Biological and molecular bases of inflamation and neurodegeneration (Alzheimer´s disease). Risk factors of Alzheimer's disease. Calcium signaling in hippocampal health and disease.

FORMATION OF HUMAN RESOURCES

Post Doctorate

1. Iván Plaza Rosales, Ph.D. Spatial Memory defects in depression and early Alzheimer's disease. 2023-2025.
2. Catherine Perez, Ph.D. Electroencephalography (EEG), eye tracking, and virtual navigation tests in depression and early Alzheimer's disease. 2023-2025.
3. Alejandro Luarte, Ph.D. Alzheimer’s disease and Periodontitis. 2020-2023.

Doctorate

1. Natali Acosta Tapia (Ph.D. Program in Sciences, mention in Molecular and Cellular Biology, and Neurosciences, Faculty of Sciences, Universidad de Chile). Thesis title: The reversible oxidation of Cys18 in Rac1 modulates the production of H2O2 and the dynamics of the actin cytoskeleton during the specification of its axon in embryonic hippocampal neurons in vitro. (08/09/2022-Present) Co-Advisor
2. Marcelo Eduardo González Montt (Ph.D. Program in Biomedical Sciences, Faculty of Medicine, Universidad de Chile). Thesis title: Periodontitis and Alzheimer´s disease: Brain Invasion, Synaptic dysfunction, and cognitive decline induced by Aggregatibacter actinomycetemcomitans. (24/10/2025-Present). Advisor
3. Jorge Arriagada Díaz (Ph.D. Program in Biomedical Sciences, Faculty of Medicine, Universidad de Chile). Thesis title: Metformin modulates the oxidation state of RyR2, improving transmission and plasticity of excitatory synapses in a model of Alzheimer's disease. (11/11/2024-Present). Advisor
4. Silvia Gleitze (Ph.D. Program in Biomedical Sciences, Faculty of Medicine, Universidad de Chile). Thesis title: Abnormal calcium signals, through ryanodine receptor channels, participate in ferroptosis induced by GPX4 inhibition, which perturbs relevant calcium signaling pathways that are required for activity-dependent gene expression in primary hippocampal neurons. (27/10/2020-14/12/2023). Co-advisor
5. Ivan Plaza Rosales (Ph.D. Program in Biomedical Sciences, Faculty of Medicine, Universidad de Chile). Thesis Title: Modification of functional connectivity as an early mechanism of alterations in spatial memory in patients with Cognitive Impairment. (10/07/2017-16/03/2020). Co-Advisor
6. Jaime Díaz Zúñiga (Ph.D. Program in Dentistry Sciences, Faculty of Dentistry, Universidad de Chile). Thesis Title: Experimental periodontitis induced by Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans and its association with Alzheimer's disease. (25/01/2017-26/04/2019) Advisor
7. Jamileth More de la Cruz (Ph.D. Program in Biomedical Sciences, Faculty of Medicine, Universidad de Chile). Thesis project title: The consumption of the antioxidant N-acetylcysteine (NAC) modulates the brain redox state and prevents cognitive deterioration in an experimental model of Alzheimer's disease. 2(6/05/2016-08/05/2019). Advisor
8. Pedro Lobos (Ph.D. Program in Biomedical Sciences, Faculty of Medicine, Universidad de Chile). Thesis title: Participation of reactive oxygen species and nuclear Ca2+ signals in activity-dependent gene expression and synaptotoxicity of the ?-amyloid peptide in hippocampal neurons. (19/04/-2018-2021) Advisor
9. Yorka Muñoz (Ph.D. Program of Science Majoring in Molecular Cell Biology and Neurosciences, Faculty of Sciences, Universidad de Chile). Thesis title: R.O.S. released by astrocytes in response to A?OS affect neuronal distribution and function of pSerSTAT3. (12/06/2014-14/12/2018) Co-advisor
10. John Alex Cordova (Ph.D. Program in Biomedical Sciences, Faculty of Medicine, Universidad de Chile). Thesis title: Calcium signals evoked in dendrites of primary rat hippocampal neurons engage RyR2-mediated calcium release for propagation to the nucleus. (30/05/2014-23/01/2017) Co-advisor
11. Victor Hugo Cornejo Corona (Ph.D. Program in Biomedical Sciences, Faculty of Medicine, Universidad de Chile). Thesis title: Participation of the transcription factor XBP1 in UBQLN1 control and its impact on the accumulation of Aß peptide in experimental models Alzheimer's Disease (AD). (09/08/2012- 8/10/2015) Co-advisor

Master

1. Antonia Figueroa Fritz (Master in Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile) Thesis title: Immunomodulatory effect of extracellular vesicles derived from astrocytes on microglial phagocytosis of synaptic components in response to virulence factors derived from Porphyromonas gingivalis. 31/03/2925-Present Co-Advisor
2. Matías Lantadilla Brito (Master in Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile). 28/08/2024-Present Advisor
3. Jorge Concha Cerda (Master in Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile). Thesis Project Title: Effect of nicotinamide administration on spatial memory, microglia status, and intrahippocampal infiltration of Th2 lymphocytes in a non-transgenic murine model of Alzheimer's Disease. (15/10/2020 - 25/07/2023) Co-Advisor
4. Barbara Alexandra Bruna Jara (Master in Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile). Participation of reactive oxygen species and the Nrf2 transcription factor in intracellular signaling induced by BDNF in primary culture of hippocampal neurons. (01/07/2015 - 29/03/2017) Advisor
5. Nadja Galusso (Master in Neurochemistry, Department of Neurochemistry, University of Stockholm). Thesis title: Do Ryanodine receptors modulate endoplasmic reticulum–mitochondria interface in an Alzheimer's disease model? (02/11/2015-05/06/2016) Advisor
6. Jamileth Y. More de la Cruz (Master in Neuroscience, Faculty of Medicine, Universidad de Chile). Effect of the downregulation of the calcium channel ryanodine receptor type 2 (RyR2) expression on the spatial memory and the hippocampal-dependent long-term potentiation (LTP). (27/05/2013-07/09/2015) Co-Advisor.
7. Pablo G. Veloso Matta (Master in Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile) Thesis title: Role of reactive oxygen species in modifying the mitochondrial network and Ryanodine Receptor expression induced by Aß peptide oligomers. (12/05/2013 – 31/06/2015) Advisor
8. Rodrigo Felix Manrique Häfelin (Master Program in Medical and Biological Sciences; Neuroscience, Faculty of Medicine, Universidad de Chile) Thesis title: Electrophysiological features of spatial learning and memory in patients with Alzheimer's disease in early stages. (04/07/2013 – 10/06/2015). Advisor

