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Diego Andrés Rojas Soto

Profesor Ayudante

Universidad Autónoma de Chile

Santiago, Chile

Transcripción en Eucariontes; infecciones respiratorias por hongos (Pneumocystis); EPOC; inflamación crónica de vías aéreas; hipersecreción de moco en pulmón.

Doctor en Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2012
Ingeniero en Biotecnología Molecular, UNIVERSIDAD DE CHILE. Chile, 2009

Profesor Ayudante Other

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2010 - 2019
Profesor Asistente (Académico) Full Time

Universidad Autónoma de Chile

Ciencias de la Salud

Santiago, Chile

2020 - At present

Investigador Part Time

Bioingentech

Santiago, Chile

2018 - 2018
Investigador Postdoctoral Full Time

Universidad de Santiago

Santiago, Chile

2019 - 2020
Investigador Postdoctoral Full Time

Universidad de Chile

Chile

2013 - 2018


Role of the Fungus <i>Pneumocystis</i> in IL1β Pathway Activation and Airways Collagen Deposition in Elastase-Induced COPD Animals Coronado, Krishna; Herrada, Carla; Rojas, Diego A. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2024)
<i>Pneumocystis</i> Exacerbates Inflammation and Mucus Hypersecretion in a Murine, Elastase-Induced-COPD Model Rojas, Diego A.; Ponce, Carolina A.; Bustos, Adriel; Cortes, Vicente; Olivares, Daniela; Vargas, Sergio L. Article ISI JOURNAL OF FUNGI (2023)
<i>Trypanosoma cruzi</i> DNA Polymerase β Is Phosphorylated In Vivo and In Vitro by Protein Kinase C (PKC) and Casein Kinase 2 (CK2) Maldonado, Edio; Rojas, Diego A.; Urbina, Fabiola; Valenzuela-Perez, Lucia; Castillo, Christian; Solari, Aldo Article ISI CELLS (2022)
Initiator-Directed Transcription: Fission Yeast Nmtl Initiator Directs Preinitiation Complex Formation and Transcriptional Initiation Rojas, Diego A.; Urbina, Fabiola; Valenzuela-Perez, Lucia; Leiva, Lorenzo; Miralles, Vicente J.; Maldonado, Edio Article ISI GENES (2022)
RNA Polymerase II Transcription in <i>Pneumocystis</i>: TFIIB from <i>Pneumocystis carinii</i> Can Replace the Transcriptional Functions of Fission Yeast <i>Schizosaccharomyces pombe</i> TFIIB In Vivo and In Vitro Rojas, Diego A.; Urbina, Fabiola; Solari, Aldo; Maldonado, Edio Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
The Catalytic Subunit of <i>Schizosaccharomyces pombe</i> CK2 (Cka1) Negatively Regulates RNA Polymerase II Transcription through Phosphorylation of Positive Cofactor 4 (PC4) Rojas, Diego A.; Urbina, Fabiola; Solari, Aldo; Maldonado, Edio Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
<i>T</i>. <i>cruzi</i> DNA polymerase beta (Tcpolβ) is phosphorylated <i>in vitro</i> by CK1, CK2 and TcAUK1 leading to the potentiation of its DNA synthesis activity Maldonado, Edio; Rojas, Diego A.; Urbina, Fabiola; Solari, Aldo Article ISI PLOS NEGLECTED TROPICAL DISEASES (2021)
Increase in secreted airway mucins and partial Muc5b STAT6/FoxA2 regulation during Pneumocystis primary infection. Rojas, Diego A; Iturra, Pablo A; Méndez, Andrea; Ponce, Carolina A; Bustamante, Rebeca; Gallo, Miriam; Bórquez, Pamela; Vargas, Sergio L Article Scientific reports (2019)
Primary infection by Pneumocystis induces Notch-independent Clara cell mucin production in rat distal airways Mendez, Andrea; Rojas, Diego A.; Ponce, Carolina A; Bustamante, Rebeca; Beltran, Carol J.; Toledo, Jorge; Garcia-Angulo, Victor A.; Henriquez, Mauricio; Vargas, Sergio L. Article ISI SCOPUS PLOS ONE (2019)
