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Genaro Christian Barrientos Briones

Profesor Asistente

UNIVERSIDAD DE CHILE

Santiago, Chile

Role of calcium in excitable cells; Secretion mechanisms during development; PHYSIOLOGY AND ENDOCRINOLOGY; INTRACELLULAR SIGNAL TRANSDUCTION; RAPID EFFECTS OF STEROID HORMONES; SeÃ±ales mediadas por calcio en musculo; Biologia celular de muscuo; Electrofisiologia de celulas musculares

Bilogia Celular Molecular y Neurociencia, UNIVERSIDAD DE CHILE. Chile, 2007
Bioquímico, UNIVERSIDAD DE CHILE. Chile, 2000

Profesor Asistente Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2012 - At present

Postdoctoral Scholar Full Time

University of California, Davis

Davis, California, Estados Unidos

2007 - 2010
Postdoctoral Scholar Full Time

University of California, Los Angeles

Los ANgles, California, Estados Unidos

2010 - 2011

Codirector de la Tesis de Magister Magíster en Ciencias Médicas, mención en Biología Celular y Molecular de Tatiana Guncay. Titulo de la tesis: Inhibición de los receptores de ryanodina previene los cambios presinápticos en la depresión a largo plazo. 2020. Universidad de Valparaiso, Facultad de Medicina.

Codirector de la Tesis de MAGÍSTER EN FISIOPATOLOGÍA de Javiera Andrea Aguilera Miranda. Titulo de la tesis: Caracterización del inflamasoma NLRP3 en el músculo esquelético de ratones obesos insulinoresistentes. Facultad de Medicina, Universidad de Chile.


