Man

Diego Andrés Rojas Soto

Profesor Ayudante

Universidad Autónoma de Chile

Santiago, Chile

Líneas de Investigación


Transcripción en Eucariontes; infecciones respiratorias por hongos (Pneumocystis); EPOC; inflamación crónica de vías aéreas; hipersecreción de moco en pulmón.

Educación

  •  Doctor en Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2012
  •  Ingeniero en Biotecnología Molecular, UNIVERSIDAD DE CHILE. Chile, 2009

Experiencia Académica

  •   Profesor Ayudante Other

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2010 - 2019

  •   Profesor Asistente (Académico) Full Time

    Universidad Autónoma de Chile

    Ciencias de la Salud

    Santiago, Chile

    2020 - At present

Experiencia Profesional

  •   Investigador Part Time

    Bioingentech

    Santiago, Chile

    2018 - 2018

  •   Investigador Postdoctoral Full Time

    Universidad de Santiago

    Santiago, Chile

    2019 - 2020

  •   Investigador Postdoctoral Full Time

    Universidad de Chile

    Chile

    2013 - 2018


 

Article (20)

Role of the Fungus <i>Pneumocystis</i> in IL1β Pathway Activation and Airways Collagen Deposition in Elastase-Induced COPD Animals
<i>Pneumocystis</i> Exacerbates Inflammation and Mucus Hypersecretion in a Murine, Elastase-Induced-COPD Model
<i>Trypanosoma cruzi</i> DNA Polymerase β Is Phosphorylated In Vivo and In Vitro by Protein Kinase C (PKC) and Casein Kinase 2 (CK2)
Initiator-Directed Transcription: Fission Yeast Nmtl Initiator Directs Preinitiation Complex Formation and Transcriptional Initiation
RNA Polymerase II Transcription in <i>Pneumocystis</i>: TFIIB from <i>Pneumocystis carinii</i> Can Replace the Transcriptional Functions of Fission Yeast <i>Schizosaccharomyces pombe</i> TFIIB In Vivo and In Vitro
The Catalytic Subunit of <i>Schizosaccharomyces pombe</i> CK2 (Cka1) Negatively Regulates RNA Polymerase II Transcription through Phosphorylation of Positive Cofactor 4 (PC4)
<i>T</i>. <i>cruzi</i> DNA polymerase beta (Tcpolβ) is phosphorylated <i>in vitro</i> by CK1, CK2 and TcAUK1 leading to the potentiation of its DNA synthesis activity
Increase in secreted airway mucins and partial Muc5b STAT6/FoxA2 regulation during Pneumocystis primary infection.
Primary infection by Pneumocystis induces Notch-independent Clara cell mucin production in rat distal airways
Endogenous overexpression of an active phosphorylated form of DNA polymerase β under oxidative stress in Trypanosoma cruzi.
Progression of Type 2 Helper T Cell-Type Inflammation and Airway Remodeling in a Rodent Model of Naturally Acquired Subclinical Primary Pneumocystis Infection.
RNA polymerase II components and Rrn7 form a preinitiation complex on the HomolD box to promote ribosomal protein gene expression in Schizosaccharomyces pombe.
The Ski Protein is Involved in the Transformation Pathway of Aurora Kinase A
Casein kinase 2 inhibits HomolD-directed transcription by Rrn7 in Schizosaccharomyces pombe.
Expression, purification, and biochemical characterization of recombinant DNA polymerase beta of the Trypanosoma cruzi TcI lineage=> requirement of additional factors and detection of phosphorylation of the native form.
Fungal colonization with Pneumocystis correlates to increasing chloride channel accessory 1 (hCLCA1) suggesting a pathway for up-regulation of airway mucus responses, in infant lungs.
Transcription directed by human core promoters with a HomolD box sequence requires DDB1, RECQL and RNA polymerase II machinery.
Identification of Ski as a target for Aurora A kinase
Rrn7 protein, an RNA polymerase I transcription factor, is required for RNA polymerase II-dependent transcription directed by core promoters with a HomolD box sequence.
Cloning of hif-1 alpha and hif-2 alpha and mRNA expression pattern during development in zebrafish

