Neurodegenerative diseases Mitochondria function Confocal microscopy Neuroscience

Tutorial research students since 2011
Graduate:
-2008-2009 Ph. D. Thesis, Ph. D. in Cell Biology, Tory A. Mattews-Roberson, Title: “Caspase-cleaved tau expression results in mitochondrial dysfunction in cortical neurons”, University of Alabama at Birmingham, Birmingham, AL, USA.
-2015-2018 . Pérez M.J., PhD in Biomedical Sciences, Title: "Caracterrización del perfil de disfunción mitocondrial en fibroblastos de pacientes con enfremedad de Alzheimer, Universidad Autónoma de Chile
-2015- 2018. Jara C., PhD in Biomedical Sciences, Title: "Efectos de la proteína tau sobre la disfunción mitocondrial y el deterioro cognitivo en el envejecimiento", Universidad Autónoma de Chile
-2016- 2018. Alarcon Illesca F., Master in Neuroscience, Title: "Estudio de las modificaciones oxidativas presentes en fibroblastos de pacientes con enfermedad de Alzheimer", Universidad Autónoma de Chile
-2016-2018. Marchant-Fuentealba R., Master in Neuroscience, Title: "Análisis genetico de proteínas mitocondriales en pacientes con enfermedad de Alzheimer" Autónoma de Chile.

Undergraduate thesis direction since 2011
-2014-2015 Vergara-Pulgar, K, B.C. Biotechnology, Universidad Santo Tomás, Santiago, Chile
-2015-2016 Vargas A, Kinesiology, UMCE, Santiago, Chile 2016.
-2015-2016 Herrera A, Kinesiology, UMCE, Santiago, Chile
-2015-2016 Molina A, Kinesiology, UMCE, Santiago, Chile
-2017-2018 Loyola R, Kinesiology, UMCE, Santiago, Chile
-2017-2018 Canelo F, Kinesiology, UMCE, Santiago, Chile
-2017-2018 Torres A, Biochemistry, P. Universidad Catolica, Santiago, Chile

Postdoctoral direction since 2011
2016-2018 Dr. Cheril Tapia. Project “Alcohol consumption affects mitochondrial function in the brain”

PhD committee
2016, PhD thesis, Osvaldo Flores, PhD program in Biomedical Sciences, thesis title: “ Neuroinflamación y sistema de melanocortinas en el consumo de alcohol”, Universidad Autónoma, Santiago, Chile.
2017, PhD thesis, Claudia Lucero, PhD program in biomedical Sciences, thesis title: "Rol de la simpatoexcitación en la deslocalización de Cx43 en el cardiomiocito y la arritmogénesis durante la insuficiencia cardiaca crónica", Universidad Autonoma, Santiago, Chile.
2019, PhD thesis, Nicolas Plaza, PhD program in Biomedical Sciences, thesis title: "Caracterización del nuevo efector VPA1328 y su contribución a la inhibición de la vía de señalización NF-kB por Vibrio parahaemolyticus", Universidad Autonoma, Santiago, Chile.
2019, Ph thesis, Rodrigo Mira, PhD program in Cellular and Mollecular Biology, thesis title: "Deterioro de la transmisión sináptica glutamatérgica en trauma cerebral inducido por golpe: Papel de la permeabilidad mitocondrial”, P. Universidad Catolica de Chile, Santiago, Chile.

Courses
-2002 Coordinator and Instructor, International Course: “New advanced co-culture techniques in neuroscience”, Millennium Institute for Advanced Studies in Cell Biology (CBB), Faculty of Sciences, Universidad de Chile, June 2002, Santiago, Chile.
-2003 Instructor, International Course: “Advanced Microscopy in Cell Biology”, EMBO-CBB, Faculty of Sciences, Universidad de Chile, Jan 2003, Santiago, Chile.
-2003 Instructor, “SEMILLA” program, “The Use of Basic Microscopy Techniques for Chilean High School Teachers”, Millennium Institute for Advanced Studies in Cell Biology (CBB), Faculty of Sciences, Universidad de Chile, March 2003, Santiago, Chile.
-2004-2005 Instructor, Confocal Imaging Facility, CRCP Biomedical Center, Fac. Cs Biológicas, PUC, Santiago, Chile.2009 Adviser, Confocal and Imaging Facility, Department of Pathology, University of Rochester Medical Center, Rochester, NY, USA.
-2012-2013 Professor, Program for Ph.D. in Medical Sciences, Course: “La interacción Celular en la Enfermedad: Mecanismos y Funciones”, Facultad de Médicina, Pontifícia Universidad Católica de Chile, Santiago, Chile.
-2014-present Cell Biology Professor, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile.
-2014-present Cell Biology Professor and coordinator, Postgraduate Program in Biomedical Sciences, Universidad Autónoma de Chile.

