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Margarita Constanza Dinamarca Ceballos

team leader

University of Basel

Basel, Suiza

Translational neuroscience, nanomedicine, and therapeutic delivery for neurodegenerative and rare diseases using human iPSC models and lipid nanoparticles.

Cell and Molecular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009
Cell and Molecular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005
Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2003

Team leader Part Time

University of Basel

Pharmaceutical Science

Suiza

2023 - At present
Senior Scientist Part Time

University of Basel

Suiza

2019 - 2022
Postdoc Full Time

University of Basel

Chile

2013 - 2018
Postdoc Full Time

University of Milan

Italia

2009 - 2013

CSO Other

NanoZymeX

Basel, Suiza

2025 - At present

Find for Rare

Find for rare

Suiza, 2025

Grant Initiative. Her research focuses on understanding brain endothelial dysfunction in alpha-mannosidosis and pioneering targeted therapeutic strategies using nanocarriers.


Charge-driven lipid nanoparticle encapsulation of enzymes for enhanced ERT with reduced immunogenicity. Sevarika B, Couvidou A, Aldawod D, Dinamarca MC, McNeil S. Article J Control Release. (2026)
Mannose-6-Phosphate-Tagged Liposomes Exhibit Increased Transcytosis Across Human Blood–Brain Barrier Model Margarita C. Dinamarca *,Boris Sevarika andScott McNeil Article Pharmaceutics (2026)
Mannose-6-phosphate-PEG-lipid conjugates improve liposomal uptake Sevarika, Boris; Capri, Deniz; Frey, Joel; Dinamarca, Margarita C.; Haussinger, Daniel; Mcneil, Scott Article ISI EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2025)
Transmission-selective muscle pathology induced by the active propagation of mutant huntingtin across the human neuromuscular synapse Dinamarca, Margarita C.; Colombo, Laura; Brykczynska, Urszula; Grimm, Amandine; Fruh, Isabelle; Hossain, Imtiaz; Gabriel, Daniela; Eckert, Anne; Mueller, Matthias; Pecho-Vrieseling, Eline Article ISI FRONTIERS IN MOLECULAR NEUROSCIENCE (2024)
Synaptic and functional alterations in the development of mutant huntingtin expressing hiPSC-derived neurons Dinamarca, Margarita C.; Colombo, Laura; Tousiaki, Natalia E.; Mueller, Matthias; Pecho-Vrieseling, Eline Article ISI FRONTIERS IN MOLECULAR BIOSCIENCES (2022)
Complex formation of APP with GABA<sub>B</sub> receptors links axonal trafficking to amyloidogenic processing Dinamarca, Margarita C.; Raveh, Adi; Schneider, Andy; Fritzius, Thorsten; Frueh, Simon; Rem, Pascal D.; Stawarski, Michal; Lalanne, Txomin; Turecek, Rostislav; Choo, Myeongjeong; et al. Article ISI NATURE COMMUNICATIONS (2019)
Modular composition and dynamics of native GABA<sub>B</sub> receptors identified by high-resolution proteomics Schwenk, Jochen; Perez-Garci, Enrique; Schneider, Andy; Kollewe, Astrid; Gauthier-Kemper, Anne; Fritzius, Thorsten; Raveh, Adi; Dinamarca, Margarita C.; Hanuschkin, Alexander; Bildl, Wolfgang; et al. Article ISI NATURE NEUROSCIENCE (2016)
Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus. Dinamarca MC, Guzzetti F, Karpova A, Lim D, Mitro N, Musardo S, Mellone M, Marcello E, Stanic J, Samaddar T, Burguière A, Caldarelli A, Genazzani AA, Perroy J, Fagni L, Canonico PL, Kreutz MR, Gardoni F, Di Luca M. Article ELIFE (2016)
The soluble extracellular fragment of neuroligin-1 targets A beta oligomers to the postsynaptic region of excitatory synapses Dinamarca MC; Di Luca M.; Godoy J.A.; Inestrosa N.C. Article ISI SCOPUS Biochemical and Biophysical Research Communications (2015)
The Synaptic Protein Neuroligin-1 Interacts with the Amyloid beta-Peptide. Is There a Role in Alzheimer's Disease? Dinamarca MC; Weinstein D.; Monasterio O.; Inestrosa N.C. Article ISI SCOPUS Biochemistry (2011)
Amyloid-beta-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the A beta peptide. Implications for the pathogenesis of Alzheimer's disease Dinamarca MC; Sagal, JP; Quintanilla R.A.; Godoy J.A.; Arrazola, MS; Inestrosa N.C. Article ISI SCOPUS Molecular Neurodegeneration (2010)
Amyloid-cholinesterase interactions. Implications for Alzheimer's disease. Inestrosa NC, Dinamarca MC, Alvarez A. Article FEBS JOURNAL (2008)
beta-amyloid oligomers affect the structure and function of the postsynaptic region: Role of the Wnt signaling pathway Dinarnarca, MC; Colombres M.; Cerpa W.; Bonansco C.; Inestrosa N.C. Article ISI NEURODEGENERATIVE DISEASES (2008)
Release of acetylcholinesterase (ACH) from beta-amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice Dinamarca MC; Arrazola M; Toledo E.; Cerpa, WF; Hancke J.; Inestrosa N.C. Article ISI SCOPUS CHEMICO-BIOLOGICAL INTERACTIONS (2008)
Hyperforin prevents beta-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer's amyloid-beta-deposits Dinamarca MC; Cerpa W.; Garrido J.; Hancke J.L.; Inestrosa N.C. Article ISI SCOPUS MOLECULAR PSYCHIATRY (2006)
Peroxisomal proliferation protects from beta-amyloid neurodegeneration Quintanilla R.A.; Toro, AS; Grandy, R; Dinamarca MC; Godoy J.A.; Inestrosa N.C. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Acetylcholinesterase-A beta complexes are more toxic than A beta fibrils in rat hippocampus - Effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss Chacón, MA; Dinamarca MC; Cerpa W.; Morgan C.; Inestrosa N.C. Article ISI AMERICAN JOURNAL OF PATHOLOGY (2004)


Postsynaptic Receptors for Amyloid-β Oligomers as Mediators of Neuronal Damage in Alzheimer's Disease. Dinamarca MC, Ríos JA, Inestrosa NC. BookReview FRONTIERS IN PHYSIOLOGY (2012)
Neurobiological effects of Hyperforin and its potential in Alzheimer's disease therapy. Griffith TN, Varela-Nallar L, Dinamarca MC, Inestrosa NC. BookReview CURRENT MEDICINAL CHEMISTRY (2010)


Acetylcholinesterase-amyloid-?-peptide interaction: Effect of Congo Red and the role of the Wnt pathway Inestrosa, N. C.; Álvarez, A; PÃ©rez-Acle T. ConferencePaper SCOPUS CURRENT ALZHEIMER RESEARCH (2005)


Postsynaptic receptors for arnyloid-beta oligomers as mediators of neuronal damage in Alzheimer's disease Dinamarca MC; Rios J.A.; Inestrosa N.C. Review ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2012)
Amyloid-cholinesterase interactions - Implications for Alzheimer's disease Inestrosa N.C.; Dinamarca MC; Álvarez, A Review ISI FEBS JOURNAL (2008)
Structure-function implications in Alzheimer's disease: Effect of a oligomers A beta central synapses Cerpa W.; Dinamarca MC; Inestrosa N.C. Review ISI CURRENT ALZHEIMER RESEARCH (2008)

2

Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1

DOMINGO BONANSCO

Profesor Titular

Instituto de Fisiologia

UNIVERSIDAD DE VALPARAISO, FACULTAD DE CIENCIAS

Valparaiso, Chile

1

Octavio Monasterio

Profesor Titular

Departamento de Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGÍA

Santiago, Chile

1

Ariel Reyes

Director de Departamento

Ciencias Biológicas

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

12

Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4

Waldo Cerpa

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Catolica de Chile

Santiago, Chile

2

Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

1

JUVENAL RÍOS

Investigador

CR de Investigación y Desarrollo

Instituto Nacional del Cáncer (INCANCER)

Santiago, Chile

1

Marcelo Chacon

Postdoc

Neurology

UTHealth

Houston, Estados Unidos

1

David Weinstein

Académico

Facultad de Medicina

Universidad del Desarrollo

Las Condes, Chile

3

Juan Godoy

Investigador

Centro de Oncologia dePrecision

Santiago, Chile

23

Margarita Dinamarca

team leader

Pharmaceutical Science

University of Basel

Basel, Suiza