Estudiamos la contribución de la respuesta integrada al estrés (REI) al proceso neurodegenerativo y al envejecimiento. Utilizando herramientas genéticas y farmacológicas, estudiamos las consecuencias de modular la REI en el envejecimiento y las enf

ADVISOR OF THESES AND RESEARCH UNITS.
-Director Undergraduate Thesis of Felipe Gómez, titled “The role of the activating transcription factor 4 (ATF4) in A Beta induced sinaptotoxicity”. Universidad Andrés Bello. February 2020– April 2021, currently on course.
-Director Undergraduate Thesis of Juan Francsico Roa, titled “The role of Nutrient Sensor GCN2 in oligodendrocytes function in a mouse model of amyotrophic lateral sclerosis” Universidad Técnica Metropolitana. July 2020, currently on course.
-Director Undergraduate Thesis of Marcela Escandón, titled “The role of Nutrient Sensor GCN2 in cognitive impairment associated to aging “. Universidad Mayor. September 2018–March 2021.
-Director Undergraduate Thesis of Alvaro Brito, titled “Nutrient Sensor GCN2 in myelination and re-myelination “. Universidad Técnica Metropolitana. March 2019–June 2020, currently on course.
-Director of PhD Thesis of the student Luis Osorio at the PhD Program in Biomedical Sciences, at Universidad de Chile titled “Study of the Impact of PERK-ATF4 signaling pathway in a model of amyotrophic lateral sclerosis” March 2015-September 2019.
-Co-Director of PhD Thesis of the student Vicente Valenzuela at the PhD Program in Biomedical Sciences, at Universidad de Chile titled “Study of the Impact of overexpression of the transcription factor XBP1s in the central nervous system in a model of amyotrophic lateral sclerosis” March 2012-September 2017.
-Co-Director Magister Thesis of Leslie Ann Bargsted Elgueda, titled “Impact of ERp57 expression in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis“. Magister Program in Biological Science, Faculty of Sciences at Universidad de Chile. March 2015–September 2016.
-Co-Director Undergraduate Thesis of Leslie Ann Bargsted Elgueda, titled “Characterization of a New Transgenic Mouse Model of Amyotrophic Lateral Sclerosis: TDP43A315T“. March 2012–September 2014.

ADVISOR OF POSTDOCTORAL INVESTIGATORS.
-Sponsoring of Dr. Nicolás Martinez Alarcón in the Postdoctoral Project titled “Synapse degeneration associated to Alzheimer’s Disease is promoted by local synaptic PKR activation” funded by FONDECYT (N° 3200932) at Fundación Ciencia & Vida.
-Sponsoring of Dr. Paulina Falcon Urrutia in the Postdoctoral Project titled “Defining the differential contribution of ER stress to oligodendrocytes and motoneurons survival on a model of c9orf72 repeat expansion pathogenesis”, funded by FONDECYT (N° 3180189) at Fundación Ciencia & Vida.

INVITED CONFERENCES and SEMINARIES.
-Matus S. “Nutrient Sensing And Redox Balance: GCN2 As a New Integrator In Aging” at the “Cellular and Molecular Aspects of Neurodegenerative Pathologies” at the XVI Annual Meeting of the Chilean Neuroscience Society. November, 9 al 13, 2020 Online.

-Matus S. “The Integrated Stress Response in health and in ALS” Baylor College of Medicine. April 24, 2019.

-Matus S. “The Integrated Stress Response in Neurodegeneration” XXXIV Annual Meeting of the Argentine Society for Research in Neuroscience. Cordova, Argentina. 3-5 October, 2019.

-Matus S. “The Integrated Stress Response in amyotrophic lateral sclerosis” ” XXXIV Annual Meeting of the Argentine Society for Research in Neuroscience. Cordova, Argentina. 3-5 October, 2019.

-Osorio L., Mallucci G., Hetz C. and Matus S. 2018 “Integrated Stress Response in Neurodegeneration” Chilean Society for Cell Biology XXXIII Annual Meeting. Puerto Varas, Chile. 22-26 October. 2018.

CONFERENCES and SEMINARIES.

2020
Matus S. “Nutrient Sensing And Redox Balance: GCN2 As a New Integrator In Aging” at the “Cellular and Molecular Aspects of Neurodegenerative Pathologies” at the XVI Annual Meeting of the Chilean Neuroscience Society. November, 9 al 13, Online.

