Man

Raúl Fabián Vivar Sánchez

Profesor Asistente

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Farmacología Cardiovascular; Fibrosis Cardiaca; Estrés metabólico y diabetes; Biología molecular; Señalización celular

Educación

  •  Farmacología, UNIVERSIDAD DE CHILE. Chile, 2012
  •  Químico Farmaceútico, UNIVERSIDAD DE CHILE. Chile, 2007

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2016 - At present


 

Article (26)

Role of FoxO3a as a negative regulator of the cardiac myofibroblast conversion induced by TGF-?1

Vivar R.; Humeres, C.; Anfossi R.; Bolivar S.; Catalán M.; Hill J.; Lavandero S.; Diaz-Araya G.

Article ISI SCOPUS
Biochimica et Biophysica Acta - Molecular Cell Research  (2020)

TGF-beta 1 induced up-regulation of B1 kinin receptor promotes antifibrotic activity in rat cardiac myofibroblasts

Catalán, Mabel; Aránguiz, Pablo; Boza, Pía; Olmedo, Ivonne; Humeres, Claudio; Vivar, Raúl; Anfossi, Renatto; Ayala, Pedro; Espinoza, Claudio; Lavandero, Sergio; Díaz-Araya, Guillermo

Article ISI SCOPUS
MOLECULAR BIOLOGY REPORTS  (2019)

The Association of Ascorbic Acid, Deferoxamine and N-Acetylcysteine Improves Cardiac Fibroblast Viability and Cellular Function Associated with Tissue Repair Damaged by Simulated Ischemia/Reperfusion

Parra-Flores P.; Riquelme, J. A.; Valenzuela-Bustamante P.; Leiva-Navarrete S.; Vivar R.; Cayupi-Vivanco J.; Castro E.; Espinoza-Pérez C.; Ruz-Cortés F.; Pedrozo Z.; Lavandero S.; Rodrigo R.; Diaz-Araya G.

Article ISI SCOPUS
ANTIOXIDANTS  (2019)

Acute lung injury by gastric fluid instillation: activation of myofibroblast apoptosis during injury resolution

Ayala, P; Torres, J; Vivar, R; Meneses, M; Olmos, P; Martin, TS; Borzone, GR

Article ISI SCOPUS
RESPIRATORY RESEARCH  (2018)

Changes in the pattern of fibrosis in the rat lung with repetitive orotracheal instillations of gastric contents=> evidence of persistent collagen accumulation.

Ayala, Pedro; Torres, Jorge; Vivar, Raúl; Olmos, Pablo R; Meneses, Manuel; Borzone, Gisella R

Article
American journal of physiology. Lung cellular and molecular physiology  (2018)

Elastin degradation products in acute lung injury induced by gastric contents aspiration.

Ayala, Pedro; Vivar, Raúl; Montalva, Rebeca; Olmos, Pablo; Meneses, Manuel; Borzone, Gisella R

Article
Respiratory research  (2018)

Expression and function of TLR4-induced B1R bradykinin receptor on cardiac fibroblasts

Munoz-Rodriguez, Claudia; Fernandez, Samuel; Miguel Osorio, Jose; Olivares, Francisco; Anfossi, Renatto; Bolivar, Samir; Humeres, Claudio; Boza, Pia; Vivar, Raul; Pardo-Jimenez, Viviana; Hemmings, Karen E.; Turner, Neil A.; Diaz-Araya, Guillermo

Article ISI SCOPUS
TOXICOLOGY AND APPLIED PHARMACOLOGY  (2018)

Heparan sulfate potentiates leukocyte adhesion on cardiac fibroblast by enhancing Vcam-1 and Icam-1 expression

Olivares-Silva, Francisco; Landaeta, Rodolfo; Aranguiz, Pablo; Bolivar, Samir; Humeres, Claudio; Anfossi, Renatto; Vivar, Raul; Boza, Pia; Munoz, Claudia; Pardo-Jimenez, Viviana; Peiro, Concepcion; Sanchez-Ferrer, Carlos F.; Diaz-Araya, Guillermo

Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE  (2018)

IFN-beta Plays Both Pro- and Anti-inflammatory Roles in the Rat Cardiac Fibroblast Through Differential STAT Protein Activation

Bolivar, Samir; Anfossi, Renatto; Humeres, Claudio; Vivar, Raul; Boza, Pia; Munoz, Claudia; Pardo-Jimenez, Viviana; Olivares-Silva, Francisco; Diaz-Araya, Guillermo

Article ISI SCOPUS
FRONTIERS IN PHARMACOLOGY  (2018)

Lipopolysaccharide Activates Toll-Like Receptor 4 and Prevents Cardiac Fibroblast-to-Myofibroblast Differentiation.

Bolívar, Samir; Santana, Roxana; Ayala, Pedro; Landaeta, Rodolfo; Boza, Pía; Humeres, Claudio; Vivar, Raúl; Muñoz, Claudia; Pardo, Viviana; Fernandez, Samuel; Anfossi, Renatto; Diaz-Araya, Guillermo

Article
Cardiovascular toxicology  (2017)

Transforming growth factor-beta and Forkhead box O transcription factors as cardiac fibroblast regulators.

Norambuena-Soto, Ignacio; Núñez-Soto, Constanza; Sanhueza-Olivares, Fernanda; Cancino-Arenas, Nicole; Mondaca-Ruff, David; Vivar, Raul; Díaz-Araya, Guillermo; Mellado, Rosemarie; Chiong, Mario

Article
Bioscience trends  (2017)

Cardiac fibroblast cytokine profiles induced by proinflammatory or profibrotic stimuli promote monocyte recruitment and modulate macrophage M1/M2 balance in vitro.

Humeres, Claudio; Vivar, Raúl; Boza, Pia; Muñoz, Claudia; Bolivar, Samir; Anfossi, Renatto; Osorio, Jose Miguel; Olivares-Silva, Francisco; García, Lorena; Díaz-Araya, Guillermo

Article
Journal of molecular and cellular cardiology  (2016)

Expression and function of toll-like receptor 4 and inflammasomes in cardiac fibroblasts and myofibroblasts: IL-1 beta synthesis, secretion, and degradation

Boza P.; Ayala, P; Vivar, R; Humeres, C.; Cáceres F.T.; Munoz, C; Garcia, L.; Hermoso M.A.; Díaz-Araya G.

Article ISI SCOPUS
MOLECULAR IMMUNOLOGY  (2016)

FoxO1 mediates TGF-beta1-dependent cardiac myofibroblast differentiation

Vivar, R; Humeres, C.; Munoz, C; Boza P.; Bolivar S.; Tapia, F; Lavandero S.; Chiong M.; Diaz-Araya, G

Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH  (2016)

4-Phenylbutyric acid prevent cytotoxicity induced by thapsigargin in rat cardiac fibroblast

Humeres, C.; Montenegro, J.; Varela, M.; Ayala, P; Vivar, R; Letelier, A; Olmedo, I; Catalán M.; Rivas, C; Baeza, P; Munoz, C; Garcia, L.; Lavandero S.; Diaz-Araya, G

Article ISI SCOPUS
Toxicology in vitro : an international journal published in association with BIBRA.  (2014)

EPAC expression and function in cardiac fibroblasts and myofibroblasts

Olmedo, I; Munoz, C; Guzmán N.; Catalán M.; Vivar, R; Ayala, P; Humeres, C.; Aranguiz, P; Garcia, L.; Velarde, V; Diaz-Araya, G

Article ISI SCOPUS
Toxicology and Applied Pharmacology  (2013)

TGF-beta 1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways

Vivar, R; Humeres, C.; Ayala, P; Olmedo, I; Catalán M.; Garcia, L.; Lavandero S.; Diaz-Araya, G

Article ISI SCOPUS
Biochimica et Biophysica Acta - Molecular Basis of Disease  (2013)

Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol

Ayala, P; Montenegro, J.; Vivar, R; Letelier, A; Urroz P.A.; Copaja M; Pivet, D; Humeres, C.; Troncoso R.; Vicencio J.M.; Lavandero S.; Diaz-Araya, G

Article ISI SCOPUS
Experimental and Molecular Pathology  (2012)

Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-1 through both PI3K/Akt and MEK-ERK pathways

Vivar, R; Humeres, C.; Varela, M.; Ayala, P; Guzmán N.; Olmedo, I; Catalán M.; Boza P.; Munoz, C; Diaz-Araya, G

Article ISI SCOPUS
Experimental and Molecular Pathology  (2012)

Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast

Catalán M.; Smolic, C; Contreras, A; Ayala, P; Olmedo, I; Copaja M; Boza P.; Vivar, R; Avalos, Y; Lavandero S.; Velarde, V; Diaz-Araya, G

Article ISI SCOPUS
Toxicology and Applied Pharmacology  (2012)

Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability

Copaja M; Venegas, D; Aranguiz, P; Canales, J; Vivar, R; Avalos, Y; Garcia, L.; Chiong M.; Olmedo, I; Catalán M.; Leyton, L; Lavandero S.; Diaz-Araya, G

Article ISI SCOPUS
Toxicology  (2012)

Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts

Copaja M; Venegas, D; Aranguiz, P; Canales, J; Vivar, R; Catalán M.; Olmedo, I; Rodríguez, AE; Chiong M.; Leyton, L; Lavandero S.; Diaz-Araya, G

Article ISI SCOPUS
Toxicology and Applied Pharmacology  (2011)

Early expression of monocyte chemoattractant protein-1 correlates with the onset of isoproterenol-induced cardiac fibrosis in rats with distinct angiotensin-converting enzyme polymorphism

Copaja Soto M, Valenzuela R, Saldaña A, Paz Ocaranza M, Jalil JE, Vio C, Lijnen P, Ordenes GE, Vivar Sanchez R, Lavandero S, Díaz-Araya G.

Article
J Renin Angiotensin Aldosterone Syst  (2008)

Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica

Greig, Douglas; Castro, Pablo; Gabrielli, Luigi; Miranda, Rodrigo; Verdejo, Hugo; Alcaino, Hernan; Bustos, Carlos; Chiong, Mario; Godoy, Ivan; Mellado, Rosemarie; Garcia, Lorena; Salas, Daniela.; Vivar, Raul; Vukasovic, José Luis; Concepción, Roberto; Diaz-Araya, Guillermo

Article SCIELO
REVISTA MEDICA DE CHILE  (2008)

Inflammation and endothelial dysfunction in patients with chronic heart failure

greig d.; Castro P. ; Gabrielli, L; Miranda, R.; Verdejo H.; Alcaino H; Bustos C.; Chiong M.; Godoy, I.; Mellado R.; Garcia, L.; Salas, D.; Vivar, R; Vukasovic, JL; Concepcion, R; Diaz-Araya, G

Article ISI
REVISTA MEDICA DE CHILE  (2008)

Phospholipase C/protein kinase C pathway mediates angiotensin II-dependent apoptosis in neonatal rat cardiac fibroblasts expressing AT1 receptor

Vivar, R; Soto C.; Copaja M; Mateluna, F; Aranguiz, P; Munoz, JP; Chiong M.; Garcia, L.; Letelier, A; Thomas, WG; Lavandero S.; Diaz-Araya, G

Article ISI SCOPUS
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY  (2008)

Proyecto (6)

Resolvins D1 and E1 novel pharmacological targets to prevent hypertension-dependent cardiac fibrosis=> a focus on cardiac fibroblast pro-inflammatory role

FONDECYT (1170425)

Proyecto
2017-2021
Coinvestigador(a)

HYPERGLYCEMIA REQUIRES FOXO1, CTGF AND TGF-?1 TO INDUCE A PROFIBROTIC AND PROINFLAMMATORY PHENOTYPE IN CARDIAC FIBROBLASTS=> NEW ANTIDIABETIC ROLE OF LIPOXINA4.

