PDI - Resultado de Búsqueda

Claudio Tomás Molina Castillo

Director Investigación

Universidad San Sebastián

Santiago, Chile

Síndrome de Sjögren, glándulas salivales, secreción.

Cirujano Dentista, UNIVERSIDAD DE CHILE. Chile, 1990
Ciencias Odontológicas, UNIVERSIDAD DE CHILE. Chile, 2001
Educación, UNIVERSIDAD MAYOR. Chile, 2008

Cirujano Dentista Other

Oficina Particular

Santiago, Chile

1990 - At present


Aberrant MUC1 accumulation in salivary glands of Sjögren's syndrome patients is reversed by TUDCA in vitro. Castro I, Albornoz N, Aguilera S, Barrera MJ, González S, Núñez M, Carvajal P, Jara D, Lagos C, Molina C, Urzúa U, Hermoso MA, González MJ. Article ISI SCOPUS Rheumatology (Oxford, England) (2020)
Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from Sjogren's syndrome patients Article ISI SCOPUS JOURNAL OF AUTOIMMUNITY (2019)
Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjögren's syndrome patients Lagos, Carolina; Jara, Daniela; Leyton, Cecilia Article ISI SCOPUS Clinical Immunology (2018)
Endoplasmic reticulum stress in autoimmune diseases: Can altered protein quality control and/or unfolded protein response contribute to autoimmunity? A critical review on Sjogrens syndrome Article ISI SCOPUS AUTOIMMUNITY REVIEWS (2018)
Impaired IRE1 alpha/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjogrens syndrome patients Sepúlveda, Denisse; Castro, Isabel; Aguilera, Sergio; Carvajal, Patricia; Lagos, Carolina; Albornoz, Nicolás; Quest, Andrew F G; Molina, Claudio; Leyton, Cecilia; Hermoso, Marcela A Article ISI SCOPUS RHEUMATOLOGY (2018)
Análisis del ambiente educacional en escuela de odontología chilena María Paz Rodríguez-Hopp; Sergio González Providell; Claudio Molina Castillo; Benjamï¿½n Martï¿½nez Rondanelli; Juan Rebolledo Article ISI SCIELO REVISTA CLINICA DE PERIODONCIA, IMPLANTOLOGIA Y REHABILITACION ORAL (2016)
Pro-inflammatory cytokines enhance ERAD and ATF6 alpha pathway activity in salivary glands of Sjogren's syndrome patients Quest, Andrew F.G. Article ISI SCOPUS JOURNAL OF AUTOIMMUNITY (2016)
OSCE as a design enabling test for admission to the dental clinic Article JOURNAL OF SCIENCE EDUCATION (2015)
MUC1/SEC and MUC1/Y overexpression is associated with inflammation in Sjogren's syndrome Sung HH; Castro, I; Gonzalez S.; Aguilera, S; Quest, AFG; Bahamondes, V; Alliende C.; Cortes, J; Molina C.; Urzua, U; et al. Article ISI SCOPUS Oral Diseases (2015)
Salivary mucins induce a Toll-like receptor 4-mediated pro-inflammatory response in human submandibular salivary cells: are mucins involved in Sjogren's syndrome? Barrera, MJ; Aguilera, S; Veerman, E; Quest, AFG; Diaz-Jimenez, D; Urzua, U; Cortes, J; Gonzalez S.; Castro, I; Molina C.; et al. Article ISI SCOPUS Rheumatology (United Kingdom) (2015)
Aberrant localization of fusion receptors involved in regulated exocytosis in salivary glands of Sjogren's syndrome patients is linked to ectopic mucin secretion Sánchez, M; Aguilera, S; Alliende C.; Bahamondes, V; Molina C.; Urzua, U; Castro, I; Gonzalez S.; Albornoz, A; Hermoso, M; et al. Article ISI SCOPUS Journal of Autoimmunity (2012)
Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in Sjogren's syndrome patients Castro, I; Aguilera, S; Brockhausen, I; Alliende C.; Molina C.; Urzua, U; Mandel, U; Bahamondes, V; Sánchez, M; Gonzalez S.; et al. Article ISI SCOPUS Rheumatology (United Kingdom) (2012)
Alterations in Type I Hemidesmosome Components Suggestive of Epigenetic Control in the Salivary Glands of Patients With Sjogren's Syndrome Gonzalez S.; Aguilera, S; Alliende C.; Urzua, U; Quest, AFG; Herrera L.; Molina C.; Hermoso, M; Ewert, P; Brito M.; et al. Article ISI SCOPUS Arthritis and Rheumatism (2011)
