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Cheril Cecilia Tapia Rojas

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

Aging, Mitochondrial function, Alzheimer Disease; Wnt signaling in the Adult Nervous System, hippocampal learning and memory.

Magister en Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2013
Doctorado en Ciencias Biologicas, Mención en Biología Celular y Molecular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile
Bioquímico, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2011

undergraduate thesis student Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

2009 - 2011
PhD student Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Ciencias Biológicas

Chile

2015 - 2016
Post-Doctoral research Full Time

Universidad Autónoma de Chile

Ciencias Biológicas

Chile

2016 - At present

Profesor ayudante PENTA UC

Pontificia Universidad Catolica de Chile (PENTA UC)

Chile

2009 - 2012
Alumno en práctica

LABORATORIO CLINICO BIONET ACHS/ARAUCO SALUD/INDISA, EN LA CIUDAD DE ILLAPEL

Chile

2009 - 2009
Profesor ayudante Curso BIO274E

P. Universidad Católica de Chile

Chile

2013 - 2014
Profesor particular de Ciencias Part Time

Home Teachers

Chile

2013 - 2015
Profesor Part Time

Universidad Bernardo O'Higgins

Chile

2014 - 2015
Profesor Part Time

PreUniversitario

Chile

2015 - At present

Función de las Mitocondrias Sinápticas y su Implicancia en la Pérdida de Memoria durante el Envejecimiento, Margrethe Olesen, Magister en Neurociencia, Universidad Autónoma.

Disfunción de las mitocondrias sinápticas y su relación con el péptido Beta- Amiloide (A?) en la enfermedad de Alzheimer. Fabián Alarcón, Magister en Neurociencia, Universidad Autónoma.


