Man

Ivonne Odette Olmedo Alegria

Assistant Profesor

Universidad de Chile

Santiago, Chile

Líneas de Investigación


My laboratory focuses in cardiac pathophysiology; we are studing the mitochondrial function and dynamic in cardiac hypertrophy induced by fructose (in vivo and in vitro models)

Educación

  •  Pharmacist, UNIVERSIDAD DE CHILE. Chile, 2007
  •  Pharmaceutical Sciences , UNIVERSIDAD DE CHILE. Chile, 2013

Experiencia Académica

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2018 - At present

Experiencia Profesional

  •   Assistant Professor Full Time

    Universidad de Chile

    Santiago, Chile

    2018 - At present

Formación de Capital Humano


Human capital training

Undergraduate Thesis Students (Last 5 years):

-BS, Universidad San Sebastián. Paz Díaz. “Role of polycystin-1 in the expression of calcium handling proteins and excitation/contraction of the cardiomyocytes”. 2016.
-BS, Universidad San Sebastián. Cecilia Anríquez. “Effect of the proteasome inhibition in the mitochondrial dynamic of the cardiomyocytes during ischemia/reperfusion". 2015 .

MSc Thesis students (Last 5 years)

MS-Universidad de Chile. Carolina Conejeros, "Participation of Miro1 in hypertrophy in neonatal rat cardiomyocytes ". 2017
MS- Universidad de Chile. Xavier Ahumada. “Effect of the inhibition of the chymotrypsin like activity of the proteosome during ischemia, in the mitochondrial structure of the rat isolated heart”. 2016
MS-Universidad de Chile. Stefanie Grace Chalmers. “Cardioprotective effect of N-acetylcysteine ??in the damage produced by ischemia, on the content of Mitofusin 2, in the isolated heart of rat". 2016


Difusión y Transferencia


Young Investigator Symposium "Participation of Miro1 in death induced by ischemia / reperfusion and in the induction of hypertrophy in cardiomyocytes", in the XXXIII Reunión Anual de la Sociedad Chilena de Ciencias Fisiológicas together with the International Society for Heart Research, Latin American Section: Huilo Huilo, 2018.

EXPLORA, Participation in the National Week of Science and Technology, 2018.

COMMUNICATIONS: Since 2014, seven posters at national and international meetings.



 

Article (27)

Polycystin-1 Is a Crucial Regulator of BIN1 Expression and T-Tubule Remodeling Associated with the Development of Dilated Cardiomyopathy

Diaz-Vesga, Magda C.; Flores-Vergara, Raul; Riquelme, Jaime A.; Llancaqueo, Marcelo; Sanchez, Gina; Vergara, Cecilia; Michea, Luis; Donoso, Paulina; Quest, Andrew F. G.; Olmedo, Ivonne; Pedrozo, Zully

Article ISI
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2023)

Communication Between Cardiomyocytes and Fibroblasts During Cardiac Ischemia/Reperfusion and Remodeling: Roles of TGF-β, CTGF, the Renin Angiotensin Axis, and Non-coding RNA Molecules

Flores-Vergara, Raul; Olmedo, Ivonne; Aránguiz-Urroz, Pablo; Riquelme, Jaime Andrés; Vivar, Raul; Pedrozo, Zully

Article
FRONTIERS IN PHYSIOLOGY  (2021)

Kaempferol Induces Cell Death and Sensitizes Human Head and Neck Squamous Cell Carcinoma Cell Lines to Cisplatin

Catalan, Mabel; Rodríguez, Catalina; Olmedo, Ivonne; Carrasco-Rojas, Javiera; Rojas, Diego.; Molina-Berrios, Alfredo; Díaz-Dosque, Mario; Jara, José A.

Article
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY  (2021)

Polycystin-1 mitigates damage and regulates CTGF expression through AKT activation during cardiac ischemia/reperfusion

Aranguiz, P.; Romero, P.; Vasquez, F.; Flores-Vergara, R.; Aravena, D.; Sanchez, G.; Gonzalez, M.; Olmedo, I; Pedrozo, Z.

Article ISI
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE  (2021)

TGF-β1 decreases CHOP expression and prevents cardiac fibroblast apoptosis induced by endoplasmic reticulum stress

Olivares-Silva, F; Espitia-Corredor, J.; Letelier, A; Vivar, Raul; Parra-Flores P.; Olmedo, Ivonne; Montenegro, J.; Pardo-Jimenez, V; Diaz-Araya G.

