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Christian Raul Castillo Rivas

Profesor Asistente

Universidad de Chile

Santiago, Chile

Estudio de la respuesta inmune innata antiparasitaria placentaria en modelos in vivo y ex vivo

Medico Veterinario, UNIVERSIDAD DE CHILE. Chile, 2012
Ciencias Silvoagropecuarias y Veterinarias, UNIVERSIDAD DE CHILE. Chile, 2017

Investigador Postdoctoral Full Time

UNIVERSIDAD DE CHILE

Facultad de Medicina

Santiago, Chile

2018 - At present
Profesor Adjunto Part Time

UNIVERSIDAD DE CHILE

Facultad de Medicina

Santiago, Chile

2018 - At present
Secretario Académico Full Time

UNIVERSIDAD DE LAS AMERICAS

Medicina Veterinaria y Agronomía

Santiago, Chile

2021 - 2023

Secretario Académico Full Time

Universidad de Las Américas

Santiago, Chile

2021 - 2023

Tesis de pregrado:
1. Christian Alfredo Gallardo Arce. “Determinación del perfil de citoquinas mediadas por receptores tipo NOD en el trofoblasto humano en respuesta a la infección con Trypanosoma cruzi” Titulo de Tecnólogo Medico, Universidad de Chile. 2016.
2. Alexandra Mackarena Sandoval Vilches. “Evaluación del efecto de fármacos antichagásicos sobre la función endotelial en modelo ex vivo de infección por Trypanosoma cruzi.”. Título de Tecnólogo Medico, Universidad de Chile. 2014.
3. Marta Fajardo Godoy, Macarena Rojas González. «Identificación mediante método de PCR de presencia de Trypanosoma cruzi en Rhipicephalus sanguineus en cánidos domésticos del sector Cerro Grande en la ciudad de La Serena ». Tesis para optar al título de Médico Veterinario. Facultad de ciencias agropecuarias, Escuela de Medicina Veterinaria, Universidad Pedro de Valdivia, sede La Serena. En curso.

Loke Award

OREGON STATE UNIVERSITY

Estados Unidos, 2016

International Federation of Placenta Association Meeting, Portland, Oregon.