Endogenous overexpression of an active phosphorylated form of DNA polymerase Î² under oxidative stress in Trypanosoma cruzi. Rojas, Diego A; Urbina, Fabiola; Moreira-Ramos, Sandra; Castillo, Christian; Kemmerling, Ulrike; Lapier, Michel; Maya, Juan Diego; Solari, Aldo; Maldonado, Edio Article PLoS neglected tropical diseases (2018)
Progression of Type 2 Helper T Cell-Type Inflammation and Airway Remodeling in a Rodent Model of Naturally Acquired Subclinical Primary Pneumocystis Infection. Iturra, Pablo A; Rojas, Diego A; Pérez, Francisco J; Méndez, Andrea; Ponce, Carolina A; Bonilla, Paula; Bustamante, Rebeca; Rodríguez, Héctor; Beltrán, Caroll J; Vargas, Sergio L Article The American journal of pathology (2018)
RNA polymerase II components and Rrn7 form a preinitiation complex on the HomolD box to promote ribosomal protein gene expression in Schizosaccharomyces pombe. Montes, Matías; Moreira-Ramos, Sandra; Rojas, Diego A; Urbina, Fabiola; Käufer, Norbert F; Maldonado, Edio Article The FEBS journal (2017)
The Ski Protein is Involved in the Transformation Pathway of Aurora Kinase A Rivas S., Armisen R; Rojas DA, Maldonado E; Huerta H., Tapia JC; Espinoza J, Colombo A.; Michea L, Hayman; MJ, Marcelain K Article Journal of Cellular Biochemistry (2016)
Casein kinase 2 inhibits HomolD-directed transcription by Rrn7 in Schizosaccharomyces pombe. Moreira-Ramos, Sandra; Rojas, Diego A; Montes, Matías; Urbina, Fabiola; Miralles, Vicente J; Maldonado, Edio Article The FEBS journal (2015)
Expression, purification, and biochemical characterization of recombinant DNA polymerase beta of the Trypanosoma cruzi TcI lineage=> requirement of additional factors and detection of phosphorylation of the native form. Maldonado, Edio; Rojas, Diego A; Moreira-Ramos, Sandra; Urbina, Fabiola; Miralles, Vicente J; Solari, Aldo; Venegas, Juan Article Parasitology research (2015)
Fungal colonization with Pneumocystis correlates to increasing chloride channel accessory 1 (hCLCA1) suggesting a pathway for up-regulation of airway mucus responses, in infant lungs. Pérez, Francisco J; Ponce, Carolina A; Rojas, Diego A; Iturra, Pablo A; Bustamante, Rebeca I; Gallo, Myriam; Hananias, Karime; Vargas, Sergio L Article Results in immunology (2014)
Transcription directed by human core promoters with a HomolD box sequence requires DDB1, RECQL and RNA polymerase II machinery. Contreras-Levicoy, Juan; Moreira-Ramos, Sandra; Rojas, Diego A; Urbina, Fabiola; Maldonado, Edio Article Gene (2012)
Identification of Ski as a target for Aurora A kinase Mosquera J, Armisen R; Zhao, HL; Rojas DA, Maldonado E; Tapia JC, Colombo A.; Hayman, MJ Article Biochemical and Biophysical Research Communications (2011)
Rrn7 protein, an RNA polymerase I transcription factor, is required for RNA polymerase II-dependent transcription directed by core promoters with a HomolD box sequence. Rojas, Diego A; Moreira-Ramos, Sandra; Zock-Emmenthal, Susanne; Urbina, Fabiola; Contreras-Levicoy, Juan; Käufer, Norbert F; Maldonado, Edio Article The Journal of biological chemistry (2011)
Cloning of hif-1 alpha and hif-2 alpha and mRNA expression pattern during development in zebrafish Rojas DA, Perez-Munizaga; DA, Centanin; L, Antonelli M; Wappner, P; Allende, ML Article Gene Expression Patterns (2007)


