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Pablo Andres Mardones Hiche

Research Associate

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Biotechnology; Biochemistry; Cell Biology; Metabolism

Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1999
Science, UNIVERSITEIT VAN AMSTERDAM. Holanda, 2013
Biochemist, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2001

Research Associate Part Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Faculty of Engineering

Santiago, Chile

2016 - 2018
Postdoctoral Fellow Other

UNIVERSIDAD DE CHILE

Facultad de Medicina

Santiago, Chile

2013 - 2016
Adjunct Professor Part Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Faculty of Engineering

Santiago, Chile

2018 - At present

Research Fellow Full Time

Max Planck Institute for Biochemistry

Munich, Alemania

2007 - 2010
Research Specialist Full Time

Howard Hughes Medical Institute / Janelia Farm Research Campus

Ashburn, VA, Estados Unidos

2010 - 2012
Research Assistant Other

Pontificia Universidad Católica de Chile

Santiago, Chile

2001 - 2003
R&D&I Coordinator - School of Engineering Part Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2016 - At present

1) Member of BRAIN Chile Committee. Accelerator program for science and technology based startups organized by The School of Engineering UC, The Center for Innovation UC - Anacleto Angelini, and Santander Chile. (2018-present)

2) Certified DC I-Corps Instructor. Methodology for customer discovery and business model generation for science and technology based startups. (2017-present).

FONDECYT Postdoctoral Fellowship

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2014

Grant awarded to perform independent postdoctoral research in Chilean academic institutions.
Biomedical Neuroscience Institute (BNI) Bridge Fellowship

Biomedical Neuroscience Institute (BNI)

Chile, 2013

Fellowship to perform independent postdoctoral research at the Biomedical Neuroscience Institute (BNI, Millennium Institute).
Academic Medical Center (AMC) PhD Scholarship

Netherlands Organisation for Scientific Research

Holanda, 2003

Scholarship to conduct PhD studies at the Academic Medical Center of the University of Amsterdam.


Biology and pathological implications of brown adipose tissue=> promises and caveats for the control of obesity and its associated complications. Tapia, Pablo; Fernández-Galilea, Marta; Robledo, Fermín; Mardones, Pablo; Galgani, José E; Cortés, Víctor A Article Biological reviews of the Cambridge Philosophical Society (2018)
Biology and pathological implications of brown adipose tissue: promises and caveats for the control of obesity and its associated complications Tapia, Pablo; Fernández-Galilea, Marta; Robledo, Fermín; Mardones, Pablo; Galgani, José E.; Cortés, Víctor A. Article Biological Reviews (2017)
Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport Mardones P.; Rubinsztein D.C.; hetz C. Article ISI SCOPUS SCIENCE SIGNALING (2016)
Regulation of Memory Formation by the Transcription Factor XBP1 Martinez, G; Vidal, RL; Mardones P.; Serrano, FG; Ardiles AO; Wirth C.; Valdés P.; Thielen P; Schneider, BL; Kerr, B.; Valdes, JL; Palacios, AG; Inestrosa, NC; Glimcher, LH; hetz C. Article ISI SCOPUS CELL REPORTS (2016)
Cyclic AMP and alkaline pH downregulate carbonic anhydrase 2 in mouse fibroblasts Mardones, Pablo; Chang, Jung Chin; Oude Elferink, Ronald P.J. Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2014)
Ae2(a,b)-deficient mice exhibit osteopetrosis of long bones but not of calvaria Jansen, Ineke D.C.; Mardones, Pablo; Lecanda, Fernando; de Vries, Teun J.; Recalde, Sergio; Hoeben, Kees A.; Schoenmaker, Ton; Ravesloot, Jan-Hindrik; van Borren, Marcel M.G.J.; van Eijden, Theo M.; Bronckers, Antonius L.J.J.; Kellokumpu, Sakari; Medina, Juan F.; Everts, Vincent; Oude Elferink, Ronald P.J. Article ISI FASEB JOURNAL (2009)
Activation of cyclic AMP Signaling in Ae2-deficient mouse fibroblasts Mardones, Pablo; Medina, Juan F.; Oude Elferink, Ronald P.J. Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The anion exchanger Ae2 is required for enamel maturation in mouse teeth Lyaruu, D.M.; Bronckers, A.L.J.J.; Mulder, L.; Mardones, P.; Medina, J.F.; Kellokumpu, S.; Oude Elferink, R.P.J.; Everts, V. Article ISI MATRIX BIOLOGY (2008)
Inefficient Chronic Activation of Parietal Cells in Ae2a,b-/- Mice Recalde, Sergio; Muruzábal, Francisco; Looije, Norbert; Kunne, Cindy; Burrell, María A.; Sáez, Elena; Martínez-Ansó, Eduardo; Salas, January T.; Mardones, Pablo; Prieto, Jesús; Medina, Juan F.; Oude Elferink, Ronald P.J. Article ISI AMERICAN JOURNAL OF PATHOLOGY (2006)
Biliary lipid secretion, bile acid metabolism, and gallstone formation are not impaired in hepatic lipase-deficient mice Amigo, L; Mardones P.; Ferrada C.; Zanlungo S.; Nervi, F; Miquel, JF; Rigotti, A. Article ISI SCOPUS HEPATOLOGY (2003)
Expression and regulation of scavenger receptor class B type I (SR-BI) in gall bladder epithelium Miquel, JF; Moreno, M.; Amigo, L; Molina, H; Mardones P.; Wistuba, II; Rigotti, A. Article ISI SCOPUS GUT (2003)
Fibrates down-regulate hepatic scavenger receptor class B type I protein expression in mice Mardones P.; Pilon, A; Bouly, M; Duran, D; Nishimoto, T; Arai H.; Kozarsky, KF; Altayo, M; Miquel, JF; Luc, G; Clavey, V; Staels, B; Rigotti, A. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
?-tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-BI)-deficient mice Mardones P.; Quiñones V.; Amigo, L; Rigotti, A.; Rozowski J.; Strobel P.; Miranda, S.; Leighton F.; Krieger M. Article SCOPUS JOURNAL OF NUTRITION (2002)
alpha-tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-BI)-deficient mice Mardones P.; Strobel P.; Miranda, S.; Leighton F.; Quiñones V.; Amigo, L; Rozowski J.; Krieger M.; Rigotti, A. Article ISI JOURNAL OF NUTRITION (2002)
Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice Mardones P.; Quiñones V.; Amigo, L; Moreno, M.; Miquel, JF; Schwarz M.; Miettinen, HE; Trigatti, B; Krieger M.; Vanpatten, S; Cohen, DE; Rigotti, A. Article ISI SCOPUS JOURNAL OF LIPID RESEARCH (2001)
Impaired biliary cholesterol secretion and decreased gallstone formation in apolipoprotein E-deficient mice fed a high-cholesterol diet Amigo, L; Quiñones V.; Mardones P.; Zanlungo S.; Miquel, JF; Nervi, F; Rigotti, A. Article ISI SCOPUS GASTROENTEROLOGY (2000)


Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I (SR-BI)-deficient mice Mardones P.; Quiñones V.; Amigo, L; Moreno, M.; Miquel, JF; Schwarz M.; Miettinen, HE; Trigatti, B; Krieger M.; Vanpatten, S; Cohen, DE; Rigotti, A. Abstract ISI GASTROENTEROLOGY (2001)


Localization and function of the anionic exchanger AE2 in developing rodent teeth Lyaruu, D.M.; Bronckers, A.L.J.J.; Mulder, L.; Mardones, P.; Medina, J.F.; Kellokumpu, S.; Oude Elferink, R.P.J.; Everts, V. ConferencePaper (2007)


The unfolded protein response (UPR) provides gain amplification to brain‐derived neurotrophic factor (BDNF) signaling in cortical mouse neurons Mardones, Pablo; Vidal, René; Martínez, Gabriela; Hetz, Claudio ConferencePoster (2016)
The unfolded protein response (UPR) regulates brain‐derived neurotrophic factor (BDNF) expression and signaling in vivo and in primary cortical neurons Mardones, Pablo; Martínez, Gabriela; Vidal, René; Hetz, Claudio ConferencePoster (2015)


Peroxisomes Get Loud: A Redox Antidote to Hearing Loss Mardones P.; hetz C. EditorialMaterial ISI SCOPUS Cell (2015)
Cell-Nonautonomous Control of the UPR: Mastering Energy Homeostasis Mardones P.; Dillin A; hetz C. EditorialMaterial ISI SCOPUS CELL METABOLISM (2014)


Investigating the function of IRE1-alpha/XBP1 in neurophysiology and synaptic plasticity. FONDECYT (3140388) Proyecto 2013-2016 Inv. Responsable
Mechanisms and Functional Role of Internally Generated Brain Activity. Howard Hughes Medical Institute Proyecto 2010-2012 Investigador(a)
A cellular model of cytosolic lipid droplet assembly in S. cerevisiae. Max Planck Foundation - German Academic Research Council (DFG) (WA 1669/2-1) Proyecto 2008-2010 Investigador(a)


Control of systemic proteostasis by the nervous system Mardones, Pablo; Martínez, Gabriela; Hetz, Claudio Review ISI SCOPUS Trends in Cell Biology (2015)
Advances in the physiological and pathological implications of cholesterol Cortes, VA; Busso, D.; Mardones P.; Maiz A.; Arteaga A.; Nervi, F; Rigotti, A. Review ISI SCOPUS Biological Reviews (2013)
Cellular mechanisms of vitamin E uptake: relevance in alpha-tocopherol metabolism and potential implications for disease Mardones P.; Rigotti, A. Review ISI JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2004)