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Margrethe Doreen Olesen Arancibia

Aging, Nerological disorders, Neurodegenerative diseases, Tauopethies, Tau protein

Neuroscience, Universidad Autónoma de Chile. Chile, 2019
Aging and Neurodegenerative Disease, Universidad Autónoma de Chile. Chile, 2025

Docente Other

Universidad Autónoma de Chile

Ciencias de la Salud

Santiago, Chile

2023 - At present

1º Lugar categoría de Postgrado “Semana del Bioquímico”

Universidad San Sebastián

Chile, 2018

An opportunity to generate, through poster presentations, the research processes for undergraduate students from various health-related fields, commemorating Biochemist's Day
Primer encuentro científico de estudiantes y profesores del Programa de Doctorado en Ciencias Biomédicas

Universidad Autónoma de Chile

Chile, 2023

Instances in which I was a presenter, presenting results from my doctoral thesis.
Paper of the Year

Society for Redox Biology and Medicine

Chile, 2025

SfRBM & SFRR-Europe have selected our inaugural Papers of the Year. The awards recognize the best paper published in each of SfRBM & SFRR-Europe’s 4 journals in 2024 - FRBM, Redox Biology, Advances in Redox Research and Redox Biochemistry and Chemistry. Free Radical Biology and Medicine (FRBM) Mitochondria-tau association promotes cognitive decline and hippocampal bioenergetic deficits during aging Margrethe Olesen, Eugenia Pradenas, Francisca Villavicencio-Tejo, George A Porter, Gail V W Johnson, Rodrigo A Quintanilla https://doi.org/10.1016/j.freeradbiomed.2024.03.017


Cyclophilin D (CypD) ablation prevents neurodegeneration and cognitive damage induced by caspase-3 cleaved tau Olesen M.A.; Villavicencio-Tejo F.; Johnson, GVW; Porter, GA; Quintanilla R.A. Article ISI Free Radical Biology and Medicine (2025)
Disentangling the role of tau pathology in autism spectrum disorders Villavicencio-Tejo F.; Olesen M.A.; Moya, ML; Quintanilla R.A. Article ISI Progress in Neuro-Psychopharmacology and Biological Psychiatry (2025)
Sulforaphane prevents cognitive decline and mitochondrial failure induced by hippocampal expression of caspase-3 cleaved tau Villavicencio-Tejo F.; Olesen M.A.; Ampuero E.; Quintanilla R.A. Article ISI Neurochemistry International (2025)
Analysis of mitochondrial DNA replisome in autism spectrum disorder: Exploring the role of replisome genes Rojas; V.; Carrasco-Gallardo; C.; Tenorio; L.; Olesen; M.A.; Tapia; V.; Carrasco; M.; Araos; P.; Quintanilla; R.A.; Ruiz; LM Article ISI (2024)
Mitochondria-tau association promotes cognitive decline and hippocampal bioenergetic deficits during the aging Pradenas Eugenia; Johnson GW; Porter Jr, G.A. Article ISI (2024)
Superoxide dismutase 2 deficiency is associated with enhanced central chemoreception in mice: Implications for breathing regulation Diaz-Jara, Esteban; Pereyra, Katherine; Vicencio, Sinay; Olesen, Margrethe A.; Schwarz, Karla G.; Toledo, Camilo; Diaz, Hugo S.; Quintanilla, Rodrigo A.; del Rio, Rodrigo Article ISI (2024)
Cyclosporine A (CsA) prevents synaptic impairment caused by truncated tau by caspase-3 Tapia-Monsalves, Carola Article ISI SCOPUS Molecular and Cellular Neuroscience (2023)
Pathological Impact of Tau Proteolytical Process on Neuronal and Mitochondrial Function: a Crucial Role in Alzheimer's Disease Olesen M.A.; Quintanilla R.A. Article ISI SCOPUS Molecular Neurobiology (2023)
Activation of the Nrf2 Pathway Prevents Mitochondrial Dysfunction Induced by Caspase-3 Cleaved Tau: Implications for Alzheimer's Disease Article ISI SCOPUS ANTIOXIDANTS (2022)
Neurodegeneration in Multiple Sclerosis: The Role of Nrf2-Dependent Pathways Quintanilla, Rodrigo A. Article ISI SCOPUS ANTIOXIDANTS (2022)
The use of fibroblasts as a valuable strategy for studying mitochondrial impairment in neurological disorders Article ISI SCOPUS Translational Neurodegeneration (2022)
Pathologically phosphorylated tau at S396/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged Wild-type mice Article ISI SCOPUS Scientific Reports (2021)
Premature synaptic mitochondrial dysfunction in the hippocampus during aging contributes to memory loss Article ISI SCOPUS Redox Biology (2020)


Contribution of tau protein on the cognitive loss and hippocampal mitochondrial impairment during aging Olesen, M; Pradenas, LE; Quintanilla R.A. Abstract ISI FREE RADICAL BIOLOGY AND MEDICINE (2023)
The activation of Nrf2 pathway prevents neurodegenerative damage induced by hippocampal expression of caspase-3 cleaved tau Villavicencio-Tejo F.; Olesen, M; LLanos, EAA; Quintanilla R.A. Abstract ISI FREE RADICAL BIOLOGY AND MEDICINE (2023)


Is tau pathology a relevant factor in neuronal damage induced by alcohol and other drugs? Olesen M.A.; Ancia, A; Quintanilla R.A. Review ISI (2026)
Unknown roles of tau pathology in neurological disorders. Challenges and new perspectives Olesen M.A.; Villavicencio-Tejo F.; Cuevas-Espinoza V.; Quintanilla R.A. Review ISI Ageing Research Reviews (2025)
Gut-Brain Axis Deregulation and Its Possible Contribution to Neurodegenerative Disorders Quintanilla, Rodrigo A. Review ISI (2024)