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Claudio Tomás Molina Castillo

Director Investigación

Universidad San Sebastián

Santiago, Chile

Síndrome de Sjögren, glándulas salivales, secreción.

Cirujano Dentista, UNIVERSIDAD DE CHILE. Chile, 1990
Ciencias Odontológicas, UNIVERSIDAD DE CHILE. Chile, 2001
Educación, UNIVERSIDAD MAYOR. Chile, 2008
Salud Pública, UNIVERSIDAD DE CHILE. Chile, 2022

Profesor Full Time

Universidad Mayor

Odontologia

Santiago, Chile

2000 - 2017
Profesor Full Time

Universidad San Sebastián

Odontología

Santiago, Chile

2017 - 2025

Cirujano Dentista Other

Oficina Particular

Santiago, Chile

1990 - At present


Integrated stress response inhibition restores hsa-miR-145-5p levels after IFN-β stimulation in salivary gland epithelial cells. Association between cellular stress and miRNA biogenesis in Sjogren's disease Castro, Isabel; Carvajal, Patricia; Aguilera, Sergio; Barrera, Maria-Jose; Matus, Soledad; Gonzalez, Sergio; Molina, Claudio; Gonzalez, Maria-Julieta Article ISI SCOPUS Journal of Autoimmunity (2025)
Giantin mediates Golgi localization of Gal3-O-sulfotransferases and affects salivary mucin sulfation in patients with Sjogren's disease Nunez, Matilde; Carvajal, Patricia; Aguilera, Sergio; Barrera, Maria-Jose; Matus, Soledad; Couto, Alicia; Landoni, Malena; Boncompain, Gaelle; Gonzalez, Sergio; Molina, Claudio; et al. Article ISI SCOPUS JCI Insight (2024)
Satisfacción de los estudiantes de Odontología con el aprendizaje blended-learning en la Universidad San Sebastián, Chile VENEGAS-GOMEZ, Macarena; Bravo-Bravo, Felipe; Silva-Lopes, Ana Article Revista de la Fundación Educación Médica (2024)
hsa-miR-424-5p and hsa-miR-513c-3p dysregulation mediated by IFN-? is associated with salivary gland dysfunction in Sjogren's syndrome patients Jara, Daniela; Hermoso, Marcela Article ISI SCOPUS Journal of Autoimmunity (2023)
The integrated stress response is activated in the salivary glands of Sjogren's syndrome patients Bahamondes, Veronica; Jara, Daniela; Matus, Soledad; Hermoso, Marcela Article ISI SCOPUS Frontiers in Medicine (2023)
Identificaciï¿½n de macrï¿½fagos y virus Epstein-Barr en biopsias de pacientes con Sï¿½ndrome de Sjï¿½gren. Gastï¿½n Negro; Isabel castro; Benjamï¿½n Martï¿½nez; Sergio Aguilera; Claudio Molina; Julieta Gonzï¿½lez; Sergio Gonzï¿½lez Article SCIELO (2022)
Small RNA Expression Profiling Reveals hsa-miR-181d-5p Downregulation Associated With TNF-a Overexpression in Sjögren’s Syndrome Patients. Article ISI SCOPUS Frontiers in Immunology (2022)
Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: Potential role in Sjögren's syndrome Barrera, María-José; Aguilera, Sergio; Castro, Isabel; Carvajal, Patricia; Jara, Daniela; Molina, Claudio; González, Sergio; González, María-Julieta Article ISI SCOPUS Autoimmunity Reviews (2021)
Tofacitinib counteracts IL-6 overexpression induced by deficient autophagy: implications in Sjögren's syndrome Barrera, María-José; Aguilera, Sergio; Castro, Isabel; Matus, Soledad; Carvajal, Patricia; Molina, Claudio; González, Sergio; Jara, Daniela; Hermoso, Marcela; González María-Julieta Article ISI SCOPUS Rheumatology (United Kingdom) (2021)
Type I Interferon dependent hsamiR-145-5p downregulation modulates MUC1 and TLR4 overexpression in salivary glands from Sjögren’s syndrome patients. Article ISI SCOPUS Frontiers in Immunology (2021)
Aberrant MUC1 accumulation in salivary glands of Sjogren's syndrome patients is reversed by TUDCA in vitro Castro I, Albornoz N, Aguilera S, Barrera MJ, González S, Núñez M, Carvajal P, Jara D, Lagos C, Molina C, Urzúa U, Hermoso MA, González MJ. Article ISI SCOPUS Rheumatology (United Kingdom) (2020)
Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from Sjogren's syndrome patients Article ISI SCOPUS JOURNAL OF AUTOIMMUNITY (2019)
Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjögren's syndrome patients Lagos, Carolina; Jara, Daniela; Leyton, Cecilia Article ISI SCOPUS Clinical Immunology (2018)
Endoplasmic reticulum stress in autoimmune diseases: Can altered protein quality control and/or unfolded protein response contribute to autoimmunity? A critical review on Sjogrens syndrome Article ISI SCOPUS AUTOIMMUNITY REVIEWS (2018)
Impaired IRE1 alpha/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjogrens syndrome patients Sepulveda, Denisse; Castro, Isabel; Aguilera, Sergio; Carvajal, Patricia; Lagos, Carolina; Albornoz, Nicolas; Quest, Andrew, F. G.; Molina, Claudio; Leyton, Cecilia; Hermoso, Marcela A. Article ISI SCOPUS RHEUMATOLOGY (2018)
Análisis del ambiente educacional en escuela de odontología chilena María Paz Rodríguez-Hopp; Sergio González Providell; Claudio Molina Castillo; Benjamï¿½n Martï¿½nez Rondanelli; Juan Rebolledo Article ISI SCIELO Revista clínica de periodoncia, implantología y rehabilitación oral (2016)
Pro-inflammatory cytokines enhance ERAD and ATF6 alpha pathway activity in salivary glands of Sjogren's syndrome patients Quest, Andrew F.G. Article ISI SCOPUS JOURNAL OF AUTOIMMUNITY (2016)
OSCE as a design enabling test for admission to the dental clinic Article JOURNAL OF SCIENCE EDUCATION (2015)
MUC1/SEC and MUC1/Y overexpression is associated with inflammation in Sjogren's syndrome Sung HH; Castro I.; Gonzalez S.; Aguilera S.; Quest A.F.G.; Bahamondes V.; Alliende C.; Cortes J.; Molina C.; Urzua, U; et al. Article ISI SCOPUS Oral Diseases (2015)
OSCE as a design enabling test for admission to the dental clinic [OSCE un diseño de prueba de habilitación de admisión a la clínica dental] Hopp, MPR; Fontealba J.; Molina C.; Providell S.G. Article SCOPUS Journal of Science Education (2015)
Salivary mucins induce a Toll-like receptor 4-mediated pro-inflammatory response in human submandibular salivary cells: are mucins involved in Sjogren's syndrome? Barrera M.J.; Aguilera S.; Veerman, E; Quest A.F.G.; Diaz-Jimenez D.; Urzua, U; Cortes J.; Gonzalez S.; Castro I.; Molina C.; et al. Article ISI SCOPUS Rheumatology (2015)
Aberrant localization of fusion receptors involved in regulated exocytosis in salivary glands of Sjogren's syndrome patients is linked to ectopic mucin secretion Sanchez M.; Aguilera S.; Alliende C.; Bahamondes V.; Molina C.; Urzua, U; Castro I.; Gonzalez S.; Albornoz A.; Hermoso M.; et al. Article ISI SCOPUS Journal of Autoimmunity (2012)
Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in Sjogren's syndrome patients Castro I.; Aguilera S.; Brockhausen, I; Alliende C.; Molina C.; Urzua, U; Mandel, U; Bahamondes V.; Sanchez M.; Gonzalez S.; et al. Article ISI SCOPUS Rheumatology (2012)
Alterations in Type I Hemidesmosome Components Suggestive of Epigenetic Control in the Salivary Glands of Patients With Sjogren's Syndrome Gonzalez S.; Aguilera S.; Alliende C.; Urzua, U; Quest A.F.G.; Herrera L.; Molina C.; Hermoso M.; Ewert, P; Brito M.; et al. Article ISI SCOPUS Arthritis and Rheumatism (2011)
Changes in Rab3D Expression and Distribution in the Acini of Sjogren's Syndrome Patients Are Associated With Loss of Cell Polarity and Secretory Dysfunction Bahamondes V.; Albornoz A.; Aguilera S.; Alliende C.; Molina C.; Castro I.; Urzua, U; Quest A.F.G.; Barrera M.J.; Gonzalez S.; et al. Article ISI SCOPUS Arthritis and Rheumatism (2011)
