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Alvaro Oscar Ardiles Araya

Full Professor

Universidad de Valparaíso

Valparaiso, Chile

Líneas de Investigación


Neuroscience, Synaptic physiology, Behavioral neuroscience, Neuromodulation, Aging and Neurodegeneration, Panexin 1 channels activity, Molecular mechanisms of Synaptopathies, Alzheimer´s disease, neuronal cytoskeleton.

Educación

  •  Neuroscience, UNIVERSIDAD DE VALPARAISO. Chile, 2011
  •  Biochemist, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2006
  •  Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2005

Experiencia Académica

  •   Assistant professor Full Time

    UNIVERSIDAD DE VALPARAISO

    MEDICINA

    Valparaiso, Chile

    2017 - 2023

  •   Lecturer professor Other

    Universidad Andrés Bello

    Ciencias Biológicas

    Viña del mar, Chile

    2011 - 2012

  •   Full professor Full Time

    UNIVERSIDAD DE VALPARAISO

    Medicina

    Valparaiso, Chile

    2023 - At present

Experiencia Profesional

  •   Young associate researcher Part Time

    Centro Interdisciplinario de Neurociencia

    Valparaiso, Chile

    2015 - 2020

  •   Postdoctoral researcher Full Time

    Universidad de Valparaiso

    Valparaiso, Chile

    2012 - 2015

  •   Lecturer professor Other

    Universidad Andres bello

    Valparaiso, Chile

    2011 - 2012

  •   Research assistant Full Time

    Centro Interdisciplinario de Neurociencia

    Valparaiso, Chile

    2005 - 2007

  •   Adjunct researcher Part Time

    Centro Interdisciplinario de Neurociencia de Valparaiso

    Valparaiso, Chile

    2021 - At present

Formación de Capital Humano


5 PhD thesis, 4 Master Thesis, and 13 Undergraduate thesis directed or co-directed.
Undergraduate
2013-2014 (Biotechnology) Oriana Ramírez Herrera. Universidad Andrés Bello
2015-2016 (Biochemistry) Francisca García Rojas. Pontificia Universidad Católica de Valparaíso.
2018-2019 (Medical technologist) Barbara Gomez and Elena Mery. Universidad de Valparaiso
2019-2020 (Medical technologist) Nicolas Rivera. Universidad de Valparaiso
2020-2022 (Medical technologist) Katherine Allende, Mayra Providell y Juan Pablo Pinochet. Universidad de Valparaiso
2021 (Biologist) Camila Fuentes. Universidad de Valparaiso
2023 (Medical technologist) Camila León, Melany Muñoz, Camila Garay, Tamara Mendoza, Ignacio Rojas. Universidad de Valparaiso
MsC
2013-2014 (MSc in Biotechnology) Oriana Ramírez Herrera. Universidad Andrés Bello
2014-2016 (MSc in Neuroscience) Carolina Flores Muñoz. Universidad de Valparaíso.
2016-2017 (MSc in Neuroscience) Luis Manriquez Cockbaine. Universidad de Valparaíso.
2021-2023 (MSc in Cellular & Molecular Biology) Gonzalo Poblete. Universidad de Valparaíso.
PhD
2018-2022 (PhD in Neuroscience) Carolina Flores Muñoz. Universidad de Valparaíso.
2018-2022 (PhD in Neuroscience) Francisca García Rojas. Universidad de Valparaíso.
2019-2023 (PhD in Neuroscience) Paula Mujica Covarrubias. Universidad de Valparaíso.
2020-2023 (PhD in Neuroscience) Claudia García. Universidad de Valparaíso.
2020- (PhD in Neuroscience) Javiera Illanes. Universidad de Valparaíso.
2022- (PhD in Neuroscience) Stefany Órdenes. Universidad de Valparaíso.


Premios y Distinciones

  •   Postdoctoral fellow FONDECYT

    FONDECYT

    Chile, 2013

    Role of pannexin1 in synaptic physiology. ID 3130759 This grant seeks to investigate the role of pannexin1 in synaptic function and plasticity in the hippocampus from mice.

  •   Inserción de Capital Humano Avanzado en la Academia CONICYT

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2015

    Panexina 1: un nuevo actor en los mecanismos patológicos asociados a la enfermedad de Alzheimer. ID 79150045

  •   CINV Postdoctoral fellowship

    Centro Interdisciplinario de Neurociencia de valparaiso

    Chile, 2012

    The purpose of this program is to support outstanding and highly motivated PhD graduates from any country who wish to initiate or continue a scientific project in one of CINV’s labs.


