Man

Cheril Cecilia Tapia Rojas

Profesor Asociado

Universidad San Sebastián

Santiago, Chile

Líneas de Investigación


Aging, Mitochondrial function, Alzheimer Disease; Wnt signaling in the Adult Nervous System, hippocampal learning and memory.

Educación

  •  Magister en Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2013
  •  Doctorado en Ciencias Biologicas, Mención en Biología Celular y Molecular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile
  •  Bioquímico, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2011

Experiencia Académica

  •   undergraduate thesis student Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    2009 - 2011

  •   PhD student Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biológicas

    Chile

    2015 - 2016

  •   Post-Doctoral research Full Time

    Universidad Autónoma de Chile

    Ciencias Biológicas

    Chile

    2016 - At present

Experiencia Profesional

  •   Profesor ayudante PENTA UC

    Pontificia Universidad Catolica de Chile (PENTA UC)

    Chile

    2009 - 2012

  •   Alumno en práctica

    LABORATORIO CLINICO BIONET ACHS/ARAUCO SALUD/INDISA, EN LA CIUDAD DE ILLAPEL

    Chile

    2009 - 2009

  •   Profesor ayudante Curso BIO274E

    P. Universidad Católica de Chile

    Chile

    2013 - 2014

  •   Profesor particular de Ciencias Part Time

    Home Teachers

    Chile

    2013 - 2015

  •   Profesor Part Time

    Universidad Bernardo O'Higgins

    Chile

    2014 - 2015

  •   Profesor Part Time

    PreUniversitario

    Chile

    2015 - At present

Formación de Capital Humano


Función de las Mitocondrias Sinápticas y su Implicancia en la Pérdida de Memoria durante el Envejecimiento, Margrethe Olesen, Magister en Neurociencia, Universidad Autónoma.

Disfunción de las mitocondrias sinápticas y su relación con el péptido Beta- Amiloide (A?) en la enfermedad de Alzheimer. Fabián Alarcón, Magister en Neurociencia, Universidad Autónoma.



 

Article (49)

Anti-P antibodies that impair memory perturb hippocampal glutamatergic receptor trafficking, synapse structure and microglia
Curcumin Improves Hippocampal Cell Bioenergetics, Redox and Inflammatory Markers, and Synaptic Proteins, Regulating Mitochondrial Calcium Homeostasis
Identifying a novel Mecp2-mediated epigenetic mechanism controlling Lonp1 in the hippocampus and its disruption by aging
PKR-driven ISR signaling controls synaptic translation and structural plasticity in an age-dependent manner
The adverse effect of a hypercaloric high-fat diet feeding on hypothalamic cellular energy homeostasis is attenuated by a hypoglycemiant
The methyl-CpG-binding protein 2 (Mecp2) regulates the hypothalamic mitochondrial function and white adipose tissue lipid metabolism
Unraveling sex differences in age-related hippocampal decline: differential mitochondrial dysfunction, Lonp1-dependent mitochondrial proteostasis and mtROS production in aged C57BL/6 mice
Contrasting Effects of an Atherogenic Diet and High-Protein/Unsaturated Fatty Acids Diet on the Accelerated Aging Mouse Model SAMP8 Phenotype
GOLPH3 Participates in Mitochondrial Fission and Is Necessary to Sustain Bioenergetic Function in MDA-MB-231 Breast Cancer Cells
Synaptic mitochondria: A crucial factor in the aged hippocampus
Wnt-5a Signaling Mediates Metaplasticity at Hippocampal CA3-CA1 Synapses in Mice
Age-Dependent Behavioral and Synaptic Dysfunction Impairment Are Improved with Long-Term Andrographolide Administration in Long-Lived Female Degus (Octodon degus)
How Many Sirtuin Genes Are Out There? Evolution of Sirtuin Genes in Vertebrates With a Description of a New Family Member
Long-term social isolation stress exacerbates sex-specific neurodegeneration markers in a natural model of Alzheimer's disease
Mitochondrial Bioenergetics, Redox Balance, and Calcium Homeostasis Dysfunction with Defective Ultrastructure and Quality Control in the Hippocampus of Aged Female C57BL/6J Mice
Pathologically phosphorylated tau at S396/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged Wild-type mice
Synaptic Mitochondria: An Early Target of Amyloid-beta and Tau in Alzheimer's Disease
Tau Deletion Prevents Cognitive Impairment and Mitochondrial Dysfunction Age Associated by a Mechanism Dependent on Cyclophilin-D
Evidence of Synaptic and Neurochemical Remodeling in the Retina of Aging Degus
Hormetic-Like Effects of L-Homocysteine on Synaptic Structure, Function, and A beta Aggregation
Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics
Premature synaptic mitochondrial dysfunction in the hippocampus during aging contributes to memory loss
Stimulation of Melanocortin Receptor-4 (MC4R) Prevents Mitochondrial Damage Induced by Binge Ethanol Protocol in Adolescent Rat Hippocampus
Wnt Signaling Pathway Dysregulation in the Aging Brain: Lessons From theOctodon degus
Adolescence binge alcohol consumption induces hippocampal mitochondrial impairment that persists during the adulthood
GALECTIN-8 Is a Neuroprotective Factor in the Brain that Can Be Neutralized by Human Autoantibodies
Non-canonical function of IRE1 alpha determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics
Wnt-7a Stimulates Dendritic Spine Morphogenesis and PSD-95 Expression Through Canonical Signaling
Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment (vol 55, pg 4473, 2018)
Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus
Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimers disease in J20-APP transgenic and wild-type mice
Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment
Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-beta (A beta)(42) peptides
Rhein-Huprine Derivatives Reduce Cognitive Impairment, Synaptic Failure and Amyloid Pathology in A beta PPswe/PS-1 Mice of Different Ages
Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease
Wnt signaling pathway improves central inhibitory synaptic transmission in a mouse model of Duchenne muscular dystrophy
Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer's Disease
Alzheimer's Disease-Related Protein Expression in the Retina of Octodon degus
Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3 beta: autoregulation of GSK-3 beta in vivo
Andrographolide Stimulates Neurogenesis in the Adult Hippocampus
beta-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats
Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?: Changes in A beta oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice
Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy
Andrographolide reduces cognitive impairment in young and mature A beta PPswe/PS-1 mice
Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents
Peroxisome Proliferators Reduce Spatial Memory Impairment, Synaptic Failure, and Neurodegeneration in Brains of a Double Transgenic Mice Model of Alzheimer's Disease
Tetrahydrohyperforin Decreases Cholinergic Markers associated with Amyloid-beta Plaques, 4-Hydroxynonenal Formation, and Caspase-3 Activation in A beta PP/PS1 Mice
Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease
Tetrahydrohyperforin prevents cognitive deficit, A beta deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1 Delta E9 model of Alzheimer's disease: a possible effect on APP processing