Undergraduate

1. José Martínez Sobarzo, Faculty of Dentistry, Universidad de Chile. Thesis title: Infection by Aggregatibacter actinomycetemcomitans: Effect on the integrity and permeability of the blood-brain barrier and implications for Alzheimer´s disease. (25/07/2025-Present) Advisor
2. Carlos Felipe Dankert, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile. Thesis Title: Lipopolysaccharides from periodontal bacteria, neuroinflammation, and the induction of neuronal ferroptosis in the development of neurodegenerative diseases: A systematic review of the literature. (05/07/2021-05/07/2023) Advisor
3. Ignacio Vega-Vásquez, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile. Thesis Title: Localization of isoforms 2 and 3 of the ryanodine receptor in dendritic spines of neurons from primary rat hippocampal cultures. 16/05/2021-16/05/2023. Advisor
4. Ignacio Leopoldo Mun?oz Bermu?dez, Faculty of Dentistry, Universidad de Chile. Thesis Title: Morphological characterization of microglia and astrocytes in response to the oral pathogen Aggregatibacter actinomycetemcomitans or to aggregates of beta-amyloid peptide. (14/112020-14/11/2022) Advisor
5. Hazel Paulina Lira Lo?pez, Faculty of Dentistry, Morphological characterization of microglia and astrocytes in response to the oral pathogen Aggregatibacter actinomycetemcomitans or to aggregates of beta-amyloid peptide. Thesis Title: Generation of calcium signals, production of ROS, and activation of the transcription factor NF-kB in brain tissue by periodontopathogens: Systematic review of the literature. (21/10/2020-21/10/2022) Advisor
6. Antonia Macarena González Bravo, Faculty of Dentistry, Universidad de Chile. Thesis Title: Variability in the response of brain cells to different serotypes of Porphyromonas gingivalis. (05/09/2020-05/09/2022) Co-Advisor
7. Valeria Parra-Torres. Faculty of Dentistry, Universidad de Chile. Thesis Title: Microbiological association between periodontitis and Alzheimer's disease: a systematic review. (2020-2022). Advisor
8. Cristopher Nicola?s Fari?as Nu?n?ez, Faculty of Dentistry, UChile (12/06/2020-12/06/2022). Thesis Title: Use of N-Acetylcysteine in periodontitis: systematic review. 01/12/2022. Advisor
9. Katherine Alejandra Olivares Sagredo, Faculty of Dentistry, Universidad de Chile. Thesis title: Possible routes of entry of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans into the brain and their association with Alzheimer's disease: systematic review of the literature. (09/09/2021-06/06/2022) Advisor
10. Sebastia?n Alejandro Cordero Quezada, Faculty of Dentistry, Universidad de Chile. (2020-2022). Thesis title: Experimental periodontitis and in vivo model of Alzheimer's disease: Comparison of neuroinflammation, learning and spatial memory. (30/08/2020-30/08/2022) Co-Advisor
11. Valentina Andrea Moscoso Garci?a, Faculty of Dentistry, Universidad de Chile. Thesis Title: Morphological changes in astrocytes produced by experimental periodontitis induced by Porphyromonas gingivalis in rats. (22/04/2020-22/04/2022) Advisor
12. Pamela Katerina Alvarado Nail, Faculty of Dentistry, Universidad de Chile. (Thesis title: Effects of methyl methacrylate on muscle cell viability, muscle strength, and endurance in mice. (28/04-2020-28/04/2022 Co-Advisor
13. Francisca Morales Benítez, Faculty of Dentistry, Universidad de Chile. Thesis Title: Periodontal status in patients affected by Alzheimer's disease: case-control study. (17/06/2020-17/06/2022) Co-Advisor
14. Francisca Valentina Villalobos Orchard, Faculty of Dentistry, Universidad de Chile. Thesis Title: Effect of experimental periodontitis induced by serotype K1 or the non-encapsulated strain K- of Porphyromonas gingivalis on spatial learning and memory in rats. (11/01/2017-11/01/2019). Co-Advisor
15. Matías Jiménez Unión, Faculty of Dentistry, UChile (2017-2019). (Thesis to qualify for the title of Dental Surgeon, Faculty of Dentistry, University of Chile. Thesis Title: Effect of palatal mono-infection by Porphyromonas gingivalis serotype K2 and K4 on the hippocampus and spatial memory of rats. 2019. Co-Advisor
16. Pedro Lobos, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile. Thesis title: Study of an antioxidant of natural origin in preventing the harmful effects of beta-amyloid peptide oligomers. (01/01/2015-09/06/2016) Advisor
17. Vivian Ribeiro de Almeida Motta, Faculty of Medicine, Federal University of Rio de Janeiro, Thesis title: Glutamate release in hippocampal neurons (01/08/2005-01/08/2007). Co-Advisor
18. Jordano Brito-Moreira, Faculty of Pharmacy, Federal University of Rio de Janeiro. Thesis title: A? oligomers induce glutamate release from hippocampal neurons (01/08/2005-01/08/2007). Co-Advisor

PRESENTATIONS IN SCIENTIFIC MEETINGS:

1. TYAN flash presentations by TWAS Young Affiliates: Andrea Cristina Paula Lima – TYAN-SISSA Workshop on Emerging Themes in Neurobiology held between 17-19 March 2026, Trieste, Italy. Invited Speaker.
2. Redox Protein Modifications, Calcium Signals, and Synaptic Plasticity in Alzheimer’s Disease and Other Neurological Disorders. Aging symposium. TWAS Young Affiliate Network (TYAN) 2025 Meeting, Campinas, Brazil (24-28/09/2025). Invited Speaker and Chair.
3. TWAS General Conference 'Building a Sustainable Future: The role of science, technology and innovation for global development. Río de Janeiro, 29/09 – 2/10/2025. Rio de Janeiro, Brazil. Invited assistant.
4. Redox modulation and contribution of ryanodine receptors to synaptic plasticity and spatial memory defects in Alzheimer´s disease. Symposium S20 T#4 Redox protein modifications, calcium signals and synaptic plasticity in Alzheimer´s disease and other neurological disorders. Society for Neurochemistry, New York, USA 21/08/2025. Invited Speaker and Chair.
5. First Dual Hub Summit, Concepción, Chile. 04-07/05/2025. Assistant.
6. Alzheimer´s Disease Physiopathology. Alzheimer's Disease Update Day, where you are invited to give a talk and participate in the day at the German Clinic, 22/10/2024. Invited Speaker, Opening Section).
7. Symposium on Translational Medicine, Universidad de la frontera, Pucón, Chile. 20-21/10/2024. Invited assistant.
8. The detrimental role of calcium signaling in Alzheimer’ disease amyloid pathology. Symposium IV - Neurotoxicity and Neuroprotection II. Chair: Victor Diogenes A.l da Silva. X MEETING OF THE NEUROTOXICITY SOCIETY- Neurotoxicity Society Biennial Meeting 2024, Salvador, Bahía 10/09/2024. Invited Speaker
9. Role of endoplasmic reticulum-mediated calcium signaling in the toxicity of Alzheimer's disease-related amyloid-beta peptide oligomers. Symposium II – Mechanisms on Neurotoxicity II. Chair: Patri?cia Schuck X MEETING OF THE NEUROTOXICITY SOCIETY- Neurotoxicity Society Biennial Meeting 2024, Salvador, Bahía 09/09/2024 Invited Speaker
10. Amyloid-beta disrupts RyR-mediated calcium signaling and neuroprotective gene expression in hippocampal neurons. Research Theme 7: Healthy Brain Ageing and Improved Therapies for Brain Disease. Access Forum Chile Sweden, Stockolm, Sweden. (09-14/07/2024) Invited Speaker and Chair
11. The Role of Calcium Signaling in Alzheimer's Disease. Advanced Program of Neuroscience- CAPES PRINT 2023 – Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil. Invited Speaker.
12. Brain Gain for a Green Earth: How Neuroscience Can Help Us Think Our Way to a Sustainable Future? Session: “The role of basic sciences in reaching environmental sustainability”. TWAS-LACREP Young Scientist Conference and 2nd TYAN Regional Meeting: "Advancing Sustainable and Innovative Social Development". Invited Speaker. 2023.
13. Session: "Biochemistry, diseases and balanced lifestyles". TWAS-LACREP Young Scientist Conference and 2nd TYAN Regional Meeting: "Advancing Sustainable and Innovative Social Development". Chair.
14. Alzheimer ?s disease. Forum 2022: Reconnecting for a Sustainable Future Presentacio?n oral | Access Forum Chile Sweden. Punta Arenas, Chile.
15. Amyloid-? oligomers disrupt neuroprotective gene expression pathways induced by hippocampal neuronal activity. Andrea Paula-Lima, Pedro Lobos Zambrano, Ignacio Vega Vásquez, Barbara Bruna, Nicole Henríquez, Tatiana Adasme , Cecilia Hidalgo. Symposium Abnormal Neuronal Function in Disease and Aging. Annual Meeting of the Chilean Society of Biology - XXVIII Annual Meeting of the Chilean Society of Ecology - XVIII Annual Meeting of the Chilean Society of Neuroscience. Invited Speaker. 5-7/12/2022
16. The role of calcium in ferroptosis-mediated neuronal death. Gleitze, Tulio Nuñez, Andrea Paula-Lima, Cecilia Hidalgo. VI. Symposium Abnormal Neuronal Function in Disease and Aging. Annual Meeting of the Chilean Society of Biology - XXVIII Annual Meeting of the Chilean Society of Ecology - XVIII Annual Meeting of the Chilean Society of Neuroscience. Oral communication
17. El péptido beta amiloide en la Enfermedad de Alzheimer: ¿Qué sabemos hasta aquí? VII Jornada Internacional de Morfofunción. Universidad Diego Portales. 02/12/2022.
18. Functional dentition and cognitive health in ?80 years Chilean population. XXXIV Reunión Anual de la IADR División Chilena. Santiago, Chile. Poster presentation. 03/11/2022
19. RANKL/OPG/IL-17A axis in Alzheimer’s-disease like pathology: potential effect of periodontitis. XXXIV Reunión Anual de la IADR División Chilena. Santiago, Chile. Poster presentation. 04/11/2022
20. Alzheimer´s disease. Access Foro Chile-Suecia 2022. Punta Arenas, Chile. Invited speaker.
21. Iron chelation and ryanodine receptor inhibition protect primary hippocampal neurons against ferroptosis. Silvia Gleitze, Pedro Lobos, Marco T. Núñez, Andrea Paula-Lima and Cecilia Hidalgo. FENS Forum 2022. Paris, France.
22. Primer encuentro de Centro Interuniversitario de Envejecimiento Saludable (CIES). 26/05/2022. Universidad de O-Higgins. Rancagua, Chile.
23. Exploring Activity-Generated Nuclear Calcium Signals in Hippocampal Neurons: From Ryanodine Receptor Contribution To Amyloid-Beta Oligomers Interruption. Lobos, P. ; Cordova, A.; Vega, I. ; Toledo, J.; Bruna, B.; Adasme, T.; Hartel, S.; Paula-Lima, A.; Hidalgo, C. European Calcium Society 2021. Poster.
24. Análisis de Resultados y Escritura de Discusión de Artículos en Ciencias Básica. Andrea Paula-Lima. Congreso Investigadores Jóvenes Revista Anacem 2021.
25. Mecanismos moleculares de neurotoxicidad y neuroprotección en la enfermedad de Alzheimer. Congreso Anual de la Asociación Nacional de Estudiantes de Bioquímica (ANEB) de Chile, 17/08/21. Invited Speaker.
26. Mecanismos moleculares de neurotoxicicidad y neuroprotección en la Enfermedad de Azheimer. Jornada de Neurociencias AENN-SEIC. 04/09/21. Invited Speaker.
27. Participación del receptor de ryanodina 2 en la disfunción mitocondrial causada por oligómeros del péptido beta-amiloide en neuronas. Avances y perspectivas en el rol de la mitocondria en fisiopatología" a realizarse en el marco del Workshop Avances en Bioquímica y Biología Redox. Octubre 2021. Universidad de Buenos Aires, Argentina and Pontificia Universidad Católica de Chile.
28. Periodontitis and Alzheimer’s Experimental Models: Neuroinflammation and Cognitive Status Comparison. Cordero, S; More J, Melgar-Rodríguez S, Vernal R, Paula-Lima A, Díaz-Zúñiga J. IADR- Chile 2021. Poster.
29. RyR2 partakes in the mitochondrial dysfunction caused by amyloid-beta oligomers. Neurodegeneration and Aging Symposium. FALAN networking 2021.
30. ¿Existe asociación entre la Enfermedad periodontal y enfermedad de Alzheimer? Jaime Díaz-Zúñiga, Samanta Melgar-Rodríguez, Jamileth More, Matías Jiménez, Francisca Villalobos, Constanza Muñoz-Manríquez, Daniel Sansores-España, Fabio Arriola-Pacheco, Víctor Martínez-Aguilar, Rolando Vernal, Andrea Paula-Lima. Presentación oral. SIMPOSIO V. Patologías de la cavidad oral y complicaciones sistémicas. Chair: Dra. Andrea Paula Lima.
31. Redox modifications and calcium-dependent synaptic proteins in the pathogenesis of Alzheimer´s disease. Speaker and Chair of the Symposium Cellular and Molecular Aspects of Neurodegenerative Pathologies. XVI Annual Meeting of the Chilean Society for Neuroscience. 10-12 Noviembre 2020.
32. The role of women in STEM sciences. International Week: Brazil 2020. Cartagena de Indias, Colombia, from August 24 to 28, 2020. Invited speaker.
33. Periodontitis as a Risk Factor for Alzheimer's disease at the Global Virtual Conference on Neurodegenerative Diseases (GVCND2020). September 28, 2020. Speaker.
34. Alzheimer's disease-like pathology triggered by Porphyromonas gingivalis: Peripheral diseases as risk factors for neuroinflammation and brain damage in the Webinar “14th International Online Congress on Alzheimer's and Dementia. London, United Kingdom. October 05, 2020. Invited speaker.
35. Mecanismos Moleculares de la Asociación entre Periodontitis y Enfermedad de Alzheimer. Invited Speaker. Dra. Andrea Paula-Lima - Univ. de Chile. 1er Congreso Virtual de la Facultad de Odontología de la Universidad De Chile: La Odontología En Todas Partes.
36. Efecto del LPS de Aggregatibacter actinomycetemcomitans serotipo-b sobre la viabilidad de células de corteza murina Dankert, Carlos; Farías, Cristopher; Lira, Hazel; Paula-Lima, Andrea. Poster presentation.
37. Alzheimer's disease and its novel pathological links in the “Cycle of Advanced Lectures of the Advanced Neuroscience Program (PAN). Carlos Chagas Filho Biophysics Institute. Rio de Janiero, Brazil (online). July 06, 2020. Speaker.
38. Calcium, Oxidants and Alzheimer's disease. Paula-Lima A. C.I.B. Seminar Series #29. Center for Integrative Biology. Universidad Mayor. Santago, 11/09/2019. Speaker