Article
Toxicology in vitro : an international journal published in association with BIBRA.  (2021)

Continuous flow synthesis of lipophilic cations derived from benzoic acid as new cytotoxic chemical entities in human head and neck carcinoma cell lines

Catalan, Mabel; Castro-Castillo, Vicente; Gajardo-de la Fuente, Javier; Aguilera, Jocelyn; Ferreira, Jorge; Ramires-Fernandez, Ricardo; Olmedo, Ivonne; Molina-Berrios, Alfredo; Palominos, Charlotte; Valencia, Marcelo; Dominguez, Marta; Souto, Jose A.; Jara, Jose A.

Article ISI
RSC MEDICINAL CHEMISTRY  (2020)

Inhibition of chymotrypsin-like activity of the proteasome by ixazomib prevents mitochondrial dysfunction during myocardial ischemia

Sanchez, Gina; Chalmers, Stefanie; Ahumada, Xavier; Montecinos, Luis; Olmedo, Ivonne; Eisner, Veronica; Riveros, Ana; Kogan, Marcelo J.; Lavandero, Sergio; Pedrozo, Zully; Donoso, Paulina

Article ISI
PLOS ONE  (2020)

Inhibition of the proteasome preserves Mitofusin-2 and mitochondrial integrity, protecting cardiomyocytes during ischemia-reperfusion injury

Olmedo I.; Pino G.; Riquelme, J. A.; Aranguiz P.; Díaz M.C.; López-Crisosto C.; Lavandero S.; Donoso P.; Pedrozo Z.; Sánchez G.

Article ISI SCOPUS
Biochimica et Biophysica Acta - Molecular Basis of Disease  (2020)

Medicinal Chemistry Targeting Mitochondria: From New Vehicles and Pharmacophore Groups to Old Drugs with Mitochondrial Activity

Catalan, Mabel; Olmedo, Ivonne; Faundez, Jennifer; Jara, Jose A.

Article ISI
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2020)

Miro1 as a novel regulator of hypertrophy in neonatal rat cardiomyocytes

Conejeros C.; Parra V.; Sanchez G.; Pedrozo Z.; Olmedo I.

Article ISI SCOPUS
Journal of Molecular and Cellular Cardiology  (2020)

TGF-β1 Induced Up-Regulation of B1 Kinin Receptor Promotes Antifibrotic Activity in Rat Cardiac Myofibroblasts

Catalan, Mabel; Aránguiz-Urroz, Pablo; Boza, Pia; Olmedo, Ivonne; Humeres, Claudio; Vivar, Raul; Anfossi Renato; Ayala, Pedro; Espinoza, Claudio; Lavandero, Sergio; Diaz-Araya, Guillermo

Article ISI
MOLECULAR BIOLOGY REPORTS  (2019)

Mechanical stretch increases L-type calcium channel stability in cardiomyocytes through a polycystin-1/AKT-dependent mechanism

Córdova-Casanova A, Olmedo I; Riquelme J, Chiong M; Sánchez G, Donoso P

Article
BBA -Molecular Cell Research  (2018)

Activation of Chymotrypsin-Like Activity of the Proteasome during Ischemia Induces Myocardial Dysfunction and Death.

Sanchez, Gina; Berrios, Daniela; Olmedo, Ivonne; Pezoa, Javier; Riquelme, Jaime A; Montecinos, Luis; Pedrozo, Zully; Donoso, Paulina

Article
PloS one  (2016)

Activation of Chymotrypsin-Like Activity of the Proteasome during Ischemia Induces Myocardial Dysfunction and Death.

Sanchez, G; Berrios, D; Olmedo, I; Pezoa, J; Riquelme, J; Montecinos, L; Pedrozo, Z; Donoso, P.

Article
PLoS One  (2016)

4-Phenylbutyric acid prevent cytotoxicity induced by thapsigargin in rat cardiac fibroblast

Humeres C.; Montenegro J.; Varela M.; Ayala P.; Vivar R.; Letelier A.; Olmedo I.; Catalán M.; Rivas C.; Baeza P.; Muñoz C.; García L.; Lavandero S.; Diaz-Araya, G

Article
TOXICOLOGY IN VITRO  (2014)

TGF-β1 Prevents Simulated ischemia/reperfusion-induced Cardiac Fibroblast Apoptosis by Activation of Both Canonical and Non-Canonical Signaling Pathways

Vivar, Raul; Humeres, Claudio; Ayala, Pedro; Olmedo, Ivonne; Catalan, Mabel; Garcia, Lorena; Lavandero, Sergio; Diaz-Araya, Guillermo

Article ISI
BIOCHIMICA ET BIOPHYSICA ACTA  (2013)

EPAC expression and function in cardiac fibroblasts and myofibroblasts

Olmedo I.; Muñoz C.; Guzmán N.; Catalán M.; Vivar R.; Ayala P.; Humeres C.; Aranguiz, P; García L.; Velarde V; Diaz-Araya, G

Article
TOXICOLOGY AND APPLIED PHARMACOLOGY  (2013)

EPAC expression and function in cardiac fibroblasts and myofibroblasts.

