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Marcelo Chacon

Postdoc

UTHealth

Houston, Estados Unidos

Huntington's disease, studying electrophysiological mechanisms that underlay early symptomatic alteration in striatal neurons. Alzheimer's disease, working on the aggregation of Tau protein as a cellular response to brain damage.

Cellular and Molecular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1999

Postdoc Full Time

PRINCETON UNIVERSITY

Estados Unidos

2009 - 2011
Postdoc Full Time

ALBERT EINSTEIN COLLEGE OF MEDICINE

Estados Unidos

2011 - 2016
Postdoc Full Time

UNIVERSITY OF TEXAS MEDICAL SCHOOL AT HOUSTON

Estados Unidos

2016 - At present


Rescue of homeostatic regulation of striatal excitability and locomotor activity in a mouse model of Huntington's disease Cao Y, Bartolomé-Martín D, Rotem N, Rozas C, Dellal SS, Chacon MA, Kadriu B, Gulinello M, Khodakhah K, Faber DS Article ISI Proceeding of the National Academy of Sciences (2015)
MHC class I protein is expressed by neurons and neural progenitors in mid-gestation mouse brain Chacon MA, Boulanger LM Article ISI MOLECULAR AND CELLULAR NEUROSCIENCE (2013)
Frizzled-1 is involved in the neuroprotective effect of Wnt3a against a beta oligomers Chacón MA; Varela-Nallar, L; Inestrosa, NC Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2008)
The functional links between prion protein and copper Varela-Nallar, L; Toledo EM; Chacón MA; Inestrosa, NC Article ISI SCIELO BIOLOGICAL RESEARCH (2006)
Human-like rodent amyloid-beta-peptide determines Alzheimer pathology in aged wild-type Octodon degu Inestrosa, NC; Reyes, AE; Chacón MA; Cerpa, W.; Villalon A.; Montiel, J; Merabachvili, G; Aldunate, R; Bozinovic F.; Aboitiz F. Article ISI SCOPUS NEUROBIOLOGY OF AGING (2005)
Acetylcholinesterase-A beta complexes are more toxic than A beta fibrils in rat hippocampus - Effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss Reyes, AE; Chacón MA; Dinamarca, MC; Cerpa, W.; Morgan C.; Inestrosa, NC Article ISI AMERICAN JOURNAL OF PATHOLOGY (2004)
beta-sheet breaker peptide prevents A beta-induced spatial memory impairments with partial reduction of amyloid deposits Chacón MA; Barría MI; Soto C.; Inestrosa, NC Article ISI SCOPUS MOLECULAR PSYCHIATRY (2004)
The N-terminal copper-binding domain of the amyloid precursor protein protects against Cu2+ neurotoxicity in vivo Cerpa, WF; Barría MI; Chacón MA; Suazo M.; Gonzalez, M.; Opazo C.; Bush, AI; Inestrosa, NC Article ISI SCOPUS FASEB JOURNAL (2004)
A human prion protein peptide (PrP59-91) protects against copper neurotoxicity Chacón MA; Barría MI; Lorca, R; Huidobro-Toro, JP; Inestrosa, NC Article ISI SCOPUS MOLECULAR PSYCHIATRY (2003)
Acetylcholinesterase induces neuronal cell loss, astrocyte hypertrophy and behavioral deficits in mammalian hippocampus Chacón MA; Reyes, AE; Inestrosa, NC Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2003)
Activation of Wnt signaling and behavioral impairments rescues neurodegeneration induced by beta-amyloid fibrils De Ferrari, GV; Chacón MA; Barría MI; garrido, JL; Godoy JA; Olivares, G; Reyes, AE; Alvarez A.; Bronfman, M; Inestrosa, NC Article ISI SCOPUS MOLECULAR PSYCHIATRY (2003)
The human prion octarepeat fragment prevents and reverses the inhibitory action of copper in the P2X(4) receptor without modifying the zinc action Lorca RA; Chacon M.; Barría MI; Inestrosa, NC; Huidobro-Toro, JP Article ISI JOURNAL OF NEUROCHEMISTRY (2003)
Wnt signaling involvement in beta-amyloid-dependent neurodegeneration Inestrosa, NC; De Ferrari, GV; garrido, JL; Alvarez A.; Olivares, GH; Barría MI; Bronfman, M; Chacón MA Article ISI SCOPUS NEUROCHEMISTRY INTERNATIONAL (2002)


Neuroprotective properties of copper binding fragments of amyloid precursor protein and prion Inestrosa, NC; Chacon M.; Barría MI; Varela-Nallar, L; Opazo C. Abstract ISI JOURNAL OF NEUROCHEMISTRY (2002)
Neuroprotective properties of copper binding fragments of APP and PrP against copper toxicity Chacon M.; Barría MI; Inestrosa, N Abstract ISI NEUROBIOLOGY OF AGING (2002)


Expression of Wnt receptors, frizzled, in rat neuronal cells Chacón MA; Columbres, M; Inestrosa, NC ConferencePaper ISI ADVANCES IN ALZHEIMER'S AND PARKINSON'S DISEASE: INSIGHTS, PROGRESS, AND PERSPECTIVES (2008)