Man

Claudia Jara Orellana

Académico-Investigador

Universidad de Las Américas

Santiago, Chile

Líneas de Investigación


Aging Neuronal biology Hippocampus Mitochondria Mitophagy Sestrin2

Educación

  •  Ciencias Biomédicas, UNIVERSIDAD AUTONOMA DE CHILE. Chile, 2018
  •  Genética, UNIVERSIDAD DE CHILE. Chile, 2010
  •  Profesor de Biología y Ciencias Naturales, UNIVERSIDAD METROPOLITANA DE CIENCIAS DE LA EDUCACION. Chile, 2006
  •  Diseño y Tratamiento Estadístico para la Investigación en Ciencias Biológicas y de la Salud, UNIVERSIDAD DE CHILE. Chile, 2011
  •  Neurociencia, UNIVERSIDAD DE CHILE. Chile, 2011
  •  Biología Celular y Molecular, UNIVERSIDAD DE CHILE. Chile, 2007
  •  Manejo de animales de Laboratorio, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2018

Experiencia Académica

  •   Postdoctoral Full Time

    UNIVERSIDAD SAN SEBASTIAN

    Santiago, Chile

    2019 - At present

  •   Docente Part Time

    Universidad Internacional SEK

    Medicina

    Santiago, Chile

    2018 - At present

  •   Docente Part Time

    Universidad Auntonoma de Chile

    Salud

    Santiago, Chile

    2019 - At present

  •   Docente Part Time

    UNIVERSIDAD CENTRAL DE CHILE

    Ciencias de la Salud

    Santiago, Chile

    2010 - 2015

  •   Tesista Pre y Postgrado Other

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2001 - 2010

  •   Estudiante Doctorado Other

    UNIVERSIDAD AUTONOMA DE CHILE

    Santiago, Chile

    2015 - 2018

  •   Académico Investigador Full Time

    Universidad de Las Américas

    Salud y Ciencias Sociales

    Chile

    2025 - At present

Experiencia Profesional

  •   Docente Part Time

    Universidad Autonoma

    Santiago, Chile

    2019 - At present

  •   Docente Part Time

    Universidad Internacional SEK

    Santiago, Chile

    2018 - At present

  •   Docente Part Time

    Universidad Central

    Santiago, Chile

    2010 - 2015

  •   Asistente de Investigación Part Time

    universidad de Chile

    Santiago, Chile

    2010 - 2015


 

Article (23)

Anti-P antibodies that impair memory perturb hippocampal glutamatergic receptor trafficking, synapse structure and microglia

Diaz-Valdivia, Nicole; Tapia-Rojas, Cheril; Alfonso Gonzalez; Micaela Ricca

Article ISI SCOPUS
Molecular Medicine  (2025)

Curcumin Improves Hippocampal Cell Bioenergetics, Redox and Inflammatory Markers, and Synaptic Proteins, Regulating Mitochondrial Calcium Homeostasis

Jara, Claudia; Torres, Angie K.; Park-Kang, Han S.; Sandoval, Lisette; Retamal, Claudio; Gonzalez, Alfonso; Ricca, Micaela; Valenzuela, Sebastian; Murphy, Michael P.; Inestrosa, Nibaldo C.; et al.

Article ISI SCOPUS
Neurotoxicity Research  (2025)

Identifying a novel Mecp2-mediated epigenetic mechanism controlling Lonp1 in the hippocampus and its disruption by aging

Llanquinao-Sandoval; J.; Cicali; K.A.; Jara; C.; Vigil-Vásquez; C.; Sjöberg-Herrera; M.K.; Ricca; M.; Valenzuela; S.; Loyola; A.; Pinti; M.; Schaller; et al.

Article ISI SCOPUS
SCIENTIFIC REPORTS  (2025)

PKR-driven ISR signaling controls synaptic translation and structural plasticity in an age-dependent manner

Martinez N.W.; Gomez F.; Tapia-Godoy, A; Roa, JF; Moreso-Contreras, F; Liu, YW; Jara C.; Tapia-Rojas C; Alfaro I.; Costa-Mattioli, M; et al.

Article ISI SCOPUS
Neurobiology of Disease  (2025)

The adverse effect of a hypercaloric high-fat diet feeding on hypothalamic cellular energy homeostasis is attenuated by a hypoglycemiant

Vivero A.; Espinoza S.; Alvarez-Indo, J; Catalán-Aguilera, J; Llontop, N; Jara C.; Porras O.; Tapia-Rojas C; Yáñez, MJ; Kerr B.

Article ISI SCOPUS
Journal of Neuroendocrinology  (2025)

Unraveling sex differences in age-related hippocampal decline: differential mitochondrial dysfunction, Lonp1-dependent mitochondrial proteostasis and mtROS production in aged C57BL/6 mice

Cicali, Karina A.; Jara, Claudia; Cortes-Diaz, Daniela; Lira, Matias; Fuentes, Italo; Catenaccio, Alejandra; Arnaiz, Josefa; Ricca, Micaela; Valenzuela, Sebastian; Oliva, Carolina A.; et al.

Article ISI
CELL DEATH & DISEASE  (2025)

Contrasting Effects of an Atherogenic Diet and High-Protein/Unsaturated Fatty Acids Diet on the Accelerated Aging Mouse Model SAMP8 Phenotype

Llanquinao, Jesus; Jara, Claudia; Cortes-Diaz, Daniela; Kerr, Bredford; Tapia-Rojas, Cheril

Article ISI SCOPUS
Neurology International  (2024)

GOLPH3 Participates in Mitochondrial Fission and Is Necessary to Sustain Bioenergetic Function in MDA-MB-231 Breast Cancer Cells

Cavieres, Viviana A.; Galarza, Abigail J.; Mardones, Gonzalo A.

Article ISI SCOPUS
Cells  (2024)

Long-term social isolation stress exacerbates sex-specific neurodegeneration markers in a natural model of Alzheimer's disease



Article ISI SCOPUS
Frontiers in Aging Neuroscience  (2023)

Mitochondrial Bioenergetics, Redox Balance, and Calcium Homeostasis Dysfunction with Defective Ultrastructure and Quality Control in the Hippocampus of Aged Female C57BL/6J Mice

Torres, Angie. K. K.; Cortes-Diaz, Daniela

Article ISI SCOPUS
International Journal of Molecular Sciences  (2023)

Pathologically phosphorylated tau at S396/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged Wild-type mice



Article ISI SCOPUS
Scientific Reports  (2021)

Synaptic Mitochondria: An Early Target of Amyloid-beta and Tau in Alzheimer's Disease

Park-Kang, Han S.; Polanco, Catalina M.; Alarcon, Fabian; Vargas-Mardones, Gabriela; Indo, Javiera A.

Article ISI SCOPUS
Journal of Alzheimer's Disease  (2021)

Tau Deletion Prevents Cognitive Impairment and Mitochondrial Dysfunction Age Associated by a Mechanism Dependent on Cyclophilin-D

Cerpa, Waldo; Quintanilla, Rodrigo A.

Article ISI SCOPUS
Frontiers in Neuroscience  (2021)

Hormetic-Like Effects of L-Homocysteine on Synaptic Structure, Function, and A beta Aggregation



Article ISI SCOPUS
Pharmaceuticals  (2020)

Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics

Li, Ying; Silva, Patricio; Criollo, Alfredo

Article ISI SCOPUS
Molecular and Cellular Oncology  (2020)

Premature synaptic mitochondrial dysfunction in the hippocampus during aging contributes to memory loss



Article ISI SCOPUS
Redox Biology  (2020)

Alcohol impairs hippocampal function: From NMDA receptor synaptic transmission to mitochondrial function.

Quintanilla, Rodrigo A.; Cerpa, Waldo

Article ISI SCOPUS
DRUG AND ALCOHOL DEPENDENCE  (2019)

Caspase-Cleaved Tau Impairs Mitochondrial Dynamics in Alzheimers Disease

Perez M.J.; Jara C.; Quintanilla R.A.

Article ISI
MOLECULAR NEUROBIOLOGY  (2018)

Contribution of Tau Pathology to Mitochondrial Impairment in Neurodegeneration

Quintanilla, Rodrigo A.

Article ISI SCOPUS
FRONTIERS IN NEUROSCIENCE  (2018)

Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus

Aranguiz, Alejandra; Cerpa, Waldo; Tapia-Rojas, Cheril; Quintanilla, Rodrigo A.

Article ISI SCOPUS
Redox Biology  (2018)

Alcohol consumption during adolescence: A link between mitochondrial damage and ethanol brain intoxication

Cerpa, Waldo; Quintanilla, Rodrigo A.