Changes in Rab3D Expression and Distribution in the Acini of Sjogren's Syndrome Patients Are Associated With Loss of Cell Polarity and Secretory Dysfunction Bahamondes, V; Albornoz, A; Aguilera, S; Alliende C.; Molina C.; Castro, I; Urzua, U; Quest, AFG; Barrera, MJ; Gonzalez S.; et al. Article ISI SCOPUS Arthritis and Rheumatism (2011)
Aberrant localization of ezrin correlates with salivary acini disorganization in Sjogren's Syndrome Perez, Paola; Olea, Nancy; Alliende, Cecilia; Leyton, Cecilia; Rowzee, Anne Article ISI RHEUMATOLOGY (2010)
Disruption of Tight Junction Structure in Salivary Glands From Sjogren's Syndrome Patients Is Linked to Proinflammatory Cytokine Exposure Ewert, P; Aguilera, S; Alliende C.; Kwon, YJ; Albornoz, A; Molina C.; Urzua, U; Quest, AFG; Olea, N.; Perez, P.; et al. Article ISI SCOPUS Arthritis and Rheumatism (2010)
Gene expression and chromosomal location for susceptibility to Sjogren's syndrome Perez, P.; Anaya, JM; Aguilera, S; Urzua, U; Munroe D.; Molina C.; Cherry, JM; Alliende C.; Olea, N.; Ruiz-Narvaez, E; et al. Article ISI SCOPUS JOURNAL OF AUTOIMMUNITY (2009)
Severe alterations in expression and localisation of alpha 6 beta 4 integrin in salivary gland acini from patients with Sjogren syndrome Velozo J.; Aguilera, S; Alliende C.; Ewert, P; Molina C.; Perez, P.; Leyton, L.; Quest, A; Brito M.; Gonzalez S.; et al. Article ISI SCOPUS ANNALS OF THE RHEUMATIC DISEASES (2009)
Reduced sulfation of muc5b is linked to xerostomia in patients with Sjogren syndrome Alliende C.; Kwon, YJ; Brito M.; Molina C.; Aguilera, S; Perez, P.; Leyton, L.; Quest, AFG; Mandel, U; Veerman, E; et al. Article ISI SCOPUS ANNALS OF THE RHEUMATIC DISEASES (2008)
Basal lamina disorganisation of the acini and ducts of labial salivary glands from patients with Sjogren's syndrome: association with mononuclear cell infiltration Molina C.; Alliende C.; Aguilera, S; Kwon, YJ; Leyton, L.; Martínez B.; Leyton, C; Perez, P.; Gonzalez, MJ Article ISI SCOPUS ANNALS OF THE RHEUMATIC DISEASES (2006)
Involvement of specific laminins and nidogens in the active remodeling of the basal lamina of labial salivary glands from patients with Sjogren's syndrome Kwon, YJ; Perez, P.; Aguilera, S; Molina C.; Leyton, L.; Alliende C.; Leyton, C; Brito M.; Romo, R; Gonzalez, MJ Article ISI SCOPUS ARTHRITIS AND RHEUMATISM (2006)
Increased acinar damage of salivary glands of patients with Sjögren's syndrome is paralleled by simultaneous imbalance of matrix metalloproteinase 3/tissue inhibitor of metalloproteinases 1 and matrix metalloproteinase 9/tissue inhibitor of metalloproteinases 1 ratios Perez, P.; Kwon, YJ; Alliende C.; Leyton, L.; Aguilera, S; Molina C.; Labra C.; Julio, M; Leyton, C; Gonzalez, MJ Article ISI SCOPUS ARTHRITIS AND RHEUMATISM (2005)
Enhanced degradation of proteins of the basal lamina and stroma by matrix metalloproteinases from the salivary glands of Sjogren's syndrome patients - Correlation with reduced structural integrity of acini and ducts Goicovich, E; Molina C.; Perez, P.; Aguilera, S; Fernández J; Olea, N.; Alliende C.; Leyton, C; Rorno, R; Leyton, L.; et al. Article ISI SCOPUS ARTHRITIS AND RHEUMATISM (2003)
Differential expression of matrix metalloproteinases in labial salivary glands of patients with primary Sjogren's syndrome - Mechanisms of exocrine parenchyma destruction Goicovich, E; Romo, R Article ISI ARTHRITIS AND RHEUMATISM (2000)