Olmedo, I; Muñoz, C; Guzmán, N; Catalán, M; Vivar, R; Ayala, P; Humeres, C; Aránguiz, P; García, L; Velarde, V; Díaz-Araya, G.

Article
TOXICOLOGY AND APPLIED PHARMACOLOGY  (2013)

Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-1 through both PI3K/Akt and MEK-ERK pathways

Vivar, R; Humeres, C.; Varela, M.; Ayala, P; Guzmán N.; Olmedo, I; Catalán M.; Boza P.; Munoz, C; Diaz-Araya, G

Article ISI SCOPUS
Experimental and Molecular Pathology  (2012)

Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast

Catalán M.; Smolic, C; Contreras, A; Ayala, P; Olmedo, I; Copaja M; Boza P.; Vivar, R; Avalos, Y; Lavandero S.; Velarde, V; Diaz-Araya, G

Article ISI SCOPUS
Toxicology and Applied Pharmacology  (2012)

Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability

Copaja M; Venegas, D; Aranguiz, P; Canales, J; Vivar, R; Avalos, Y; Garcia, L.; Chiong M.; Olmedo, I; Catalán M.; Leyton, L; Lavandero S.; Diaz-Araya, G

Article ISI SCOPUS
Toxicology  (2012)

Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts

Copaja M; Venegas, D; Aranguiz, P; Canales, J; Vivar, R; Catalán M.; Olmedo, I; Rodríguez, AE; Chiong M.; Leyton, L; Lavandero S.; Diaz-Araya, G

Article ISI SCOPUS
Toxicology and Applied Pharmacology  (2011)

Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice

Lasagna-Reeves, C; Gonzalez-Romero, D; Barria, MA; Olmedo, I; Clos, A; Ramanujam, VMS; Urayama, A; Vergara, L; Kogan, MJ; Soto C.

Article ISI SCOPUS
Biochemical and Biophysical Research Communications  (2010)

Multifunctionalized Gold Nanoparticles with Peptides Targeted to Gastrin-Releasing Peptide Receptor of a Tumor Cell Line

Hosta-Rigau, L; Olmedo, I; Arbiol, J; Cruz, LJ; Kogan, MJ; Albericio, F.

Article ISI SCOPUS
Bioconjugate Chemistry  (2010)

Gold Nanoparticles and Microwave Irradiation Inhibit Beta-Amyloid Amyloidogenesis

Araya, E.; Olmedo, I; Bastus, NG; Guerrero, S; Puntes, VF; Giralt E.; Kogan, MJ

Article ISI SCOPUS
NANOSCALE RESEARCH LETTERS  (2008)

How changes in the sequence of the peptide CLPFFD-NH(2) can modify the conjugation and stability of gold nanoparticles and their affinity for beta-amyloid fibrils

Olmedo, I; Araya, E.; Sanz, F; Medina, E; Arbiol, J; Toledo, P; Alvarez-Lueje, A; Giralt E.; Kogan, MJ

Article ISI SCOPUS
BIOCONJUGATE CHEMISTRY  (2008)

Ni/Ni Oxides Nanoparticles with Potential Biomedical Applications Obtained by Displacement of a Nickel-Organometallic Complex

Rodriguez-Llamazares, S; Merchan, J; Olmedo, I; Marambio, HP; Munoz, JP; Jara P.; Sturm, JC; Chornik, B; Peña O.; Yutronic, N; Kogan, MJ

Article ISI SCOPUS
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY  (2008)

Abstract (2)

Kinin B1 and B2 receptor activation reduces collagen I secretion through PKC-PLA2-COX2 participation in rat neonate cardiac myofibroblast

Diaz, MC; Boza P.; Olmedo, I; Velarde, MV; Diaz-Araya, G

Abstract ISI
FEBS JOURNAL  (2012)

TGF-beta 1 regulates EPAC-1 protein expression and function in cardiac fibroblasts and myofibroblasts

Olmedo, I; Catalán M.; Guzmán N.; Velarde, MV; Diaz-Araya, G

Abstract ISI
FEBS JOURNAL  (2011)

BookWhole (1)

Nanoparticles Functionalized with Bioactive Molecules: Biomedical Applications

Olmedo, I; Guerrero A.R.; Araya, E.; Kogan, M. J.