Statins change the cytokine profile in Trypanosoma cruzi-infected U937 macrophages and murine cardiac tissue through Rho-associated kinases inhibition Gonzalez-Herrera, Fabiola; Clayton, Natasha S.; Guzman-Rivera, Daniela; Carrillo, Ileana; Castillo, Christian; Catalan, Mabel; Anfossi, Renatto; Quintero-Pertuz, Helena; Quilaqueo, Maria Elena; Olea-Azar, Claudio; Rivera-Meza, Mario; Kemmerling, Ulrike; Ridley, Anne J.; Vivar, Raul; Diego Maya, Juan Article ISI FRONTIERS IN IMMUNOLOGY (2023)
Notch receptor expression in Trypanosoma cruzi-infected human umbilical vein endothelial cells treated with benznidazole or simvastatin revealed by microarray analysis Campos-Estrada, Carolina; Gonzalez-Herrera, Fabiola; Greif, Gonzalo; Carillo, Ileana; Guzman-Rivera, Daniela; Liempi, Ana; Robello, Carlos; Kemmerling, Ulrike; Castillo, Christian; Diego Maya, Juan Article ISI SCOPUS Cell Biology International (2020)
Differential infectivity of two Trypanosoma cruzi strains in placental cells and tissue Medina, Lisvaneth; Castillo, Christian; Liempi, Ana; Herbach, Mathias; Cabrera, Gonzalo; Valenzuela, Lucía; Galanti, Norbel; de los Angeles Curto, María; Schijman, Alejandro G.; Kemmerling, Ulrike Article ISI SCOPUS ACTA TROPICA (2018)
Endogenous overexpression of an active phosphorylated form of DNA polymerase beta under oxidative stress in Trypanosoma cruzi Rojas, Diego A.; Urbina, Fabiola; Moreira-Ramos, Sandra; Castillo, Christian; Kemmerling, Ulrike; Lapier, Michel; Maya, Juan Diego; Solari, Aldo; Maldonado, Edio; Clos, Joachim Article ISI SCOPUS PLOS NEGLECTED TROPICAL DISEASES (2018)
Host-parasite interaction: changes in human placental gene expression induced by Trypanosoma cruzi Castillo, C; Carrillo, I; Libisch, G; Juiz, N; Schijman, A; Robello C.; Kemmerling, U Article ISI SCOPUS PARASITES & VECTORS (2018)
Old Yellow Enzyme from Trypanosoma cruzi Exhibits In Vivo Prostaglandin F-2 alpha Synthase Activity and Has a Key Role in Parasite Infection and Drug Susceptibility Diaz-Viraque, F; Chiribao, ML; Trochine, A; Gonzalez-Herrera, F; Castillo, C; Liempi, A; Kemmerling, U; Maya, JD; Robello C. Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2018)
Erratum for GonzÃ¡lez-Herrera et al., "Simvastatin Attenuates Endothelial Activation through 15-Epi-Lipoxin A4 Production in Murine Chronic Chagas Cardiomyopathy". González-Herrera, Fabiola; Cramer, Allysson; Pimentel, Pollyana; Castillo, Christian; Liempi, Ana; Kemmerling, Ulrike; Machado, Fabiana S; Maya, Juan D Article Antimicrobial agents and chemotherapy (2017)
Ex vivo infection of human placental chorionic villi explants with Trypanosoma cruzi and Toxoplasma gondii induces different Toll-like receptor expression and cytokine/chemokine profiles Castillo, Christian; Mu?oz, Lorena; Carrillo, Ileana; Liempi, Ana; Gallardo, Christian; Galanti, Norbel; Maya, Juan Diego; Kemmerling, Ulrike Article ISI SCOPUS AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2017)
Ex vivo infection of human placental chorionic villi explants with Trypanosoma cruzi and Toxoplasma gondii induces different Toll-like receptor expression and cytokine/chemokine profiles. Castillo, Christian; Muñoz, Lorena; Carrillo, Ileana; Liempi, Ana; Gallardo, Christian; Galanti, Norbel; Maya, Juan Diego; Kemmerling, Ulrike Article AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2017)
Simvastatin Attenuates Endothelial Activation through 15-Epi-Lipoxin A4 Production in Murine Chronic Chagas Cardiomyopathy. González-Herrera, Fabiola; Cramer, Allysson; Pimentel, Pollyana; Castillo, Christian; Liempi, Ana; Kemmerling, Ulrike; Machado, Fabiana S; Maya, Juan D Article Antimicrobial agents and chemotherapy (2017)
Toll-like receptor-2 mediates local innate immune response against Trypanosoma cruzi in ex vivo infected human placental chorionic villi explants Castillo, C; Munoz, L; Carrillo, I; Liempi, A; Medina, L; Galanti, N; Maya, JD; Kemmerling, U Article ISI SCOPUS Placenta (2017)
Trypanosoma cruzi induces cellular proliferation in the trophoblastic cell line BeWo. Droguett, Daniel; Carrillo, Ileana; Castillo, Christian; Gómez, Fresia; Negrete, Miguel; Liempi, Ana; Muñoz, Lorena; Galanti, Norbel; Maya, Juan Diego; Kemmerling, Ulrike Article Experimental parasitology (2017)
Caspase-8 activity is part of the BeWo trophoblast cell defense mechanisms against Trypanosoma cruzi infection Carrillo Ileana, Droguett; Daniel, Castillo; Christian, Liempi; Ana, Muñoz; Lorena, Maya; Juan Diego, Galanti Article EXPERIMENTAL PARASITOLOGY (2016)
A local innate immune response against Trypanosoma cruzi in the human placenta=> The epithelial turnover of the trophoblast. Liempi, Ana; Castillo, Christian; Carrillo, Ileana; Muñoz, Lorena; Droguett, Daniel; Galanti, Norbel; Maya, Juan Diego; Kemmerling, Ulrike Article MICROBIAL PATHOGENESIS (2016)
A local innate immune response against Trypanosoma cruzi in the human placenta=> The epithelial turnover of the trophoblast. Liempi, Ana; Castillo, Christian; Carrillo, Ileana; Muñoz, Lorena; Droguett, Daniel; Galanti, Norbel; Maya, Juan Diego; Kemmerling, Ulrike Article Microbial pathogenesis (2016)
Caspase-8 activity is part of the BeWo trophoblast cell defense mechanisms against Trypanosoma cruzi infection. Carrillo, Ileana; Droguett, Daniel; Castillo, Christian; Liempi, Ana; Muñoz, Lorena; Maya, Juan Diego; Galanti, Norbel; Kemmerling, Ulrike Article Experimental parasitology (2016)
Role of placental barrier integrity in infection by Trypanosoma cruzi Díaz-Luján, C.; Triquell, M.F.; Castillo, C.; Hardisson, D.; Kemmerling, U.; Fretes, R.E. Article ISI SCOPUS ACTA TROPICA (2016)
Role of placental barrier integrity in infection by Trypanosoma cruzi. Díaz-Luján, C; Triquell, M F; Castillo, C; Hardisson, D; Kemmerling, U; Fretes, R E Article Acta tropica (2016)
Efficacy of quercetin against chemically induced murine oral squamous cell carcinoma. Droguett, Daniel; Castillo, Christian; Leiva, Elba; Theoduloz, Cristina; Schmeda-Hirschmann, Guillermo; Kemmerling, Ulrike Article Oncology letters (2015)