 

Article (33)

The antiseizure medication valproate increases hemichannel activity found in brain cells, which could worsen disease outcomes
A centronuclear myopathy-causing mutation in dynamin-2 disrupts neuronal morphology and excitatory synaptic transmission in a murine model of the disease
mGluR-dependent plasticity in rodent models of Alzheimer's disease
Neurobiology of Disorganized Attachment: A Review of Primary Studies on Human Beings
Pannexin-1 Modulates Inhibitory Transmission and Hippocampal Synaptic Plasticity
Probenecid, an Old Drug with Potential New Uses for Central Nervous System Disorders and Neuroinflammation
The unfolded protein response transcription factor XBP1s ameliorates Alzheimer's disease by improving synaptic function and proteostasis
The Long-Term Pannexin 1 Ablation Produces Structural and Functional Modifications in Hippocampal Neurons
The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer's Disease Mouse Model
Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging
A Multisubcellular Compartment Model of AMPA Receptor Trafficking for Neuromodulation of Hebbian Synaptic Plasticity
Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer’s Disease
Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation
Dynamin Superfamily at Pre- and Postsynapses: Master Regulators of Synaptic Transmission and Plasticity in Health and Disease
Evidence of Synaptic and Neurochemical Remodeling in the Retina of Aging Degus
Redox modifications in synaptic components as biomarkers of cognitive status, in brain aging and disease
Lack of Pannexin 1 Alters Synaptic GluN2 Subunit Composition and Spatial Reversal Learning in Mice
IRE1 signaling exacerbates Alzheimer's disease pathogenesis
Molecular and Cellular Mechanisms of Synaptopathies
Genetic variants associated with neurodegenerative Alzheimer disease in natural models
Inhibition of DNA Methylation Impairs Synaptic Plasticity during an Early Time Window in Rats
Metabotropic Glutamate Receptors Induce a Form of LTP Controlled by Translation and Arc Signaling in the Hippocampus
Regulation of Memory Formation by the Transcription Factor XBP1
Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer's Disease
Alzheimer's Disease-Related Protein Expression in the Retina of Octodon degus
Pannexin 1 regulates bidirectional hippocampal synaptic plasticity in adult mice
Integrity of mGluR-LTD in the Associative/Commissural Inputs to CA3 Correlates with Successful Aging in Rats
Octodon degus (Molina 1782): A model in comparative biology and biomedicine
Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease
Pull-Push Neuromodulation of LTP and LTD Enables Bidirectional Experience-Induced Synaptic Scaling in Visual Cortex
The elusive crypt olfactory receptor neuron: evidence for its stimulation by amino acids and cAMP pathway agonists
Calcium channel subtypes differentially regulate fusion pore stability and expansion
A rapid exocytosis mode in chromaffin cells with a neuronal phenotype

BookSection (2)

Transcranial Red LED Therapy: A Promising Non-Invasive Treatment to Prevent Age-Related Hippocampal Memory Impairment.
Redox Homeostasis in Neural Plasticity and the Aged Brain

Proyecto (15)

Therapeutic hypothermia reduces hypoxia-mediated brain injury in male offspring from experimental preeclampsia. Role of brain vascular response and endothelial VEGF/VEGFR2/NO signaling pathway
Dynamin 2 contribution to the cytoskeleton-dependent synaptopathy on Alzheimer´s disease
Desarrollo de una cobertura cutánea costo efectiva “PanexpatchTM” para el tratamiento de úlceras venosas
Over-activation of Panx1 in neurons leads to intracellular Ca2+ overload and subsequent defects in neuronal cytoskeleton and signaling receptor trafficking supporting synaptic defects in an Alzheimer´s disease model
Proteostaser-1: una terapia génica enfocada a disminuir la neurodegeneración y aumentar la función cognitiva en la enfermedad de Alzheimer
Role of promigratory activation of VEGFR2 in the brain angiogenesis and its potential implication in learning and memory of offspring born to preeclampsia
Panexina 1=> un nuevo actor en los mecanismos patológios asociados a la enfermedad de Alzheimer
Proteostaser-1=> una terapia génica enfocada a disminuir la neurodegeneración y aumentar la función cognitiva en la enfermedad de Alzheimer.
A NOVEL ROLE OF PANNEXIN 1 CHANNELS IN THE SYNAPTOPATHY ASSOCIATED TO THE SOLUBLE AMYLOID ? OLIGOMERS IN ALZHEIMER´S DISEASE
ASTAXANTINA Y ANTIENVEJECIMIENTO CEREBRAL
ROL DE PANEXIN 1 EN LA FISIOLOGIA SINAPTICA.
Centro de neurociencia sensorial desde la señal de transducción hasta el código neural
GENE DOSAGE EFFECTS IN CHOLINERGIC AND GLUTAMATERGIC DYSFUNCTION OF IMMORTALIZED NEURONAL CELLS DERIVED FROM THE TRISOMY 16 MOUSE, AN ANIMAL MODEL OF HUMAN DOWN SYNDROME
CAMBIOS EN LA EFICIENCIA SECRETORA DEBIDO A REDISTRIBUCION DE ZONAS SECRETORAS ACTIVAS Y CANALES CALCIO EN CELULAS CROMAFINES DIFERENCIADAS
CAMBIOS EN LA EFICIENCIA SECRETORA DEBIDO A REDISTRIBUCION DE ZONAS SECRETORAS ACTIVAS Y CANALES CALCIO EN CELULAS CROMAFINES DIFERENCIADAS