FONDECYT (11160531)

Proyecto
2016-2019
Inv. Responsable

Myofibroblast in the lung after instillation of whole gastric juice in a rat model=> A normal reparative process or a starting point for the development of chronic fibrosis?

FONDECYT (11140913)

Proyecto
2014-2017
Personal técnico y/o de apoyo

Role of TLR4 and inflammasome in the differentiation and acquisition of a proinflammatory phenotype of adult rat cardiac myofibroblast

FONDECYT (1130300)

Proyecto
2013-2015
Personal técnico y/o de apoyo

LA REGULACION DIFERENCIAL DE FOXO1 Y FOXO3A POR TGF-BETA1, MODULA TANTO LA DIFERENCIACION COMO EL AUMENTO DE LA ACTIVIDAD ANTIAPOPTOTICA/ANTIOXIDANTE DE FIBROBLASTOS CARDIACOS

FONDECYT (3130657)

Proyecto
2012-2015
Inv. Responsable

TGF-beta1 inhibe la apoptosis de fibroblastos cardiacos sometidos a isquemia/reperfusión simulada, a través de la activación de las vías canónica y no canónica

PFCHA (21080518)

Proyecto
2008-2012
Inv. Responsable

Review (1)

Cardiac fibroblasts as sentinel cells in cardiac tissue: Receptors, signaling pathways and cellular functions

Diaz-Araya, G; Vivar, R; Humeres, C.; Boza P.; Bolivar S.; Munoz, C

Review ISI SCOPUS
Pharmacological Research  (2015)

21
Raúl Vivar

Profesor Asistente

Universidad de Chile

Santiago, Chile

12
SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

9
Claudia Muñoz

Postdoctorado

Universidad de Chile

Santiago, Chile

7
Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

7
Pablo Aránguiz

Jefe de Carrera

Escuela de Ciencias de la Salud

Universidad Vina del Mar

Viña del Mar, Chile

6
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

5
Renatto Anfossi

Coordinador de Investigación

Unidad de Investigación

Hospital Regional Libertador Bernardo O'Higgins

Rancagua, Chile

5
Guillermo Díaz

Académico

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

4
Ivonne Olmedo

Assistant Profesor

Programa de Fisiopatología

Universidad de Chile

Santiago, Chile

3
Francisco Olivares

Pharmacology PhD(c)

Department of Pharmaceutical and Toxicological Chemistry

Universidad de Chile

Santiago, Chile

2
Daniela Salas

2
Douglas Greig

Médico Jefe

Cardiología

P. Universidad Católica de Chile

Santiago, Chile

2
Rosemarie Mellado

Jefe de carrera / Académica

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

2
Hugo Verdejo

Profesor Asociado

División de Enferemedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Yenniffer Ávalos

Profesor Asistente

Departamento de Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Marcela Hermoso

Full Professor

School of Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Rodrigo Troncoso

Associate Professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

1
Pedro Ayala

Profesor investigador asistente

Departamento de Enfermedades Respiratorias

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Luigi Gabrielli

Profesor Asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

1
Patricio Baeza

adjunt profesor

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaiso, Chile

1
Viviana Pardo

Profesional docente

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

1
Rodrigo Troncoso

Assistant professor

Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos

Santiago de Chile, Chile

1
Paula Valenzuela

Senior Researcher

Nuevos Materiales Avanzados

Leitat Chile

Santiago, Chile

1
Ariel Contreras

assistance professor

Institute for Research in Dental Science

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Jaime Riquelme

Assistant Professor

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

1
Pablo Castro

JEFE DIVISION

DIVISION ENFERMEDADES CARDIOVASCULARES

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

1
Zully Pedrozo

Associated Professor

Physiology and Biophysical

Universidad de Chile

SANTIAGO DE CHILE, Chile

1
Sebastián Leiva

Lab Manager

Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile