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Paulina Donoso Laurent

Full Professor

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Cardiovascular physiology, cell calcium regulation, cardiac regulatory mechanism of hypertrophy, redox regulation

Educación

  •  Physiology, FACULTAD DE MEDICINA. Chile, 1988
  •  Biochemist, UNIVERSIDAD DE CHILE. Chile, 1974

Experiencia Académica

  •   Full Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    1974 - At present

Experiencia Profesional

  •   Full professor Full Time

    Facultad de Medicina. Universidad de Chile

    Santiago, Chile

    1974 - At present

Formación de Capital Humano


2018 Isidora Mujica. Master thesis supervisor: "Efecto de la obesidad producida por una dieta alta en grasa sobre el balance redox celular"

2017 Felipe Araneda Rios. Master thesis supervisor: "Arritmogénesis en ratones alimentados con dieta rica en ácidos grasos saturados"

2016 Pablo Romero Romano. Master thesis supervisor: "Rol de la policistina I en el daño inducido por Isquemia y reperfusión en el corazón"

2016 Yildy Priscilla Utreras Mendoza. PhD thesis supervisor: " Identificación de la vía de señalización asociada al desarrollo de hipertrofia cardiaca en ratones C57BL/6J alimentados con dieta alta en grasa "

2014 Javier Pezoa Muñoz. Master thesis supervisor: "Degradación de RyR2 en corazones de rata sometidos a isquemia-reperfusión: rol de las calpaínas y el proteasoma"



 

Article (8)

Inhibition of chymotrypsin-like activity of the proteasome by ixazomib prevents mitochondrial dysfunction during myocardial ischemia
Inhibition of the proteasome preserves Mitofusin-2 and mitochondrial integrity, protecting cardiomyocytes during ischemia-reperfusion injury
High-Fat-Diet-Induced Obesity Produces Spontaneous Ventricular Arrhythmias and Increases the Activity of Ryanodine Receptors in Mice
Mechanical stretch increases L-type calcium channel stability in cardiomyocytes through a polycystin-1/AKT-dependent mechanism
Activation of Chymotrypsin-Like Activity of the Proteasome during Ischemia Induces Myocardial Dysfunction and Death
Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart
Exercise Preconditioning of Myocardial Infarct Size in Dogs Is Triggered by Calcium
Stimulation of NOX2 in isolated hearts reversibly sensitizes RYR2 channels to activation by cytoplasmic calcium

BookWhole (1)

Posttranslational modifications of cardiac ryanodine receptors/calcium release channels by reactive oxygen species and reactive nitrogen species

Proyecto (4)

The role of Polycystin-1 in the development of heart failure. T-tubule system regulation and c-MyC dependent BIN-1 expression
. Role of ryanodine receptors in the development of cardiac hypertrophy induced by a high fat diet in mice
Effect of proteasome inhibition on the content of mitofusins 1 and 2 and the preservation of mitochondrial function following cardiac ischemia-reperfusion
Dynamic changes of cardiac ryanodine receptors during ischemia reperfusion and its relevance to the design of cardioprotective measures
11
Paulina Donoso

Full Professor

Physiology and Biophysics

UNIVERSIDAD DE CHILE

Santiago, Chile

7
Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

4
Zully Pedrozo

Associated Professor

Physiology and Biophysical

Universidad de Chile

SANTIAGO DE CHILE, Chile

3
Jaime Riquelme

Assistant Professor

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

2
Ivonne Olmedo

Assistant Profesor

Programa de Fisiopatología

Universidad de Chile

Santiago, Chile

2
SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

2
Genaro Barrientos

Profesor Asistente

Fisiologia y Biofisica, ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Victor Parra

Médico titular

ICBM, Facultad de Medicina

Instituto Nacional del Tórax y Universidad de Chile

Santiago, Chile

1
Paola Llanos

Profesor Asistente

Instituto de Investigacion en Ciencias Biomédicas

FACULTAD DE ODONTOLOGIA. UNIVERSIDAD DE CHILE

Santiago, Chile

1
Veronica Eisner

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
M. Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

1
Pablo Aránguiz

Jefe de Carrera

Escuela de Ciencias de la Salud

Universidad Vina del Mar

Viña del Mar, Chile