Ad Hoc Reviewer
Ad hoc reviewer for following journals: Progress in Neurobiology, Acta Neuropathologica, Neurobiology of Aging, Neurobiology of Disease, Journal of Biological Chemistry, Journal of Neurochemistry, Journal of Neuroscience, Free Radical Biology and Medicine, Cellular and Molecular Neurobiology, British Journal of Pharmacology, Neuroscience Letters, Cellular Physiology and Biochemistry, Neurochemistry International and Neuroscience.

Ad hoc reviewer for international grants and postdoctoral fellowships from Alzheimer´s Society, UK, Alzheimer´s Association, USA, and Neurological Foundation of New Zealand, Auckland, New Zealand.

AD-Hoc Committee
-2008 Consultant, Morphology Imaging Core Facility, Department of Pathology, University of Rochester Medical Center, Rochester, New York, USA.
-2009-2014 Editor, ISRN Toxicology, Hindawi Publishing Corporation.
-2014-present Academic Coordinator, Postgraduate Program in Biomedical Sciences, Universidad Autónoma de Chile.

Membership of scientific societies
2006-present Society for Neuroscience, Regular Member;
2014-present Chilean Society for Cell Biology, Regular Member

International Meetings since 2011 (*corresponding author)

-J. R. Hom, R. A. Quintanilla, D. L. Hoffman, K. L. Bentley, J. D. Molkentin, S. S. Sheu, G. A. Porter (2011). The embryonic mitochondrial permeability transition pore controls cardiac myocyte mitochondrial maturation and differentiation. 55 Annual Meeting Biophysical Society, Baltimore, MA, March 5-9, 2011, USA.
-R. A. Quintanilla and G. V. W. Johnson (2011). Truncated tau and Ab cooperatively impair mitochondrial biology in cortical neurons. Mitochondrial biology symposium: advances in mitochondrial dynamics and mitochondrial-cytosolic communications, NIH, Bethesda, MA, May 16-17, 2011, USA.
-J. R. Hom, R. Quintanilla, D. L. Hoffman, K. L. Bentley, J. D. Molkentin, S. S. Sheu, G. A. Porter (2011). The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation. Mitochondrial biology symposium: advances in mitochondrial dynamics and mitochondrial-cytosolic communications, NIH, Bethesda, MA, May 16-17, 2011, USA.
-S. M. Pritchard, R. A. Quintanilla, and G. V. W. Johnson (2011). Tau may exacerbate mitochondrial dysfunction induced by beta-amyloid or kainic acid. 41th Annual Meeting for Society for Neuroscience, Washington, DC, November 12-16, 2011, USA.
-B. C. Avendaño, S. Contreras-Duarte, R. A. Quintanilla, V. Velarde, J. C. Sáez, and J. A. Orellana (2013). Cx43 hemichannel activity induced by cytokines and high glucose inhibit the glucose transport sensitive to insulin in human endothelial cells. LVI Reunión Anual Sociedad de Biología de Chile, Puerto Varas, Nov 9-14, Chile.
-R. A Quintanilla*, J. A. Godoy, R. von Bernhardi, N. C. Inestrosa, G. V.W. Johnson (2014). Phosphorylated tau potentiates A?-induced mitochondrial damage in mature neurons. XXVIII Reunión Anual Sociedad de Biología Celular de Chile, Puerto Varas, Nov 26-30, Chile.
-R. A. Quintanilla*, K. A. Vergara, F. Cabezas-Opázo (2015). Pathological forms of tau affects mitochondrial dynamics. 45th Annual Meeting for American Society of Neuroscience, Chicago, Oct 17-21, USA.
-C. Jara O., J. A. Godoy, N. C. Inestrosa, G. V.W. Johnson, and R. A. Quintanilla* (2015). Expression of truncated tau affects synaptic function in cultured neurons. XXIX Reunión Anual Sociedad de Biología Celular de Chile, Puerto Varas, Oct 25-30, Chile.
-K. Vergara and R. A. Quintanilla* (2015). Pathological forms of tau affects mitochondrial dynamics in Alzheimer’s disease. XXIX Reunión Anual Sociedad de Biología Celular de Chile, Puerto Varas, Oct 25-30, Chile.
