Man

Genaro Christian Barrientos Briones

Profesor Asistente

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Role of calcium in excitable cells; Secretion mechanisms during development; PHYSIOLOGY AND ENDOCRINOLOGY; INTRACELLULAR SIGNAL TRANSDUCTION; RAPID EFFECTS OF STEROID HORMONES; Señales mediadas por calcio en musculo; Biologia celular de muscuo; Electrofisiologia de celulas musculares

Educación

  •  Bilogia Celular Molecular y Neurociencia, UNIVERSIDAD DE CHILE. Chile, 2007
  •  Bioquímico, UNIVERSIDAD DE CHILE. Chile, 2000

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2012 - At present

Experiencia Profesional

  •   Postdoctoral Scholar Full Time

    University of California, Davis

    Davis, California, Estados Unidos

    2007 - 2010

  •   Postdoctoral Scholar Full Time

    University of California, Los Angeles

    Los ANgles, California, Estados Unidos

    2010 - 2011

Formación de Capital Humano


Codirector de la Tesis de Magister Magíster en Ciencias Médicas, mención en Biología Celular y Molecular de Tatiana Guncay. Titulo de la tesis: Inhibición de los receptores de ryanodina previene los cambios presinápticos en la depresión a largo plazo. 2020. Universidad de Valparaiso, Facultad de Medicina.

Codirector de la Tesis de MAGÍSTER EN FISIOPATOLOGÍA de Javiera Andrea Aguilera Miranda. Titulo de la tesis: Caracterización del inflamasoma NLRP3 en el músculo esquelético de ratones obesos insulinoresistentes. Facultad de Medicina, Universidad de Chile.



 

Article (31)

Long-term potentiation and spatial memory training stimulate the hippocampal expression of RyR2 calcium release channels

Sanchez-Robledo, Virginia; Barrientos, Genaro; Cristina Paula-Lima, Andrea

Article ISI
FRONTIERS IN CELLULAR NEUROSCIENCE  (2023)

Activation of the NLRP3 Inflammasome Increases the IL-1β Level and Decreases GLUT4 Translocation in Skeletal Muscle during Insulin Resistance

Barrientos, Genaro; Llanos, Paola

Article Scopus, PubMed
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2021)

Classic and Novel Sex Hormone Binding Globulin Effects on the Cardiovascular System in Men

Barrientos, Genaro

Article SCOPUS
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY  (2021)

NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle

Cruz, Gonzalo; Barrientos, Genaro; Llanos, Paola

Article ISI
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2021)

Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy

Pavez, Mario; Wilson, Carlos; Ramos, Sebastian; Barrientos, Genaro; Silva, Patricio; Llanos, Paola; Westenbrink, B. Daan

Article ISI
BIOLOGICAL RESEARCH  (2021)

Androgen-Regulated Cardiac Metabolism in Aging Men

Barrientos, Genaro; Llanos, Paola

Article ISI
FRONTIERS IN ENDOCRINOLOGY  (2020)

The polyphenol ellagic acid exerts anti-inflammatory actions via disruption of store-operated calcium entry (SOCE) pathway activators and coupling mediators

Kaul S.; Zou Z.; Mathias C.B.; Bose D.D.

Article ISI SCOPUS
 (2020)

Calcium Release Mediated by Redox-Sensitive RyR2 Channels Has a Central Role in Hippocampal Structural Plasticity and Spatial Memory

More, Jamileth Y.; Lobos, Pedro E.; Galaz, José L.; Figueroa, Paula L.; Namias, Silvia

Article ISI SCOPUS
ANTIOXIDANTS & REDOX SIGNALING  (2018)

High-Fat-Diet-Induced Obesity Produces Spontaneous Ventricular Arrhythmias and Increases the Activity of Ryanodine Receptors in Mice

Said, M; Bull, R

Article ISI SCOPUS
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2018)

Mechanical stretch increases L-type calcium channel stability in cardiomyocytes through a polycystin-1/AKT-dependent mechanism

Cordova-Casanova, A; Olmedo, I; Riquelme, JA; Barrientos, G; Gillette, TG; Pedrozo, Z

Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH  (2018)

Role of ABCA1 on membrane cholesterol content, insulin-dependent Akt phosphorylation and glucose uptake in adult skeletal muscle fibers from mice

Diaz-Vega A.; Quinteros-Waltemath O.