Pathologically phosphorylated tau at S396/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged Wild-type mice Article ISI/SCOPUS SCIENTIFIC REPORTS (2021)
Synaptic Mitochondria: An Early Target of Amyloid-beta and Tau in Alzheimer's Disease Park-Kang, Han S.; Polanco, Catalina M.; Alarcon, Fabian; Vargas-Mardones, Gabriela; Indo, Javiera A. Article ISI JOURNAL OF ALZHEIMERS DISEASE (2021)
Tau Deletion Prevents Cognitive Impairment and Mitochondrial Dysfunction Age Associated by a Mechanism Dependent on Cyclophilin-D Cerpa, Waldo; Quintanilla, Rodrigo A. Article ISI FRONTIERS IN NEUROSCIENCE (2021)
Evidence of Synaptic and Neurochemical Remodeling in the Retina of Aging Degus Ardiles, Alvaro O; Araya, Joaquin; Acosta, Monica L. Article ISI SCOPUS Frontiers in Neuroscience (2020)
Hormetic-Like Effects of L-Homocysteine on Synaptic Structure, Function, and A beta Aggregation Article ISI SCOPUS PHARMACEUTICALS (2020)
Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics Li, Ying; Silva, Patricio; Criollo, Alfredo Article ISI Molecular and Cellular Oncology (2020)
Wnt Signaling Pathway Dysregulation in the Aging Brain: Lesson From the Octodon Degus Inestrosa, Nibaldo C; Tapia-Rojas Cheril; Lindsay, Carolina B; Zolezzi, Juan Manuel Article ISI SCOPUS Frontiers in Cell and Developmental Biology (2020)
Adolescence binge alcohol consumption induces hippocampal mitochondrial impairment that persists during the adulthood Quintanilla, R. A Article ISI SCOPUS NEUROSCIENCE (2019)
GALECTIN-8 Is a Neuroprotective Factor in the Brain that Can Be Neutralized by Human Autoantibodies Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2019)
It’s all about tau Vergara, E. H.; Johnson, G. V. W.; Quintanilla, R. A Article ISI/SCOPUS PROGRESS IN NEUROBIOLOGY (2019)
Non-canonical function of IRE1 alpha determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics Durand, Sylvere; Mortenson, David E.; Hazari, Younis; Sassano, Maria L.; Pihan, Philippe; van Vliet, Alexander R.; Gonzalez-Quiroz, Matias; Kerkhofs, Martijn; Kaufman, Randal J.; Luke Wiseman, R.; et al. Article ISI SCOPUS Nature Cell Biology (2019)
Wnt-7a Stimulates Dendritic Spine Morphogenesis and PSD-95 Expression Through Canonical Signaling Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2019)
Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment (vol 55, pg 4473, 2018) Tapia-Rojas, Cheril; Carvajal, Francisco J.; Orellana, Juan A.; Cerpa, Waldo; Quintanilla, Rodrigo A. Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2018)
Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus Aránguiz, Alejandra; Cerpa, Waldo; Tapia-Rojas, Cheril; Quintanilla, Rodrigo A. Article ISI SCOPUS REDOX BIOLOGY (2018)
Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimers disease in J20-APP transgenic and wild-type mice Tapia-Rojas, Cheril; Inestrosa, Nibaldo C Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2018)
Possible role of mitochondrial permeability transition pore in the pathogenesis of Huntington disease. Quintanilla, Rodrigo A; Tapia, Cheril; Pérez, María José Article Biochemical and biophysical research communications (2017)
Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-beta (A beta)(42) peptides Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2016)
Rhein-Huprine Derivatives Reduce Cognitive Impairment, Synaptic Failure and Amyloid Pathology in A beta PPswe/PS-1 Mice of Different Ages Serrano, Felipe; Tapia-Rojas, Cheril; Carvajal, Francisco; Cisternas, Pedro; Viayna, Elisabet; Sola, Irene; Munoz-Torrero, Diego; Inestrosa, Nibaldo Article ISI CURRENT ALZHEIMER RESEARCH (2016)
Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease Tapia-Rojas, C; Aranguiz, F; Varela-Nallar, L; Inestrosa, NC Article Brain Pathology (2016)
Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease. Tapia-Rojas, Cheril; Aranguiz, Florencia; Varela-Nallar, Lorena; Inestrosa, Nibaldo C Article Brain pathology (Zurich, Switzerland) (2016)
Wnt signaling pathway improves central inhibitory synaptic transmission in a mouse model of Duchenne muscular dystrophy Fuenzalida, M; Espinoza, C.; Perez, MA; Tapia-Rojas, C; Cuitino, L; Brandan, E.; Inestrosa, NC Article NEUROBIOLOGY OF DISEASE (2016)
Wnt signaling pathway improves central inhibitory synaptic transmission in a mouse model of Duchenne muscular dystrophy. Fuenzalida, Marco; Espinoza, Claudia; Pérez, Miguel Ángel; Tapia-Rojas, Cheril; Cuitino, Loreto; Brandan, Enrique; Inestrosa, Nibaldo C Article Neurobiology of disease (2016)
Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer's Disease Inestrosa, NC; rios ja, Cisternas P.; Tapia-Rojas, C; Rivera, DS; Braidy, N; Zolezzi, JM; Godoy, JA; Carvajal, FJ; Ardiles AO, Bozinovic F.; Palacios, AG; Sachdev, PS Article Brain Pathology (2015)
Alzheimer's Disease-Related Protein Expression in the Retina of Octodon degus Du, Lucia Y.; Chang, Lily Y-L.; Ardiles, Alvaro O; Tapia-Rojas, Cheril; Araya, Joaquin; Inestrosa, Nibaldo C; Palacios, Adrian G; Acosta, Monica L.; Padmanabhan, Jaya Article ISI SCOPUS PLOS ONE (2015)
Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3 beta=> autoregulation of GSK-3 beta in vivo Tapia-Rojas, C; Schuller, A; Lindsay C.B., Ureta R.C.; Mejias-Reyes C., Hancke; J, Melo F.; Inestrosa, N. C. Article BIOCHEMICAL JOURNAL (2015)