Transcriptional Initiation in Ribosomal Protein Genes in the Fission Yeast Schizosaccharomyces pombe Rojas, DA; Moreira-Ramos, S; Urbina F.; Maldonado E. BookSection (2018)


la infección respiratoria con el hongo Pneumocystis induce estrés oxidativo y fibrosis en vías aéreas de animales con enfermedad obstructiva pulmonar crónica (EPOC). Coronado, K.; Herrada, C.; Lorca, V.; Hueichapán, V.; Contreras C.; Rojas, DA ConferencePoster (2023)
Pneumocystis carinii induce la hipersecreción de moco en las vías aéreas de manera sinérgica en animales con enfermedad obstructiva pulmonar crónica (EPOC) a través de un mecanismo dependiente de la vía STAT6. Rojas, DA; Bustos, A.; Cortés V.; Olivares, D ConferencePoster (2022)
Rol de Pneumocystis carinii en la modulación de la vía IL1b en un modelo animal de EPOC. Bustos, A.; Cortés V.; Olivares, D; Rojas, DA ConferencePoster (2022)
Pneumocystis carinii induces mucus hypersecretion via STAT6 and NFkB pathways in immunocompromised individuals. Rojas, DA; Olmos, E. ConferencePoster (2021)
Pneumocystis carinii induces mucus hypersecretion in a COPD-elastase induced rat model. Rojas, DA ConferencePoster (2020)
Induction of Muc5b and Muc5ac via STAT6/FoxA2 pathway during Pneumocystis primary infection. Rojas, DA; Iturra, P; Mendez, A.; Ponce, CA; Bustamante, R; Vargas, SL ConferencePoster (2018)
Pneumocystis y mucinas durante la infección primaria. Rojas, DA ConferencePoster (2018)
Pneumocystis carinii induce la hipersecreción de moco en animales inmunocompetentes a través de la activación de la vía STAT6/FoxA2 Rojas, DA; Mendez, A.; Iturra, P; Ponce, CA; Vargas, SL ConferencePoster (2016)
Caracterización de la respuesta secretora en vías aéreas del hospedero durante la infección primaria de Pneumocystis naturalmente adquirido en ratas inmunocompetentes Rojas, DA; Iturra, P; Ponce, CA; Mendez, A.; Bustamante, R; Vargas, SL ConferencePoster (2015)
Progression of STAT6-related mucus increase during naturally acquired primary infection by Pneumocystis in immunocompetent rats. Rojas, DA; Iturra, P; Ponce, CA; Pérez F.; Bustamante, R; Ponce N.; Vargas, SL ConferencePoster (2014)


Role of Pneumocystis in the severity of chronic mucus hypersecretion during the pathogenesis of COPD. Rojas, Diego A. Proyecto (2019)
Desarrollo de un prototipo de ensayo de inhibición de la enzima proteína fosfatasa 2a de mytilus par a la detección y cuantificación de toxinas diarreicas en muestras de extractos de mariscos y conservas. FONDEF (ID16I10145) Proyecto 2017-2019 Investigador(a)
ELUCIDATION OF PNEUMOCYSTIS-INDUCED PATHOLOGY AND SEQUELS IN MURINE MODELS, AND EVALUATION OF SELECTED MARKERS OF LUNG DAMAGE IN AUTOPSIED INFANT LUNGS. FONDECYT (1140412) Proyecto 2014-2018 Coinvestigador(a)
ROL DE FOXA2 EN LA REMODELACION Y RESPUESTA SECRETORA DEL EPITELIO RESPIRATORIO INDUCIDO POR LA INFECCION DE PNEUMOCYSTIS CARINII. FONDECYT (3140391) Proyecto 2013-2016 Inv. Responsable


The Oxidative Stress and Chronic Inflammatory Process in Chagas Disease: Role of Exosomes and Contributing Genetic Factors Maldonado, Edio; Rojas, Diego A.; Urbina, Fabiola; Solari, Aldo Review ISI OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)
The Use of Antioxidants as Potential Co-Adjuvants to Treat Chronic Chagas Disease Maldonado, Edio; Rojas, Diego A.; Urbina, Fabiola; Solari, Aldo Review ISI ANTIOXIDANTS (2021)
Dual and Opposite Roles of Reactive Oxygen Species (ROS) in Chagas Disease: Beneficial on the Pathogen and Harmful on the Host Maldonado, Edio; Rojas, Diego A.; Morales, Sebastian; Miralles, Vicente; Solari, Aldo Review ISI OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)