Aberrant localization of ezrin correlates with salivary acini disorganization in Sjogren's Syndrome Perez, Paola; Olea, Nancy; Alliende, Cecilia; Leyton, Cecilia; Rowzee, Anne Article ISI RHEUMATOLOGY (2010)
Disruption of Tight Junction Structure in Salivary Glands From Sjogren's Syndrome Patients Is Linked to Proinflammatory Cytokine Exposure Ewert, P; Aguilera S.; Alliende C.; Kwon, YJ; Albornoz A.; Molina C.; Urzua, U; Quest A.F.G.; Olea, N.; Perez P.; et al. Article ISI SCOPUS Arthritis and Rheumatism (2010)
Gene expression and chromosomal location for susceptibility to Sjogren's syndrome Perez P.; Anaya, JM; Aguilera S.; Urzua, U; Munroe D.; Molina C.; Cherry, JM; Alliende C.; Olea, N.; Ruiz-Narvaez, E; et al. Article ISI SCOPUS JOURNAL OF AUTOIMMUNITY (2009)
Severe alterations in expression and localisation of alpha 6 beta 4 integrin in salivary gland acini from patients with Sjogren syndrome Velozo J.; Aguilera S.; Alliende C.; Ewert, P; Molina C.; Perez P.; Leyton L.; Quest, A.; Brito M.; Gonzalez S.; et al. Article ISI SCOPUS ANNALS OF THE RHEUMATIC DISEASES (2009)
Reduced sulfation of muc5b is linked to xerostomia in patients with Sjogren syndrome Alliende C.; Kwon, YJ; Brito M.; Molina C.; Aguilera S.; Perez P.; Leyton L.; Quest A.F.G.; Mandel, U; Veerman, E; et al. Article ISI SCOPUS ANNALS OF THE RHEUMATIC DISEASES (2008)
Basal lamina disorganisation of the acini and ducts of labial salivary glands from patients with Sjogren's syndrome: association with mononuclear cell infiltration Molina C.; Alliende C.; Aguilera S.; Kwon, YJ; Leyton L.; Martinez B.; Leyton C.; Perez P.; González, MJ Article ISI SCOPUS ANNALS OF THE RHEUMATIC DISEASES (2006)
Involvement of specific laminins and nidogens in the active remodeling of the basal lamina of labial salivary glands from patients with Sjogren's syndrome Kwon, YJ; Perez P.; Aguilera S.; Molina C.; Leyton L.; Alliende C.; Leyton C.; Brito M.; Romo, R; González, MJ Article ISI SCOPUS ARTHRITIS AND RHEUMATISM (2006)
Increased acinar damage of salivary glands of patients with Sjögren's syndrome is paralleled by simultaneous imbalance of matrix metalloproteinase 3/tissue inhibitor of metalloproteinases 1 and matrix metalloproteinase 9/tissue inhibitor of metalloproteinases 1 ratios Perez P.; Kwon, YJ; Alliende C.; Leyton L.; Aguilera S.; Molina C.; Labra C.; Julio, M; Leyton C.; González, MJ Article ISI SCOPUS ARTHRITIS AND RHEUMATISM (2005)
Enhanced degradation of proteins of the basal lamina and stroma by matrix metalloproteinases from the salivary glands of Sjogren's syndrome patients - Correlation with reduced structural integrity of acini and ducts Goicovich, E; Molina C.; Perez P.; Aguilera S.; FernÃ¡ndez J.; Olea, N.; Alliende C.; Leyton C.; Rorno, R; Leyton L.; et al. Article ISI SCOPUS ARTHRITIS AND RHEUMATISM (2003)
Differential expression of matrix metalloproteinases in labial salivary glands of patients with primary Sjogren's syndrome - Mechanisms of exocrine parenchyma destruction Goicovich, E; Romo, R Article ISI ARTHRITIS AND RHEUMATISM (2000)
Differential expression of matrix metalloproteinases in labial salivary glands of patients with primary Sjogren's syndrome -: Mechanisms of exocrine parenchyma destruction Perez P.; Goicovich, E; Alliende C.; Aguilera S.; Leyton C.; Molina C.; Pinto R.; Romo, R; Martinez B.; González, MJ Article ISI ARTHRITIS AND RHEUMATISM (2000)


