Man

Juan Alejandro Godoy Zeballos

Tecnologo Medico

Laboratorio Clinico Cruz del Sur

Santiago, Chile

Líneas de Investigación


Neurociencias: Neurobiologia y señalización neuronal, estudio de la sinapsis neuronal

Educación

  •  Tecnologo Medico, UNIVERSIDAD DE CHILE. Chile, 1981
  •  Ciencias Biológicas- Microbiologia, UNIVERSIDAD DE CHILE. Chile, 1992
  •  Biomedicina, UNIVERSITAT POMPEU FABRA. España, 2018

Experiencia Académica

  •   Investigador Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biológicas

    santiago, Chile

    1999 - 2019

Experiencia Profesional

  •   Investigador CARE-Chile UC Full Time

    Pontificia Univeversidad Católica de Chile

    Santiago, Chile

    1999 - 2019

  •   Tecnologo Medico Full Time

    Laboratorio Clinico Cruz del Sur

    santiago, Chile

    1990 - At present


 

Article (41)

Mitostasis, Calcium and Free Radicals in Health, Aging and Neurodegeneration
Morphological neurite changes induced by porcupine inhibition are rescued by Wnt ligands
Oportunidad en la salud digital: una respuesta al control de las demencias
Modulating Wnt signaling at the root: Porcupine and Wnt acylation
Serine-Arginine Protein Kinase SRPK2 Modulates the Assembly of the Active Zone Scaffolding Protein CAST1/ERC2
Nicotine Modulates Mitochondrial Dynamics in Hippocampal Neurons
The Exocyst Component Exo70 Modulates Dendrite Arbor Formation, Synapse Density, and Spine Maturation in Primary Hippocampal Neurons
Wnt3a ligand facilitates autophagy in hippocampal neurons by modulating a novel GSK-3 beta-AMPK axis
Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer's Disease
Multiple Cryptosporidium parvum subtypes detected in a unique isolate of a Chilean neonatal calf with diarrhea
The soluble extracellular fragment of neuroligin-1 targets A beta oligomers to the postsynaptic region of excitatory synapses
Wnt5a inhibits K+ currents in hippocampal synapses through nitric oxide production
Phosphorylated tau potentiates A beta-induced mitochondrial damage in mature neurons
Role of Sirt1 During the Ageing Process: Relevance to Protection of Synapses in the Brain
Wnt-5 alpha increases NO and modulates NMDA receptor in rat hippocampal neurons
Wnt-5a Ligand Modulates Mitochondrial Fission-Fusion in Rat Hippocampal Neurons
ATP Induces NO Production in Hippocampal Neurons by P2X(7) Receptor Activation Independent of Glutamate Signaling
Canonical Wnt signaling protects hippocampal neurons from A beta oligomers: role of non-canonical Wnt-5a/Ca2+ in mitochondrial dynamics
Nicotine Prevents Synaptic Impairment Induced by Amyloid-beta Oligomers Through alpha 7-Nicotinic Acetylcholine Receptor Activation
Peroxisome Proliferator-Activated Receptor (PPAR) gamma and PPAR alpha Agonists Modulate Mitochondrial Fusion-Fission Dynamics: Relevance to Reactive Oxygen Species (ROS)-Related Neurodegenerative Disorders?
Tetrahydrohyperforin Decreases Cholinergic Markers associated with Amyloid-beta Plaques, 4-Hydroxynonenal Formation, and Caspase-3 Activation in A beta PP/PS1 Mice
Tetrahydrohyperforin Induces Mitochondrial Dynamics and Prevents Mitochondrial Ca2+ Overload after A beta and A beta-AChE Complex Challenge in Rat Hippocampal Neurons
Thiazolidinediones Promote Axonal Growth through the Activation of the JNK Pathway
SIRT1 Regulates Dendritic Development in Hippocampal Neurons
Amyloid-beta Peptide Fibrils Induce Nitro-Oxidative Stress in Neuronal Cells
Amyloid-beta-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the A beta peptide. Implications for the pathogenesis of Alzheimer's disease
Wnt-5a Modulates Recycling of Functional GABA(A) Receptors on Hippocampal Neurons
Wnt-5a occludes A beta oligomer-induced depression of glutamatergic transmission in hippocampal neurons
Wnt-5a/JNK Signaling Promotes the Clustering of PSD-95 in Hippocampal Neurons
Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons
Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons
Peroxisomal proliferation protects from beta-amyloid neurodegeneration
Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling
The anti-inflammatory and cholinesterase inhibitor bifunctional compound IBU-PO protects from beta-amyloid neurotoxicity by acting on Wnt signaling components
M1 muscarinic receptor activation protects neurons from beta-amyloid toxicity. A role for Wnt signaling pathway
Wnt-3a overcomes ?-amyloid toxicity in rat hippocampal neurons
Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons
Activation of Wnt signaling and behavioral impairments rescues neurodegeneration induced by beta-amyloid fibrils
Protein kinase C inhibits amyloid beta-peptide neurotoxicity by acting on members of the Wnt pathway
Acetylcholinesterase-amyloid-?-peptide interaction and Wnt signaling involvement in A? neurotoxicity
Acetylcholinesterase-amyloid-beta-peptide interaction and Wnt signaling involvement in A beta neurotoxicity

Abstract (2)

Role of hippocampal P2X7 receptors in the release of NO by ATP and related nucleotides
Peroxisomal proliferation prevents beta-amyloid-neurotoxicity in rat hippocampal neurons

ConferencePaper (1)

Peroxisomal proliferation prevents beta-amyloid neurodegeneration

Review (4)

Are microRNAs the Molecular Link Between Metabolic Syndrome and Alzheimer’s Disease?
Signaling pathway cross talk in Alzheimer's disease
Wnt Signaling Modulates Pre- and Postsynaptic Maturation: Therapeutic Considerations
Trolox and 17 beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway
48
Juan Godoy

Tecnologo Medico

Laboratorio Clinico Cruz del Sur

Santiago, Chile

42
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

9
Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

8
JUVENAL RÍOS

Investigador

CR de Investigación y Desarrollo

Instituto Nacional del Cáncer (INCANCER)

Santiago, Chile

8
Waldo Cerpa

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Catolica de Chile

Santiago, Chile

6
Juan Zolezzi

Associate Professor

School of Medicine

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

6
Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

6
Ivan Alfaro

Associate Professor, Director of Innovation and Technology Development

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

5
DOMINGO BONANSCO

Profesor Titular

Instituto de Fisiologia

UNIVERSIDAD DE VALPARAISO, FACULTAD DE CIENCIAS

Valparaiso, Chile

5
Francisco Carvajal

asistente de investigacion

Universidad de Magallanes

punta arenas, Chile

3
Gonzalo Olivares

ASSISTANT PROFESSOR

NEUROCIENCIA

Universidad de Chile

SANTIAGO, Chile

3
Giancarlo De Ferrari

Full Professor

Biological Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

2
Ariel Reyes

Director de Departamento

Ciencias Biológicas

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

2
PEDRO ZAMORANO

Profesor Asociado

Depto Biomédico

Universidad de Antofagasta

Antofagasta, Chile

2
Matías Lira

Postdoc

Universidad San Sebastián

Santiago, Chile

2
Andrés Couve

Profesor Titular

Neurociencia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Rommy von Bernhardi

Full Professor

Neurology

DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Jose Garrido

Investigador asesor, part time

Universidad San Sebastián

Puerto Montt, Chile

2
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

2
Duxan Arancibia

Investigador Posdoctoral

Biomédico

Universidad de Antofagasta

Antofagasta, Chile

1
Alvaro Ardiles

Full Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

1
RUBEN MERCADO

Academico

Pediatria y Cirugia Infantil Occidente

UNIVERSIDAD DE CHILE. FACULTAD DE MEDICINA. UNIDAD DOCENTE DE PARASITOLOGÍA.

Santiago, Chile

1
Jorge Parodi

Director de laboratorio

Universidad Mayor de Chile

Temuco, Chile

1
Rodrigo Varas

Profesor Asociado

Universidad Autónoma de Chile

Talca, Chile

1
Maria Barria

Investigador, Associate Professor

Universidad San Sebastián

Puerto Montt, Chile

1
Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Rodrigo Fuentealba

Postdoctoral Research Associate

Departamento de Inmunología Clínica y Reumatología / Facultad de Medicina

Pontificia Universidad Católica

Santiago, Chile

1
Claudio Allard

PROFESOR ASISTENTE

Química y Biología

Universidad de Atacama

Copiapó, Chile

1
Sebastian Peña

Instructor Adjunto

Pediatría y Cirugía Infantil Occidente

Universidad de Chile

Santiago, Chile

1
Marcelo Chacon

Postdoc

Neurology

UTHealth

Houston, Estados Unidos

1
Loreto Cuitiño

Investigador Asociado

Oftalmología

Hospital Clínico Universidad de Chile

229788866, Chile

1
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Daniela Barrera

PhD Student

Environ SPA

Santiago, Chile