Article ISI SCOPUS
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids  (2018)

Ryanodine receptor-mediated calcium release has a key role in hippocampal LTD induction

Barrientos G.C.

Article ISI SCOPUS
Frontiers in Cellular Neuroscience  (2018)

Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats

Arias-Cavieres, Alejandra; Miguel Vicente, Jose; Adasme ,Tatiana; Hidalgo, Jorge; Humeres, Alexis; Valdes-Undurraga, Ismael; Barrientos, Genaro

Article ISI SCOPUS
FRONTIERS IN MOLECULAR NEUROSCIENCE  (2018)

Ca2+/Calmodulin-Dependent Protein Kinase II and Androgen Signaling Pathways Modulate MEF2 Activity in Testosterone-Induced Cardiac Myocyte Hypertrophy

Troncoso, MF

Article ISI SCOPUS
FRONTIERS IN PHARMACOLOGY  (2017)

Membrane Cholesterol in Skeletal Muscle=> A Novel Player in Excitation-Contraction Coupling and Insulin Resistance.

Barrientos, G; Sánchez-Aguilera, P; Jaimovich, E; Hidalgo, C; Llanos, P

Article
Journal of Diabetes Research  (2017)

GSK-3β/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy.

Duran, J; Oyarce, C; Pavez, M; Valladares, D; Basualto-Alarcon, C; Lagos, D; Barrientos, G; Troncoso, M; Ibarra, C; Estrada, M

Article
PLoS One  (2016)

GSK-3β/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy.

Duran J, Oyarce C; Pavez M, Valladares D; Basualto-Alarcon C, Lagos D; Barrientos G, Troncoso MF; Ibarra C, Estrada M.

Article
PLOS ONE  (2016)

Cholesterol removal from adult skeletal muscle impairs excitation-contraction coupling and aging reduces caveolin-3 and alters the expression of other triadic proteins

Barrientos, G; Llanos P.; Hidalgo J.; Bolanos, P; Caputo, C; Riquelme, A.; Sánchez, G; Quest, AFG; Hidalgo, C

Article ISI SCOPUS
FRONTIERS IN PHYSIOLOGY  (2015)

Glucose-Dependent Insulin Secretion in Pancreatic beta-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors

Llanos P.; Contreras-Ferrat, A; Barrientos, G; Valencia M; Mears, D; Hidalgo, C

Article ISI SCOPUS
PLOS ONE  (2015)

Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscle.

Barrientos, GC; Feng, W; Truong, K; Matthaei, KI; Yang, TZ; Allen, PD; Lopez, JR; Pessah, IN

Article
JOURNAL OF BIOLOGICAL CHEMISTRY  (2012)

Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscle.

Barrientos, Genaro C; Feng, Wei; Truong, Kim; Matthaei, Klaus I; Yang, Tianzhong; Allen, Paul D; Lopez, José R; Pessah, Isaac N

Article
The Journal of biological chemistry  (2012)

Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle.

Cherednichenko, G; Zhang, R.; Bannister, RA; Timofeyev, V; Li N., Fritsch; EB, Feng; W, Barrientos; GC, Schebb; NH, Hammock; BD, Beam; KG, Chiamvimonvat; N, Pessah

Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-PHYSICAL SCIENCES  (2012)

Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle.