39. Mujeres, Ciencias y la Enfermedad de Alzheimer, XXXI Reunión Anual de la International Association for Dental Research. Santiago, 29/08/2019. Speaker
40. Ryanodine Receptor Calcium Release Channels in Alzheimer's Disease - E.C.C. and Therapeutic Discovery Beyond Muscle de la 2019 Gordon Research Conference on Muscle: Excitation-Contraction. Lucca, Italy. 19–24/5/2019. Speaker
41. Alzheimer’s disease-like features triggered by oral Porphyromonas gingivalis infection depends on the bacterial serotype. 1st TYAN Regional Conference for Latin America and Caribbean Region: Science in Latin America: today and tomorrow, Rio de Janeiro, Brazil, 27-29 November 2019. Speaker
42. Virtual Reality for Early Detection of Alzheimer's disease. Neurosur 2018 Symposium: Frontiers in Neurotechnology: A Latin American Perspective. Universidad de Chile, Santiago, Chile. 5/12/2018. Speaker
43. Neuroinflammation and Alzheimer´s disease, Curso Nociones en Neurociencia Integrativa: Comprendiendo funciones y patologías cerebrales desde un punto de vista interdisciplinario. Universidad de Concepción. Concepción, 6–13/09/2018. Speaker
44. Avances en la comprensión y búsqueda de nuevos Biomarcadores en Enfermedad de Alzheimer, 1er Simposio Internacional de Actualización en Enfermedades Neurodegenerativas. Instituto Nacional de Geriatría. Santiago, 8–9/06/ 2018. Speaker
45. Porphyromonas gingivalis induce spatial-memory and learning decline in Sprague-Dawley rats. J. Díaz-Zúñiga, J. More, S. Melgar-Rodríguez, R. Vernal, A. Paula-Lima. Federación Iberopanamericana de Periodoncia. Santiago, Chile. 15-18/11/2017.
46. Periodontal pathogens induce the increment of inflammatory cytokines and oxidation molecules on microglia. J. Díaz-Zúñiga1, J. More, S. Melgar-Rodríguez, Y. Muñoz, R. Vernal, A. Paula-Lima. The role of glia in health and disease of the nervous system. ISN-IBRO Course. Buenos Aires, Argentina: 19-21/10/2017.
47. Reactive oxygen species mediate synaptic plasticity defects in a model of Alzheimer's Disease. Symposium Oxidative stress, aging and neurodegeneration. Andréa Paula-Lima. IUPS 38th World Congress, Rio de Janeiro, Brasil. http://iups2017.com/ (http://iups2017.com/). Chair of the Symposium "Oxidative stress, aging and neurodegeneration" 5/8/2017.
48. RyR-mediated calcium release and mitochondrial R.O.S. generation partake in the synaptic dysfunction caused by amyloid beta-peptide oligomers. 1st International Conference of TWAS Young Affiliates Network. Rio de Janeiro, Brasil. 22-24/8/2017. Chair Sesión Presentaciones TYAN.
49. The antioxidant N-acetylcysteine prevents the RyR2 down-regulation associated to an A.D. model displaying impaired spatial learning and memory More J, Montecinos, L, Sanchez G, Valdes; Hidalgo, Paula-Lima, AC. IUPS 38th World Congress, Rio de Janeiro, Brazil. http://iups2017.com/ (http://iups2017.com/)
50. Periodontal pathogens induce an increase in pro-inflammatory cytokines and morphological changes in hippocampal cells. Díaz-Zúñiga J, More J, Muñoz Y; Melgar-Rodriguez S; Galaz JL; Vernal R; Paula-Lima A. IUPS 38th World Congress, Rio de Janeiro, Brasil. http://iups2017.com/ (http://iups2017.com/)
51. Fixation-related potentials and visual exploration during a virtual water maze task in aging and early Alzheimer's disease. 13th International Conference on Alzheimer's and Parkinson's diseases (AD/PD 2017). Viena, Austria. 28/3-2/4.
52. A?Os-activated astrocytes generate a R.O.S. signal that affects the distribution and function of pSerStat3 in neurons. Muñoz Y, Paula-Lima AC, Nuñez T. Alzheimer's Association International Annual Conference in Toronto, Canada. 22-28/6/2016.
53. ROS released by astrocytes in response to A?Os affect neuronal distribution and function of pSerSTAT3. Muñoz Y, Paula-Lima AC, Nuñez T. Society for Neuroscience, San Diego, U.S.A. 12-16/11/2016.
54. Ca2+ and ROS participate in BDNF signaling: a novel role for Nrf2. Bruna B, Lobos P, Galaz JL Hidalgo C, Paula-Lima AC & Adasme T. Chilean Society for Cell Biology, Puerto Varas, Chile. 2-6/11/2016.
55. Aggregatibacter actinomycetemcomitans trigger pro-inflammatory cytokines release in brain-derived cells. Díaz-Zúñiga J, More J, Paula-Lima AC. Chilean Society for Cell Biology, Puerto Varas, Chile. 2-6/11/2016.
56. Ryanodine receptor and atlastin-2 shape calcium signals in single rat hippocampal neuron dendrites. Córdova JA, Ramírez OA, Cerda M, Lobos P, Paula-Lima AC, Couve A, Härtel S, Hidalgo C. Advances & Breakthroughs in Calcium Signaling", Honolulu, Hawaii, E.U.A. 6-13/4/2016.
57. Anomalous calcium/redox signaling in rats exposed to amyloid-beta oligomers: functional and behavioral correlates with early Alzheimer's patients. Paula-Lima AC., More J, Hafelin R., Barattini P., SanMartín C., Adasme T., Valdés JL, Behrens MI, Brunetti E, Maldonado P, Hidalgo C. Advances & Breakthroughs in Calcium Signaling", Honolulu, Hawaii, E.U.A. 6-13/4/2016.
58. Role of RYR2-mediated calcium release in synaptic plasticity defects and memory loss induced by soluble Abeta oligomers. Paula-Lima AC., More, J., Barattini P., Adasme T., Valdés J.L., Hidalgo C.. Neurochemistry Symposium, 23rd IUBMB Congress. Foz do Iguaçu, Brasil. 24-28/08/2015. Invited speaker.
59. Calcium dysregulation in a rodent model of Alzheimer's disease. Paula-Lima AC, More J, Barattini P., Adasme T. Valdés J.L., Hidalgo C. Invited to Symposium on Aging and Neurodegeneration, XI Meeting of the Chilean Society of Neuroscience, Coquimbo, Chile. 22-25/09/2015. Invited speaker
60. Ryanodine receptor and atlastin-2 shapes calcium signals in single rat hippocampal neuron dendrites. Córdova JA, Ramírez O, Cerda M., Lobos P., Paula-Lima AC, Couve A, Härtel S, Hidalgo C. The Young Neuroscientist Symposium, XI Meeting of the Chilean Society of Neuroscience, Coquimbo, Chile. 22-25/09/2015.
61. Amyloid-? oligomers produce changes in the pSer727-STAT3 in primary hippocampal neurons. Muñoz, Y. Paula-Lima AC., Nuñez, T. Poster. XI Meeting of the Chilean Society of Neuroscience, Coquimbo, Chile. 22-25/09/2015.
62. Cerebral and behavioral dysfunction during spatial navigation in patients at the early stage of Alzheimer's disease. Paula-Lima A.C.; Häfelin R., Valdes J.L.; Behrens M.I.; Maldonado P.; Hidalgo C.; Brunetti E. 9th World Congress International Brain Research Organization (IBRO 2015). Rio de Janeiro, Brasil. 7-11/07/2015.
63. Redox-sensitive RyR2-mediated calcium release has a key role in hippocampal learning and memory defects produced by soluble Abeta oligomers. Paula-Lima A.C., More J., Barattini P., SanMartin C., Adasme T., Valdés JL, Hidalgo C. 12th International Conference on Alzheimer's and Parkinson's diseases (AD/PD 2015). Nice, Francia. 18-22/03/2015. Oral communication.
64. R.O.S., calcium and mitochondrial dysfunction in Alzheimer's Disease. Paula-Lima A.C. Symposium Disorders in the ageing brain: from the molecular mechanism to the remediation. XXXVIII Annual Meeting of the Brazilian Society for Neuroscience and Behavior 10-13/09/2014. Buzios. Brazil. Invited speaker.
65. R.O.S., calcium and mitochondrial dysfunction in Alzheimer's Disease. Paula-Lima A.C. UK-Brazil Frontiers of Science Symposium 23-26/02/2014 The Royal Society at Chicheley Hall, Buckhamshiere, UK. Invited speaker Flash Poster Presentation.
66. R.O.S., calcium and mitochondrial dysfunction in Alzheimer's Disease. Paula-Lima, A.C. Faculty of Life Sciences, The University of Manchester, Manchester, U.K. 28/02/2014. Invited speaker.
67. Decreased RyR2 expression correlates with impaired learning and spatial memory. More, J., Valdes, J.L., Paula-Lima, A.C., Hidalgo, C. 05- FENS 2014 – Milan, Italia. 05-09/07/2014.
68. R.O.S. and ryanodine receptor-mediated Ca2+ signals are key components of bdnf-induced synaptic plasticity. Adasme, T., Paula-Lima, A.C., Hidalgo, C. FENS 2014 – Milan, Italia. 05-09/07/2014.
69. Endoplasmic reticulum, mitochondria and crosstalk between Ca2+ and R.O.S. in the synaptic dysfunction triggered by amyloid-? peptide oligomers. Paula-Lima, A.C., Barattini, P., SanMartin, C.D., Hidalgo C. FENS 2014 – Milan, Italia. 05-09/07/2014.
70. Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca2+ uptake in primary hippocampal neurons. Paula-Lima, A.C., San Martin, C., Garcia, A., Hartel, S., Nuñez, M.T., Hidalgo C. XII PABMB Congress. Puerto Varas, Chile. 09– 14/11/2013.
71. Role of mitochondria in neuronal Ca2+ and ROS signals induced by the Alzheimer's disease-associated amyloid-? peptide oligomers. Barattini P, SanMartín CD, Hidalgo C, Paula-Lima AC. .
72. XII PABMB Congress. Puerto Varas, Chile. 09– 14/11/2013.
73. Amyloid-? peptide oligomers impair spatial learning and decrease c-fos and RyR2 hippocampal protein levels. More J, Valdés JL, Paula-Lima AC, Hidalgo C. XII PABMB Congress. Puerto Varas, Chile. 09– 14/11/2013.