Long-term potentiation and spatial memory training stimulate the hippocampal expression of RyR2 calcium release channels Valdes-Undurraga, Ismael; Lobos, Pedro; Sanchez-Robledo, Virginia; Arias-Cavieres, Alejandra; SanMartin, Carol D.; Barrientos, Genaro; More, Jamileth; Munoz, Pablo; Cristina Paula-Lima, Andrea; Hidalgo, Cecilia; Adasme, Tatiana Article ISI FRONTIERS IN CELLULAR NEUROSCIENCE (2023)
Activation of the NLRP3 Inflammasome Increases the IL-1β Level and Decreases GLUT4 Translocation in Skeletal Muscle during Insulin Resistance Américo-Da-Silva, Luan; Aguilera, Javiera; Quinteros-Waltemath, O.; Sanchez-Aguilera, Pablo; Russell, Javier; Cadagan, Cynthia; Meneses-Valdes, R; SÁnchez, Gina Luisa; Estrada, Manuel; Jorquera, G; Barrientos, Genaro; Llanos, Paola Article Scopus, PubMed INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Classic and Novel Sex Hormone Binding Globulin Effects on the Cardiovascular System in Men Basualto-Alarcón, Carla; Llanos Vidal, Paola; Garcia-Rivas, Gerardo; Troncoso, Mayarling Francisca; Lagos, Daniel; Barrientos, Genaro; Estrada, Manuel Article SCOPUS INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2021)
NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle Jorquera, Gonzalo; Russell, Javier; Monsalves-Alvarez, Matias; Cruz, Gonzalo; Valladares-Ide, Denisse; Basualto-Alarcon, Carla; Barrientos, Genaro; Estrada, Manuel; Llanos, Paola Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy Troncoso, Mayarling Francisca; Pavez, Mario; Wilson, Carlos; Lagos, Daniel; Duran, Javier; Ramos, Sebastian; Barrientos, Genaro; Silva, Patricio; Llanos, Paola; Basualto-Alarcon, Carla; Westenbrink, B. Daan; Lavandero, Sergio; Estrada, Manuel Article ISI BIOLOGICAL RESEARCH (2021)
Androgen-Regulated Cardiac Metabolism in Aging Men Barrientos, Genaro; Llanos, Paola; Basualto-Alarcon, Carla; Estrada, Manuel Article ISI FRONTIERS IN ENDOCRINOLOGY (2020)
The polyphenol ellagic acid exerts anti-inflammatory actions via disruption of store-operated calcium entry (SOCE) pathway activators and coupling mediators Murphy M.T.; Qin X.; Kaul S.; Barrientos G.; Zou Z.; Mathias C.B.; Thomas D.; Bose D.D. Article ISI SCOPUS (2020)
Calcium Release Mediated by Redox-Sensitive RyR2 Channels Has a Central Role in Hippocampal Structural Plasticity and Spatial Memory More, Jamileth Y.; Bruna, Barbara A.; Lobos, Pedro E.; Galaz, José L.; Figueroa, Paula L.; Namias, Silvia; Sánchez, Gina L.; Barrientos, Genaro C.; Valdés, José L.; Paula-Lima, Andrea C.; Hidalgo, Cecilia; Adasme, Tatiana Article ISI SCOPUS ANTIOXIDANTS & REDOX SIGNALING (2018)
High-Fat-Diet-Induced Obesity Produces Spontaneous Ventricular Arrhythmias and Increases the Activity of Ryanodine Receptors in Mice Sanchez, G; Araneda, F; Pena, JP; Finkelstein, JP; Riquelme, JA; Montecinos, L; Barrientos, G; Llanos, P; Pedrozo, Z; Said, M; Bull, R; Donoso, P Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Mechanical stretch increases L-type calcium channel stability in cardiomyocytes through a polycystin-1/AKT-dependent mechanism Cordova-Casanova, A; Olmedo, I; Riquelme, JA; Barrientos, G; Sanchez, G; Gillette, TG; Lavandero, S; Chiong, M; Donoso, P; pedrozo, Z Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2018)
Role of ABCA1 on membrane cholesterol content, insulin-dependent Akt phosphorylation and glucose uptake in adult skeletal muscle fibers from mice SÃ¡nchez-Aguilera P.; Diaz-Vega A.; Campos C.; Quinteros-Waltemath O.; Cerda-Kohler H.; Barrientos G.; Contreras-Ferrat A.; Llanos P. Article ISI SCOPUS Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (2018)
Ryanodine receptor-mediated calcium release has a key role in hippocampal LTD induction Arias-Cavieres A.; Barrientos G.C.; SÃ¡nchez G.; Elgueta C.; MuÃ±oz P.; Hidalgo C. Article ISI SCOPUS Frontiers in Cellular Neuroscience (2018)
Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats Arias-Cavieres, Alejandra; More, Jamileth; Miguel Vicente, Jose; Adasme ,Tatiana; Hidalgo, Jorge; Luis Valdes, Jose; Humeres, Alexis; Valdes-Undurraga, Ismael; Sanchez, Gina; Hidalgo, Cecilia; Barrientos, Genaro Article ISI SCOPUS FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)
Ca2+/Calmodulin-Dependent Protein Kinase II and Androgen Signaling Pathways Modulate MEF2 Activity in Testosterone-Induced Cardiac Myocyte Hypertrophy Duran J.; Lagos D.; Pavez M.; Troncoso M.F.; Ramos S.; Barrientos G.; Ibarra C.; Lavandero S.; Estrada M. Article ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2017)
Membrane Cholesterol in Skeletal Muscle=> A Novel Player in Excitation-Contraction Coupling and Insulin Resistance. Barrientos, G; Sánchez-Aguilera, P; Jaimovich, E; Hidalgo, C; Llanos, P Article Journal of Diabetes Research (2017)
GSK-3β/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy. Duran, J; Oyarce, C; Pavez, M; Valladares, D; Basualto-Alarcon, C; Lagos, D; Barrientos, G; Troncoso, M; Ibarra, C; Estrada, M Article PLoS One (2016)
GSK-3β/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy. Duran J, Oyarce C; Pavez M, Valladares D; Basualto-Alarcon C, Lagos D; Barrientos G, Troncoso MF; Ibarra C, Estrada M. Article PLOS ONE (2016)
Cholesterol removal from adult skeletal muscle impairs excitation-contraction coupling and aging reduces caveolin-3 and alters the expression of other triadic proteins Barrientos, G; Llanos P.; Hidalgo J.; Bolanos, P; Caputo, C.; Riquelme A.; Sánchez G; Quest, AFG; Hidalgo C. Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2015)
Glucose-Dependent Insulin Secretion in Pancreatic beta-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors Llanos P.; Contreras-Ferrat, A; Barrientos, G; Valencia, M; Mears, D; Hidalgo C. Article ISI SCOPUS PLOS ONE (2015)
Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscle. Barrientos, GC; Feng, W; Truong, K; Matthaei, KI; Yang, TZ; Allen, PD; Lopez, JR; Pessah, IN Article JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscle. Barrientos, Genaro C; Feng, Wei; Truong, Kim; Matthaei, Klaus I; Yang, Tianzhong; Allen, Paul D; Lopez, José R; Pessah, Isaac N Article The Journal of biological chemistry (2012)
Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Cherednichenko, G; Zhang, R.; Bannister, RA; Timofeyev, V; Li N., Fritsch; EB, Feng; W, Barrientos; GC, Schebb; NH, Hammock; BD, Beam; KG, Chiamvimonvat; N, Pessah Article PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-PHYSICAL SCIENCES (2012)
Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Cherednichenko, Gennady; Zhang, Rui; Bannister, Roger A; Timofeyev, Valeriy; Li, Ning; Fritsch, Erika B; Feng, Wei; Barrientos, Genaro C; Schebb, Nils H; Hammock, Bruce D; Beam, Kurt G; Chiamvimonvat, Nipavan; Pessah, Isaac N Article Proceedings of the National Academy of Sciences of the United States of America (2012)
Basal Bioenergetic Abnormalities in Skeletal Muscle from Ryanodine Receptor Malignant Hyperthermia-susceptible R163C Knock-in Mice Giulivi, C; Ross-Inta, C; Omanska-Klusek, A; Napoli, E; Sakaguchi, D; Barrientos, G; Allen, PD; Pessah, IN Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Functional and Biochemical Properties of Ryanodine Receptor Type 1 Channels from Heterozygous R163C Malignant Hyperthermia-Susceptible Mice Feng, W; Barrientos, GC; Cherednichenko, G; Yang, TZ; Padilla, IT; Truong, K; Allen, PD; Lopez, JR; Pessah, IN Article Molecular Pharmacology (2011)
Functional and biochemical properties of ryanodine receptor type 1 channels from heterozygous R163C malignant hyperthermia-susceptible mice. Feng, Wei; Barrientos, Genaro C; Cherednichenko, Gennady; Yang, Tianzhong; Padilla, Isela T; Truong, Kim; Allen, Paul D; Lopez, José R; Pessah, Isaac N; * W.F. and G.C.B. contributed equally to this work. Article Molecular pharmacology (2011)
The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels. Barrientos, Genaro; Bose, Diptiman D; Feng, Wei; Padilla, Isela; Pessah, Isaac N Article Molecular pharmacology (2009)
A transverse tubule NADPH oxidase activity stimulates calcium release from isolated triads via ryanodine receptor type 1 S-glutathionylation Hidalgo C.; Sánchez G; Barrientos, G; Aracena-Parks, P Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Fast kinetics of calcium dissociation from calsequestrin Beltran M.; Barrientos, G; Hidalgo C. Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2006)
TNP-8N(3)-ADP photoinactivation of the phosphatase activity of FITC-modified SERCA Barrientos, G; Taylor M.; Hidalgo C.; Cavieres, JD Article ISI ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2003)
Annexin VI is attached to transverse-tubule membranes in isolated skeletal muscle triads Barrientos, G; Hidalgo C. Article ISI SCOPUS JOURNAL OF MEMBRANE BIOLOGY (2002)


