Bioinformatics, cheminformatics, computational chemogenomics, prediction of protein-ligand interactions, prediction of protein-DNA interactions, computer-aided drug design, rational protein engineering, molecular modelling

UNDERGRADUATE THESES

Claudio Ponce Acosta: "Detection of protein-ligand binding site residues by a physicochemical and spatial uniqueness approach", biochemistry undergraduate thesis, School of Biological Sciences, UC. Start: 2018. Graduation: 2019.

Francisca Durán Osorio: "Computer-aided rational design of fXa inhibitors with aryl piperazine peptide structure", chemistry and pharmacy undergraduate thesis (co-advisor), 2021, School of Chemistry and Pharmacy, UC: Start: 2020. Graduation: 2021.

Carlos Vigil: "Weak binding paradox for de novo target prediction", biochemistry undergraduate thesis, School of Biological Sciences, UC. Start: 2021. Graduation: 2022.

Tomás Cáceres: "In silico characterization of auxin binding affinity and specificity to TIR1/AFB5 receptors", biochemistry undergraduate thesis, School of Biological Sciences, UC. Start: 2023. Graduation: 2024.

Miguel Saez: "Prediction of drug targets by network-based inference guided by chemical and structural similarities", biochemistry undergraduate thesis, School of Biological Sciences, UC. Start: 2022. Graduation: 2024.

GRADUATE THESES

Daniela Herrera Toro: “Rational engineering of resveratrol o-methyltransferase enzyme for the biological synthesis of pinoestilbene”. Graduate Program in Engineering Sciences UC, Area Chemistry and Bioprocesses. Start: 2016. Graduation: 2022.

Andrés Ibacache Chia: "In silico identification of inhibitory molecules of monocarboxylate transporters and experimental validation of their effects on tumor cells". Graduate Program in Biological Sciences UC, Molecular Genetics and Microbiology. Start: 2019. Graduation: 2024.

Joaquín Gutiérrez Benavente: "Rational design of oligopeptides for the inhibition of the bacterial enzyme choline trimethylamine lyase". Graduate Program in Biological Sciences UC, Molecular Genetics and Microbiology. Start: 2020. Graduation: 2025 (anticipated).

Hade Ramos Acevedo: "Assessing the genetic diversity of Andes Orthohantavirus: Impact of non-synonymous single nucleotide variations on gene expression and response to the innate immune system". Graduate Program in Biological Sciences UC, Molecular Genetics and Microbiology (co-advisor). Start: 2023. Graduation: 2027 (anticipated).

Fabián Melo Montenegro. Graduate Program in Biological and Medical Engineering UC (co-advisor). Start: 2025. Graduation: 2029 (anticipated).

Intellectual Property - Software Registration
F. Melo, M. Lima, D. Bustamante, A. Schüller, F. Rodriguez, J. Cares, L. Almonacid: Online Application System for Graduate Programs – SPEL. Pontificia Universidad Católica de Chile. Department of Intellectual Rights, Inscription Nº 252895, April 2015.