BookSection (3)

Mitochondrial Dysfunction as a Key Event during Aging: From Synaptic Failure to Memory Loss
Ethanol Consumption Affects Neuronal Function: Role of the Mitochondria
New discoveries on the hyperforin derivative, tetrahydrohyperforin: Closer to an Alzheimer'S disease treatment?

Errata (1)

Publisher Correction: Non-canonical function of IRE1? determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics (Nature Cell Biology, (2019), 21, 6, (755-767), 10.1038/s41556-019-0329-y)

Generic (1)

WNT Signaling Is a Key Player in Alzheimer’s Disease

Review (8)

Synaptic mitochondria in aging and neurodegenerative diseases: Functional decline and vulnerability
Phosphorylated tau as a toxic agent in synaptic mitochondria: implications in aging and Alzheimer's disease
Effect of Alcohol on Hippocampal-Dependent Plasticity and Behavior: Role of Glutamatergic Synaptic Transmission
Alcohol impairs hippocampal function: From NMDA receptor synaptic transmission to mitochondrial function
It's all about tau
Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimers disease
Alcohol consumption during adolescence: A link between mitochondrial damage and ethanol brain intoxication
Possible role of mitochondrial permeability transition pore in the pathogenesis of Huntington disease
1
CAROLA OTTH