-M. J. Pérez, D. P. Ponce, C. Osorio-Fuentealba, A. Elorza, M. I. Behrens, and R. A. Quintanilla* (2015). Evaluation of mitochondrial function in Alzheimer’s disease fibroblasts. XXIX Reunión Anual Sociedad de Biología Celular de Chile, Puerto Varas, Oct 25-30, Chile.
-M. J. Pérez, D. Ponce, C. Osorio-Fuentealba, M. I. Behrens, and R. A. Quintanilla* (2016). Mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer`s disease. International Symposium Biology of Neuropsychiatric Disorders, April 27-29, Valparaiso, Chile.
-C. Jara, M. J. Pérez, K. Vergara, and R. A. Quintanilla* (2016). Tau pathology enhances mitochondrial dynamics impairment induced by A? in Alzheimer´s disease. International Symposium Biology of Neuropsychiatric Disrorders, April 27-29, Valparaiso, Chile.
-M. J. Pérez, D. Ponce, C. Osorio-Fuentealba, M. I. Behrens, and R. A. Quintanilla* (2016). Mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer`s disease. Mitochondrial Medicine: Developing new treatments for mitochondrial disease, Wellcome Genome Campus, Hinxton, Cambridge, May 4-6, UK.
-R. A. Quintanilla* (2016). Pathological forms of tau affect mitochondrial function. Implications for the pathogenesis of Alzheimer´s disease. 7th World Congress on Targeting Mitochondria, Oct 24-26, Berlin, Germany.
-Ch. Tapia-Rojas, F. J. Carvajal, R. Mira, W. Cerpa, J. A. Orellana and R. A. Quintanilla* (2016). Adolescent binge-drinking alcohol consumption alters the mitochondrial dynamics and bioenergetics in the hippocampus of adult brain. XXX Reunión Anual Sociedad de Biología Celular de Chile, Puerto Varas, Nov 2-6, Chile.
-M. J. Pérez, D. Ponce, C. Osorio-Fuentealba, M.I. Behrens, R. A. Quintanilla* (2016). Alzheimer`s disease fibroblasts present a characteristic mitochondrial dysfunction profile. XXX Reunión Anual Sociedad de Biología Celular de Chile, Puerto Varas, Nov 2-6, Chile.
-C. Jara, M. J. Pérez, I. Morales , and R. A. Quintanilla (2016). Truncated tau induces mitochondrial dynamics impairment in Alzheimer`s disease. XXX Reunión Anual Sociedad de Biología Celular de Chile, Puerto Varas, Nov 2-6, Chile.
-C. Jara and R. A Quintanilla* (2016). Expression of pathological forms of tau affects synaptic function in cultured neurons. 46 th Annual Meeting for American Society of Neuroscience, San Diego, Nov 12-16, USA.
-M.J Pérez, D. Ponce, M.I. Behrens, R.A. Quintanilla* (2017). Proteolytic Processing of OPA1 is Altered in Fibroblasts Patients with Sporadic Alzheimer´s Disease. International meeting on mitochondrial pathology (EuroMit), Cologne June 11-15, 2017.
-C. Tapia-Rojas, A. Torres, F. Carvajal, R. Mira, C. Arce, W. Cerpa, R. A. Quintanilla* (2017). Adolescent binge alcohol consumption affects hippocampal function through the impairment of mitochondrial dynamics and bioenergetics in the adulthood. 47th Annual Meeting for American Society of Neuroscience, Washington DC, Nov 11-15, USA.
-R. A. Quintanilla*, C. Jara, C. Tapia-Rojas, E. Vergara-Hernandez (2017). Genetic ablation of tau reduces oxidaive damage and improves mitochondrial bioenergetics during the aging. 47th Annual Meeting for American Society of Neuroscience, Washington DC, Nov 11-15, USA.
-M. J. Perez, D. Ponce, M. I. Behrens, R. A. Quintanilla* (2018). Mitochondrial permeability transition pore leads to mitochondrial dysfunction in fibroblasts of patients with Alzheimer´s disease. Cell Symposia Multifaceted Mitochondria, San Diego, Jun 4-6, USA.
-R. A. Quintanilla*, C. Tapia-Rojas, W. Cerpa, J. A. Orellana, E. Karahanian, C. Osorio-Fuentealba (2018). Adolescent binge alcohol consumption affects neuronal communication through the impairment of mitochondrial function in the adulthood. RSA 2018 Annual Meeting, San Diego, Jun 16-20, USA.

