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Renatto Claudio Anfossi Matus

Jefe de Investigación

Hospital Regional Libertador Bernardo O'Higgins

Rancagua, Chile

Líneas de Investigación


Gestión Científica Hospitalaria

Educación

  •  Químico Farmacéutico, UNIVERSIDAD DE CHILE. Chile, 2016

Experiencia Académica

  •   Investigador Full Time

    UNIVERSIDAD DE CHILE

    Ciencias Químicas y Farmacéuticas

    Santiago, Chile

    2016 - 2017

  •   Investigador Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Chile

    2017 - 2019

  •   Investigador Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biológicas

    Chile

    2016 - 2016

  •   Jefe Full Time

    HOSPITAL REGIONAL RANCAGUA

    Rancagua, Chile

    2022 - At present

Experiencia Profesional

  •   Investigador Full Time

    Universidad de Chile

    Chile

    2017 - 2019

  •   Jefe Departamento de Investigación Full Time

    Hospital Regional Libertador Bernardo O'Higgins

    Rancagua, Chile

    2022 - At present


 

Article (17)

Saccular Limited Dorsal Myeloschisis: A New Indication for Prenatal Surgery? Case Series and Scoping Review

Müller JM; Corral EA; Cabrera-Morales M; Las Heras F; Lindsay CB; Lu VM; Anfossi R.

Article
Fetal Diagn Ther (2026)  (2026)

Differences between Myeloschisis and Myelomeningocele in Patients Undergoing Prenatal Repair of Open Spina Bifida

Muller; J.M.; Sereño; E.C.; Jimenez; A.; Zapata; R.; Echeverria; S.; Jara; J.P.; Santibanez; A.; Lindsay; C.; Anfossi; R

Article ISI
Fetal Diagnosis and Therapy  (2025)

Prenatal Repair of Spina Bifida Using Uterine Wound Retractor: A Single-Center Cohort Study

Corral E.; Müller JM; Jimenez A.; Figuera, J; Echeverria S.; Roldan, Y.; Lindsay CB; Anfossi R.; Sepulveda W.

Article ISI
Fetal Diagnosis and Therapy  (2025)

Vaccine effectiveness in reducing COVID-19-related hospitalization after a risk-age-based mass vaccination program in a Chilean municipality: A comparison of observational study designs

Urquidi, Cinthya; Valenzuela, Maria T.; Ponce, Alexander; Menares, Veronica; Anfossi, Renato

Article ISI
 (2024)

Interferon-β decreases LPS-induced neutrophil recruitment to cardiac fibroblasts

Vivar, Raul; Ayala, Pedro; Roman-Torres, Mauricio

Article ISI SCOPUS
Frontiers in Cell and Developmental Biology  (2023)

Lipoxin A4 prevents high glucose-induced inflammatory response in cardiac fibroblast through FOXO1 inhibition

Catalán, Mabel; Vivar, Raul

Article ISI SCOPUS
Cellular Signalling  (2023)

SGK1 is necessary to FoxO3a negative regulation, oxidative stress and cardiac fibroblast activation induced by TGF-β1

Catalán, Mabel; Vivar, Raill

Article ISI SCOPUS
Cellular Signalling  (2023)

Statins change the cytokine profile in Trypanosoma cruzi-infected U937 macrophages and murine cardiac tissue through Rho-associated kinases inhibition

Clayton, Natasha S.; Catalán, Mabel; Ridley, Anne J.; Vivar, Raul; Diego Maya, Juan

Article ISI SCOPUS
Frontiers in Immunology  (2023)

FoxO1 is required for high glucose-dependent cardiac fibroblasts into myofibroblast phenoconversion

Vivar, Raul; Catalán, Mabel; Contreras, Alejandra; Aranguiz, Pablo

Article ISI SCOPUS
Cellular Signalling  (2021)

In cardiac fibroblasts, interferon-beta attenuates differentiation, collagen synthesis, and TGF-beta 1-induced collagen gel contraction

Espitia-Corredor, J. A.

Article ISI SCOPUS
Cytokine  (2021)

Role of FoxO3a as a negative regulator of the cardiac myofibroblast conversion induced by TGF-beta 1

Humeres C.; Bolivar S.

Article ISI SCOPUS
Biochimica et Biophysica Acta - Molecular Cell Research  (2020)

TGF-beta 1 induced up-regulation of B1 kinin receptor promotes antifibrotic activity in rat cardiac myofibroblasts

Ayala, Pedro

Article ISI SCOPUS
MOLECULAR BIOLOGY REPORTS  (2019)

Expression and function of TLR4-induced B1R bradykinin receptor on cardiac fibroblasts

Munoz-Rodriguez, Claudia; Fernandez, Samuel; Miguel Osorio, Jose; Olivares, Francisco; Vivar, Raul; Hemmings, Karen E.; Turner, Neil A.

