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Carolina Angélica Ponce Olmos

Lab Manager Lab Infecciones Rspiratorias

UNIVERSIDAD DE CHILE

Santiago, Chile

Pneumocystis infections; Clinical trials in respiratory infections; Estudio de la Infección por Pneumocystis sp.y su diagnóstico

Magister en Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2005
Bioquímico, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 1991

Instructor Full Time

UNIVERSIDAD DE CHILE

Facultad de Medicina

Santiago, Chile

2001 - 2002
Instructor Part Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Ciencias Biológicas

Santiago, Chile

1993 - 1996

Profesional Lab Manager Full Time

Universidad de Chile

Santiago, Chile

2002 - At present
Asistente de Investigación Full Time

Universidad de Chile

Santiago, Chile

1998 - 2001
Asistente de Investigación Full Time

Hospital Luis Calvo Mackenna

Santiago, Chile

1996 - 1998
Asistente de Investigación Part Time

Pontificia Universidad Católica de Santiago

Santiago, Chile

1993 - 1996
Asistente de Investigación Full Time

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1992 - 1993

1.- Codirector Tesis de Magíster en Ciencias Biomédicas: “Caracterización de cambios histológicos del epitelio respiratorio durante la infección primaria por Pneumocystis carinii en ratas"
Alumna: Paula Bonilla Zamudio, Universidad de Chile, 2010

2.- Codirector Tesis de Pregrado para optar al título de Bioquímico:“Expresión de la proteína SP-A, SP-B y TNF-alfa durante la infección primaria por Pneumocystis jirovecii en lactantes fallecidos con diagnóstico presuntivo de Síndrome de muerte Súbita (SMS)”.
Alumna Jocelyn Patricia Brito Echeverria. Universdidad de Chile, 2004


Pneumocystis jirovecii colonisation in pregnant women and newborns in Lima, Peru [Colonización por Pneumocystis jirovecii en mujeres gestantes y recién nacidos en Lima, Perú] Garcia C.; Ochoa T.; Neyra E.; Bustamante B.; Ponce C.; Calderon E.J.; Vargas, S.L. Article SCOPUS Revista Iberoamericana de Micologia (2020)
Increase in secreted airway mucins and partial Muc5b STAT6/FoxA2 regulation during Pneumocystis primary infection. Rojas, Diego A; Iturra, Pablo A; Méndez, Andrea; Ponce, Carolina A; Bustamante, Rebeca; Gallo, Miriam; Bórquez, Pamela; Vargas, Sergio L Article Scientific reports (2019)
Niflumic Acid Reverses Airway Mucus Excess and Improves Survival in the Rat Model of Steroid-Induced Pneumocystis Pneumonia PÃ©rez F.J.; Iturra P.A.; Ponce, C.A.; Magne F.; Garcia-Angulo V.; Vargas, S.L. Article ISI SCOPUS FRONTIERS IN MICROBIOLOGY (2019)
Primary infection by Pneumocystis induces Notch-independent Clara cell mucin production in rat distal airways Mendez, Andrea; Rojas, Diego A.; Ponce, Carolina A; Bustamante, Rebeca; Beltran, Carol J.; Toledo, Jorge; Garcia-Angulo, Victor A.; Henriquez, Mauricio; Vargas, Sergio L. Article ISI SCOPUS PLOS ONE (2019)
Progression of Type 2 Helper T Cell-Type Inflammation and Airway Remodeling in a Rodent Model of Naturally Acquired Subclinical Primary Pneumocystis Infection. Iturra, Pablo A; Rojas, Diego A; Pérez, Francisco J; Méndez, Andrea; Ponce, Carolina A; Bonilla, Paula; Bustamante, Rebeca; Rodríguez, Héctor; Beltrán, Caroll J; Vargas, Sergio L Article The American journal of pathology (2018)
High Prevalence of Pneumocystis jirovecii Dihydropteroate Synthase Gene Mutations in Patients with a First Episode of Pneumocystis Pneumonia in Santiago, Chile, and Clinical Response to Trimethoprim-Sulfamethoxazole Therapy. Ponce, Carolina A; Chabé, Magali; George, Claudio; Cárdenas, Alejandra; Durán, Luisa; Guerrero, Julia; Bustamante, Rebeca; Matos, Olga; Huang, Laurence; Miller, Robert F; Vargas, Sergio L Article Antimicrobial agents and chemotherapy (2017)
Importance of tissue sampling, laboratory methods, and patient characteristics for detection of Pneumocystis in autopsied lungs of non-immunosuppressed individuals. Vargas, S L; Ponce, C; Bustamante, R; Calderón, E; Nevez, G; De Armas, Y; Matos, O; Miller, R F; Gallo, M J Article European journal of clinical microbiology & infectious diseases => official publication of the European Society of Clinical Microbiology (2017)
Diagnosis of the primary infection by pneumocystis in autopsy specimens from two infants using lung impression smears (touch preps) Ponce, C.A.; Bustamante R.I.; Gallo, M; Vargas, S.L. Article SCOPUS Medical Mycology Case Reports (2014)
Fungal colonization with Pneumocystis correlates to increasing chloride channel accessory 1 (hCLCA1) suggesting a pathway for up-regulation of airway mucus responses, in infant lungs Pérez F.J.; Ponce, C.A.; Rojas, D.A; Iturra P.A.; Bustamante R.I.; Gallo, M; Hananias, K; Vargas, S.L. Article SCOPUS Results in Immunology (2014)
Near-Universal Prevalence of Pneumocystis and Associated Increase in Mucus in the Lungs of Infants With Sudden Unexpected Death Vargas SL, Ponce CA; Gallo M., Pérez F.; Astorga, JF; Bustamante R, Chabe M; Durand-Joly, I; Iturra P., Miller RF; Aliouat, E; Dei-Cas, E Article Clinical Infectious Diseases (2013)
Pneumocystis colonization in older adults and diagnostic yield of single versus paired noninvasive respiratory sampling. Vargas, Sergio L; Pizarro, Patricia; López-Vieyra, Mónica; Neira-Avilés, Patricia; Bustamante, Rebeca; Ponce, Carolina A Article Clinical infectious diseases => an official publication of the Infectious Diseases Society of America (2010)
Pneumocystis colonization is highly prevalent in the autopsied lungs of the general population Carolina A. Ponce, Myriam Gallo; Rebeca Bustamante, Sergio L. Vargas Article Clinical Infectious Diseases (2010)
Seroepidemiological study of Pneumocystis jirovecii infection in healthy infants in Chile using recombinant fragments of the P. jirovecii major surface glycoprotein Djawe, K; Daly, KR; Vargas SL, Santolaya ME; Ponce CA, Bustamante R; Koch, J; Levin L, Walzer Article International Journal of Infectious Diseases (2010)
Pneumocystis is not a direct cause of sudden infant death syndrome Vargas SL, Ponce CA; Galvez P, Ibarra C.; Haas, EA; Chadwick, AE; Krous, HF Article Pediatric Infectious Disease Journal (2007)
Sudden infant death syndrome and activating GNAS1 gene mutations Roman, R; Lopez, P; Johnson, MC; Boric, MA; Gallo, M; Ponce C.; Vargas S.; Codner, E; Cassorla F. Article ISI SCOPUS FETAL AND PEDIATRIC PATHOLOGY (2007)
Detection of Pneumocystis carinii f. sp hominis and viruses in presumably immunocompetent infants who died in the hospital or in the community Vargas SL, Ponce CA; Luchsinger V, Silva C.; Gallo M., Lopez R.; Belletti, J; Velozo L., Ávila R.; Palomino, MA; Benveniste, S; Avendano, LF Article JOURNAL OF INFECTIOUS DISEASES (2005)
Pregnancy and asymptomatic carriage of Pneumocystis jiroveci Vargas, SL; Ponce, CA; Sanchez, CA; Ulloa, AV; Bustamante, R; Juarez, G Article ISI EMERGING INFECTIOUS DISEASES (2003)
Distribution of Pneumocystis carinii f. sp. hominis types in the lung of a child dying of Pneumocystis pneumonia. Ambrose, H E; Ponce, C A; Wakefield, A E; Miller, R F; Vargas, S L Article Clinical infectious diseases => an official publication of the Infectious Diseases Society of America (2001)
Search for primary infection by Pneumocystis carinii in a cohort of normal, healthy infants Vargas SL, Hughes; WT, Santolaya ME; Ulloa, AV; Ponce CA, Cabrera; CE, Cumsille; F, Gigliotti Article Clinical Infectious Diseases (2001)
Enhanced differentiation of HL-60 leukemia cells to macrophages induced by ciprofibrate 12. Bronfman M., Ponce C., Rojas S., Roth A., Loyola G., Vollrath V. and Chianale J. Article European Journal of cell Biology 1998, 77;214-219. (1998)