Cherednichenko, Gennady; Zhang, Rui; Bannister, Roger A; Timofeyev, Valeriy; Li, Ning; Fritsch, Erika B; Feng, Wei; Barrientos, Genaro C; Schebb, Nils H; Hammock, Bruce D; Beam, Kurt G; Chiamvimonvat, Nipavan; Pessah, Isaac N

Article
Proceedings of the National Academy of Sciences of the United States of America  (2012)

Basal Bioenergetic Abnormalities in Skeletal Muscle from Ryanodine Receptor Malignant Hyperthermia-susceptible R163C Knock-in Mice

Giulivi, C; Ross-Inta, C; Omanska-Klusek, A; Napoli, E; Sakaguchi, D; Barrientos, G; Allen, PD; Pessah, IN

Article ISI
JOURNAL OF BIOLOGICAL CHEMISTRY  (2011)

Functional and Biochemical Properties of Ryanodine Receptor Type 1 Channels from Heterozygous R163C Malignant Hyperthermia-Susceptible Mice

Feng, W; Barrientos, GC; Cherednichenko, G; Yang, TZ; Padilla, IT; Truong, K; Allen, PD; Lopez, JR; Pessah, IN

Article
Molecular Pharmacology  (2011)

Functional and biochemical properties of ryanodine receptor type 1 channels from heterozygous R163C malignant hyperthermia-susceptible mice.

Feng, Wei*; Barrientos*, Genaro C; Cherednichenko, Gennady; Yang, Tianzhong; Padilla, Isela T; Truong, Kim; Allen, Paul D; Lopez, José R; Pessah, Isaac N; * W.F. and G.C.B. contributed equally to this work.

Article
Molecular pharmacology  (2011)

The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels.

Barrientos, Genaro; Bose, Diptiman D; Feng, Wei; Padilla, Isela; Pessah, Isaac N

Article
Molecular pharmacology  (2009)

A transverse tubule NADPH oxidase activity stimulates calcium release from isolated triads via ryanodine receptor type 1 S-glutathionylation

Hidalgo, C; Sánchez, G; Barrientos, G; Aracena-Parks, P

Article ISI SCOPUS
JOURNAL OF BIOLOGICAL CHEMISTRY  (2006)

Fast kinetics of calcium dissociation from calsequestrin

Beltran M.; Barrientos, G; Hidalgo, C

Article ISI SCIELO SCOPUS
BIOLOGICAL RESEARCH  (2006)

TNP-8N(3)-ADP photoinactivation of the phosphatase activity of FITC-modified SERCA

Barrientos, G; Taylor M.; Hidalgo, C

Article ISI
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES  (2003)

Annexin VI is attached to transverse-tubule membranes in isolated skeletal muscle triads

Barrientos, G; Hidalgo, C

Article ISI SCOPUS
JOURNAL OF MEMBRANE BIOLOGY  (2002)

Abstract (3)

Role of RyR2-mediated calcium release in synaptic plasticity, learning and memory in control and AD-model rats

Hidalgo, C; More, J.; Valdes, I; SanMartin, C.; Muñoz, P; Barrientos, G; Valdés, JL; Sánchez, G; Paula Lima A.

Abstract ISI
JOURNAL OF NEUROCHEMISTRY  (2015)

TNP-8N(3)-ADP photoinactivation and labelling of sarcoplasmic reticulum of skeletal muscle

Barrientos, G; Tahir, MW; Hidalgo, C

Abstract ISI
BIOPHYSICAL JOURNAL  (2007)

Do adult skeletal muscle traverse tubules contain caveola?

Barrientos, G; Quest, A.

Abstract ISI
JOURNAL OF GENERAL PHYSIOLOGY  (2004)

Proyecto (9)

The NLRP3 Inflammasome in skeletal muscle: a novel link between cholesterol accumulation and the defective insulin-mediated glucose transport in insulin resistance

Paola Llanos; Barriento, G.

Proyecto
 (2019)

Hippocampal Ryanodine Receptors-Calcium Release Channels Mediate Activity-Generated Postsynaptic Calcium Signals and their Propagation to the Nucleus

Adasme, T.