74. Hippocampal synaptic plasticity requires Ca2+ signals generated by ryanodine receptor-mediated Ca2+ release. Hidalgo C, Adasme T, Barrientos G, Haeger P, More J, Paula-Lima A.C., Valdes, I. XII PABMB Congress. Puerto Varas, Chile. 9-14/11/ 2013.
75. Ryanodine receptor-mediated Ca2+ signals and R.O.S. are key components of synaptic plasticity promoted by the neurotrophin BDNF. Adasme T., Paula-Lima A.C., Hidalgo C. XII PABMB Congress. Puerto Varas, Chile 9-14/11/ 2013.
76. Calcium and R.O.S. jointly contribute to the synaptic plasticity defects induced by amyloid beta-peptide oligomers, the distinctive markers of Alzheimer's disease. Paula-Lima A.C., Hidalgo C. TWAS 24th General Meeting. Buenos Aires, Argentina. 9-14/11/2013.
77. Neuronal Communication Fails in Alzheimer's disease. Paula-Lima, A.C., San Martin, C., Adasme, T., Hidalgo C. "13rd TWAS-ROLAC Young Scientists Conference". Rio de Janeiro, Brazil. 6-8/05/2013. Invited to poster presentation.
78. ROS-dependent RyR-mediated calcium release mediates the defective synaptic plasticity and mitochondrial fragmentation produced by soluble Abeta oligomers. Paula-Lima A.C., Adasme T., SanMartin C., Härtel S., Carrasco M.A., Hidalgo C. 11th International Conference on Alzheimer's and Parkinson's diseases (AD/PD). Invited speaker. Florence, Italia. 6-10/03/ 2013.
79. R.O.S. and calcium in Alzheimer's disease. Paula-Lima, A.C. Invited Speaker in the Symposium entitled "Role of reactive oxygen species in the physiology and pathophysiology of the CNS·" in the I FALAN (Federación de Asociaciones Latinoamericanas y del Caribe de Neurociencias) Meeting. Cancún, México. 4-9/11/2012. Invited speaker.
80. Unraveling the Ca2+ signaling pathways that mediate the neuronal dysfunctions induced by amyloid-? peptide oligomers. Paula-Lima A.C., San Martin C., Baratini P., Perez-Luco T., Plaza J., Adasme T. and Hidalgo C. Invited Speaker. Minisymposium IV "Cell Physiology". XXVI Annual Meeting of the Society for Cell Biology of Chile. Puerto Varas, Chile. 23-27/10/2012. Invited speaker.
81. Synaptic plasticity induced by BDNF requires R.O.S. and RyR-mediated Ca2+ signals. Adasme T., Figueroa P., Bruna B., Paula-Lima A.C., Hidalgo C. XXVI Annual Meeting of the Society for Cell Biology of Chile. Puerto Varas, Chile. 23-27/10/2012.
82. Role of mitochondria in neuronal Ca2+ and R.O.S. signals induced by the Alzheimer's disease-associated amyloid-? peptide oligomers. SanMartín C.D., Hidalgo C., Paula-Lima A.C. XXVI Annual Meeting of the Society for Cell Biology of Chile. Puerto Varas, Chile. 23-27/10/2012.
83. The E.R. stress factor XBP1 controls secretion of amyloid-? in experimental models of Alzheimer's Disease. Cornejo V.H., Thielen P., Vidal R., Molina C., Martinez G., Paula-Lima A.C. and Hetz C. XXVI Annual Meeting of the Society for Cell Biology of Chile. Puerto Varas, Chile. 23-27/10 2012.
84. Calcium and R.O.S. jointly contribute to the synaptic plasticity defects induced by amyloid-? peptide oligomers, the distinctive markers of Alzheimer's disease. Paula-Lima A.C. and Hidalgo C. Presentación oral. XII Conferencia & XXII General Meeting of TWAS (The World Academy of Sciences), Tianjin, China, 17-22/09/2012.
85. RyR-mediated calcium signals underlie hippocampal spine remodeling, LTP induction and memory formation. Hidalgo C, Adasme T, SanMartín CD, Casas MM, Figueroa P, Molina C, Haeger P, Sánchez G, Paula-Lima AC. 12th Symposium of the European Calcium Society, Tolouse, Francia. 9-12/09/2012.
86. The antioxidant N-Acetyl-Cysteine prevents the mitochondrial fragmentation induced by soluble Amyloid-? peptide oligomers by inhibiting RyR-Mediated Ca2+ Release. Paula-Lima AC, SanMartin CD, Adasme T., Hidalgo C. 8th FENS Forum of Neurosciences. FENS 2012, Barcelona, España. 14-18/07/2012.
87. Amyloid ?-peptide oligomers stimulate RyR-mediated Ca2+ release inducing mitochondrial fragmentation in hippocampal neurons and prevent RyR-mediated dendritic spine remodeling produced by BDNF. Paula-Lima A.C., Adasme T., San Martín C., Sebollela A., Hetz C., Carrasco M.A., Ferreira S.T., Hidalgo C. Puerto Varas. Annual Meeting of the Chilean Society for Cell Biology. 6-9/11/ 2011. Invited speaker.
88. Iron and amyloid ? peptide oligomers enhance ryanodine receptor-mediated calcium release in primary hippocampal neurons, which in turn stimulates mitochondrial fission. Hidalgo C., SanMartin C., Paula-Lima A.C., Hartel S., Garcia A., Nuñez M.T. 8th IBRO Congress in Neuroscience, Florence, Italy, 14-18/07/2011.
89. A? oligomers induce glutamate release from hippocampal neurons. Brito-Moreira, J., Paula-Lima A.C., Bomfim T.R., Oliveira F.F., Sepulveda F.J., De Mello F.G., Aguayo L.G., Panizzutti R., Ferreira S.T. "23rd Biennial Joint Meeting of the International Society for Neurochemistry (ISN) and the European Society for Neurochemistry (ESN)". Athens, Greece, 28/08-09/09/2011.
90. Amyloid beta-peptide oligomers impair calcium-mediated dendritic spine remodeling. Paula-Lima A.C., Adasme T., San Martin C.D., Hidalgo C. Bayer Science & Education Foundation. Mainau Island, Germany, 26 de Junio a 01/07/ 2011. Invited speaker.
91. Amyloid beta-peptide oligomers stimulate sustained Ca2+ release mediated by ryanodine receptors in hippocampal neurons, prompting mitochondrial fragmentation and preventing BDNF-induced spine remodeling. Paula-Lima A.C., Adasme T., SanMartín C., Härtel S., Carrasco M.A. and Hidalgo C. "10th International Conference on Alzheimer and Parkinson (ADPD)", Talk. Barcelona, Spain, 9-13/03/2011. Invited speaker.
92. A? oligomers prevent Ca2+-mediated dendritic spine remodeling. Paula-Lima A.C. Symposium Mechanisms of Neuroplasticity: A view from an aged synapse. Centro Interdisciplinario de Neurociencias de Valparaíso, Valparaiso, Chile, International Brain Organization. Talk. 26/11/ 2010.
93. A? oligomers stimulate Ca2+ release from intracellular stores via ryanodine receptors (RyR) and prevent RyR-mediated dendritic spine remodeling promoted by BDNF in hippocampal neurons. Paula-Lima A.C., Adasme T., SanMartín, C., Sebollela A., Hetz C., Carrasco M.A., Ferreira S.T., Hidalgo C. 39th Society for Neuroscience Annual Meeting San Diego, E.U.A. 13-17/11/2010.
94. A? oligomers stimulate Ca2+ release from intracellular stores via ryanodine receptors (RyR) and prevent RyR-mediated dendritic spine remodeling promoted by BDNF in hippocampal neurons. Paula-Lima A.C., Adasme T., SanMartín, C., Sebollela A., Hetz., C., Carrasco M.A., Ferreira S.T., Hidalgo C. Society for Neuroscience 11th Annual Chapter Awards Reception and Social, 39nd Society for Neuroscience Annual Meeting, San Diego, California, E.U.A. 13/11/2010. Travel Award Recipients Poster Session.
95. Iron and Amyloid ? Peptide Oligomers Stimulate Mitochondrial Fission in Primary Hippocampal Neurons. SanMartín C.D., Paula-Lima A.C., Härtel S., García A., Núñez M.T., Hidalgo C. 39th Society for Neuroscience Annual Meeting, San Diego, E.U.A. 13-17/11/2010.
96. A? Oligomers Instigate the Release of excitatory amino acids from Hippocampal Neurons. Brito-Moreira, J., Paula-Lima A.C., Bomfim T.R., Oliveira F.F., Sepúlveda, F.J., De Mello, F.G., Aguayo, L.G., Panizzutti, R.A, Ferreira S.T. The Alzheimer´s Association International Conference, Hawaii, EUA. 10-15/07/ 2010.
97. Iron and Amyloid ? Peptide Oligomers Stimulate Mitochondrial Fission in Primary Hippocampal Neurons by Enhancing Ryanodine Receptor-Mediated Calcium Release. San Martín C.D., Paula-Lima A.C., Härtel, S., García, A., Núñez, M.T., Hidalgo, C. LIII Reunión Anual Sociedad de Biología de Chile. 30/09/2010.
98. A? Oligomers Instigate the Release of excitatory amino acids from Hippocampal Neurons. Brito-Moreira J., Paula-Lima A.C., Bomfim T.R., Oliveira F.F., Sepúlveda F.J., De Mello F.G., Aguayo L.G., Panizzutti R.A, Ferreira S.T. The Alzheimer´s Association International Conference, Hawaii, EUA. 10 – 15/07/2010.
99. La estimulación eléctrica de campo modula la expresión de la isoforma 2 del receptor de ryanodina (RyR2) en neuronas de hipocampo en cultivo primario. Espinoza I., Riquelme D., Adasme T., Paula-Lima A.C., Leal N., Hidalgo C., Carrasco, M.A. LII Meeting of the Chilean Society for Biology, Pucón, Chile. 17-20/11/2009.
100. Amyloid-? oligomers prevent ryanodine receptor-mediated spine morphology changes induced by the brain-derived neurotrophic factor. Adasme T., Paula-Lima A.C., Sebollela A., Fernandez P., Ferreira S.T., Carrasco M.A., Hidalgo C. LII Meeting of the Chilean Society for Biology, Pucón, Chile. 17-20/11/2009.
101. A? oligomers and fibrils increase extracellular excitatory amino acids in cultured hippocampal neurons. Brito-Moreira, J., Paula-Lima A.C., Bomfim T.R., Oliveira F.F., Sepulveda F.J., De Mello F.G., Aguayo L.G., Panizzutti R., Ferreira S.T. XXIV Annual Meeting of the Federation of Experimental Biology Societies (FESBE), Águas de Lindóia, SP, Brasil. 19-22/08/2009.