Andrographolide Stimulates Neurogenesis in the Adult Hippocampus Varela-Nallar, L; Arredondo, SB; Tapia-Rojas, C; Hancke, J; Inestrosa, NC Article Neural Plasticity (2015)
Andrographolide Stimulates Neurogenesis in the Adult Hippocampus. Varela-Nallar, Lorena; Arredondo, Sebastian B; Tapia-Rojas, Cheril; Hancke, Juan; Inestrosa, Nibaldo C Article Neural plasticity (2015)
beta-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats Cuevas CA, Tapia-Rojas; C, Cespedes; C, Inestrosa; NC, Vio Article BioMed Research International (2015)
Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?: Changes in AÎ² oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice. Tapia-Rojas, Cheril; Lindsay, Carolina B; Montecinos-Oliva, Carla; Arrazola, Macarena S; Retamales, Rocio M; Bunout, Daniel; Hirsch, Sandra; Inestrosa, Nibaldo C Article Molecular neurodegeneration (2015)
Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?=> Changes in A beta oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice Tapia-Rojas, C; Lindsay, CB; Montecinos-Oliva, C; Arrazola MS, Retamales; RM, Bunout; D, Hirsch; S, Inestrosa Article Molecular Neurodegeneration (2015)
Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy Cavieres, Viviana A.; Gonzlez, Alexis; Muoz, Vanessa C.; Yefi, Claudia P.; Bustamante, Hianara A.; Barraza, Rafael R.; Tapia-Rojas, Cheril; Otth, Carola.; Barrera, Mara Jos; Gonzlez, Carlos; et al. Article ISI SCOPUS PLOS ONE (2015)
Î²-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats. Cuevas, Catherina A; Tapia-Rojas, Cheril; Cespedes, Carlos; Inestrosa, Nibaldo C; Vio, Carlos P Article BioMed research international (2015)
Andrographolide reduces cognitive impairment in young and mature A beta PPswe/PS-1 mice Serrano, FG; Tapia-Rojas, C; Carvajal, FJ; Hancke, J; Cerpa, W.; Inestrosa, NC Article MOLECULAR NEURODEGENERATION (2014)
Andrographolide reduces cognitive impairment in young and mature AÎ²PPswe/PS-1 mice. Serrano, Felipe G; Tapia-Rojas, Cheril; Carvajal, Francisco J; Hancke, Juan; Cerpa, Waldo; Inestrosa, Nibaldo C Article Molecular neurodegeneration (2014)
Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents Viayna E, Sola I; Bartolini M, De Simone A; Tapia-Rojas, C; Serrano, FG; Sabaté R, Juarez-Jimenez; J, Pérez B; Luque FJ, Andrisano V; Clos MV, Inestrosa; NC, Munoz-Torrero Article Journal of Medicinal Chemistry (2014)
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents. Viayna, Elisabet; Sola, Irene; Bartolini, Manuela; De Simone, Angela; Tapia-Rojas, Cheril; Serrano, Felipe G; Sabaté, Raimon; Juárez-Jiménez, Jordi; Pérez, Belén; Luque, F Javier; Andrisano, Vincenza; Clos, M Victòria; Inestrosa, Nibaldo C; Muñoz-Torrero, Diego Article Journal of medicinal chemistry (2014)
Peroxisome Proliferators Reduce Spatial Memory Impairment, Synaptic Failure, and Neurodegeneration in Brains of a Double Transgenic Mice Model of Alzheimer's Disease Inestrosa, NC; Carvajal, FJ; Zolezzi, JM; Tapia-Rojas, C; Serrano, F; Karmelic D, Toledo EM; Toro, A.; Toro, J. Article Journal of Alzheimer's Disease (2013)
Peroxisome proliferators reduce spatial memory impairment, synaptic failure, and neurodegeneration in brains of a double transgenic mice model of Alzheimer's disease. Inestrosa, Nibaldo C; Carvajal, Francisco J; Zolezzi, Juan M; Tapia-Rojas, Cheril; Serrano, Felipe; Karmelic, Daniel; Toledo, Enrique M; Toro, Andrés; Toro, Jessica; Santos, Manuel J Article Journal of Alzheimer's disease : JAD (2013)
Tetrahydrohyperforin Decreases Cholinergic Markers associated with Amyloid-beta Plaques, 4-Hydroxynonenal Formation, and Caspase-3 Activation in A beta PP/PS1 Mice Carvajal, FJ; Zolezzi, JM; Tapia-Rojas, C; Godoy, JA; Inestrosa, NC Article Journal of Alzheimer's Disease (2013)
Tetrahydrohyperforin decreases cholinergic markers associated with amyloid-Î² plaques, 4-hydroxynonenal formation, and caspase-3 activation in AÎ²PP/PS1 mice. Carvajal, Francisco J; Zolezzi, Juan M; Tapia-Rojas, Cheril; Godoy, Juan A; Inestrosa, Nibaldo C Article Journal of Alzheimer's disease : JAD (2013)
Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease Ardiles, A. O.; Tapia-Rojas C.C., Mandal M; Alexandre F, Kirkwood A.; Inestrosa, N. C. Article Proceedings of the National Academy of Sciences of the United States of America (2012)
Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease. Ardiles, Alvaro O; Tapia-Rojas, Cheril C; Mandal, Madhuchhanda; Alexandre, Frédéric; Kirkwood, Alfredo; Inestrosa, Nibaldo C; Palacios, Adrian G Article Proceedings of the National Academy of Sciences of the United States of America (2012)
Tetrahydrohyperforin prevents cognitive deficit, A beta deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1 Delta E9 model of Alzheimer's disease=> a possible effect on APP processing Inestrosa, NC; Tapia-Rojas, C; Griffith TN, Carvajal; FJ, Benito MJ; Rivera-Dictter, A; Alvarez, AR; Serrano, FG; Hancke, JL; Burgos, PV; Parodi, J; Varela-Nallar, L Article Translational Psychiatry (2011)
Tetrahydrohyperforin prevents cognitive deficit, AÎ² deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1Î”E9 model of Alzheimer's disease: a possible effect on APP processing. Inestrosa, N C; Tapia-Rojas, C; Griffith, T N; Carvajal, F J; Benito, M J; Rivera-Dictter, A; Alvarez, A R; Serrano, F G; Hancke, J L; Burgos, P V; Parodi, J; Varela-Nallar, L Article Translational psychiatry (2011)