Altered Expression of the MicroRNA Biogenesis Machinery Components Correlates with Inflammatory Parameters in Salivary Glands of Patient with Sjogren's Disease Aguilera S.; Carvajal P.; Castro I.; Barrera M.J.; Gonz lez, S; Molina C.; Gonz lez, MJ Abstract ISI ARTHRITIS & RHEUMATOLOGY (2024)
THREE DIMENSIONAL HSG CELLS CULTURE AS A MODEL TO STUDY THE EXOCITIC PROCESS IN SALIVARY GLANDS OF SJOGREN'S SYNDROME PATIENTS Cortes J.; Aguilera S.; Hidalgo J.; Bahamondes V.; Urra H.; Barrera M.J.; Castro I.; Molina C.; Gonzalez S.; Leyton C.; et al. Abstract ISI ANNALS OF THE RHEUMATIC DISEASES (2014)
ARE SALIVARY MUCINS ABLE TO TRIGGER A PROINFLAMMATORY RESPONSE? Barrera M.J.; Aguilera S.; Hermoso M.; Langjahr P.; Cortes J.; Castro I.; Molina C.; Gonzalez S.; Alliende C.; Bahamondes V.; et al. Abstract ISI ANNALS OF THE RHEUMATIC DISEASES (2013)
ALTERATIONS OF VAMP2 AND SINTAXIN-2 IN SALIVARY ACINAR CELLS MODIFY THE SECRETION PROCESS IN SJOGREN'S SYNDROME PATIENTS Sanchez M.; Aguilera S.; Barrera M.J.; Alliende C.; Bahamondes V.; Castro I.; Gonzalez S.; Molina C.; Leyton C.; Urzua, U; et al. Abstract ISI ANNALS OF THE RHEUMATIC DISEASES (2012)
Overexpression and subcellular distribution of muc1 in salivary glands from Sjogren's syndrome patients Castro I.; Aguilera S.; Alliende C.; Leyton C.; Leyton L.; Ewert, P; Brito M.; Espinosa,M; Perez P.; Molina C.; et al. Abstract ISI ANNALS OF THE RHEUMATIC DISEASES (2007)
Dramatic redistribution of alpha 6 beta 4 integrin in acini from salivary glands of patients Sjogren's syndrome Velozo J.; Aguilera S.; Molina C.; Alliende C.; Ewert, P; Kwon Y.; Perez P.; Brito M.; Castro I.; Leyton C.; et al. Abstract ISI ANNALS OF THE RHEUMATIC DISEASES (2006)
Involvement of laminin1 and 5 and nidogen 1 and 2 in basal lamina remodeling of acini salivary glands from patients with Sjogren's syndrome. Kwon, YJ; Aguilera S.; Molina C.; Alliende C.; Leyton L.; Brito M.; Perez P.; Leyton C.; González, MJ Abstract ISI ARTHRITIS AND RHEUMATISM (2005)
MUC5B expression in Sjogren's syndrome patients Kwon Y.; Brito M.; Alliende C.; Aguilera S.; Molina C.; Mandel, U; Clausen, H; Veerman, E; Leyton L.; Perez P.; et al. Abstract ISI ANNALS OF THE RHEUMATIC DISEASES (2005)
Transcriptional profile of the salivary gland epithelium in Sjogren's syndrome patients Perez P.; Urzua, U; Munroe D.; Aguilera S.; Kwon Y.; Molina C.; Alliende C.; Leyton C.; Gonzalez M. Abstract ISI ANNALS OF THE RHEUMATIC DISEASES (2005)
Cell Proliferation in Sjogren syndrome patients' salivary glands. Alliende C.; Ledesma, AL; Molina C.; Aguilera S.; González, MJ Abstract ISI JOURNAL OF DENTAL RESEARCH (2003)
Changes in pattern of mucin in lip salivary glands of patients with Sjogren's Syndrome Molina C.; Perez P.; Alliende C.; Espinosa,M; Kwon, YJ; Aguilera S.; Leyton C.; González, MJ; Mayor, U Abstract ISI JOURNAL OF DENTAL RESEARCH (2003)
Unbalanced transcription of MMP-9/TIMP-1 genes in patients with Sjogren's syndrome. Perez P.; Molina C.; Aguilera S.; Kwon, YJ; González, MJ Abstract ISI JOURNAL OF DENTAL RESEARCH (2003)
Changes in the structure and function of salivary glands in patients with Sjogrens syndrome are accompanied by enhanced activity of metalloproteinases Molina C.; Aguilera S.; Alliende C.; Leyton C.; Goroovich, E; González, MJ Abstract ISI JOURNAL OF DENTAL RESEARCH (2000)


