Web_0007_pi_8.png_thumb90

José Luis Valdés Guerrero

Profesor Asociado

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


APRENDIZAJE y MEMORIA; ALERTA Y MOTIVACION; SISTEMAS NEUROMODULADORES;

Educación

  •  Ciencias Biomedicas, UNIVERSIDAD DE CHILE. Chile, 2005
  •  Biologia, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1999

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2009 - 2017

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2017 - At present

Experiencia Profesional

  •   Postdoctorado Full Time

    Pontificia UNiversidad Catolica de Chile

    Santiago, Chile

    2005 - 2006

  •   Postdoctorado Full Time

    University of Arizona

    Tucosn, Estados Unidos

    2007 - 2008

  •   Profesor Asociado Full Time

    Universidad de Chile

    Santiago, Chile

    2009 - At present

Formación de Capital Humano


Magister en Neurociencias (Universidad de Chile)
Mabel Barceló (2005); Felipe Faundez (2024); Francisca Verdugo (2024);Morin Henríquez (2024); Luis Antilao (2023); Camila Ramirez (2022); Hector Espinoza (2022); Nicole Abarca (2022); Norton Contreras (2021); Benjamin Carrasco (2020); Jessica Sanchez (2018); Rodrigo Cisneros (2017); Stephanie Cortez (2017); Javier Silva (2017); Marcos Domic (2017); Gonzalo Bustamante (2016); Mauricio Toro (2015); Jamileth More (2015); Noemí Grinspun (2013); Juan Pablo Osorio (2012).

Magister en Bioquimica (Universidad de Chile
Juan Galindo. Graduado (April del 2016).

Doctorado en Ciencias Biomédicas (Universidad de Chile)
Javier Rios (co-advisor, 2023); Miguel Concha (Co-advisor, 2019); Yerko Fuentealba (2018); Noemi Grinspun (2017); Ingrid Buller (2017).

Doctorado en Ciencias Medicas (Universidad de Chile)
NIcole Rogers Graduada (10 de enero, 2019)

Doctorado en Neurociencias (PUCCH)
Maria Alexandra Garcia (2022).

Postdoc
Marcos Contreras (2010-2012)
Margarita Borquez (2017-2018)
Alexandra Garcia (2022-2023)



 

Article (28)

Cortico-Hippocampal Oscillations Are Associated With the Developmental Onset of Hippocampal-Dependent Memory
Females of the four-eyed frog,<i> Pleurodema</i><i> thaul</i> (Anura, Leptodactylidae), respond behaviourally to conspecific male scent
Alzheimer's Disease-Like Pathology Triggered by Porphyromonas gingivalis in Wild Type Rats Is Serotype Dependent
Differential navigational strategies during spatial learning in a new modified version of the Oasis maze
Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, Neuroinflammation and Cell Death, Improving the Behavioral Outcome Following Perinatal Asphyxia
c-Fos expression in the ascending arousal system induced by physical exercise in rats: Implication for memory performance
Effort Displayed During Appetitive Phase of Feeding Behavior Requires Infralimbic Cortex Activity and Histamine H1 Receptor Signaling
Timing Is of the Essence: Improvement in Perception During Active Sensing
Calcium Release Mediated by Redox-Sensitive RyR2 Channels Has a Central Role in Hippocampal Structural Plasticity and Spatial Memory
Long-lasting, reversible and non-neurotoxic inactivation of hippocampus activity induced by neosaxitoxin
N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer's Disease Rat Model
Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats
Asynchronous ripple oscillations between left and right hippocampi during slow-wave sleep
Local Klotho enhances neuronal progenitor proliferation in the adult hippocampus
Targeting Sentinel Proteins and Extrasynaptic Glutamate Receptors=> a Therapeutic Strategy for Preventing the Effects Elicited by Perinatal Asphyxia?
Effect of perinatal asphyxia on tuberomammillary nucleus neuronal density and object recognition memory=> A possible role for histamine?
Regulation of Memory Formation by the Transcription Factor XBP1
The Histaminergic Tuberomamillary Nucleus Is Involved in Appetite for Sex, Water and Amphetamine
Lack of phonotactic preferences of female frogs and its consequences for signal evolution.
Off-Line Reactivation of Experience-Dependent Neuronal Firing Patterns in the Rat Ventral Tegmental Area.
Further Studies on the Hypothesis of PARP-1 Inhibition as a Strategy for Lessening the Long-Term Effects Produced by Perinatal Asphyxia: Effects of Nicotinamide and Theophylline on PARP-1 Activity in Brain and Peripheral Tissue
Histamine and motivation.
The histaminergic tuberomammillary nucleus is critical for motivated arousal.
The parietal association cortex of the rat.
The infralimbic cortical area commands the behavioral and vegetative arousal during appetitive behavior in the rat.
Arousal and differential Fos expression in histaminergic neurons of the ascending arousal system during a feeding-related motivated behaviour.
Differential effects of infralimbic cortical lesions on temperature and locomotor activity responses to feeding in rats.
Specific activation of histaminergic neurons during daily feeding anticipatory behavior in rats.