Mitochondrial Dysfunction as a Key Event during Aging: From Synaptic Failure to Memory Loss Baloyannis, Stavros BookSection (2019)
Ethanol Consumption Affects Neuronal Function: Role of the Mitochondria Perez, MJ; Taskin, Eylem; Guven, Celal; Sevgiler, Yusuf BookSection (2017)
New discoveries on the hyperforin derivative, tetrahydrohyperforin: Closer to an Alzheimer'S disease treatment? BookSection (2015)


Disfunción Mitocondrial en la Sinapsis Neuronal, Envejecimiento y Neurogeneración PAI (PAI7717009) Proyecto 2018-2020 Inv. Responsable
Phosphorylated tau in the synaptic mitochondria and its contribution to cognitive impairment during aging FONDECYT (11170546) Proyecto 2017-2020 Inv. Responsable


Effect of Alcohol on Hippocampal-Dependent Plasticity and Behavior: Role of Glutamatergic Synaptic Transmission Quintanilla, R. A Review ISI SCOPUS (2020)
Alcohol impairs hippocampal function: From NMDA receptor synaptic transmission to mitochondrial function PÃ©rez M.J.; Quintanilla, R. A Review ISI SCOPUS DRUG AND ALCOHOL DEPENDENCE (2019)
It's all about tau Deaton, CA; Johnson, GVW Review ISI SCOPUS PROGRESS IN NEUROBIOLOGY (2019)
Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimers disease Review ISI SCOPUS NEURAL REGENERATION RESEARCH (2018)
Alcohol consumption during adolescence: A link between mitochondrial damage and ethanol brain intoxication Torres, AK; Vergara, EH Review ISI SCOPUS Birth Defects Research (2017)

