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Paulina Donoso Laurent

Full Professor

UNIVERSIDAD DE CHILE

Santiago, Chile

Cardiovascular physiology, cell calcium regulation, cardiac regulatory mechanism of hypertrophy, redox regulation

Physiology, FACULTAD DE MEDICINA. Chile, 1988
Biochemist, UNIVERSIDAD DE CHILE. Chile, 1974

Full Professor Full Time

UNIVERSIDAD DE CHILE

Medicine

Santiago, Chile

1974 - At present

Full professor Full Time

Facultad de Medicina. Universidad de Chile

Santiago, Chile

1974 - At present

2018 Isidora Mujica. Master thesis supervisor: "Efecto de la obesidad producida por una dieta alta en grasa sobre el balance redox celular"

2017 Felipe Araneda Rios. Master thesis supervisor: "Arritmogénesis en ratones alimentados con dieta rica en ácidos grasos saturados"

2016 Pablo Romero Romano. Master thesis supervisor: "Rol de la policistina I en el daño inducido por Isquemia y reperfusión en el corazón"

2016 Yildy Priscilla Utreras Mendoza. PhD thesis supervisor: " Identificación de la vía de señalización asociada al desarrollo de hipertrofia cardiaca en ratones C57BL/6J alimentados con dieta alta en grasa "

2014 Javier Pezoa Muñoz. Master thesis supervisor: "Degradación de RyR2 en corazones de rata sometidos a isquemia-reperfusión: rol de las calpaínas y el proteasoma"


Inhibition of chymotrypsin-like activity of the proteasome by ixazomib prevents mitochondrial dysfunction during myocardial ischemia Sanchez, Gina; Chalmers, Stefanie; Ahumada, Xavier; Montecinos, Luis; Olmedo, Ivonne; Eisner, Veronica; Riveros, Ana; Kogan, Marcelo J.; Lavandero, Sergio; Pedrozo, Zully; Donoso, Paulina Article ISI PLOS ONE (2020)
Inhibition of the proteasome preserves Mitofusin-2 and mitochondrial integrity, protecting cardiomyocytes during ischemia-reperfusion injury Olmedo I.; Pino G.; Riquelme, J. A.; Aranguiz P.; DÃaz M.C.; LÃ³pez-Crisosto C.; Lavandero S.; Donoso P.; Pedrozo Z.; SÃ¡nchez G. Article ISI SCOPUS Biochimica et Biophysica Acta - Molecular Basis of Disease (2020)
High-Fat-Diet-Induced Obesity Produces Spontaneous Ventricular Arrhythmias and Increases the Activity of Ryanodine Receptors in Mice Sanchez, G; Araneda, F; Pena, JP; Finkelstein, JP; Riquelme, JA; Montecinos, L; Barrientos, G; Llanos, P; Pedrozo, Z; Said, M; Bull, R; Donoso, P Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Mechanical stretch increases L-type calcium channel stability in cardiomyocytes through a polycystin-1/AKT-dependent mechanism Cordova-Casanova, A; Olmedo, I; Riquelme, JA; Barrientos, G; Sanchez, G; Gillette, TG; Lavandero, S; Chiong, M; Donoso, P; pedrozo, Z Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2018)
Activation of Chymotrypsin-Like Activity of the Proteasome during Ischemia Induces Myocardial Dysfunction and Death Sanchez, Gina; Berrios, Daniela; Olmedo, Ivonne; Pezoa, Javier=> Riquelme; Jaime, Montecinos; L, Pedrozo; Zully, Donoso Article PLoS One (2016)
Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart Becerra, R; Roman, B; Di Carlo, MN; Mariangelo, JI; Salas, M; Sánchez, G; donoso, P; Schinella, GR; Vittone, L; Wehrens, XH; Mundina-Weilenmann, C; Said, M Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2016)
Exercise Preconditioning of Myocardial Infarct Size in Dogs Is Triggered by Calcium Parra, VM; Macho P; Sánchez G; Donoso P.; Domenech RJ Article ISI SCOPUS Journal of Cardiovascular Pharmacology (2015)
Stimulation of NOX2 in isolated hearts reversibly sensitizes RYR2 channels to activation by cytoplasmic calcium Donoso, Paulina; Finkelstein, Jose Pablo; Montecinos, Luis; Said, Matilde; Sánchez, Gina; Vittone, Leticia; Bull, Ricardo Article JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2014)


Posttranslational modifications of cardiac ryanodine receptors/calcium release channels by reactive oxygen species and reactive nitrogen species Donoso P.; Hidalgo C.; Sánchez G BookWhole SCOPUS Systems Biology of Free Radicals and Antioxidants (2014)


The role of Polycystin-1 in the development of heart failure. T-tubule system regulation and c-MyC dependent BIN-1 expression Pedrozo, Zully; Donoso, Paulina; Sanchez, Gina Proyecto (2018)
. Role of ryanodine receptors in the development of cardiac hypertrophy induced by a high fat diet in mice Donoso, Paulina; Sanchez, Gina; Bull, Ricardo; Pedrozo, Zully; Barrientos, Genaro Proyecto (2016)
Effect of proteasome inhibition on the content of mitofusins 1 and 2 and the preservation of mitochondrial function following cardiac ischemia-reperfusion Sanchez, Gina; Donoso, Paulina Proyecto (2013)
Dynamic changes of cardiac ryanodine receptors during ischemia reperfusion and its relevance to the design of cardioprotective measures Donoso, Paulina; Sánchez Vergara, Gina Proyecto (2011)