Article ISI SCOPUS
Birth  (2017)

The Identification of Congeners and Aliens by Drosophila Larvae

Del Pino F.; Jara C.; Pino L.; Medina-Munoz, MC; Álvarez E.; Godoy-Herrera, R

Article ISI SCOPUS
PLOS ONE  (2015)

The Neuro-Ecology of Drosophila Pupation Behavior

Del Pino F.; Jara C.; Pino L.; Godoy-Herrera, R

Article ISI SCOPUS
PLOS ONE  (2014)

BookSection (4)

Transcranial Red LED Therapy: A Promising Non-Invasive Treatment to Prevent Age-Related Hippocampal Memory Impairment

Claudia Jara, Débora Buendía, Álvaro Ardiles, Pablo Muñoz, Cheril Tapia-Rojas

BookSection
 (2022)

Mitochondrial Dysfunction as a Key Event during Aging: From Synaptic Failure to Memory Loss

Stavros Baloyannis

BookSection
 (2020)

Ethanol Consumption Affects Neuronal Function: Role of theMitochondria

Quintanilla, Rodrigo A.; Eylem Taskin

BookSection
 (2018)

New Targets for Diagnosis and Treatment Against Alzheimer????sDisease: The Mitochondrial Approach

Quintanilla, Rodrigo A.

BookSection
 (2016)

Proyecto (2)

Disfunción Mitocondrial en la Sinapsis Neuronal, Envejecimiento yNeurogeneración



Proyecto
 (2017)

Phosphorylated tau in the synaptic mitochondria and its contribution to cognitive impairment during aging

Cheril Tapia-Rojas

Proyecto
 (2017)

Review (3)

Phosphorylated tau as a toxic agent in synaptic mitochondria: implications in aging and Alzheimer's disease

Torres A.K.; Rivera, BI; Polanco C.M.; Jara C.; Tapia-Rojas C

Review ISI SCOPUS
Neural Regeneration Research  (2022)

Alcohol impairs hippocampal function: From NMDA receptor synaptic transmission to mitochondrial function

Pérez M.J.; Quintanilla, R. A

Review ISI SCOPUS
DRUG AND ALCOHOL DEPENDENCE  (2019)

Mitochondrial Dysfunction Contributes to the Pathogenesis of Alzheimer's Disease

Cabezas-Opazo, FA; Vergara-Pulgar, K; Perez M.J.; Jara C.; Osorio-Fuentealba C.; Quintanilla R.A.

Review ISI SCOPUS
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY  (2015)

1
Patricia Burgos

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

2
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

1
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
César Osorio

Associate Professor

Kinesiología

Universidad Metropolitana de Ciencias de la Educación

Santiago, Chile

1
Alfredo Criollo

Associated Professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

3
Waldo Cerpa

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Catolica de Chile

Santiago, Chile

6
Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

1
Daniela Rivera

Profesora Asociada

Universidad Mayor de Chile

Santiago, Chile

2
MANUEL VARAS

Associated Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Eugenia Morselli

Profesor Asociado de Planta Ordinaria

Fisiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago de Chile, Chile

1
Patricio Silva

Investigador Principal FONDEF

Departamento de Biología Celular y Molecular

Universidad de Chile

Santiago, Chile

1
Yenniffer Ávalos

Profesor Asistente

Departamento de Biología

Universidad de Santiago de Chile

Santiago, Chile

23
Cheril Tapia

Profesor Asociado

Facultad de Ciencias

Universidad San Sebastián

Santiago, Chile

1
Maria Loyola

Principal Investigator

Fundación Ciencia & Vida

Santiago, Chile

1
Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

1
Macarena Arrázola

Profesor Asistente

Centro de Biología Integrativa

Universidad Mayor

Santiago, Chile

1
Claudio Perez

Profesor Asociado

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Sebastián Valenzuela

Director de Area Veterinaria

Area Veterinaria

Fundación Ciencia para la Vida

Santiago, Chile

1
Cristina Bertocchi

Assistant Professor

Department of Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Karina Cereceda

Investigador post doctoral

Diagnóstico

Fundación Arturo López Pérez

Providencia, Chile

32
Claudia Jara

Académico-Investigador

Universidad de Las Américas

Santiago, Chile

1
Maria Hernandez

Investigador Post Doctoral

Universidad de Chile

Santiago, Chile

2
Micaela Ricca

Subdirección Área Veterinaria

Área Veterinaria

Fundación Ciencia & Vida

Santiago, Chile

1
Diego Tapia

Asistente de Investigación

Universidad San Sebastián

Santiago, Chile

3
JESÚS LLANQUINAO

Postdoctorado

Investigación del cáncer

Fundación Arturo López Pérez (FALP)

Santiago, Chile

2
Daniela Cortés

Asistente de investigación

Fundación Ciencia y Vida

HUECHURABA, Chile

2
Margrethe Olesen