102. Iron and amyloid ? oligomers stimulate ryanodine receptor-mediated calcium release and mitochondrial fission in hippocampal neurons. SanMartín C.D., Paula-Lima A.C., Eisner V., Härtel S., García A., Muñoz P., Núñez M.T., Hidalgo C. V Annual Meeting of the Chilean Society for Neurosciences, Coquimbo, Chile. 23-25/09/2009.
103. Changes in ryanodine receptor expression and activity in hippocampal neurons exposed to BDNF or amyloid ? peptide oligomers. Paula-Lima A.C., Adasme T., Sebollela A., Humeres A., Muñoz P., Olivero P., Leal N., Ferreira S.T., Carrasco M.A., Hidalgo C. SBBq-Conesul Young Scientist Symposia during the XXXVIII Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology, Águas de Lindóia, SP, Brasil. 16-19/05 2009.
104. Changes in ryanodine receptor expression and activity in hippocampal neurons exposed to BDNF or amyloid ? peptide oligomers. Adasme T., Paula-Lima A.C., Humeres A., Muñoz P., Olivero P., Leal N., Ferreira S.T., Carrasco M.A., Hidalgo C. 37nd Society for Neuroscience Annual Meeting, Washington, DC, E.U.A. 15-19/11/2008.
105. Function and expression of ryanodine receptors in hippocampal neurons exposed to ?-amyloid peptide aggregates. Paula-Lima A.C., Adasme T., Humeres A., Sebollela A., Hetz C., Carrasco M.A., Ferreira S.T., Hidalgo C. I IBRO/LARC Neurosciences Congress for Latin America, the Caribbean and the Iberian Peninsula, Buzios, R.J., Brazil. 01-04/11/ 2008.
106. Oligomers and fibrils of the ?-amyloid peptide increase extracellular excitatory amino acids in hippocampal cultures. Brito-Moreira J., Paula-Lima, A.C., Oliveira F.F., Bomfim T.R., De Mello F.G., Panizzutti R.A., Ferreira S.T. I IBRO/LARC Neurosciences Congress for Latin America, Caribbean and the Iberian Peninsula. Buzios, Rio de Janeiro, Brazil. 01-04/11/2008.
107. Involvement and interplay of glutamate and GABAA receptors in the toxicity of the beta-amyloid peptide. Paula-Lima A.C., Brito-Moreira J., Almeida V., Panizzutti R.A., Ferreira S.T. XXII Reunión Annual de la Sociedad Chilena de Biología Celular, Pucon, Chile. 07-11/10/2007.
108. Taurine blocks the accumulation of extracellular glutamate and prevents neurotoxicity induced by ?-amyloid in hippocampal and cortical neurons. Paula-Lima A.C., Brito-Moreira J., Panizzutti R.A., De Felice F.G., de Mello F.G., Ferreira S.T. Annals of the XXI Annual Meeting of the Federation of Experimental Biology Societies, Águas de Lindóia, Sao Paulo, Brasil. 23-26/08/2006.
109. Human apolipoprotein A-I interacts with beta-amyloid (A?) and protects cortical and hippocampal neurons against A?-induced toxicity. Brito-Moreira, J., Paula-Lima, A.C., Tricerri, M.A., Ferreira, S.T. Annals of the XXI Annual Meeting of the Federation of Experimental Biology Societies, Águas de Lindóia, SP, Brazil. 23-26/08/2006.
110. Human apolipoprotein A-I interacts with beta-amyloid (A?) and protects cortical and hippocampal neurons against A?-induced toxicity. Brito-Moreira J., Paula-Lima A.C., Tricerri M.A. e Ferreira S.T. XXXV Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology, Águas de Lindóia, SP, Brazil. 01-04/07/2006.
111. The amyloid cascade and the anti-Abeta treatment Paula-Lima A.C. Round Table "New therapeutic approaches in the treatment of Alzheimer's disease". XXIII Brazilian Congress of Psychiatry, Belo Horizonte, Minas Gerais, Brazil. 03-06/10/ 2005. Invited speaker.
112. Activation of GABA A receptors by taurine and muscimol blocks the neurotoxicity of beta-amyloid in hippocampal and cortical neurons. Paula-Lima A.C., Brito-Moreira J., Panizzutti R.A., De Felice F.G., Ferreira S.T. XXXIV Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology, Águas de Lindóia, Sao Paulo, Brazil 02-05/07/2005.
113. Activation of GABA receptors prevents the neurotoxicity of beta-amyloid in rat cortical neurons. Paula-Lima A.C, Brito-Moreira J., De Felice F.G., de Mello F.G., Ferreira S.T. XXXIII Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology, Caxambú, MG, Brazil. 15-18/05/2004. Invited speaker.
114. Stability of honeycomb beta-amyloid aggregates investigated by light microscopy and light scattering in comparison with general Mie scattering theory. Holub O., Paula-Lima A.C., Ferreira S.T. XXXIII Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology, Caxambú, MG, Brazil. 15-18/05/2004.
115. Large aggregates of the amyloid-? peptide 1-42: Honeycomb formation and stability investigated by light microscopy and light scattering in comparison with general Mie scattering theory. A potential in vitro model system for amyloid plaques? Holub, O., Paula-Lima A.C., Ferreira S.T. I Latin American Protein Society (LAPS) Meeting, Angra dos Reis, Rio de Janeiro, Brazil. 8-12/11/2004.
116. Inhibitors of amyloidogenesis decrease intracellular amyloid accumulation in a cortical cell line derived from trisomy 16 mouse. Paula-Lima A.C., Arriagada C., Cardenas A.M., Toro R., Caviedes R., Caviedes P., Ferreira S.T. First Neuroscience Symposium of the International Institute for Neuroscience of Natal, Natal, RN, Brazil. 03-07/04/2004.
117. Novel anti-amyloidogenic compounds decrease the intracellular accumulation of amyloid in a cortical cell line derived from trisomy 16 mouse. Paula-Lima A.C., Arriagada C., Cardenas A.M., Toro R., Caviedes R., Caviedes P., Ferreira S.T. XXXII Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology, Caxambú, MG, Brazil. 17-20/05/ 2003.
118. Nitrophenols reduce the content of intracellular amyloid in the CTb neuronal cell line, derived from the trisomy 16 mouse. Paula-Lima A.C., Arriagada C., Cardenas A.M., Toro R., Caviedes R., Caviedes P., Ferreira S.T. 32nd Society for Neuroscience Annual Meeting, Washington, DC, E.U.A. 02-07/11/2002.
119. On the role of electrostatic interactions in beta-amyloid stability. Louzada, P.R., Paula-Lima A.C., De Felice F.G., Ferreira S.T. XXXI Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology, Caxambú, Minas Gerais, Brasil. 18-21/05/2002.
120. Taurine protects neurons in culture against beta-amyloid neurotoxicity by activation of the gabaergic transmission. Louzada, P.R., Paula-Lima A.C., Mendonça-Silva D.L., Noel F.F., de Mello F.G., Ferreira S.T. XXXI Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology, Caxambú, Minas Gerais, Brasil. 18-21/05/2002.
121. Contributions of electrostatic interactions to the stability of amyloid fibrils formed by amylin and beta-amyloid. Lopes D.H., Louzada P.R., Paula-Lima A.C., De Felice F.G., Ferreira S.T. XXX Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology, Caxambú, Minas Gerais, Brazil. 19-22/05/2001.
122. Role of glutamatergic and gabaergic transmission on beta-amyloid neurotoxicity. Possible implications for alzheimers disease therapeutics. Louzada P.R., Paula-Lima A.C., Mendonça-Silva D.L., Noel F.N., de Mello F.G., Ferreira S.T. III Reunião de Pesquisadores em Doença de Alzheimer e Desordens Relacionadas, Rio de Janeiro, Rio de Janeiro, Brasil. 24/11/2001.
123. Role of glutamatergic neurotransmission on amyloid-beta 1-42 aggregation and neurotoxicity in embryonic avian retina. Paula-Lima A.C., Louzada P.R., Mendonça-Silva D.L., Noel F.F., de Mello F.G., Ferreira S.T. XXX Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology, Caxambú, Minas Gerais, Brasil. 19-22/05/2001.
124. Inhibitors of sphingolipid biosynthesis and their effects on Trypanosoma cruzi growth in axenic culture. Paula-Lima A.C., Santiago A.P., Mendonça-Previato L., Previato J.O. Annals of the XXIX Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology -.Caxambú, Minas Gerais, Brasil. 27-30/05/2000.
125. Ether lipids X ceramides in GPI anchors of trypanosomatids: first round. Heise N., Paula-Lima A.C., Hart D.T., Mendonça-Previato L., Previato J.O., Heise N. XXVI Annual Meeting on Basic Research in Chagas'Disease, Caxambú, Minas Gerais, Brasil. 02-05/09/1999.
126. Effects of fungal sphingolipid biosynthetic pathway inhibitors over Trypanosoma cruzi in axenic culture. Paula-Lima A.C., Santiago A.P., Mendonça-Previato L., Previato J.O., Heise N. XXVI Annual Meeting on Basic Research in Chagas'Disease, Caxambú, Minas Gerais, Brasil. 02-05/09/1999.
127. Ação de antifúngicos na biossíntese de esfingolipídeos em Trypanossoma cruzi. Paula-Lima A.C., Mendonça-Previato L., Previato J.O., Heise N. Anais da V Semana de Microbiologia e Imunologia, Instituto de Microbiologia Professor Paulo de Góes, Rio de Janeiro, Rio de Janeiro, Brasil. 27/09 a 01/10/1999.
128. Partial purification of O-alfa-N-acetylglucosaminyl transferase of Trypanosoma cruzy y-strain. Dias W.B., Paula-Lima A.C., Agrellos O.A., Solla-Pena M., Heise N., Mendonça-Previato L., Previato J.O. Annals of the XXVII Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology, Caxambu, Minas Gerais, Brasil. 16-20/05/1999.