Efficacy of quercetin against chemically induced murine oral squamous cell carcinoma. Droguett, Daniel; Castillo, Christian; Leiva, Elba; Theodoluz, Cristina; Schmeda, Guillermo Article Oncology, Letters (2015)
Trypanosoma cruzi infectivity assessment in "in vitro" culture systems by automated cell counting. Liempi, Ana; Castillo, Christian; Cerda, Mauricio; Droguett, Daniel; Duaso, Juan; Barahona, Katherine; Hernández, Ariane; Díaz-Luján, Cintia; Fretes, Ricardo; Härtel, Steffen; Kemmerling, Ulrike Article Acta tropica (2015)
IFPA Meeting 2013 Workshop Report III=> Maternal placental immunological interactions, novel determinants of trophoblast cell fate, dual ex vivo perfusion of the human placenta Abumaree, MH; Brownbill, P; Burton, G; Castillo, C; Chamley, L; Croy, BA; Drewlo, S; Dunk, C; Girard S., Hansson; S, Jones S.; Jurisicova, A; Lewis R., Letarte; M, Parast; M, Pehrson; C, Rappolee; D, Schneider H.; Tannetta, D; Varmuza, S; Wadsackt, C; Wallace, AE; Zenerino, C; Lash, GE Article Placenta (2014)
IFPA Meeting 2013 Workshop Report III=> maternal placental immunological interactions, novel determinants of trophoblast cell fate, dual ex vivo perfusion of the human placenta. Abumaree, M H; Brownbill, P; Burton, G; Castillo, C; Chamley, L; Croy, B A; Drewlo, S; Dunk, C; Girard, S; Hansson, S; Jones, S; Jurisicova, A; Lewis, R; Letarte, M; Parast, M; Pehrson, C; Rappolee, D; Schneider, H; Tannetta, D; Varmuza, S; Wadsack, C; Wallace, A E; Zenerino, C; Lash, G E Article Placenta (2014)
Toxic and therapeutic effects of Nifurtimox and Benznidazol on Trypanosoma cruzi ex vivo infection of human placental chorionic villi explants Rojo, Gemma; Castillo, Christian; Duaso, Jan; Liempi, Ana; Droguett, Daniel; Galanti, Norbel; Maya, Juan Diego; Lopez-Muñoz, Rodrigo Article ACTA TROPICA (2014)
Toxic and therapeutic effects of Nifurtimox and Benznidazol on Trypanosoma cruzi ex vivo infection of human placental chorionic villi explants rojo, gemma; Castillo, Christian; Duaso, Juan; Liempi, Ana; Droguett, D.; Galanti, Norbel; Maya, Juan Diego.; López-Muñoz, Rodrigo; Kemmerling, Ulrike Article ISI ACTA TROPICA (2014)
Trypanosoma cruzi induces trophoblast differentiation: A potential local antiparasitic mechanism of the human placenta? Liempi, Ana; Castillo, Christian; Duaso, Juan; Droguett, Daniel; Sandoval, Alexandra; Barahona Katherine; Hernández Ariane; Galanti, Norbel; Maya, Juan Diego.; Kemmerling, Ulrike Article ISI SCOPUS PLACENTA (2014)
Phospholipase C gamma and ERK1/2 Mitogen Activated Kinase Pathways are differentially modulated by Trypanosoma cruzi during tissue invasion in human placenta Castillo, C; Villarroel, A.; Duaso, J; Galanti, N; Cabrera, G; Maya JD, Kemmerling U Article Experimental Parasitology (2013)
Phospholipase C gamma and ERK1/2 mitogen activated kinase pathways are differentially modulated by Trypanosoma cruzi during tissue invasion in human placenta Castillo, Christian; Villaroel, Arturo; Duaso, Juan; Galanti, Norbel; Cabrera, Gonzalo; Maya, Juan Diego Article Experimental Parasitology (2013)
Phospholipase C gamma and ERK1/2 mitogen activated kinase pathways are differentially modulated by Trypanosoma cruzi during tissue invasion in human placenta. Castillo, Christian; Villarroel, Arturo; Duaso, Juan; Galanti, Norbel; Cabrera, Gonzalo; Maya, Juan Diego; Kemmerling, Ulrike Article Experimental parasitology (2013)
Protective role of acetylsalicylic acid in experimental Trypanosoma cruzi infection=> evidence of a 15-epi-lipoxin A4-mediated effect Molina-Berríos, Alfredo; Campos-Estrada, Carolina; Henriquez, Natalia; Faúndez, Mario; Torres, Gloria; Castillo, Christian; Escanilla Sebastian, Kemmerling Ulrike; Morello Antonio, López-Muñoz Rodrigo Article PLoS Neglected Tropical Diseases (2013)
The Interaction of Classical Complement Component C1 with Parasite and Host Calreticulin Mediates Trypanosoma cruzi Infection of Human Placenta Castillo, C; Ramirez, G.; Valck C, Aguilar L; Maldonado I, Rosas C; Galanti, N; Kemmerling U, Ferreira A Article PLOS Neglected Tropical Diseases (2013)
The interaction of classical complement component C1 with parasite and host calreticulin mediates Trypanosoma cruzi infection of human placenta Castillo, Christian; Ramirez, Galia; Valck, Carolina; Aguilar, Lorena; Maldonado, Ismael; Rosas, Carlos; Galanti, Norbel Article PLoS Neglected Tropical Diseases (2013)
The interaction of classical complement component C1 with parasite and host calreticulin mediates Trypanosoma cruzi infection of human placenta. Castillo, Christian; Ramírez, Galia; Valck, Carolina; Aguilar, Lorena; Maldonado, Ismael; Rosas, Carlos; Galanti, Norbel; Kemmerling, Ulrike; Ferreira, Arturo Article PLoS neglected tropical diseases (2013)
Role of matrix metalloproteinases 2 and 9 in ex vivo Trypanosoma cruzi infection of human placental chorionic villi Castillo, C; Lopez-Munoz, R; Duaso, J; Galanti, N; Jaña F., Ferreira; J, Cabrera; G, Maya; J D, Kemmerling U Article Placenta (2012)
Role of matrix metalloproteinases 2 and 9 in ex vivo Trypanosoma cruzi infection of human placental chorionic villi Castillo, Christian; Lopez-Muñoz, Rodrigo; Duaso, Juan; Galanti, Norbel; Jaña, Fabian; Ferreira, Jorge; Cabrera, Gonzalo; Maya, Juan Diego Article PLACENTA (2012)
Role of matrix metalloproteinases 2 and 9 in ex vivo Trypanosoma cruzi infection of human placental chorionic villi. Castillo, C; López-Muñoz, R; Duaso, J; Galanti, N; Jaña, F; Ferreira, J; Cabrera, G; Maya, J D; Kemmerling, U Article Placenta (2012)
Reorganization of extracellular matrix in placentas from women with asymptomatic chagas disease=> mechanism of parasite invasion or local placental defense? Duaso, Juan; Yanez, Erika; Castillo, Christian; Cabrera. Gonzalo, Corral; Gladys, Maya; Juan Diego, Zulantay; Ines, Apt Article Journal of Tropical Medicine (2011)