BookSection (1)

Transcriptional Initiation in Ribosomal Protein Genes in the Fission Yeast Schizosaccharomyces pombe

ConferencePoster (10)

la infección respiratoria con el hongo Pneumocystis induce estrés oxidativo y fibrosis en vías aéreas de animales con enfermedad obstructiva pulmonar crónica (EPOC).
Pneumocystis carinii induce la hipersecreción de moco en las vías aéreas de manera sinérgica en animales con enfermedad obstructiva pulmonar crónica (EPOC) a través de un mecanismo dependiente de la vía STAT6.
Rol de Pneumocystis carinii en la modulación de la vía IL1b en un modelo animal de EPOC.
Pneumocystis carinii induces mucus hypersecretion via STAT6 and NFkB pathways in immunocompromised individuals.
Pneumocystis carinii induces mucus hypersecretion in a COPD-elastase induced rat model.
Induction of Muc5b and Muc5ac via STAT6/FoxA2 pathway during Pneumocystis primary infection.
Pneumocystis y mucinas durante la infección primaria.
Pneumocystis carinii induce la hipersecreción de moco en animales inmunocompetentes a través de la activación de la vía STAT6/FoxA2
Caracterización de la respuesta secretora en vías aéreas del hospedero durante la infección primaria de Pneumocystis naturalmente adquirido en ratas inmunocompetentes
Progression of STAT6-related mucus increase during naturally acquired primary infection by Pneumocystis in immunocompetent rats.

Proyecto (4)

Role of Pneumocystis in the severity of chronic mucus hypersecretion during the pathogenesis of COPD.
Desarrollo de un prototipo de ensayo de inhibición de la enzima proteína fosfatasa 2a de mytilus par a la detección y cuantificación de toxinas diarreicas en muestras de extractos de mariscos y conservas.
ELUCIDATION OF PNEUMOCYSTIS-INDUCED PATHOLOGY AND SEQUELS IN MURINE MODELS, AND EVALUATION OF SELECTED MARKERS OF LUNG DAMAGE IN AUTOPSIED INFANT LUNGS.
ROL DE FOXA2 EN LA REMODELACION Y RESPUESTA SECRETORA DEL EPITELIO RESPIRATORIO INDUCIDO POR LA INFECCION DE PNEUMOCYSTIS CARINII.

Review (3)

The Oxidative Stress and Chronic Inflammatory Process in Chagas Disease: Role of Exosomes and Contributing Genetic Factors
The Use of Antioxidants as Potential Co-Adjuvants to Treat Chronic Chagas Disease
Dual and Opposite Roles of Reactive Oxygen Species (ROS) in Chagas Disease: Beneficial on the Pathogen and Harmful on the Host
23
Diego Rojas

Profesor Ayudante

Instituto de Ciencias Biomédicas (ICB)

Universidad Autónoma de Chile

Santiago, Chile

1
Caroll Beltrán

Profesor Asistente, Investigador Principal

Medicina

Universidad de Chile, Fac Medicina

SANTIAGO, Chile

1
Jorge Toledo

Investigador

Centro de Investigacion Clinica Avanzada CICA

Universidad de Chile, Hospital Clinico Universidad de Chile

Santiago, Chile

1
Sergio Vargas

Investigador Académico

Universidad de Chile

Santiago, Chile

1
Andrea Méndez

Académico Disciplinar Investigador

Facultad de Salud y Ciencias Sociales

Universidad de Las Américas

Santiago, Chile

1
Mauricio Henriquez

Profesor asistente

PROGRAMA DE FISIOLOGÍA Y BIOFíSICA

Universidad de Chile / Facultad de Medicina

Santiago, Chile

1
Carolina Ponce

Lab Manager Lab Infecciones Rspiratorias

Microbiología Y MIcología

UNIVERSIDAD DE CHILE

Santiago, Chile