MAIN DISSEMINATION AND OTHER ACTIVITIES:

Television & Video Features
• Italian Television Feature (RaiNews) (2026): Featured in a special report regarding contributions to brain research and knowledge exchange during the TWAS workshop for young scientists. Trieste, Italy.
• "La Metro TV" (2025): Interview regarding the latest contributions to Alzheimer's research.
• MEGA News (2022): Expert commentary on the first breakthrough medications for Alzheimer's.
• Noches Nerd - TVN (2022): Episode "Nutrition and Neurodegeneration," explaining hippocampal function and memory.
• Futuro 360 - CNN Chile (2019): Special feature on the future of biochemistry and brain-computer interfaces.
• TVChile Internacional - "INNOVA" (2013): Featured segment on Alzheimer's research for the international signal.
• Conecta2 - TVN International (2013): Live interview on global Alzheimer's awareness.
• Chilevisión News (2017): Video report on BNI research led by Dr. Andrea Paula Lima and Dr. Enzo Brunetti.
• Reuters Agency (2015): International editorial video feature: "Eye Movement link to Alzheimer's disease."
Radio & Podcasts
• "Ciencia Pop" (2023): Discussion on science communication with Gabriel León.
• Radio Cooperativa Ciencia (2023): News feature on Alzheimer's research developments.
• ADN Radio - "Woman STEM" (2018): In-depth interview on the role of women in scientific leadership.
• Radio Universidad de Chile - "To Your Health" (2015): Discussing the relationship between Alzheimer's Disease and Music.
• Radio Universidad de Chile - "Mentalizados" (2015): Conversation on the brain, memory, and the cellular basis of neurodegeneration.
• "Milenio" Program (2012): Interview regarding neurobiology findings and research breakthroughs.
• Citizen Forum (2012): Radio broadcast on "Communication between neurons."