Proyecto
 (2017)

Hippocampal Ryanodine Receptors-Calcium Release Channels Mediate Activity-Generated Postsynaptic Calcium Signals and their Propagation to the Nucleus

FONDECYT (1170053)

Proyecto
2017-2020
Coinvestigador(a)

Red internacional para el estudio del transporte de glucosa y la exitabilidad celular del músculo esquelético en obesidad



Proyecto
 (2017)

ROLE OF RYANODINE RECEPTORS IN THE DEVELOPMENT OF CARDIAC HYPERTROPHY INDUCED BY A HIGH FAT DIET IN MICE

FONDECYT (1160704)

Proyecto
2016-2019
Coinvestigador(a)

Role of Ryanodine receptors in the development of cardiac hypertrophy induced by a high fat diet in mice

FONDECYT (1160704)

Proyecto
2016-2018
Coinvestigador(a)

Role of ryanodine receptors in the development on cardiac hypertrophy induced by a high fat diet in mice



Proyecto
 (2016)

PARTICIPATION OF CALCIUM- AND REDOX-INDUCED RYANODINE RECEPTOR-MEDIATED CALCIUM RELEASE IN SUSTAINED HIPPOCAMPAL LTP

FONDECYT (1100052)

Proyecto
2010-2014
Personal técnico y/o de apoyo

ACTIVACION Y REGULACION DE LOS CANALES DE LIBERACION DE CALCIO-RECEPTORES DE RYANODINA DE MUSCULO Y NEURONAS

FONDECYT (8980009)

Proyecto
1998-2002
Personal técnico y/o de apoyo

3
Manuel Estrada

/Associate Professor / PI

Physiology and Biophysics

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS (ICBM), PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA

Santiago, Chile

1
SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

9
Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

1
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

3
Tatiana Adasme

Coordinadora de Estudios

Oficina de Apoyo a la Investigación Clínica

Universidad Chile

Santiago, Chile

7
Paola Llanos

Profesor Asistente

Instituto de Investigacion en Ciencias Biomédicas

FACULTAD DE ODONTOLOGIA. UNIVERSIDAD DE CHILE

Santiago, Chile

2
José Valdés

Profesor Asociado

Neurociencia

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Andrea Paula-Lima

Profesora Asociada

Instituto de Investigación en Ciencias Odontológicas

UNIVERSIDAD DE CHILE

Santiago, Chile

28
Genaro Barrientos

Profesor Asistente

Fisiologia y Biofisica, ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Pablo Muñoz

Profesor titular

Patología y Fisiología

UNIVERSIDAD DE VALPARAÍSO

Valparaiso, Chile

2
Jaime Riquelme

Assistant Professor

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

2
Paulina Donoso

Full Professor

Physiology and Biophysics

UNIVERSIDAD DE CHILE

Santiago, Chile

8
M. Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

1
Andrea Paula-Lima

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

1
Patricio Silva

Investigador Principal FONDEF

Departamento de Biología Celular y Molecular

Universidad de Chile

Santiago, Chile

2
Zully Pedrozo

Associated Professor

Physiology and Biophysical

Universidad de Chile

SANTIAGO DE CHILE, Chile

3
Jamileth More

Investigador

Neurologia

Hospital Clinico Universidad de Chile

Santiago, Chile

3
Carla Basualto

Académico, Profesor Asociado

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

1
José Galaz

Estudiante de Posgrado

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

1
Barbara Bruna

Postdoctoral Researcher

Hospital Clinico universidad de Chile-Universidad de Chile

Santiago, Chile

1
ALEXIS HUMERES

DIRECTOR

MORFOFUNCIÓN

Universidad Diego Portales

SANTIAGO, Chile

1
Javier Russell

Académico Investigador

Kinesiología

Universidad Santo Tomás

Santiago, Chile

1
Pedro Lobos

Posdoctoral Research

Universidad de Chile

Santiago, Chile

2
Mayarling Troncoso

Académico Asistente

Tecnología Médica

Universidad de Chile

Santiago, Chile