2019
-Falcón P., Brito A., Escandón M. and Matus S. “GCN2-induced eIF2aphosphorylation is necessary for remyelination”. Chilean Society for Cell Biology XXXIII Annual Meeting. November 25-29, 2019, Puerto Varas –Chile. ORAL PRESENTATION
-Escandón M., Falcón P. and Matus S. “Low Protein diets activates the integrated stress response and protects against aging”. Chilean Society for Cell Biology XXXIII Annual Meeting. November 25-29, 2019, Puerto Varas –Chile. POSTER PRESENTATION
Osorio L., Jerez C., Mallucci G., Hetz C. and Matus S. “Modulation of the integrated stress response in a murine model of amyotrophic lateral sclerosis”. Chilean Society for Cell Biology XXXIII Annual Meeting. November 25-29, 2019, Puerto Varas –Chile. ORAL PRESENTATION
-Brito A., Falcón P., Escandón M., Jerez C., Marambio Y. and Matus S. “The nutrient stress sensor GCN2 is important in the central nervous system in mouse”. Chilean Society for Cell Biology XXXIII Annual Meeting. November 25-29, 2019, Puerto Varas –Chile. POSTER PRESENTATION
Brito A., Falcón P., Escandón M., Jerez C., Marambio Y. and Matus S. “GCN2 plays a protective role in a pharmacological demyelination model”. Neuroscience. 19-23 October, 2019. Chicago, IL, EEUU. POSTER PRESENTATION
Martínez N., Matus S. and Alfaro I. “Local Synaptic PKR activation is involved in amiloyd-beta oligomer induced synapse degeneration”. Neuroscience. 19-23 October, 2019. Chicago, IL, EEUU. POSTER PRESENTATION
Martínez N., Osorio L. and Matus S. “The Integrated Stress Response in Neurodegeneration” Sociedad Argentina de Neurociencias. 3-5 October, 2019. Villa Carlos Paz, Córdova, Argentina. ORAL PRESENTATION (S. Matus)
María-José Barrera, Sergio Aguilera, Patricia Carvajal, Isabel Castro, Daniela Jara, Sergio González, Claudio Molina, Soledad Matus and María-Julieta González “Decreased Autophagy In Salivary Glands Of Primary Sjögren’s Syndrome Patients Could Be Associated With An Increased Expression Of Inflammatory Markers”. European Congress of Rheumatology. 12-15/06/2019. Madrid. España. POSTER PRESENTATION

2018
-Falcón P., Brito A., Escandón M., Matus S. “GCN2 plays a protective role in Cuprizone induced demyelination” Cold Spring Harbor Asia. Novel Insights into Glial Function & Dysfunction. December 3-7, 2018. Suzhou, China. POSTER PRESENTATION
-Osorio L., Jerez C., Mallucci G., Hetz C. and Matus S. “Modulation of the integrated stress response protects against amyotrophic lateral sclerosis in a murine model of the disease” Chilean Society for Cell Biology XXXII Annual Meeting. October 22-26, 2018, Puerto Varas –Chile. POSTER PRESENTATION
-Falcón P., Brito A., and Matus S. “GCN2 plays a protective role in a pharmacological demyelination model” Chilean Society for Cell Biology XXXII Annual Meeting. October 22-26, 2018, Puerto Varas –Chile. POSTER PRESENTATION
-Osorio L., Jerez C., Mallucci G., Hetz C. and Matus S. “Integrated Stress Response in Neurodegeneration” Symposium “Integrated Stress Response in health and disease“. Chilean Society for Cell Biology XXXII Annual Meeting. October 22-26, 2018, Puerto Varas –Chile. ORAL PRESENTATION (S. Matus)
-Falcon P, Brito A. and Matus S. “Nutrient Sensor GCN2 in myelination and re-myelination”. FASEB Conference: Nutrient Sensing and Metabolic Signaling. 5/8/2018- 10/8/2018 Snowmass, Colorado. United States. POSTER PRESENTATION (S. Matus)
-María-José Barrera, Sergio Aguilera, Patricia Carvajal, Isabel Castro, Daniela Jara, Sergio González, Claudio Molina, Soledad Matus and María-Julieta González “Decreased Autophagy In Salivary Glands Of Primary Sjögren’s Syndrome Patients Could Be Associated With An Increased Expression Of Inflammatory Markers”. European Congress of Rheumatology. 12-15/06/2019. Madrid. España. POSTER PRESENTATION

2017
Bargsted L., Budini M., Muñoz N., Osorio L., Hetz C. and Matus S. “Impaired stress responses and misfolding of TDP-43 in a mouse model of FTD-ALS”. EMBO Meeting. “Impaired stress responses and misfolding of TDP-43 in a mouse model of FTD-ALS” June 14-17, 2017. Heidelbeg. Germany. POSTER PRESENTATION
Bargsted L., Budini M., Muñoz N., Osorio L., Hetz C. and Matus S. “Neurodegeneration and Impaired stress responses in a TDP-43 mouse model of FTD-ALS”. Gordon Research Conference: Amyotrophic Lateral Sclerosis (ALS) & Related Motor Neuron Diseases. July, 23-28, 2017. Stoweflake Conference Center. Stowe. Vermont. United States. POSTER PRESENTATION
Bargsted L., Osorio L., and Matus S. 2017 “Integrated Stress Response in Neurodegeneration” Chilean Neuroscience Society Meeting. Castro, Chile. 29 Sept -2 October. 2017. ORAL PRESENTATION
Bargsted L., Budini M., Muñoz N., Osorio L., Hetz C. and Matus S. “Impaired stress responses and misfolding of TDP-43 in a mouse model of FTD-ALS”. EMBO. EMBL Symposium: Mechanisms of Neurodegeneration. 14/06/17 –17/06/17. Heidelbeg. Germany. POSTER PRESENTATION

2016
Bargsted L., Muñoz N., Hetz C. and Matus S. 2015. “Protein (mis) folding in ALS.” Gordon Conference “Stress Proteins in Growth, Development & Disease”. July 5-10. Tuscany Il Ciocco, Italy. (Speaker).