BookWhole SCOPUS
The Power of Functional Resins in Organic Synthesis  (2009)

Proyecto (7)

Remote ischemic preconditioning: role of NOX2-containing extracellular vesicles in Nrf2 and NLRP3 inflammasome activity in cardioprotection

SÁnchez, Gina Luisa; Olmedo, I; Donoso P.; Pedrozo Z.

Proyecto
 (2022)

Red para el estudio de enfermedades cardiopulmonares de alta letalidad (REECPAL)

Henríquez Mauricio, Pedrozo Zully, Olmedo Ivonne, Parra Valentina, Ebensperger Germán, Zagolín Mónica, Fernández Gonzalo, ,

Proyecto
 (2018)

Miro1 regulates mitochondrial function and dynamics in cardiac hypertrophy induced by fructose

FONDECYT (11170962)

Proyecto
2017-2020
Inv. Responsable

"Effects of proteasome inhibition on the content of Mitofusins 1 and 2 and the preservation of mitochondrial function following cardiac ischemia reperfusion"

FONDECYT (1130407)

Proyecto
2013-2016
Postdoctorado

PARTICIPACION DE LAS PROTEINAS MIRO EN LA FUNCION MITOCONDRIAL DURANTE ISQUEMIA/REPERFUSION CARDIACA.

FONDECYT (3140449)

Proyecto
2013-2017
Inv. Responsable

“Nanobiotecnología para la terapia y el diagnóstico de tumores sólidos cancerígenos”.

Secretaría de Estado de Cooperación Internacional, Barcelona, España (AECI-A/3116/05)

Proyecto
2007-2007
Tesista

“Desarrollo de nuevos nanomateriales=> manipulación de la auto agregación y de la conformación de proteínas para reducir su toxicidad”.

Secretaria de Estado de Cooperación Internacional, Barcelona, España (A/5987/06)

Proyecto
2006-2006
Tesista

Review (2)

Mitochondria in oral cancer stem cells: Unraveling the potential drug targets for new and old drugs

Olmedo, Ivonne; Martinez, Daniela; Carrasco-Rojas, Javiera; Jara, Jose A.

Review ISI
LIFE SCIENCES  (2023)

Peptides and metallic nanoparticles for biomedical applications

Kogan, MJ; Olmedo, I; Hosta, L; Guerrero, AR; Cruz, LJ; Albericio, F.

Review ISI
NANOMEDICINE  (2007)

28
Ivonne Olmedo

Assistant Profesor

Programa de Fisiopatología

Universidad de Chile

Santiago, Chile

8
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

6
SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

5
Zully Pedrozo

Associated Professor

Physiology and Biophysical

Universidad de Chile

SANTIAGO DE CHILE, Chile

4
Pablo Aránguiz

Jefe de Carrera

Escuela de Ciencias de la Salud

Universidad Vina del Mar

Viña del Mar, Chile

4
Raúl Vivar

Profesor Asistente

Universidad de Chile

Santiago, Chile

3
Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

3
Eyleen Araya

Academic

Chemical Sciences

Universidad Andres Bello

santiago, Chile

2
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

2
Paulina Donoso

Full Professor

Physiology and Biophysics

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Jaime Riquelme

Assistant Professor

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

2
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

2
José Jara

Assistant Professor

Research Institute of Dental Sciences

Universidad de Chile

Santiago, Chile

2
Yenniffer Ávalos

Profesor Asistente

Departamento de Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Simon Guerrero

Investigador

Instituto de Investigación Interdisciplinar en Ciencias Biomédicas SEK

Universidad SEK

Santiago, Chile

1
Claudia Muñoz

Postdoctorado

Universidad de Chile

Santiago, Chile

1
Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Valentina Parra

Profesora Asistente / Assistant Professor

Departamento de Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Veronica Eisner

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Magda Díaz

1
Jennifer Faúndez

Phd(c) del programa de Doctorado Biotecnología y Bioemprendimiento

Universidad San Sebastián

Santiago, Chile

1
Ariel Contreras

assistance professor

Institute for Research in Dental Science

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Pedro Toledo

Profesor Titular

Departamento Ingeniería Química

UNIVERSIDAD DE CONCEPCIÓN - DEPARTAMENTO DE INGENIERÍA QUÍMICA

Concepción, Chile