Arquitectura y remodelamiento de la matriz extracelular en glándulas salivales BookSection (2017)
Histopatología de la glándula salival menor Parra-Medina, R.; Sarmiento-Monroy, JC BookSection (2017)
Matriz extracelular de glándulas salivales en el síndrome de Sjögren Alliende, Cecilia; Goicovich, Eduardo; Anaya, José Manuel BookSection (2001)


CYTOKINES INDUCE ALTERATIONS IN STRESS RESPONSE PATHWAYS OF THE ENDOPLASMIC RETICULUM IN SALIVARY GLANDS OF SÖGREN'S SYNDROME PATIENTS=> CAN THESE BE MODULATED BY EPIGENETIC MECHANISMS? FONDECYT (1160015) Proyecto 2016-2020 Coinvestigador(a)
Cambio en los niveles de metilación de los genes de E-cadherina, MLH1 y p16INK4A y su asociación con la infección por virus papiloma humano, en biopsias de lesiones leucoplásicas Universidad Mayor (100730) Proyecto 2014-2015 Inv. Responsable
Cambio en los niveles de metilación del DNA y patrones de expresión de miRNA, en muestras de saliva de individuos que consumen tabaco y alcohol. Estudio piloto Universidad Mayor (100729) Proyecto 2014-2015 Coinvestigador(a)
ANALYSIS OF MOLECULAR CHANGES IN STRESS RESPONSE PATHWAYS OF THE ENDOPLASMIC RETICULUM AND GOLGI ASSOCIATED WITH SALIVARY GLAND HYPOFUNCTION IN SJOGREN'S SYNDROME PATIENTS FONDECYT (1120062) Proyecto 2012-2016 Coinvestigador(a)
ANALYSIS OF MOLECULAR CHANGES IN STRESS RESPONSE PATHWAYS OF THE ENDOPLASMIC RETICULUM AND GOLGI ASSOCIATED WITH SALIVARY GLAND HYPOFUNCTION IN SJOGREN'S SYNDROME PATIENTS FONDECYT (1120062) Proyecto 2012-2016 Coinvestigador(a)
ALTERACIONES EN LA RUTA EXOCITICA DE GLANDULAS SALIVALES DE PACIENTES CON SINDROME DE SJOGREN Y SUS CONSECUENCIAS EN LA HIPOSECRECION FONDECYT (1080006) Proyecto 2008-2012 Coinvestigador(a)
ALTERACIONES EN LA RUTA EXOCITICA DE GLANDULAS SALIVALES DE PACIENTES CON SINDROME DE SJOGREN Y SUS CONSECUENCIAS EN LA HIPOSECRECION FONDECYT (1080006) Proyecto 2008-2012 Coinvestigador(a)
CARACTERIZACION CELULAR Y MOLECULAR DE COMPLEJOS DE UNION EN ACINOS Y DUCTOS DE GLANDULAS SALIVALES DE PACIENTES CON SINDROME DE SJÃ–GREN=> EFECTO DE CITOQUINAS. FONDECYT (1050192) Proyecto 2005-2008 Coinvestigador(a)
ALTERACIONES EN LA RELACION MATRIZ EXTRACELULAR- CELULA EPITELIAL=> MECANISMO DE DANO ALTERNATIVOS EN EL SINDROME DE SJOGREN PRIMARIO FONDECYT (1020755) Proyecto 2002-2005 Coinvestigador(a)


Oral manifestations and their treatment in Sjogren's syndrome Gonzalez S.; Sung, H; Sepulveda D.; Gonzalez, MJ; Molina C. Review ISI ORAL DISEASES (2014)
Oral dryness in Sjogren's syndrome patients. Not just a question of water Castro, I; Sepulveda D.; Cortes, J; Quest, AFG; Barrera, MJ; Bahamondes, V; Aguilera, S; Urzua, U; Alliende C.; Molina C.; et al. Review ISI SCOPUS Autoimmunity Reviews (2013)
Sjogren's syndrome and the epithelial target: A comprehensive review Barrera, MJ; Bahamondes, V; Sepulveda D.; Quest, AFG; Castro, I; Cortes, J; Aguilera, S; Urzua, U; Molina C.; Perez, P.; et al. Review ISI SCOPUS Journal of Autoimmunity (2013)
Mechanotransduction and epigenetic control in autoimmune diseases Gonzalez S.; Aguilera, S; Urzua, U; Quest, AFG; Molina C.; Alliende C.; Hermoso, M; Gonzalez, MJ Review ISI SCOPUS Autoimmunity Reviews (2011)