Article ISI SCOPUS
TOXICOLOGY AND APPLIED PHARMACOLOGY  (2018)

Heparan sulfate potentiates leukocyte adhesion on cardiac fibroblast by enhancing Vcam-1 and Icam-1 expression

Aranguiz, Pablo; Vivar, Raul

Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE  (2018)

IFN-beta Plays Both Pro- and Anti-inflammatory Roles in the Rat Cardiac Fibroblast Through Differential STAT Protein Activation

Vivar, Raul

Article ISI SCOPUS
FRONTIERS IN PHARMACOLOGY  (2018)

Lipopolysaccharide Activates Toll-Like Receptor 4 and Prevents Cardiac Fibroblast-to-Myofibroblast Differentiation

Anfossi R.

Article ISI SCOPUS
CARDIOVASCULAR TOXICOLOGY  (2017)

Cardiac fibroblast cytokine profiles induced by proinflammatory or profibrotic stimuli promote monocyte recruitment and modulate macrophage M1/M2 balance in vitro

Osorio J.M.; Olivares-Silva F.

Article ISI SCOPUS
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY  (2016)

Proyecto (4)

CHEMICAL-BIOLOGICAL STUDY (IN VITRO AND IN VIVO) OF NEW ANALOGUES OF TRIAZOLOPYRIDINES AS ANTI-TRYPANOSOME CRUZI, THE EFFECT ON STEROL PATHWAYS

Dr. Michel Lapier Quezada.

Proyecto
 (2019)

HYPERGLYCEMIA REQUIRES FOXO1, CTGF AND TGF-ß1 TO INDUCE A PROFIBROTIC AND PROINFLAMMATORY PHENOTYPE IN CARDIAC FIBROBLASTS: NEW ANTIDIABETIC ROLE OF LIPOXINA4.



Proyecto
 (2017)

MYOFIBROBLAST IN THE LUNG AFTER INSTILLATION OF WHOLE GASTRIC JUICE IN A RAT MODEL: A NORMAL REPARATIVE PROCESS OR A STARTING POINT FOR THE DEVELOPMENT OF CHRONIC FIBROSIS?.

Ayala, Pedro

Proyecto
 (2017)

ROLE OF TLR4 AND INFLAMMASOME IN THE DIFFERENTIATION AND ACQUISITION OF A PROINFLAMMATORY PHENOTYPE OF ADULT RAT CARDIAC MYOFIBROBLAST



Proyecto
 (2015)

9
Guillermo Díaz

Académico

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

2
SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
María Santolaya

Pediatra infectologa, Profesor titular

Pediatria, Campus Oriente

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, DEPARTAMENTO DE PEDIATRÍA ORIENTE

Santiago, Chile

1
Maria Valenzuela

DECANA

Universidad San Sebastián

Santiago, Chile

5
Raúl Vivar

Profesor Asistente

Universidad de Chile

Santiago, Chile

1
Mario Rivera

Profesor Asociado

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

3
Pablo Aránguiz

Jefe de Carrera

Escuela de Ciencias de la Salud

Universidad Vina del Mar

Viña del Mar, Chile

5
Mabel Catalán

Profesora Asistente

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

21
Renatto Anfossi

Jefe de Investigación

Departamento de Investigación

Hospital Regional Libertador Bernardo O'Higgins

Rancagua, Chile

1
Claudia Cortes

Profesor Asociado

Medicina

Universidad de Chile

Santiago, Chile

1
Christian Castillo

Profesor Asistente

Instituto Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

5
Francisco Olivares

Pharmacology PhD(c)

Department of Pharmaceutical and Toxicological Chemistry

Universidad de Chile

Santiago, Chile

1
Paula Valenzuela

Senior Researcher

Nuevos Materiales Avanzados

Leitat Chile

Santiago, Chile

1
Pedro Ayala

Profesor investigador asistente

Departamento de Enfermedades Respiratorias

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Alvaro Santibañez

Estudiante de doctorado. pHD (c)

Instituto de Ciencias Biomédicas (ICBM)

Universidad de Chile

Santiago, Chile

5
Claudia Muñoz

Postdoctorado

Universidad de Chile

Santiago, Chile

1
Alejandro Sepúlveda

Docente investigador

Salud Pública y Epidemiología

Universidad de Los Andes

Santiago, Chile

2
Viviana Pardo

Profesional docente

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

5
Fabiola González

Investigadora Postdoctoral

Universidad de Chile

Santiago, Chile

2
Jose Muller

1
Carolina Lindsay

Bioquímica - Unidad de Investigación

Dpto. de Investigación e Innovación

Hospital Dr. Franco Ravera Zunino

Rancagua, Chile

1
Daniela Guzmán

Docente

Escuela de Química y Farmacia

Universidad Andrés Bello

Santiago, Chile