BookSection (1)

Molecular, cellular and behavioural effects produced by perinatal asphyxia: protection by poly(ADP-ribose) polymerase 1 (PARP-1) inhibition

Proyecto (10)

Mesenchymal stem cell-derived secretome: A multitarget intervention to reduce long-term disabilities induced by in utero opioid exposure
Apoyo a la formación de Redes Internacionales entre centros de Investigación
Mesenchymal stem cells-secretome provides protection in neonatal hypoxia-reoxygenation. Mechanisms and translational studies
Test de navegación virtual detecta de forma rápida y precisa el deterioro cognitivo inicial en personas mayores
The precise timing of motor modulations as a mechanism for active sensing in the visual system
Biomedical Neuroscience Institute
Center for Neuroscience of Memory, (CENEM),
High order perception of needs and emotions
Role of hippocampal histaminergic activity during acquisition and consolidation of memory
Defective Calcium/Redox signaling and anomalous elctrical brain activity in rats injected with amyloid beta oligomers: Functional and behavioural correlates with alzheimer's patients

Review (1)

Targeting Sentinel Proteins and Extrasynaptic Glutamate Receptors: a Therapeutic Strategy for Preventing the Effects Elicited by Perinatal Asphyxia?
28
José Valdés

Profesor Asociado

Neurociencia

UNIVERSIDAD DE CHILE

Santiago, Chile

5
Jamileth More

Investigador

Neurologia

Hospital Clinico Universidad de Chile

Santiago, Chile

4
Andrea Paula-Lima

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

3
Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

3
Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

3
Pedro Maldonado

Profesor Titular

Departamento de Neurociencias

FACULTAD DE MEDICINA. U. DE CHILE

Santiago, Chile

2
Andrea Paula-Lima

Profesora Asociada

Instituto de Investigación en Ciencias Odontológicas

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Tatiana Adasme

Coordinadora de Estudios

Oficina de Apoyo a la Investigación Clínica

Universidad Chile

Santiago, Chile

2
Andrea Tapia

Profesor adjunto

Facultad de Farmacia

Universidad de Valparaíso

valparaiso, Chile

2
Genaro Barrientos

Profesor Asistente

Fisiologia y Biofisica, ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

2
M. Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

1
Maria Riveros

Profesor asistente

Fisiología

Universidad del Desarrollo

Santiago, Chile

1
Edgardo Rojas

Académico e Investigador

Ciencias Químicas y Biológicas

Universidad Bernardo OHiggins

Santiago, Chile

1
Bruce Cassels

Profesor Titular

Departamento de Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile

1
Barbara Bruna

Postdoctoral Researcher

Hospital Clinico universidad de Chile-Universidad de Chile

Santiago, Chile

1
José Galaz

Estudiante de Posgrado

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

1
ALEXIS HUMERES

DIRECTOR

MORFOFUNCIÓN

Universidad Diego Portales

SANTIAGO, Chile

1
Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

1
Pedro Lobos

Posdoctoral Research

Universidad de Chile

Santiago, Chile

1
Mario Herrera-Marschitz

Profesor titular

Mol. & Clin. Pharmacology

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, PROGRAMA FARMACOLOGIA MOLECULAR & CLINICA, ICBM

Santiago, Chile

1
Camilo Allende

Docente

Universidad del Desarrollo

Santiago, Chile