Pneumocystis primary infection in infancy: Additional French data and review of the literature Nevez G.; Guillaud-Saumur T.; Cros P.; Papon N.; Vallet S.; Quinio D.; Minoui-Tran A.; PilorgÃ© L.; De Parscau L.; Sizun J.; Ochoa T.J.; Bustamante B.; Ponce C.; Vargas, S.L.; Le Gal S. ConferencePaper ISI SCOPUS MEDICAL MYCOLOGY (2020)


Recognition of the Primary Infection by Pneumocystis in infants=> A silent threat to public health PCI (ELAC2014/H) Proyecto 2015-2019 Coinvestigador(a)
Elucidation of Pneumocystis-induced pathology and sequels in murine models, and evaluation of selected markers of lung damage in autopsied infant lungs. FONDECYT (1140412) Proyecto 2014-2017 Coinvestigador(a)
Characterization of the mucus-secreting response to Pneumocystis by the respiratory epithelium=> A potential cofactor for increased severity of respiratory disease in the immunocompetent host. FONDECYT (1100225) Proyecto 2010-2014 Coinvestigador(a)
Caracterización de formas emergentes de infección por Pneumocystis jirovecii en la población y su impacto epidemiológico FONDECYT (1060750) Proyecto 2006-2009 Coinvestigador(a)
Adquisición de Pneumocystis por personal de la salud al estar en contacto con pacientes con neumonía por Pneumocystis OIAC=> Concurso deInvestigación Clínica y Clínica Básica Proyecto 2005-2006 Investigador(a)
Mecanismos patógenicos de la infección primaria por Pneumocystis carinii y su relevancia en el Síndrome de Muerte Súbita del Lactante FONDECYT (1011059) Proyecto 2001-2004 Coinvestigador(a)
Fundamentos para el diagnóstico de la infección primaria por Pneumocystis carinii un reservorio de contagio no conocido para pacientes debilitados y/o inmunocomprometidos. FONDEF (1960940) Proyecto 1996-2000 Coinvestigador(a)
Modulación de proteina Quinasa C por acil-coenzimas A por función de receptores intracelulares. Rol en diferenciación celular y carcinogénesis no-genotóxica FONDEF (685/94) Proyecto 1995-1996 Investigador(a)
El sistema xilanolítico del hongo Penicillium purpurogenum=> identificación y caracterización de sus enzimas, su expresión en levaduras y preparación de mutantes del hongo FONDECYT (1930673) Proyecto 1993-1995 Investigador(a)