Man

Juan Alejandro Godoy Zeballos

Investigador

Centro de Oncologia dePrecision

Santiago, Chile

Líneas de Investigación


Neurociencias: Neurobiologia y señalización neuronal, estudio de la sinapsis neuronal

Educación

  •  Tecnologo Medico, UNIVERSIDAD DE CHILE. Chile, 1981
  •  Ciencias Biológicas- Microbiologia, UNIVERSIDAD DE CHILE. Chile, 1992
  •  Biomedicina, UNIVERSITAT POMPEU FABRA. España, 2018

Experiencia Académica

  •   Investigador Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biológicas

    santiago, Chile

    1999 - 2019

Experiencia Profesional

  •   Investigador CARE-Chile UC Full Time

    Pontificia Univeversidad Católica de Chile

    Santiago, Chile

    1999 - 2019

  •   Investigador Full Time

    CARE-UC Chile

    Santiago, Chile

    2000 - 2019


 

Article (41)

Mitostasis, Calcium and Free Radicals in Health, Aging and Neurodegeneration

Herrera-Fernandez, Victor; Swaby, Bronte

Article ISI
Biomolecules  (2021)

Morphological neurite changes induced by porcupine inhibition are rescued by Wnt ligands



Article ISI
CELL COMMUNICATION AND SIGNALING  (2021)

Oportunidad en la salud digital: una respuesta al control de las demencias

Juan A. Godoy; Carola Ríos L.; Pía Venegas A.; Carolina López R.; José Luis Álvarez; Camila Ramírez M.

Article ISI SCIELO
REVISTA MEDICA DE CHILE  (2020)

Modulating Wnt signaling at the root: Porcupine and Wnt acylation

Inestrosa, N. C.

Article ISI SCOPUS
PHARMACOLOGY THERAPEUTICS  (2019)

Serine-Arginine Protein Kinase SRPK2 Modulates the Assembly of the Active Zone Scaffolding Protein CAST1/ERC2

Arancibia, Duxan; Cruz, Yocelin; Barrera, Daniela P.; Godoy, Juan A; Garner, Craig C.; Zamorano, Pedro

Article ISI
CELLS  (2019)

Nicotine Modulates Mitochondrial Dynamics in Hippocampal Neurons

Godoy, Juan A; Valdivieso, Angel G.; Inestrosa, Nibaldo C

Article ISI SCOPUS
Molecular Neurobiology  (2018)

The Exocyst Component Exo70 Modulates Dendrite Arbor Formation, Synapse Density, and Spine Maturation in Primary Hippocampal Neurons

Lira M.; Cruz Y.; Inestrosa, N. C.

Article ISI SCOPUS
MOLECULAR NEUROBIOLOGY  (2018)

Wnt3a ligand facilitates autophagy in hippocampal neurons by modulating a novel GSK-3 beta-AMPK axis

Godoy, Juan A; Inestrosa, Nibaldo C

Article ISI SCOPUS
CELL COMMUNICATION AND SIGNALING  (2018)

Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer's Disease

Inestrosa, NC; Rios, JA; Cisternas P.; Tapia-Rojas, C; Braidy, N; Godoy JA; Ardiles AO; Bozinovic F.; Sachdev, PS

Article ISI SCOPUS
Brain Pathology  (2015)

Multiple Cryptosporidium parvum subtypes detected in a unique isolate of a Chilean neonatal calf with diarrhea

Mercado R.; Peña S.; Ozaki, LS.; Fredes, F; Godoy, J

Article ISI SCOPUS
Parasitology Research  (2015)

The soluble extracellular fragment of neuroligin-1 targets A beta oligomers to the postsynaptic region of excitatory synapses

Dinamarca, MC; Di Luca M.; Godoy JA; Inestrosa, NC

Article ISI SCOPUS
Biochemical and Biophysical Research Communications  (2015)

Wnt5a inhibits K+ currents in hippocampal synapses through nitric oxide production

Parodi, Jorge; Montecinos-Oliva, Carla; Varas, Rodrigo; Alfaro, Iván E.; Serrano, Felipe G.; Varas-Godoy, Manuel; Muñoz, Francisco J.; Cerpa, Waldo; Godoy, Juan A; Inestrosa, Nibaldo C

Article ISI SCOPUS
Molecular and Cellular Neuroscience  (2015)

Phosphorylated tau potentiates A beta-induced mitochondrial damage in mature neurons

Quintanilla, RA; von Bernhardi R.; Godoy JA; Inestrosa, NC; Johnson, GVW

Article ISI SCOPUS
NEUROBIOLOGY OF DISEASE  (2014)

Role of Sirt1 During the Ageing Process: Relevance to Protection of Synapses in the Brain

Zolezzi J.M.; Braidy, N; Inestrosa, N. C.

Article ISI SCOPUS
MOLECULAR NEUROBIOLOGY  (2014)

Wnt-5 alpha increases NO and modulates NMDA receptor in rat hippocampal neurons

Godoy JA; Cerpa, W.; Huidobro-Toro, JP; Inestrosa, NC

Article ISI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  (2014)

Wnt-5a Ligand Modulates Mitochondrial Fission-Fusion in Rat Hippocampal Neurons

Ordenes, D; Silva-Alvarez, C; Braidy, N; Inestrosa, N. C.

Article ISI SCOPUS
JOURNAL OF BIOLOGICAL CHEMISTRY  (2014)

ATP Induces NO Production in Hippocampal Neurons by P2X(7) Receptor Activation Independent of Glutamate Signaling

Codocedo, Juan Francisco; Godoy, Juan Alejandro; Poblete, Maria Ines; Inestrosa, Nibaldo C; Mongin, Alexander A.

Article ISI SCOPUS
PLOS ONE  (2013)

Canonical Wnt signaling protects hippocampal neurons from A beta oligomers: role of non-canonical Wnt-5a/Ca2+ in mitochondrial dynamics

Silva-Alvarez, C; Arrazola, MS; Godoy JA; Ordenes, D; Inestrosa, NC

Article ISI SCOPUS
FRONTIERS IN CELLULAR NEUROSCIENCE  (2013)

Nicotine Prevents Synaptic Impairment Induced by Amyloid-beta Oligomers Through alpha 7-Nicotinic Acetylcholine Receptor Activation

Inestrosa, NC; Godoy JA; Vargas JY; Arrazola, MS; Rios, JA; Serrano, FG; Farias GG.

Article ISI SCOPUS
NEUROMOLECULAR MEDICINE  (2013)

Peroxisome Proliferator-Activated Receptor (PPAR) gamma and PPAR alpha Agonists Modulate Mitochondrial Fusion-Fission Dynamics: Relevance to Reactive Oxygen Species (ROS)-Related Neurodegenerative Disorders?

Zolezzi, Juan M.; Ordenes, Daniela; Godoy, Juan A; Carvajal, Francisco J.; Santos, Manuel J.; Inestrosa, Nibaldo C; Ferreira, Sergio T.

Article ISI SCOPUS
PLOS ONE  (2013)

Tetrahydrohyperforin Decreases Cholinergic Markers associated with Amyloid-beta Plaques, 4-Hydroxynonenal Formation, and Caspase-3 Activation in A beta PP/PS1 Mice

Tapia-Rojas, C; Godoy JA; Inestrosa, NC

Article ISI SCOPUS
Journal of Alzheimer's Disease  (2013)

Tetrahydrohyperforin Induces Mitochondrial Dynamics and Prevents Mitochondrial Ca2+ Overload after A beta and A beta-AChE Complex Challenge in Rat Hippocampal Neurons

Rios, JA; Ordenes, D; Silva-Alvarez, C; Godoy JA; Inestrosa, NC

Article ISI SCOPUS
Journal of Alzheimer's Disease  (2013)

Thiazolidinediones Promote Axonal Growth through the Activation of the JNK Pathway

Quintanilla, Rodrigo A.; Godoy, Juan A; Alfaro, Ivan; Cabezas, Deny; Bernhardi, Rommy von; Bronfman, Miguel; Inestrosa, Nibaldo C; Allinquant, Bernadette

Article ISI SCOPUS
PLOS ONE  (2013)

SIRT1 Regulates Dendritic Development in Hippocampal Neurons

Codocedo, Juan F.; Allard, Claudio; Godoy, Juan A; Inestrosa, Nibaldo C; Allinquant, Bernadette

Article ISI SCOPUS
PLOS ONE  (2012)

Amyloid-beta Peptide Fibrils Induce Nitro-Oxidative Stress in Neuronal Cells

ILL-Raga G.; Ramos-Fernandez, E; Guix FX; Tajes M.; Bosch-Morato M.; Palomer E.; Godoy, J; Belmar S; Cerpa, W.; Simpkins, JW; Inestrosa, NC; Munoza, FJ

Article ISI SCOPUS
Journal of Alzheimer's Disease  (2010)

Amyloid-beta-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the A beta peptide. Implications for the pathogenesis of Alzheimer's disease

Dinamarca, MC; Sagal, JP; Quintanilla, RA; Godoy JA; Arrazola, MS; Inestrosa, NC

Article ISI SCOPUS
Molecular Neurodegeneration  (2010)

Wnt-5a Modulates Recycling of Functional GABA(A) Receptors on Hippocampal Neurons

Cuitino, L; Godoy JA; Farias GG.; couve, a; Bonansco, C.; Fuenzalida, M; Inestrosa, NC

Article ISI SCOPUS
Journal of Neuroscience  (2010)

Wnt-5a occludes A beta oligomer-induced depression of glutamatergic transmission in hippocampal neurons

Cerpa, W.; Farias GG.; Godoy JA; Fuenzalida, M; Bonansco, C.; Inestrosa, NC

Article ISI SCOPUS
Molecular Neurodegeneration  (2010)

Wnt-5a/JNK Signaling Promotes the Clustering of PSD-95 in Hippocampal Neurons

Farias GG.; alfaro ie; Cerpa, W.; Grabowski CP; Godoy JA; Bonansco, C.; Inestrosa, NC

Article ISI SCOPUS
JOURNAL OF BIOLOGICAL CHEMISTRY  (2009)

Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons

Cerpa, W.; Godoy JA; Alfaro I.; Farlas, GG; Metcalfe MJ; Fuentealba, R; Bonansco, C.; Inestrosa, NC

Article ISI SCOPUS
JOURNAL OF BIOLOGICAL CHEMISTRY  (2008)

Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons

Farias GG.; Valles, AS; Colombres M.; Godoy JA; Toledo EM; Lukas, RJ; Inestrosa, NC

Article ISI SCOPUS
JOURNAL OF NEUROSCIENCE  (2007)

Peroxisomal proliferation protects from beta-amyloid neurodegeneration

Quintanilla, RA; Toro, AS; Grandy, R; Dinamarca, MC; Godoy JA; Inestrosa, NC

Article ISI SCOPUS
JOURNAL OF BIOLOGICAL CHEMISTRY  (2005)

Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling

Inestrosa, NC; Godoy JA; Quintanilla, RA; Koenig, CS; Bronfman, M

Article ISI SCOPUS
EXPERIMENTAL CELL RESEARCH  (2005)

The anti-inflammatory and cholinesterase inhibitor bifunctional compound IBU-PO protects from beta-amyloid neurotoxicity by acting on Wnt signaling components

Farias GG.; Godoy JA; Adani, R; Meshulam, H; Avila J.; Amitai, G; Inestrosa, NC

Article ISI SCOPUS
NEUROBIOLOGY OF DISEASE  (2005)

M1 muscarinic receptor activation protects neurons from beta-amyloid toxicity. A role for Wnt signaling pathway

Farias GG.; Godoy JA; Hernández F.; Avila J.; Fisher, A; Inestrosa, NC

Article ISI
NEUROBIOLOGY OF DISEASE  (2004)

Wnt-3a overcomes ?-amyloid toxicity in rat hippocampal neurons

Mullendorff, K; Bronfman, M; Inestrosa, N. C.

Article SCOPUS
EXPERIMENTAL CELL RESEARCH  (2004)

Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons

Alvarez, AR; Godoy JA; Mullendorff, K; Olivares, GH; Bronfman, M; Inestrosa, NC

Article ISI
EXPERIMENTAL CELL RESEARCH  (2004)

Activation of Wnt signaling and behavioral impairments rescues neurodegeneration induced by beta-amyloid fibrils

De Ferrari, GV; Chacón MA; Barría MI; garrido, JL; Godoy JA; Olivares, G; Alvarez A.; Bronfman, M; Inestrosa, NC

Article ISI SCOPUS
MOLECULAR PSYCHIATRY  (2003)

Protein kinase C inhibits amyloid beta-peptide neurotoxicity by acting on members of the Wnt pathway

garrido, JL; Godoy, J; Alvarez A.; Bronfman, M; Inestrosa, NC

Article ISI
FASEB JOURNAL  (2002)

Acetylcholinesterase-amyloid-?-peptide interaction and Wnt signaling involvement in A? neurotoxicity

Inestrosa, N. C.; Alvarez A.; Godoy, J; Reyes A.

Article SCOPUS
Acta Neurologica Scandinavica, Supplement  (2000)

Acetylcholinesterase-amyloid-beta-peptide interaction and Wnt signaling involvement in A beta neurotoxicity

Inestrosa, NC; Alvarez A.; Godoy, J; Reyes A.; De Ferrari, GV

Article ISI
ACTA NEUROLOGICA SCANDINAVICA  (2000)

Abstract (2)

Role of hippocampal P2X7 receptors in the release of NO by ATP and related nucleotides

Wilson, IMP; Godoy, J; Inestrosa, N; Huidobro-Toro, JP

Abstract ISI
PURINERGIC SIGNALLING  (2010)

Peroxisomal proliferation prevents beta-amyloid-neurotoxicity in rat hippocampal neurons

Quintanilla, RA; Godoy JA; Toro, A.; Inestrosa, NC

Abstract ISI
JOURNAL OF NEUROCHEMISTRY  (2005)

ConferencePaper (1)

Peroxisomal proliferation prevents beta-amyloid neurodegeneration

Quintanilla, RA; Godoy JA; Toro, A.; Inestrosa, NC

ConferencePaper ISI
New Trends in Alzheimer and Parkinson Related Disorders: ADPD 2005  (2005)

Review (4)

Are microRNAs the Molecular Link Between Metabolic Syndrome and Alzheimer's Disease?

Inestrosa, N. C.

Review ISI SCOPUS
MOLECULAR NEUROBIOLOGY  (2016)

Signaling pathway cross talk in Alzheimer's disease

Godoy JA; Rios, JA; Braidy, N; Inestrosa, NC

Review ISI SCOPUS
CELL COMMUNICATION AND SIGNALING  (2014)

Wnt Signaling Modulates Pre- and Postsynaptic Maturation: Therapeutic Considerations

Farias GG.; Godoy JA; Cerpa, W.; Varela-Nallar, L; Inestrosa, NC

Review ISI SCOPUS
Developmental Dynamics  (2010)

Trolox and 17 beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway

Quintanilla, RA; Metcalfe MJ; Hitschfeld, M; Olivares, G; Godoy JA; Inestrosa, NC

Review ISI SCOPUS
JOURNAL OF BIOLOGICAL CHEMISTRY  (2005)

48
Juan Godoy

Investigador

Centro de Oncologia dePrecision

Santiago, Chile

42
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

9
Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

8
JUVENAL RÍOS

Investigador

CR de Investigación y Desarrollo

Instituto Nacional del Cáncer (INCANCER)

Santiago, Chile

8
Waldo Cerpa

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Catolica de Chile

Santiago, Chile

6
Juan Zolezzi

Associate Professor

School of Medicine

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

6
Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

6
Ivan Alfaro

Associate Professor, Director of Innovation and Technology Development

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

5
DOMINGO BONANSCO

Profesor Titular

Instituto de Fisiologia

UNIVERSIDAD DE VALPARAISO, FACULTAD DE CIENCIAS

Valparaiso, Chile

5
Francisco Carvajal

asistente de investigacion

Universidad de Magallanes

punta arenas, Chile

3
Gonzalo Olivares

ASSISTANT PROFESSOR

NEUROCIENCIA

Universidad de Chile

SANTIAGO, Chile

3
Giancarlo De Ferrari

Full Professor

Biological Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

2
Ariel Reyes

Director de Departamento

Ciencias Biológicas

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

2
PEDRO ZAMORANO

Profesor Asociado

Depto Biomédico

Universidad de Antofagasta

Antofagasta, Chile

2
Matías Lira

Postdoc

Universidad San Sebastián

Santiago, Chile

2
Andrés Couve

Profesor Titular

Neurociencia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Rommy von Bernhardi

Full Professor

Neurology

DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Jose Garrido

Investigador asesor, part time

Universidad San Sebastián

Puerto Montt, Chile

2
Sebastian Belmar

2
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

2
Duxan Arancibia

Investigador Posdoctoral

Biomédico

Universidad de Antofagasta

Antofagasta, Chile

1
Alvaro Ardiles

Full Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

1
RUBEN MERCADO

Academico

Pediatria y Cirugia Infantil Occidente

UNIVERSIDAD DE CHILE. FACULTAD DE MEDICINA. UNIDAD DOCENTE DE PARASITOLOGÍA.

Santiago, Chile

1
Jorge Parodi

Director de laboratorio

Universidad Mayor de Chile

Temuco, Chile

1
Rodrigo Varas

Profesor Asociado

Universidad Autónoma de Chile

Talca, Chile

1
Maria Barria

Investigador, Associate Professor

Universidad San Sebastián

Puerto Montt, Chile

1
Felix Diaz

1
Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Rodrigo Fuentealba

Postdoctoral Research Associate

Departamento de Inmunología Clínica y Reumatología / Facultad de Medicina

Pontificia Universidad Católica

Santiago, Chile

1
Claudio Allard

PROFESOR ASISTENTE

Química y Biología

Universidad de Atacama

Copiapó, Chile

1
Sebastian Peña

Instructor Adjunto

Pediatría y Cirugía Infantil Occidente

Universidad de Chile

Santiago, Chile

1
Marcelo Chacon

Postdoc

Neurology

UTHealth

Houston, Estados Unidos

1
Loreto Cuitiño

Investigador Asociado

Oftalmología

Hospital Clínico Universidad de Chile

229788866, Chile

1
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Daniela Barrera

PhD Student

Environ SPA

Santiago, Chile