Matus S., Valenzuela V., Nasiff M and Hetz C. 2014 ”Disturbances of ER proteostasis in ALS”. The Milton Safenowitz Post Doctoral Fellowship Workshop (Sponsored by the Greater New York Chapter of The ALS Association), June 19-20. New York, EEUU.

Vicente Valenzuela, Melissa Nassif, Leslie Bargsted, Yerko Fuentealba Claudio Hetz and Soledad Matus. “Functional Contribution of the Transcription Factor ATF4 to the Pathogenesis of Amyotrophic Lateral Sclerosis (ALS)” Chilean Society for Cell Biology XXVIII Annual Meeting. October 23-27, 2013, Puerto Varas –Chile.

M. Calegaro, S. Matus, P. Thielen, L. Glimcher and C. Hetz C. 2008. XBP-1 deficiency protects against Amyotrophic Lateral Sclerosis due to increased autophagy. I Congress IBRO/LARC of Neurosciences for Latin America, Caribbean and Iberian Peninsula. September 1-4. Buzios, RJ, Brazil.

C. Hetz, P. Thielen, S. Matus, M. Nassif, R.H. Brown and L. Glimcher. 2008. XBP-1 deficiency in neurons protects against amyotrophic lateral sclerosis by increasing autophagy. Sporadic Neurodegeneration: Genes, Environment and Therapeutic Strategies. july 31-august 01 . Boston, USA.

Matus S. “Geroscience” at “Envejecer, un desafió y una oportunidad”. Department of Cognitive Neurology and Dementia. September 1, 2017.
Matus S. Talk at FONDAP Geroscience Center for Brain Health and Metabolism. May 25th 2017 Faculty of Sciences. Universidad de Chile.

PARTICIPATION AS EDITOR
- Scientific Report, Editorial Board Member (2018).
- Frontiers in Neuroscience, Guest Editor (2019).

OUTREACH ACTIVITIES

NON SCIENTIFIC (SOCIETY) ACTIVITIES.

- Speaker at “Encuentros El Mercurio”. “Ayuno Intermitente ¿Moda o Hábito Saludable?” September 30, 2020. Virtual Conference.
-Talk at “Protagonistas 2030”. 29 August 2018. Casa Piedra, Santiago, Chile. “Muévete por tu salud: ciencia, alimentación y deporte”. “Encuentros El Mercurio”.
-Talk at “Encuentros El Mercurio”. "LA REVOLUCIÓN DE LA TENDENCIA LOW CARB" 28 March 2018. Centro Cívico Vitacura.
-Talk at “Festival Puerto Ideas”. Auditorium Colegio San Luis. Antofagasta, Chile. April 8th, 2017. Aging Pannel.

PARTICIPATION IN BOARDS
-From December 2018 part of “Puerto de Ideas” Scientific Advisory Board.
-From August 2019 part of “Instituto de Neuroprotección Infantil (INPI)” Scientific Advisory Board.

2018
-Interview at "Exploradores" - Miércoles 28 de noviembre 2018. 24 horas.
-Interview at "Futuro 360", CNN Chile, capítulo 21: Prolongación de la vida 27-11-2018
-Talk at Protagonistas 2030. 29 de agosto de 2018, Casa Piedra, Santiago, Chile. “Muévete por tu salud: ciencia, alimentación y deporte”
-Talk at “Encuentros El Mercurio”. "LA REVOLUCIÓN DE LA TENDENCIA LOW CARB" 28/03/2018 Centro Cívico Vitacura

2017
Talk at “Festival Puerto Ideas”. Auditorium Colegio San Luis. Antofagasta, Chile. April 8th, 2017. Aging Pannel.
Seminar to students and Professors of the Psychology Faculty at Universidad Santo Tomás, Antofagasta. April 7th, 2017.
Talk at FONDAP Geroscience Center for Brain Health and Metabolism. May 25th 2017 Faculty of Sciences. Universidad de Chile.
TV Interview at news Program TVN, about Aging and Science.
Participation as host of the TV Program “Patria Científica” by VTR CHILE, May Edition.
Radio Interview in “Radio Oasis”. “Intensamente” Program. May 15th 2017.
Radio Interview in “Radio La Clave”. “Pensar es Clave” Program. April 4th 2017.
Radio Interview in “Radio Bio-Bio Norte”. “MaderoFM” Program. April 20th 2017.
Interview at YA magazine “El Mercurio”. April 4th 2017.
Interview at Paula.cl “To age with another eyes” March 27th 2017.
2016
TV Interview: TV Interview at news Program TVN, about our research in ALS field and open to the community our progression and contribution in this pathology. March 27th 2016.
2105
News Paper Interview, “La Tercera” about the research in ALS we develop at the laboratory. November 2015.