Arquitectura y remodelamiento de la matriz extracelular en glándulas salivales BookSection (2017)
Histopatología de la glándula salival menor Parra-Medina, R; Sarmiento-Monroy, JC BookSection (2017)
Matriz extracelular de glándulas salivales en el síndrome de Sjögren Alliende, Cecilia; Goicovich, Eduardo; Anaya, José Manuel BookSection (2001)


Mechanotransduction and epigenetic control in autoimmune diseases (vol 10, pg 175, 2011) Gonzalez S.; Aguilera S.; Urzua, U; Quest A.F.G.; Molina C.; Alliende C.; Hermoso M.; González, MJ Errata ISI SCOPUS Autoimmunity Reviews (2011)


Pro-inflammatory cytokines decrease unsaturated cardiolipin levels and/or mithophagy, promoting mitochondrial damage and its extracellular release in salivary epithelial cells of Sjögren's syndrome patients Barrera, María; Molina, Claudio TomÁs Proyecto (2024)
Pro-inflammatory cytokines induce a Golgi stress condition in salivary glands from Sjögren's syndrome patients and H2S diminishes such stress condition Castro, Isabel; Molina, Claudio TomÁs Proyecto (2023)
El estrés celular inducido por la inflamación altera el metabolismo de los miRNAs en glándulas salivales de pacientes con síndrome de Sjögren Gonzalez, Maria-Julieta; Molina, Claudio TomÁs Proyecto (2021)


Oral manifestations and their treatment in Sjogren's syndrome Gonzalez S.; Sung, H; Sepulveda D.; González, MJ; Molina C. Review ISI ORAL DISEASES (2014)
Oral dryness in Sjogren's syndrome patients. Not just a question of water Castro I.; Sepulveda D.; Cortes J.; Quest A.F.G.; Barrera M.J.; Bahamondes V.; Aguilera S.; Urzua, U; Alliende C.; Molina C.; et al. Review ISI SCOPUS Autoimmunity Reviews (2013)
Sjogren's syndrome and the epithelial target: A comprehensive review Barrera M.J.; Bahamondes V.; Sepulveda D.; Quest A.F.G.; Castro I.; Cortes J.; Aguilera S.; Urzua, U; Molina C.; Perez P.; et al. Review ISI SCOPUS Journal of Autoimmunity (2013)
Mechanotransduction and epigenetic control in autoimmune diseases Gonzalez S.; Aguilera S.; Urzua, U; Quest A.F.G.; Molina C.; Alliende C.; Hermoso M.; González, MJ Review ISI SCOPUS Autoimmunity Reviews (2011)