Major Press & Journal Features
• TYAN and TWAS bring global South scientists specializing in neuroscience to Trieste (2026). https://twas.org/article/tyan-and-twas-bring-global-south-scientists-specializing-neuroscience-trieste
• El Mercurio (2019): "Women are gaining ground in science and increasingly faster."
• New Woman Magazine (2018): Feature on the personal and professional story of fighting Alzheimer's.
• El Mostrador (2018): Highlighted for receiving the Adelina Gutiérrez Award of Excellence.
• Diario Financiero - Health Portfolio (2017): Using virtual reality to analyze early signs of Alzheimer's.
• La Tercera Trends (2015): "Chilean scientists detect Schizophrenia and Alzheimer by eye movements."
• El Mercurio (2013): Analysis of eye movements as a diagnostic tool for Alzheimer's.
• The Second / Terra / BioBio (2013): Extensive coverage on natural antioxidants and preventative neurobiology.

Academic Outreach & Institutional News
• V ICOD Congress (2024): Presentation on the advancement of disciplinary knowledge.
• CCEO Science Fair (2023): Keynote for dental students at the University of Chile.
• UdeC Faculty of Biological Sciences (2023): Panel on translational medicine and neurobiology.
• Chilean Society of Neurosciences (2018): Report on research to reverse cognitive deterioration.
• UFRO Portal (2016): Academic cooperation program for project formulation in teaching and research.
• Faculty of Dentistry News (2013): "The cellular search in Alzheimer's."
• University of Chile (2011): "Building the Chile of the Future" – Image of Excellence in Research.