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Sergio Orlando Aguilera Covarrubias

Reumatólogo

CLÍNICA INDISA

Santiago, Chile

Mecanismos moleculares y celulares de la secreción y sus alteraciones en síndrome de Sjögren y otras enfermedades que producen síntomas Sicca. Mecanismos patogénicos y epigenéticos en glándulas salivales de pacientes con Síndrome de Sjögren

Médico cirujano, UNIVERSIDAD DE CHILE. Chile
Reumatólogo, UNIVERSIDAD DE CHILE. Chile

REUMATÓLOGO Full Time

Clínica INDISA

Chile

2000 - At present


Aberrant MUC1 accumulation in salivary glands of Sjögren's syndrome patients is reversed by TUDCA in vitro. Castro I, Albornoz N, Aguilera S, Barrera MJ, González S, Núñez M, Carvajal P, Jara D, Lagos C, Molina C, Urzúa U, Hermoso MA, González MJ. Article ISI SCOPUS Rheumatology (Oxford, England) (2020)
Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from Sjogren's syndrome patients Cortes, J; Hidalgo, J; Aguilera, S; Castro, I; Brito, M; Urra, H; Perez, P; Barrera, MJ; Carvajal, P; Urzua, U; Gonzalez, S; Molina, C; Bahamondes, V; Hermoso, M; Gonzalez, MJ Article ISI SCOPUS JOURNAL OF AUTOIMMUNITY (2019)
Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjögren's syndrome patients Lagos, Carolina; Carvajal, Patricia; Castro, Isabel; Jara, Daniela; González, Sergio; Aguilera, Sergio; Barrera, María-José; Quest, Andrew F.G.; Bahamondes, Verónica; Molina, Claudio; Urzúa, Ulises; Hermoso, Marcela A.; Leyton, Cecilia; González, María-Julieta Article ISI SCOPUS Clinical Immunology (2018)
Endoplasmic reticulum stress in autoimmune diseases: Can altered protein quality control and/or unfolded protein response contribute to autoimmunity? A critical review on Sjogrens syndrome Barrera, Maria-Jose; Aguilera, Sergio; Castro, Isabel; Gonzalez, Sergio; Carvajal, Patricia; Molina, Claudio; Hermoso, Marcela A.; Gonzalez, Maria-Julieta Article ISI SCOPUS AUTOIMMUNITY REVIEWS (2018)
Impaired IRE1 alpha/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjogrens syndrome patients Sepúlveda, Denisse; Barrera, María-José; Castro, Isabel; Aguilera, Sergio; Carvajal, Patricia; Lagos, Carolina; González, Sergio; Albornoz, Nicolás; Bahamondes, Verónica; Quest, Andrew F G; Urzúa, Ulises; Molina, Claudio; Leyton, Cecilia; Hermoso, Marcela A; González, María-Julieta Article ISI SCOPUS RHEUMATOLOGY (2018)
Pro-inflammatory cytokines enhance ERAD and ATF6 alpha pathway activity in salivary glands of Sjogren's syndrome patients Barrera, María-José; Aguilera, Sergio; Castro, Isabel; Cortés, Juan; Bahamondes, Verónica; Quest, Andrew F.G.; Molina, Claudio; González, Sergio; Hermoso, Marcela; Urzúa, Ulises; Leyton, Cecilia; González, María-Julieta Article ISI SCOPUS JOURNAL OF AUTOIMMUNITY (2016)
MUC1/SEC and MUC1/Y overexpression is associated with inflammation in Sjogren's syndrome Sung HH; Castro, I; Gonzalez S.; Aguilera, S; Smorodinsky NI; Quest, AFG; Bahamondes, V; Alliende C.; Cortes, J; Molina C.; Urzua, U; Barrera, MJ; Hermoso, M; Herrera L.; Leyton, C; Gonzalez, MJ Article ISI SCOPUS Oral Diseases (2015)
Salivary mucins induce a Toll-like receptor 4-mediated pro-inflammatory response in human submandibular salivary cells: are mucins involved in Sjogren's syndrome? Barrera, MJ; Aguilera, S; Veerman, E; Quest, AFG; Diaz-Jimenez, D; Urzua, U; Cortes, J; Gonzalez S.; Castro, I; Molina C.; Bahamondes, V; Leyton, C; Hermoso, MA; Gonzalez, MJ Article ISI SCOPUS Rheumatology (United Kingdom) (2015)


Arquitectura y remodelamiento de la matriz extracelular en glándulas salivales en el síndrome de Sjögren Claudio Molina; Sergio González; Isabel Castro; María-José Barrera; Sergio Aguilera ; María-Julieta González; Anaya JM, Sarmiento-Monroy JC, García-Carrasco M BookSection (2017)
Mucins in Salivary Gland Development, Regeneration, and Disease Castro, Isabel; Barrera, María-José; González, Sergio; Aguilera, Sergio; Urzúa, Ulises; Cortés, Juan; González, María- Julieta; Seunghee Cha, DDS, PhD BookSection (2017)


Cytokines induce alterations in stress response pathways of the endoplasmic reticulum in salivary glands of Sjogrens syndrome patients: can these be modulated by epigenetic mechanisms? María Julieta González Burgos Proyecto (2016)
ANALYSIS OF MOLECULAR CHANGES IN STRESS RESPONSE PATHWAYS OF THE ENDOPLASMIC RETICULUM AND GOLGI ASSOCIATED WITH SALIVARY GLAND HYPOFUNCTION IN SJÖGREN'S SYNDROME PATIENTS María Julieta González Burgos Proyecto (2012)
ALTERACIONES EN LA RUTA EXOCÍTICA DE GLÁNDULAS SALIVALES DE PACIENTES CON SÍNDROME DE SJÖGREN Y SUS CONSECUENCIAS EN LA HIPOSECRECION María Julieta González Burgos Proyecto (2008)