Role of RyR2-mediated calcium release in synaptic plasticity, learning and memory in control and AD-model rats Hidalgo C.; More, J.; Valdes, I; SanMartin, C.; Muñoz P; Barrientos, G; Valdes, JL; Sánchez G; Paula Lima A. Abstract ISI JOURNAL OF NEUROCHEMISTRY (2015)
TNP-8N(3)-ADP photoinactivation and labelling of sarcoplasmic reticulum of skeletal muscle Barrientos, G; Tahir, MW; Hidalgo C.; Cavieres, JD Abstract ISI BIOPHYSICAL JOURNAL (2007)
Do adult skeletal muscle traverse tubules contain caveola? Barrientos, G; Quest, A Abstract ISI JOURNAL OF GENERAL PHYSIOLOGY (2004)


The NLRP3 Inflammasome in skeletal muscle: a novel link between cholesterol accumulation and the defective insulin-mediated glucose transport in insulin resistance Paola Llanos; Barriento, G.; Jorquera, G.; Tapia, M.; Estrada, M.; Buvinic, S. Proyecto (2019)
Hippocampal Ryanodine Receptors-Calcium Release Channels Mediate Activity-Generated Postsynaptic Calcium Signals and their Propagation to the Nucleus Hidalgo C.; Barrientos, G.; Sanchez, G.; Hidalgo, J.; Muñoz, P.; Adasme, T. Proyecto (2017)
Hippocampal Ryanodine Receptors-Calcium Release Channels Mediate Activity-Generated Postsynaptic Calcium Signals and their Propagation to the Nucleus FONDECYT (1170053) Proyecto 2017-2020 Coinvestigador(a)
Red internacional para el estudio del transporte de glucosa y la exitabilidad celular del músculo esquelético en obesidad Llanos, P; Barrientos, G. Proyecto (2017)
ROLE OF RYANODINE RECEPTORS IN THE DEVELOPMENT OF CARDIAC HYPERTROPHY INDUCED BY A HIGH FAT DIET IN MICE FONDECYT (1160704) Proyecto 2016-2019 Coinvestigador(a)
Role of Ryanodine receptors in the development of cardiac hypertrophy induced by a high fat diet in mice FONDECYT (1160704) Proyecto 2016-2018 Coinvestigador(a)
Role of ryanodine receptors in the development on cardiac hypertrophy induced by a high fat diet in mice Donoso, P; Barrientos, G.; Sanchez, G.; Bull, R; Pedrozo, Z. Proyecto (2016)
PARTICIPATION OF CALCIUM- AND REDOX-INDUCED RYANODINE RECEPTOR-MEDIATED CALCIUM RELEASE IN SUSTAINED HIPPOCAMPAL LTP FONDECYT (1100052) Proyecto 2010-2014 Personal técnico y/o de apoyo
ACTIVACION Y REGULACION DE LOS CANALES DE LIBERACION DE CALCIO-RECEPTORES DE RYANODINA DE MUSCULO Y NEURONAS FONDECYT (8980009) Proyecto 1998-2002 Personal técnico y/o de apoyo