Review (2)

Alzheimer's disease in the human eye. Clinical tests that identify ocular and visual information processing deficit as biomarkers
Role of Tau Protein in Neuronal Damage in Alzheimer's Disease and Down Syndrome
46
Alvaro Ardiles

Full Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

12
Adrian Palacios

Profesor

Instituto de Neurosciencia

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

4
Carolina Flores

Investigador Postdoctoral

Neurociencias

Universidad de Valparaíso

Valparaíso, Chile

4
Claudia Duran-Aniotz

Profesor Asociado

Escuela de Psicología

Universidad Adolfo Ibánez

Santiago, Chile

4
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Ana Cárdenas

Professor

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

3
Daniela López

Profesora Adjunta

UNIVERSIDAD DE VALPARAISO

Viña de Mar, Chile

2
Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

2
Pablo Caviedes

Full professor

ICBM

PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA, ICBM, FAC. DE MEDICINA, U. DE CHILE

Santiago, Chile

2
Joaquìn Araya

Profesor Asistente

Facultad de Salud

Universidad Santo Tomás

Santiago, Chile

1
sandra espinoza

asistente de investigacion

Laboratorio Neuroinmunologia

Fundacion Ciencias para la Vida/Universidad San Sebastian

Santiago, Chile

1
Víctor Cornejo

Profesor Asistente

Facultad de Ciencias Biológicas

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Claudio Cordova

Investigador asistente

Medicina

Universidad de Valparaíso

Valparaíso, Chile

1
John Ewer

Profesor titular

Neurociencia

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

1
Maria Yolanda Espinosa

Full Professor

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

1
Alejandro Weinstein

Professor

Escuela de Ingenieria Civil Biomedica

Universidad de Valparaiso

Valparaiso, Chile

1
Francisco Carvajal

asistente de investigacion

Universidad de Magallanes

punta arenas, Chile

1
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

1
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

1
MIGUEL PEREZ

Associate Professor

Pontificia Universidad Catolica de Valparaiso

VALPARAISO, Chile

1
Andrea Paula-Lima

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

1
Paula Diaz

PhD (c)

Departamento de Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Arlek Gonzalez

INVESTIGADOR POST-DOCTORAL

CENTRO INTERDISCIPLINARIO DE NEUROCIENCIA, UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

1
Juan Godoy

Investigador

Centro de Oncologia dePrecision

Santiago, Chile

1
Juan Zolezzi

Associate Professor

School of Medicine

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

1
Marcelo Arancibia

Principal investigator

Universidad de Valparaíso

Viña del Mar, Chile

1
Pablo Muñoz

Profesor titular

Patología y Fisiología

UNIVERSIDAD DE VALPARAÍSO

Valparaiso, Chile

1
Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

1
Danilo Bilches

Staff Scientist

Instituto de Neurociencia Biomedica

Santiago, Chile

1
Pablo Lizana

Profesor Adjunto - Jornada Completa

Instituto de Biología

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

1
Nora Lutz

Directora Departamento Salud Pública

Salud Pública

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

1
Claudia Garcia

Candidata a doctora

Ciencias

Universidad de Valparaíso

Valparaíso, Chile

1
JUVENAL RÍOS

Investigador

CR de Investigación y Desarrollo

Instituto Nacional del Cáncer (INCANCER)

Santiago, Chile

1
Pablo Mardones

Research Associate

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Alex Vielma

Postdoctoral researcher

Centro Interdisciplinario de Neurociencias de Valparaíso

Valparaiso, Chile

1
Luz Delgado

Investigador

Fundacion Ciencia para la vida

Chile

1
Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Francisco Bozinovic

Full professor

Ecology

Pontifical Catholic University of Chile

Santiago, Chile

1
Cristian Núñez

Profesor de Fisiología

Escuela de Medicina

Universidad de Magallanes

Punta Arenas, Chile

1
Oliver Schmachtenberg

Investigador titular

Instituto de Biología

Universidad de Valparaíso, CINV

Valparaíso, Chile

1
Débora Buendía

Académico - adjunto

Ingeniería Civil Biomédica

Universidad de Valparaíso

Valparaíso, Chile

1
YORLEY DUARTE

profesor Asistente

Universidad Andrés Bello

Santiago, Chile

1
David Naranjo

Profesor titular

Neurociencia

Universidad de Valparaíso

VALPARAISO, Chile