Man

Pablo Andres Mardones Hiche

Research Associate

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Biotechnology; Biochemistry; Cell Biology; Metabolism

Educación

  •  Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1999
  •  Science, UNIVERSITEIT VAN AMSTERDAM. Holanda, 2013
  •  Biochemist, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2001

Experiencia Académica

  •   Research Associate Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Faculty of Engineering

    Santiago, Chile

    2016 - 2018

  •   Postdoctoral Fellow Other

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Santiago, Chile

    2013 - 2016

  •   Adjunct Professor Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Faculty of Engineering

    Santiago, Chile

    2018 - At present

Experiencia Profesional

  •   Research Fellow Full Time

    Max Planck Institute for Biochemistry

    Munich, Alemania

    2007 - 2010

  •   Research Specialist Full Time

    Howard Hughes Medical Institute / Janelia Farm Research Campus

    Ashburn, VA, Estados Unidos

    2010 - 2012

  •   Research Assistant Other

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2001 - 2003

  •   R&D&I Coordinator - School of Engineering Part Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2016 - At present

Difusión y Transferencia


1) Member of BRAIN Chile Committee. Accelerator program for science and technology based startups organized by The School of Engineering UC, The Center for Innovation UC - Anacleto Angelini, and Santander Chile. (2018-present)

2) Certified DC I-Corps Instructor. Methodology for customer discovery and business model generation for science and technology based startups. (2017-present).


Premios y Distinciones

  •   FONDECYT Postdoctoral Fellowship

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2014

    Grant awarded to perform independent postdoctoral research in Chilean academic institutions.

  •   Biomedical Neuroscience Institute (BNI) Bridge Fellowship

    Biomedical Neuroscience Institute (BNI)

    Chile, 2013

    Fellowship to perform independent postdoctoral research at the Biomedical Neuroscience Institute (BNI, Millennium Institute).

  •   Academic Medical Center (AMC) PhD Scholarship

    Netherlands Organisation for Scientific Research

    Holanda, 2003

    Scholarship to conduct PhD studies at the Academic Medical Center of the University of Amsterdam.


 

Article (16)

Biology and pathological implications of brown adipose tissue=> promises and caveats for the control of obesity and its associated complications.
Biology and pathological implications of brown adipose tissue: promises and caveats for the control of obesity and its associated complications
Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport
Regulation of Memory Formation by the Transcription Factor XBP1
Cyclic AMP and alkaline pH downregulate carbonic anhydrase 2 in mouse fibroblasts
Ae2(a,b)-deficient mice exhibit osteopetrosis of long bones but not of calvaria
Activation of cyclic AMP Signaling in Ae2-deficient mouse fibroblasts
The anion exchanger Ae2 is required for enamel maturation in mouse teeth
Inefficient Chronic Activation of Parietal Cells in Ae2a,b-/- Mice
Biliary lipid secretion, bile acid metabolism, and gallstone formation are not impaired in hepatic lipase-deficient mice
Expression and regulation of scavenger receptor class B type I (SR-BI) in gall bladder epithelium
Fibrates down-regulate hepatic scavenger receptor class B type I protein expression in mice
?-tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-BI)-deficient mice
alpha-tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-BI)-deficient mice
Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice
Impaired biliary cholesterol secretion and decreased gallstone formation in apolipoprotein E-deficient mice fed a high-cholesterol diet

Abstract (1)

Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I (SR-BI)-deficient mice

ConferencePaper (1)

Localization and function of the anionic exchanger AE2 in developing rodent teeth

ConferencePoster (2)

The unfolded protein response (UPR) provides gain amplification to brain‐derived neurotrophic factor (BDNF) signaling in cortical mouse neurons
The unfolded protein response (UPR) regulates brain‐derived neurotrophic factor (BDNF) expression and signaling in vivo and in primary cortical neurons

EditorialMaterial (2)

Peroxisomes Get Loud: A Redox Antidote to Hearing Loss
Cell-Nonautonomous Control of the UPR: Mastering Energy Homeostasis

Proyecto (3)

Investigating the function of IRE1-alpha/XBP1 in neurophysiology and synaptic plasticity.
Mechanisms and Functional Role of Internally Generated Brain Activity.
A cellular model of cytosolic lipid droplet assembly in S. cerevisiae.

Review (3)

Control of systemic proteostasis by the nervous system
Advances in the physiological and pathological implications of cholesterol
Cellular mechanisms of vitamin E uptake: relevance in alpha-tocopherol metabolism and potential implications for disease
24
Pablo Mardones

Research Associate

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

15
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

9
Juan Miquel

Full Professor

Gastroenterology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

8
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Pablo Strobel

Prrofesional de laboratorio

Facultad Ciencias Veterinarias

Universidad Austral de Chile

Valdivia, Chile

1
Victor Cortes

Associate professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Dolores Busso

Associate Professor

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

1
Alvaro Ardiles

Full Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

1
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
daniel duran

Profesor

Bioquímica Clínica e Inmunología

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Adrian Palacios

Profesor

Instituto de Neurosciencia

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile