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DOMINGO CHRISTIAN BONANSCO HERRERA

Profesor Titular

UNIVERSIDAD DE VALPARAISO, FACULTAD DE CIENCIAS

Valparaiso, Chile

Synaptic Plasticity; Learning and Memory; Astroglial Modulation of Synaptic Plasticity mediated by Gliotransmitters ; Electrophysiology of synaptic transmission in neurological and neurodegenerative diseases.

Neurobiologia y Cs. de la Conducta, UNIVERSIDAD DE CHILE. Chile, 1993
Neurociencia Celular y Molecular, Universidad Complutense, Insto. Cajal CSIC. España, 1998
Licenciado en Biologia, UNIVERSIDAD DE CHILE. Chile, 1986

Assistant Profesor Full Time

UNIVERSIDAD DE PLAYA ANCHA DE CIENCIAS DE LA EDUCACION

Sciences

Valparaiso, Chile

1988 - 2000
Full professor Full Time

UNIVERSIDAD DE VALPARAISO

Sciences

Valparaiso, Chile

2000 - At present

Director and Full Professor Full Time

Universidad de Valparaiso, Facultad de Ciencias; Instituto de Fisiologia

Valparaiso, Chile

2000 - At present
Assistant Professor Full Time

U. de PLaya Ancha, Fac. Ciencias, Depto. Biología

Valparaiso, Chile

1988 - 2000

ALTERACIONES EN LA EXCITABILIDAD NEURONAL Y ASTROGLIAL EN RATAS EPILÉPTICAS MODIFICAN LA PLASTICIDAD SINÁPTICA, JUAN CARLOS MORALES, PROGRAMA DE DOCTORADO EN CIENCIAS, MENCIÓN NEUROCIENCIA, FACULTAD DE CIENCIAS, U. VALPARAÍSO, 2013. (Director, EN CURSO).

PAPEL DE LA ASTROGLIA EN LA EPILEPTOGÉNESIS, CARLA ALVARES FERRADAS, PROGRAMA DE DOCTORADO EN CIENCIAS, MENCIÓN NEUROCIENCIA, FACULTAD DE CIENCIAS, U. VALPARAÍSO, 2012. (Director, EN CURSO).

SEÑALIZACIÓN ASTROCITO–ASTROCITO Y PLASTICIDAD SINÁPTICA, MARIO WELLMANN, PROGRAMA DE MAGÍSTER EN CIENCIAS, MENCIÓN NEUROCIENCIA, FACULTAD DE CIENCIAS, U. VALPARAÍSO, 2012. (Director, EN CURSO).

"EFECTOS DE WNT-5a EN LA NEUROTRANSMISIÓN GABAÉRGICA EN UN MODELO MURINO DE DISTROFIA MUSCULAR DE DUCHENNE, CLAUDIA ESPINOZA MARTINEZ, MAGISTER CS. BIOLÓGICAS M/ NEUROCIENCIA, FAC. CIENCIAS U. VALPARAÍSO, 2011 (Co-Director)

“Participación de la vía Wnt en transducción de señales de la función sináptica y su papel en la enfermedad de Alzheimer”, Waldo Cerpa, PROGRAMA DE DOCTORADO EN CIENCIAS, MENCIÓN BIOLOGÍA CELULAR Y MOLECULAR, FACULTAD DE CIENCIAS BIOLÓGICAS, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, 2009. (Co-Director).

“Modulación de la actividad sináptica gabaérgica por coactivación de receptores para endocanabinodes y acetilcolina en el hipocampo”, Alejandro Couve, PROGRAMA DE MAGÍSTER EN CIENCIAS, MENCIÓN NEUROCIENCIA, FACULTAD DE CIENCIAS, U. VALPARAÍSO, 2010. (Co-Director).

“Efectos de la Gliotoxina Fluorocitrato sobre la transmisión sináptica CA3-CA1 en Hipocampo”, Juan Cristian Rojas, MAGISTER CS. BIOLÓGICAS M/ NEUROCIENCIA, FAC. CIENCIAS U. VALPARAÍSO, 2010 (Director).

“Maduración de las Propiedades de Excitabilidad y Eficacia Sinaptica en las Respuestas Reflejas en Médula Espinal Aislada del Mutante taiep”, Marco Fuenzalida Nuñez, MAGISTER CS. BIOLÓGICAS M/ NEUROCIENCIA, FAC. CIENCIAS U. VALPARAÍSO, 2002 (Director).

EMINENT SCIENTIST OF THE YEAR 2008 FOR SOUTH AMERICA

World Scientists Forum of the International Research Promotion Council (IRPC)

Chile, 2008

Neurology and Neurobiology area


Gliotransmission: A Novel Target for the Development of Antiseizure Drugs Riquelme J.; Wellmann M.; Sotomayor-ZÃ¡rate R.; Bonansco C. Article ISI SCOPUS Neuroscientist (2020)
Programming of Dopaminergic Neurons by Early Exposure to Sex Hormones=> Effects on Morphine-Induced Accumbens Dopamine Release, Reward, and Locomotor Behavior in Male and Female Rats Velasquez, VB; Zamorano, GA; Martinez-Pinto, J; Bonansco, C; Jara, P; Torres, GE; Renard, GM; Sotomayor-Zarate, R Article Frontiers in Pharmacology (2019)
Astroglial Ca 2+ -dependent hyperexcitability requires p2y 1 purinergic receptors and pannexin-1 channel activation in a chronic model of epilepsy Wellmann M., Álvarez-Ferradas C.; Maturana C.J., Sáez J.C. Article Frontiers in Cellular Neuroscience (2018)
Astroglial Ca 2+ -dependent hyperexcitability requires p2y 1 purinergic receptors and pannexin-1 channel activation in a chronic model of epilepsy Wellmann M.; Álvarez-Ferradas C.; Maturana C.J.; Sáez J.C.; Bonansco C. Article ISI SCOPUS Frontiers in Cellular Neuroscience (2018)
Neonatal exposure to oestradiol increases dopaminergic transmission in nucleus accumbens and morphine-induced conditioned place preference in adult female rats Bonansco, C.; Martinez-Pinto, J.; Silva, R. A.; Velasquez, V. B.; Martorell, A.; Selva, M. V.; Espinosa, P.; Moya, P. R.; Cruz, G.; Andres, M. E.; Sotomayor-Zarate, R. Article ISI SCOPUS JOURNAL OF NEUROENDOCRINOLOGY (2018)
SVCT2 Expression and Function in Reactive Astrocytes Is a Common Event in Different Brain Pathologies Salazar K., Martínez F.; Pérez-Martín M., Cifuentes M.; Trigueros L., Ferrada L.; Espinoza F., Saldivia N.; Bertinat R., Forman K.; Oviedo M.J., López-Gambero A.J.; Bonansco C., Bongarzone E.R. Article Molecular Neurobiology (2017)
Plasticity of Hippocampal Excitatory-Inhibitory Balance: Missing the Synaptic Control in the Epileptic Brain. Bonansco Christian; Fuenzalida Marco. Article NEURAL PLASTICITY (2016)
Enhanced astroglial Ca2+ signaling increases excitatory synaptic strength in the epileptic brain. Álvarez-Ferradas, Carla; Morales, Juan Carlos; Wellmann, Mario; Nualart, Francisco; Roncagliolo, Manuel; Fuenzalida, Marco; Bonansco, Christian Article Glia (2015)
A new rapid kindling variant for induction of cortical epileptogenesis in freely moving rats Bonansco, C. Article ISI SCOPUS FRONTIERS IN CELLULAR NEUROSCIENCE (2014)
A new rapid kindling variant for induction of cortical epileptogenesis in freely moving rats Bonansco, C. Article Frontiers in Cellular Neuroscience (2014)
Glutamate released spontaneously from astrocytes sets the threshold for synaptic plasticity Bonansco, C.; couve, a; Perea G.; Ferradas, CA; Roncagliolo, M; Fuenzalida, M Article ISI SCOPUS European Journal of Neuroscience (2011)
HYPEREXCITABLE ASTROCYTES INCREASE THE PROBABILITY OF GLUTAMATE RELEASE AT CA3-CA1 SYNAPSES IN SLICES FROM KINDLED EPILEPTIC RATS Bonansco, C; Alvarez-Ferrada, C; Morales, JC; Fuenzalida M.; Roncagliolo, M Article GLIA (2011)
HYPEREXCITABLE ASTROCYTES INCREASE THE PROBABILITY OF GLUTAMATE RELEASE AT CA3-CA1 SYNAPSES IN SLICES FROM KINDLED EPILEPTIC RATS Bonansco, C.; Alvarez-Ferrada, C; Morales, JC; Fuenzalida, M; Roncagliolo, M Article GLIA (2011)
Wnt-5a Modulates Recycling of Functional GABA(A) Receptors on Hippocampal Neurons Cuitino, L; Godoy JA; Farias GG.; couve, a; Bonansco, C.; Fuenzalida, M; Inestrosa, NC Article ISI SCOPUS Journal of Neuroscience (2010)
Wnt-5a Modulates Recycling of Functional GABA(A) Receptors on Hippocampal Neurons Cuitino, L; Godoy, JA; Farias GG., Couve; A, Bonansco; C., Fuenzalida; M, Inestrosa Article Journal of Neuroscience (2010)
Wnt-5a occludes A beta oligomer-induced depression of glutamatergic transmission in hippocampal neurons Cerpa, W; Farias, GG; Godoy, JA; Fuenzalida M.; Bonansco, C; Inestrosa, NC Article Molecular Neurodegeneration (2010)
Wnt-5a occludes A beta oligomer-induced depression of glutamatergic transmission in hippocampal neurons Cerpa, W.; Farias GG.; Godoy JA; Fuenzalida, M; Bonansco, C.; Inestrosa, NC Article ISI SCOPUS Molecular Neurodegeneration (2010)
CHANGES OF RELEASE PROPERTIES ON CA3-CA1 SYNAPSES INDUCED BY METABOLIC ARREST OF ASTROCYTES IN HIPPOCAMPAL SLICES Bonansco, C; Fuenzalida M.; Aliaga, E; Roncagliolo, M Article GLIA (2009)
Developmental Increase of Asynchronic Glutamate Release From Hippocampal Synapses in Mutant taiep Rat Fuenzalida, M; Aliaga, E; Olivares, V; Roncagliolo, M; Bonansco, C. Article Synapse (2009)
Developmental Increase of Asynchronic Glutamate Release From Hippocampal Synapses in Mutant taiep Rat Fuenzalida M.; Aliaga, E; Olivares, V; Roncagliolo, M; Bonansco, C Article SYNAPSE (2009)
Developmental Increase of Asynchronic Glutamate Release From Hippocampal Synapses in Mutant taiep Rat Fuenzalida, M; Aliaga, E; Olivares, V; Roncagliolo, M; Bonansco, C. Article ISI SCOPUS SYNAPSE (2009)
Wnt-5a/JNK Signaling Promotes the Clustering of PSD-95 in Hippocampal Neurons Farias GG.; alfaro ie; Cerpa, W.; Grabowski CP; Godoy JA; Bonansco, C.; Inestrosa, NC Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
beta-amyloid oligomers affect the structure and function of the postsynaptic region: Role of the Wnt signaling pathway Dinarnarca, MC; Colombres M.; Cerpa, W.; Bonansco, C.; Inestrosa, NC Article ISI NEURODEGENERATIVE DISEASES (2008)
beta-amyloid oligomers affect the structure and function of the postsynaptic region: Role of the Wnt signaling pathway Dinarnarca, MC; Colombres, M; Cerpa, W; Bonansco, C; Inestrosa, NC Article NEURODEGENERATIVE DISEASES (2008)
beta-amyloid oligomers affect the structure and function of the postsynaptic region=> Role of the Wnt signaling pathway Dinarnarca, MC; Colombres M., Cerpa; W., Bonansco; C., Inestrosa Article NEURODEGENERATIVE DISEASES (2008)
Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons Cerpa, W.; Godoy JA; Alfaro I.; Farlas, GG; Metcalfe MJ; Fuentealba, R; Bonansco, C.; Inestrosa, NC Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Asynchronic transmission in the CA3-CA1 hippocampal synapses in the neurological mutant taiep rat Bonansco, C.; Fuenzalida, M; Olivares, V; Molina C.; Roncagliolo, M Article ISI SCOPUS JOURNAL OF NEUROSCIENCE RESEARCH (2007)
Developmental impairment of compound action potential in the optic nerve of myelin mutant taiep rats Roncagliolo, M; Schlageter, C; Leon, C.; Couve, E.; Bonansco, C.; Eguibar, JR Article ISI SCOPUS BRAIN RESEARCH (2006)
Developmental impairment of compound action potential in the optic nerve of myelin mutant taiep rats Roncagliolo, M; Schlageter, C; Leon, C.; Couve, E.; Bonansco, C.; Eguibar, JR Article BRAIN RESEARCH (2006)
Altered synaptic and electrical properties of lumbar motoneurons in the neurological glial mutant taiep rat Bonansco, C.; Fuenzalida, M; Roncagliolo, M Article ISI EXPERIMENTAL BRAIN RESEARCH (2004)
Altered synaptic and electrical properties of lumbar motoneurons in the neurological glial mutant taiep rat Bonansco, C.; Fuenzalida, M; Roncagliolo, M Article EXPERIMENTAL BRAIN RESEARCH (2004)
Immature developmental pattern of the monosynaptic reflex in isolated spinal cord of glial mutant taiep rats Fuenzalida, M; Roncagliolo P.; Bonansco, C.; Roncagliolo, M Article ISI Developmental Brain Research (2004)
Immature developmental pattern of the monosynaptic reflex in isolated spinal cord of glial mutant taiep rats Fuenzalida, M; Roncagliolo, P; Bonansco, C.; Roncagliolo, M Article Developmental Brain Research (2004)
Asynchronous excitatory post synaptic currents evoked in hippocampal CA1 pyramidal cells of the glial mutant taiep rat Bonansco, C; Fuenzalida M.; Roncagliolo, M Article GLIA (2003)
Cellular mechanisms underlying the rhythmic bursts induced by NMDA microiontophoresis at the apical dendrites of CA1 pyramidal neurons Bonansco, C; Buno, W Article ISI HIPPOCAMPUS (2003)
Synaptic and electrical properties of lumbar motoneurons in the glial mutant Taiep rat along the neonatal period Bonansco, C; Roncagliolo, M Article GLIA (2002)
Tetanic stimulation of schaffer collaterals induces rhythmic bursts via NMDA receptor activation in rat CA1 pyramidal neurons Bonansco, C. Article PMID:12201628 [PubMed - indexed for MEDLINE] HIPPOCAMPUS (2002)
Voltage-clamp analysis of the potentiation of the slow Ca2+-activated K+ current in hippocampal pyramidal neurons Borde, M; Bonansco, C.; De Sevilla D.F.; Le Ray D.; Buno, W Article SCOPUS HIPPOCAMPUS (2000)
The activity-dependent potentiation of the slow Ca2+-activated K+ current regulates synaptic efficacy in rat CA1 pyramidal neurons Borde, M; Bonansco, C.; Buno, W Article PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (1999)
Ionic components of the electrical response of chromaffin cells from the toad (Caudiverbera caudiverbera) adrenal gland. Nassar-Gentina, Veronica; Christian, Bonansco Article Comp Biochem Physiol C. (1993)
IONIC COMPONENTS OF THE ELECTRICAL RESPONSE OF CHROMAFFIN CELLS FROM THE TOAD (CAUDIVERBERA-CAUDIVERBERA) ADRENAL-GLAND NASSARGENTINA, V; BONANSCO, C; LUXORO, M Article ISI COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY ENDOCRINOLOGY (1993)


CHANGES OF RELEASE PROPERTIES ON CA3-CA1 SYNAPSES INDUCED BY METABOLIC ARREST OF ASTROCYTES IN HIPPOCAMPAL SLICES Bonansco, C.; Fuenzalida, M; Aliaga, E; Roncagliolo, M Abstract GLIA (2009)
Asynchronous excitatory post synaptic currents evoked in hippocampal CA1 pyramidal cells of the glial mutant taiep rat Bonansco, C.; Fuenzalida, M; Roncagliolo, M Abstract GLIA (2003)
Myelin mutant taiep rat show an alteration in the spinal cord (SC) monosynaptic responses Roncagliolo, M; Fuenzalida, M; Bonansco, C.; Díaz I.; Morales, BE; Eguibar, JR Abstract GLIA (2002)
Synaptic and electrical properties of lumbar motoneurons in the glial mutant Taiep rat along the neonatal period Bonansco, C.; Roncagliolo, M Abstract GLIA (2002)


?-amyloid oligomers affect the structure and function of the postsynaptic region: Role of the Wnt signaling pathway Dinamarca M.C.; Colombres M.; Cerpa, W.; Inestrosa, N. C.; Bonansco, C. ConferencePaper NEURODEGENERATIVE DISEASES (2008)


GABAergic neurotransmission is critical for controlling the prefrontal cortex spike timing dependent plasticity in schizophrenia FONDECYT (1171006) Proyecto 2017-2021 Coinvestigador(a)
NEONATAL PROGRAMMING=> SEX HORMONES EXCESS DISRUPTS MIDBRAIN DOPAMINE FUNCTION IN THE ADULTHOOD. FONDECYT (1160398) Proyecto 2016-2020 Coinvestigador(a)
REGULATION OF LONG-TERM PLASTICITY AT INHIBITORY CIRCUITS BY ACETYLCHOLINE=> NEW ROLE OF PARVALBUMIN-POSITIVE INTERNEURONS IN THE HIPPOCAMPAL FUNCTION AND MEMORY FONDECYT (1130614) Proyecto 2013-2017 Coinvestigador(a)
THE ROLE OF ASTROGLIAL EXCITABILITY ON THE MODULATION OF SYNAPTIC PLASTICITY DURING THE PROGRESSION OF HIPPOCAMPAL EPILEPSY FONDECYT (1130491) Proyecto 2013-2017 Inv. Responsable
ROLE OF MTOR PATHWAY AND L-BDNF TRANSCRIPT IN THE VALPROATE MODEL OF AUTISM FONDECYT (1110855) Proyecto 2011-2014 Coinvestigador(a)
CONTRIBUTION OF GLUTAMATE RELEASED BY ASTROCYTES TO HIPPOCAMPAL EPILEPTOGENESIS FONDECYT (1100385) Proyecto 2010-2013 Inv. Responsable
MODULACION PRESINAPTICA MEDIADA POR ASTROCITOS EN NEURONAS PIRAMIDALES DE CA1 DEL HIPOCAMPO. FONDECYT (1061074) Proyecto 2006-2009 Inv. Responsable
NEUROBIOLOGIA DEL MUTANTE MIELINICO TAIEP.ALTERACIONES EN LA INTERACCION NEURONA-GLIA DURANTE EL DESARROLLO Y SUS EFECTOS SOBRE LA EXCITABILIDAD DE TRACTOS Y SINAPSIS CENTRALES FONDECYT (1991004) Proyecto 1999-2002 Coinvestigador(a)


Priming of GABAergic Long-term Potentiation by Muscarinic Receptors Morales-Weil K.; Moreno M.; Ahumada J.; Arriagada J.; Fuentealba P.; Bonansco C.; Fuenzalida M. Review ISI SCOPUS (2020)