profesor titular

microbiologia clinica

UNIVERSIDAD AUSTRAL DE CHILE. FACULTAD DE MEDICINA. INSTITUTO DE MICROBIOLOGIA CLINICA

VALDIVIA, Chile

1
Francisco Melo

Profesor Titular

Genetica Molecular y Microbiologia

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Juan Opazo

Profesor Titular

Facultad de Medicina y Ciencia

Universidad San Sebastián

Valdivia, Chile

5
Patricia Burgos

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

2
GONZALO MARDONES

Associate Professor

Medicine

Universidad San Sebastián

Valdivia, Chile

1
Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

3
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

1
Andreas Schuller

Associate Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Evelyn Pardo

Investigadora Independiente

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

SANTIAGO , Chile

3
Adrian Palacios

Profesor

Instituto de Neurosciencia

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

24
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Carolina Oliva

Investigadora y Coordinadora Áreas STEM

Vicerrectoría de Investigación y Doctorados

Universidad Autónoma de Chile

Santiago, Chile

1
Jorge Parodi

Director de laboratorio

Tonalli Ltda

Temuco, Chile

4
Juan Zolezzi

Associate Professor

School of Medicine

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

2
Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

1
Francisco Morera

Assistant Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Sandra Hirsch

planta

ECRAN

INTA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Daniel Bunout

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

2
Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
MIGUEL PEREZ

Associate Professor

Universidad Vina del Mar

Vina del Mar, Chile

1
Julio Cardenas

Associated Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

2
Christian Gonzalez

Full Professor

Biologia

Universidad de Chile

Santiago, Chile

1
Alfredo Criollo

Associated Professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

3
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

8
Waldo Cerpa

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Catolica de Chile

Santiago, Chile

11
Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

1
Luis Vargas

Full Professor

Universidad Austral de Chile

Valdivia, Chile

1
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

2
Daniela Rivera

Profesora Asociada

Universidad Mayor de Chile

Santiago, Chile

2
MANUEL VARAS

Associated Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Eugenia Morselli

Profesor Asociado de Planta Ordinaria

Fisiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago de Chile, Chile

1
Loreto Cuitiño

Investigador Asociado

Oftalmología

Hospital Clínico Universidad de Chile

229788866, Chile

1
Patricio Silva

Investigador Principal FONDEF

Departamento de Biología Celular y Molecular

Universidad de Chile

Santiago, Chile

1
Yenniffer Ávalos

Profesor Asistente

Departamento de Biología

Universidad de Santiago de Chile

Santiago, Chile

66
Cheril Tapia

Profesor Asociado

Facultad de Ciencias

Universidad San Sebastián

Santiago, Chile

1
JUVENAL RÍOS

Investigador

CR de Investigación y Desarrollo

Instituto Nacional del Cáncer (INCANCER)

Santiago, Chile

1
Philippe Pihán

Posdoctorado

Fisiología

Universidad de Chile

Santiago, Chile

1
Claudia Yefi

Assistant professor

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

5
Alvaro Ardiles

Full Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

1
Maria Loyola

Principal Investigator

Fundación Ciencia & Vida

Santiago, Chile

1
Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

1
Carlos Cespedes

Tecnologo Medico

Fisiologia

P. Universidad Católica de Chile

Santiago, Chile

1
Macarena Arrázola

Profesor Asistente

Centro de Biología Integrativa

Universidad Mayor

Santiago, Chile

1
Claudio Perez

Profesor Asociado

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Sebastián Valenzuela

Director de Area Veterinaria

Area Veterinaria

Fundación Ciencia para la Vida

Santiago, Chile

1
Daniela Rebolledo

Académico

Centro de Excelencia en Biomedicina de Magallanes

Punta Arenas, Chile

1
Cristina Bertocchi

Assistant Professor

Department of Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Juan Godoy

Investigador

Centro de Oncologia dePrecision

Santiago, Chile

1
Hianara Bustamante

Profesora Auxiliar

Instituto de Microbiología Clínica

Universidad Austral de Chile

Valdivia, Chile

1
Karina Cereceda

Investigador post doctoral

Diagnóstico

Fundación Arturo López Pérez

Providencia, Chile

2
Joaquìn Araya

Profesor Asistente

Facultad de Salud

Universidad Santo Tomás

Santiago, Chile

1
Claudia Metz

Docente Investigador

Universidad San Sebastián

Santiago, Chile

19
Claudia Jara

Académico-Investigador

Universidad de Las Américas

Santiago, Chile

1
Viviana Cavieres

Postdoctoral Researcher

Medicina y Ciencias

Universidad San Sebastián

Santiago , Chile

7
Francisco Carvajal

asistente de investigacion

Universidad de Magallanes

punta arenas, Chile

1
Maria Hernandez

Investigador Post Doctoral

Universidad de Chile

Santiago, Chile

2
Micaela Ricca

Subdirección Área Veterinaria

Área Veterinaria

Fundación Ciencia & Vida

Santiago, Chile

1
María Barake

Becaria Postdoctoral

Facultad de Medicina y ciencia

Universidad San Sebastián

Santiago, Chile

1
Matías Lira

Postdoc

Universidad San Sebastián

Santiago, Chile

1
Diego Tapia

Asistente de Investigación

Universidad San Sebastián

Santiago, Chile

1
Sebastián Arredondo

Investigador postdoctoral

Universidad Andrés Bello

Santiago, Chile

1
Carolina Lindsay

Bioquímica - Unidad de Investigación

Dpto. de Investigación e Innovación

Hospital Dr. Franco Ravera Zunino

Rancagua, Chile

3
JESÚS LLANQUINAO

Postdoctorado

Investigación del cáncer

Fundación Arturo López Pérez (FALP)

Santiago, Chile

2
Daniela Cortés

Asistente de investigación

Fundación Ciencia y Vida

HUECHURABA, Chile