Talks and Symposia since 2011:

-2011 Atlantic Health, Department of Neurosciences, title of the presentation: “Truncated tau and Abeta cooperatively impair mitochondria function. Implications for the pathogenesis of Alzheimer’s disease”, Morristown, New Jersey, USA, May 2011.
-2012 Facultad de Médicina, Pontifícia Universidad Católica de Chile, title of the presentation: “Estudio de la función y biología mitocondrial en biomedicina”, Santiago, Chile, October.
-2013 Facultad de Medicina, Pontificia Universidad Católica de Chile, title of the presentation: “Defectos en la proteínas tau y huntingtina afectan la función mitocondrial. Implicancias en la patogénesis de la enfermedad de Alzheimer y Huntington”, Santiago, Chile, December.
-2014 Facultad de Ciencias, Universidad de Chile, title of the presentation: Defectos en la proteína tau afectan la función mitocondrial. Implicancias en la patogénesis de la enfermedad de Alzheimer ”, Santiago, Chile, April.
-2014 Centro de Investigación Biomédica, Universidad Autónoma de Chile, title of the presentation: “ Estudio de la función mitocondrial en enfermedades del envejecimiento”, Santiago, Chile, November.
-2015 Programa Disciplinario de Fisiopatología, ICBM, Facultad de Medicina, Universidad de Chile, title of the presentation: “Formas patológicas de la proteína tau afectan la función mitocondrial. Implicaciones en la patogénesis de la enfermedad de Alzheimer”, Santiago, Chile, August.
-2016 International symposium: Alzheimer´s disease, Challenges and new vistas, Universidad Autonoma de Chile, title of the presentation: “New avenues for diagnostic and treatment against Alzheimer´s disease. The Mitochondrial Approach”, Santiago, Chile, August.
-2016 Seminario Internacional de Políticas Públicas en Alcohol, Universidad Diego Portales, title of presentation:”Nuevas implicancias del sistema de melanocortinas en el consumo de alcohol por atracón en adolescentes”, Santiago, Chile, October.
-2017 Department of Pharmacology and Physiology, University of Rochester, title of the presentation: “Adolescent alcohol consumption impairs brain function through mitochondrial failure”, Rochester, New York, November-
-2018 Congreso del Futuro Maule, Talca, Chile, title of presentation: "Cerebro y energia", Talca, Enero.
-2018 Seminario Actualizaciones en la neurobiologia del alcohol y cannabis, Universidad Autonoma-P. Universidad Catolica, title of the presentation: "Abuso de alcohol en adolescentes. Consecuencias sobre la función y el metabolismo neuronal", Santiago, Chile, Septiembre.
-2018 Seminario Departamento de Biología Celular y Molecular, Facultad de Ciencias, P. Universidad Catolica de Chile, title of the presentation: "Contribución de la proteína tau y la disfunción mitocondrial al deterioro cognitivo presente en el envejecimiento", Santiago, Chile, Octubre.