigates possible role of meats and dairy products in their treatment." 03/20/2013.

26. Pure online journal
Noticia.cl.http: //www.puranoticia.cl/front/contenido/2013/03/20/noticia-68303.php

27. News "Antioxidant that could prevent Alzheimer's." 03/21/2013. The Second Online.http: //www.lasegunda.com/Noticias/Buena-Vida/2013/03/832216/Antioxidante-que-podria-prevenir-el-Alzheimer

28. News "Scientific of U Chile investigates benefits of antioxidant that could prevent Alzheimer's." 03/21/2013. Terra.http: //noticias.terra.cl/nacional/cientifica-de-u-de-chile-investiga-beneficios-de-antioxidante-que-podria-prevenir-el-Alzheimer,8e4ce01a4fc8d310VgnCLD2000000ec6eb0aRCRD.html

29. News "Scientific investigates antioxidant benefits that could prevent Alzheimer's disease". Bio Bio Technology. Biobiochile.cl. 03/21/2013. http://bni.cl/var/files/biobio_paula.pdf

30. Interview live on Alzheimer's in the Conecta2 program on the international signal of National Television of Chile. 03/21/2013. http://www.facebook.com/Conecta2TvChile
News "Natural antioxidant could prevent Alzheimer's disease." - 24 Hours -

31. Interview on Alzheimer's in TVChile Program - INNOVA program of TV CHILE internacional. international signal of National Television of Chile. https://vimeo.com/71040875

32. News "Young Researcher of the Millennium Institute of Neuroscience Biomedical receives international award" Web page of the Millennium Scientific Initiative. News 14/03 / 2012.http: //www.iniciativamilenio.cl/noticias/noti_det.php? Id = 1418

33. Citizen Forum Program: Communication between neurons. INTERVIEW Radio Broadcast. Radio University of Chile2012

34. El Mercurio Daily Report: Scientists represent Chile in an international meeting with 23 novelties. June 30, 2011.
Outstanding young people selected at the Lindau Meeting in Germany.

35. Image of Researchers and creators of excellence. University of Chile. Building the Chile of the future. University of Chile. 2011

36. Newspaper El Mercurio 2011 Dentistry advances in equipment for Research. Periodistic note by Cecilia Espinosa Cortés