Mechanism of Congenital Chagas disease: Effective placental Trypanosoma cruzi infection depends on parasite-derived exovesicles Kemmerling U. Proyecto (2022)
Modulation of the receptor for advanced glycation end products (RAGE) in a Host-pathogen model: an immunobiological approach to improve placental barrier integrity Castillo, Christian Proyecto (2022)
Congenital Chagas Disease Consortium: Identification and validation of biomarkers to improve the control of congenital Chagas disease Ulrike Kemmerling; Castillo, C Proyecto (2019)
Mechanism of Congenital Chagas disease: Effective Trypanosoma cruzi placental infection depends on specific host-derived microRNAs Ulrike Kemmerling; Castillo, C; Maya, Juan D; Olea, C. Proyecto (2019)
Cardiopatía chagásica crónica: Evaluación preclínica del rol de la alarmina HMGB1 como blanco terapéutico Christian Castillo; Maya, Juan D Proyecto (2018)
Cardiopatía chagásica crónica=> Evaluación preclínica del rol de la alarmina HMGB1 como blanco terapéutico FONDECYT (3180452) Proyecto 2018-2021 Inv. Responsable
Congenital Chagas disease research Consortium EU CELAC R&I funding agencies/CONICYT (ELAC2014/HID-0328) Proyecto 2015-2017 Personal técnico y/o de apoyo
Red de Colaboración Internacional entre Chile y Uruguay para el Estudio de la Expresión Génica en Enfermedades Infecciosas y Cancer PCI (130118) Proyecto 2013-2014 Tesista
Mechanism of congenital Chagas disease=> Effective infection depends on the interplay between T. cruzi and the trophoblast in the human placenta FONDECYT (1120230) Proyecto 2012-2015 Tesista
Advanced Center for Traning and Research in the Design of Pharmacological and Immunological Strategies for the Control of Parasitic and Neoplasic Aggressions PFCHA (act-112) Proyecto 2010-2013 Tesista
CONGENITAL CHAGAS" DISEASE=> MECHANISMS OF TRYPANOSOMA CRUZI INFECTION AND INVASION IN HUMAN PLACENTA FONDECYT (11080166) Proyecto 2008-2011 Tesista