Man

Margrethe Doreen Olesen Arancibia

Líneas de Investigación


Aging, Nerological disorders, Neurodegenerative diseases, Tauopethies, Tau protein

Educación

  •  Neuroscience, Universidad Autónoma de Chile. Chile, 2019
  •  Aging and Neurodegenerative Disease, Universidad Autónoma de Chile. Chile, 2025

Experiencia Académica

  •   Docente Other

    Universidad Autónoma de Chile

    Ciencias de la Salud

    Santiago, Chile

    2023 - At present

Premios y Distinciones

  •   1º Lugar categoría de Postgrado “Semana del Bioquímico”

    Universidad San Sebastián

    Chile, 2018

    An opportunity to generate, through poster presentations, the research processes for undergraduate students from various health-related fields, commemorating Biochemist's Day

  •   Primer encuentro científico de estudiantes y profesores del Programa de Doctorado en Ciencias Biomédicas

    Universidad Autónoma de Chile

    Chile, 2023

    Instances in which I was a presenter, presenting results from my doctoral thesis.

  •   Paper of the Year

    Society for Redox Biology and Medicine

    Chile, 2025

    SfRBM & SFRR-Europe have selected our inaugural Papers of the Year. The awards recognize the best paper published in each of SfRBM & SFRR-Europe’s 4 journals in 2024 - FRBM, Redox Biology, Advances in Redox Research and Redox Biochemistry and Chemistry. Free Radical Biology and Medicine (FRBM) Mitochondria-tau association promotes cognitive decline and hippocampal bioenergetic deficits during aging Margrethe Olesen, Eugenia Pradenas, Francisca Villavicencio-Tejo, George A Porter, Gail V W Johnson, Rodrigo A Quintanilla https://doi.org/10.1016/j.freeradbiomed.2024.03.017


 

Article (12)

Analysis of mitochondrial DNA replisome in autism spectrum disorder: Exploring the role of replisome genes

Rojas; V.; Carrasco-Gallardo; C.; Tenorio; L.; Olesen; M.A.; Tapia; V.; Carrasco; M.; Araos; P.; Quintanilla; R.A.; Ruiz; L.M.

Article ISI SCOPUS
Autism Research  (2025)

Cyclophilin D (CypD) ablation prevents neurodegeneration and cognitive damage induced by caspase-3 cleaved tau

olesen, MA; Villavicencio-Tejo, F; Johnson, GVW; Porter, GA; Quintanilla, RA

Article ISI SCOPUS
Free Radical Biology and Medicine  (2025)

Disentangling the role of tau pathology in autism spectrum disorders

Villavicencio-Tejo, F; olesen, MA; Moya, ML; Quintanilla, RA

Article ISI SCOPUS
Progress in Neuro-Psychopharmacology and Biological Psychiatry  (2025)

Sulforaphane prevents cognitive decline and mitochondrial failure induced by hippocampal expression of caspase-3 cleaved tau

Villavicencio-Tejo, F; olesen, MA; Ampuero, E; Quintanilla, RA

Article ISI SCOPUS
Neurochemistry International  (2025)

Mitochondria-tau association promotes cognitive decline and hippocampal bioenergetic deficits during the aging

Pradenas Eugenia; Johnson GW; Porter Jr, G.A.

Article ISI SCOPUS
Free Radical Biology and Medicine  (2024)

Superoxide dismutase 2 deficiency is associated with enhanced central chemoreception in mice: Implications for breathing regulation

Diaz-Jara, Esteban; Pereyra, Katherine; Vicencio, Sinay; Olesen, Margrethe A.; Schwarz, Karla G.; Toledo, Camilo; Diaz, Hugo S.; Quintanilla, Rodrigo A.; Del Rio, Rodrigo

Article ISI SCOPUS
Redox Biology  (2024)

Cyclosporine A (CsA) prevents synaptic impairment caused by truncated tau by caspase-3

Tapia-Monsalves, Carola

Article ISI SCOPUS
Molecular and Cellular Neuroscience  (2023)

Pathological Impact of Tau Proteolytical Process on Neuronal and Mitochondrial Function: a Crucial Role in Alzheimer's Disease

olesen, MA; Quintanilla, RA

Article ISI SCOPUS
Molecular Neurobiology  (2023)

Activation of the Nrf2 Pathway Prevents Mitochondrial Dysfunction Induced by Caspase-3 Cleaved Tau: Implications for Alzheimer's Disease

Villavicencio-Tejo, Francisca; Olesen, Margrethe A.; Aranguiz, Alejandra; Quintanilla, Rodrigo A.

Article ISI
ANTIOXIDANTS  (2022)

Neurodegeneration in Multiple Sclerosis: The Role of Nrf2-Dependent Pathways

Quintanilla, Rodrigo A.

Article ISI
ANTIOXIDANTS  (2022)

Pathologically phosphorylated tau at S396/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged Wild-type mice



Article ISI
SCIENTIFIC REPORTS  (2021)

Premature synaptic mitochondrial dysfunction in the hippocampus during aging contributes to memory loss



Article ISI
REDOX BIOLOGY  (2020)

Abstract (2)

Contribution of tau protein on the cognitive loss and hippocampal mitochondrial impairment during aging

Olesen, M; Pradenas, LE; Quintanilla, RA

Abstract ISI
FREE RADICAL BIOLOGY AND MEDICINE  (2023)

The activation of Nrf2 pathway prevents neurodegenerative damage induced by hippocampal expression of caspase-3 cleaved tau

Villavicencio-Tejo, F; Olesen, M; LLanos, EAA; Quintanilla, RA

Abstract ISI
FREE RADICAL BIOLOGY AND MEDICINE  (2023)

Review (4)

Is tau pathology a relevant factor in neuronal damage induced by alcohol and other drugs?

olesen, MA; Ancia, A; Quintanilla, RA

Review ISI
 (2026)

Unknown roles of tau pathology in neurological disorders. Challenges and new perspectives

olesen, MA; Villavicencio-Tejo, F; Cuevas-Espinoza, V; Quintanilla, RA

Review ISI SCOPUS
Ageing Research Reviews  (2025)

Gut-Brain Axis Deregulation and Its Possible Contribution to Neurodegenerative Disorders

Quintanilla, Rodrigo A.

Review ISI SCOPUS
Neurotoxicity Research  (2024)

The use of fibroblasts as a valuable strategy for studying mitochondrial impairment in neurological disorders

Olesen, Margrethe A.; Villavicencio-Tejo, Francisca; Quintanilla, Rodrigo A.

Review ISI
TRANSLATIONAL NEURODEGENERATION  (2022)

1
Nancy Calisto

Académico

Ingeniería Química

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

1
Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Gino Corsini

Director Instituto Ciencias Biomédicas

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Cristian Iribarren

PostDoc

Chemistry and Biomedical Sciences

Linnaeus University

Kalmar, Suecia

3
Francisca Villavicencio

Asistente investigación

Instituto ciencias biomédicas

Universidad Autónoma de Chile

santiago, Chile

1
Laura Navarro

Docente investigadora

Ciencias Biomédicas

Universidad Autónoma de Chile

SANTIAGO, Chile

1
Esteban Díaz

Assistant Professor

Universidad Autónoma de Chile

Santiago, Chile

18
Margrethe Olesen