CAROLA OTTH

profesor titular

microbiologia clinica

UNIVERSIDAD AUSTRAL DE CHILE. FACULTAD DE MEDICINA. INSTITUTO DE MICROBIOLOGIA CLINICA

VALDIVIA, Chile

Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

PATRICIA BURGOS

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

GONZALO MARDONES

Associate Professor

Medicine

Universidad San Sebastián

Valdivia, Chile

Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

Evelyn Pardo

Investigadora Independiente

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

SANTIAGO , Chile

Adrian Palacios

Profesor

Instituto de Neurosciencia

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Juan Zolezzi

Associate Professor

School of Medicine

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

Julio Cardenas

Associated Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

Christian Gonzalez

Full Professor

Biologia

Universidad de Chile

Santiago, Chile

Alfredo Criollo

Associated Professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

Waldo Cerpa

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Catolica de Chile

Santiago, Chile

Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

Patricio Silva

Investigador Principal FONDEF

Departamento de Biología Celular y Molecular

Universidad de Chile

Santiago, Chile

Yenniffer Ávalos

Profesor Asistente

Departamento de Biología

Universidad de Santiago de Chile

Santiago, Chile

Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

Philippe Pihán

Posdoctorado

Fisiología

Universidad de Chile

Santiago, Chile

Claudia Yefi

Assistant professor

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

Alvaro Ardiles

Full Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

Claudio Perez

Profesor Asociado

Pontificia Universidad Catolica de Chile

Santiago, Chile

Daniela Rebolledo

Académico

Centro de Excelencia en Biomedicina de Magallanes

Punta Arenas, Chile

Cristina Bertocchi

Assistant Professor

Department of Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

Hianara Bustamante

Profesora Auxiliar

Instituto de Microbiología Clínica

Universidad Austral de Chile

Valdivia, Chile

Joaquìn Araya

Profesor Asistente

Facultad de Salud

Universidad Santo Tomás

Santiago, Chile

Claudia Metz

Docente Investigador

Universidad San Sebastián

Santiago, Chile

Claudia Jara

Post Doctoral

CEBICEM

Universidad San Sebastián

Santiago, Chile

Viviana Cavieres

Postdoctoral Researcher

Medicina y Ciencias

Universidad San Sebastián

Santiago , Chile

Francisco Carvajal

asistente de investigacion

Universidad de Magallanes

punta arenas, Chile

Maria Hernandez

Investigador Post Doctoral

Universidad de Chile

Santiago, Chile

María Barake

Becaria Postdoctoral

Facultad de Medicina y ciencia

Universidad San Sebastián

Santiago, Chile

Matías Lira

Postdoc

Universidad San Sebastián

Santiago, Chile

Diego Tapia

Asistente de Investigación

Universidad San Sebastián

Santiago, Chile

JESÚS LLANQUINAO

Postdoctorado

Programa de comunicación celular en cáncer

Universidad del Desarrollo

Santiago, Chile

Cheril Cecilia Tapia Rojas

Líneas de Investigación

Educación

Magister en Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2013

Doctorado en Ciencias Biologicas, Mención en Biología Celular y Molecular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile

Bioquímico, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2011

Experiencia Académica

undergraduate thesis student Full Time

PhD student Full Time

Post-Doctoral research Full Time

Experiencia Profesional

Profesor ayudante PENTA UC

Alumno en práctica

Profesor ayudante Curso BIO274E

Profesor particular de Ciencias Part Time

Profesor Part Time

Profesor Part Time

Formación de Capital Humano

Article (44)

BookSection (3)

Proyecto (2)

Disfunción Mitocondrial en la Sinapsis Neuronal, Envejecimiento y Neurogeneración

Phosphorylated tau in the synaptic mitochondria and its contribution to cognitive impairment during aging

Review (5)