Man

Fernando José Bustos Fernández

Profesor Asistente

Universidad Andres Bello

Santiago, Chile

Líneas de Investigación


Neuroscience, Gene Editing, Neurodegeneration, Autism Spectrum Disorder

Educación

  •  Celular and Molecular Biology, UNIVERSIDAD DE CONCEPCION. Chile, 2014
  •  Bioengineering, UNIVERSIDAD DE CONCEPCION. Chile, 2009

Experiencia Académica

  •   Instructor Cell Biology Seminars Part Time

    UNIVERSIDAD ANDRES BELLO

    Medicine

    Santiago, Chile

    2013 - 2014

  •   Instructor Genetic Engineering Lab Part Time

    UNIVERSIDAD ANDRES BELLO

    Santiago, Chile

    2012 - 2013

  •   Invited Lecturer Molecular Neuroscience Part Time

    MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    Cambridge, Estados Unidos

    2016 - At present

Experiencia Profesional

  •   Senior Scientist Other

    Genosur

    Chile

    2021 - At present

Premios y Distinciones

  •   Pew Latin American Fellowship

    PEW LATIN AMERICAN FELLOWS PROGRAM IN BIOMEDICAL SCIENCES

    Estados Unidos, 2015

    Pew Latin American Fellowship in Biomedical Sciences to fund Postdoctoral training at MIT

  •   Simons Center for the Social Brain

    Simons Center for the Social Brain

    Estados Unidos, 2014

    Postdoctoral Fellowship by the Simons Center for the Social Brain to conduct Postdoctoral training at MIT

  •   Best PhD thesis in Cell Biology

    Sociedad de Biologia Celular de Chile

    Chile, 2014

    Awarded with the best PhD thesis in Cell Biology by Chilean Foundation for Cellular Biology and Chilean Society for Cellular Biology.

  •   Outstanding Young Neuroscientist

    Sociedad Chilena de Neurociencia

    Chile, 2013

    Selected as Outstanding Young Neuroscientist by the Chilean Society for Neuroscience

  •   Scholarship American Society for Cell Biology

    American Society for Cell Biology

    Estados Unidos, 2012

    Scholarship from the American Society for Cell Biology to attend the annual meeting held 15-19 december at San Francisco, California, USA.

  •   Best undergraduate - master’s thesis in Cell Biology

    Sociedad de Biologia Celular de Chile

    Chile, 2010

    Best undergraduate - master’s thesis in Cell Biology 2010 awarded by Chilean Foundation for Cellular Biology and Chilean Society for Cellular Biology.

  •   AFS scholarship

    American Field Service

    Estados Unidos, 2002

    American Field Service (AFS) scholarship to study abroad for a year program in USA to conduct senior yeah in high school.


 

Article (17)

Antiviral activity of an endogenous parvoviral element

Angélica Bravo; Fernández-García, Leandro; Ibarra-Karmy, Rodrigo; Gonzalo A. Mardones; Luis Mercado; Fernando J Bustos; Robert J Gifford; Gloria Arriagada

Article ISI
VIRUSES-BASEL  (2023)

Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons

Arredondo, Cristian; Cefaliello, Carolina; Dyrda, Agnieszka; Jury, Nur; Martinez, Pablo; Diaz, Ivan; Amaro, Armando; Tran, Helene; Morales, Danna; Pertusa, Maria; Stoica, Lorelei; Fritz, Elsa; Corvalan, Daniela; Abarzua, Sebastian; Mendez-Ruette, Maxs; Fernandez, Paola; Rojas, Fabiola; Kumar, Meenakshi Sundaram; Aguilar, Rodrigo; Almeida, Sandra; Weiss, Alexandra; Bustos, Fernando J.; Gonzalez-Nilo, Fernando; Otero, Carolina; Tevy, Maria Florencia; Bosco, Daryl A.; Saez, Juan C.; Kahne, Thilo; Gao, Fen-Biao; Berry, James D.; Nicholson, Katharine; Sena-Esteves, Miguel; Madrid, Rodolfo; Varela, Diego; Montecino, Martin; Brown, Robert H.; Van Zundert, Brigitte

Article ISI
NEURON  (2022)

Dynein light-chain dynlrb2 is essential for murine leukemia virus traffic and nuclear entry

Pietrantoni, Gianfranco; Gaete-Argel, Aracelly; Herrera-Rojo, Diego; Ibarra-Karmy, Rodrigo; Bustos, Fernando J.; Valiente-Echeverria, Fernando; Arriagada, Gloria

Article ISI
JOURNAL OF VIROLOGY  (2021)

SARS-CoV-2 infection in asymptomatic healthcare workers at a clinic in Chile

Olmos, Claudio; Campana, Gonzalo; Monreal, Victor; Pidal, Paola; Sanchez, Nannet; Airola, Constanza; Sanhueza, Dayan; Tapia, Patricio; Munoz, Ana Maria; Corvalan, Felipe; Hurtado, Sebastian; Meneses, Claudio; Orellana, Ariel; Montecino, Martin; Arriagada, Gloria; Bustos, Fernando Jose

Article ISI
PLOS ONE  (2021)

Downregulation of the Polycomb-Associated Methyltransferase Ezh2 during Maturation of Hippocampal Neurons Is Mediated by MicroRNAs Let-7 and miR-124

Guajardo, Laura; Aguilar, Rodrigo; Bustos, Fernando J; Nardocci, Gino; Gutierrez, Rodrigo A.; Van Zundert, Brigitte; Montecino, Martin

Article ISI
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2020)

Epigenetic silencing of the osteoblast-lineage gene program during hippocampal maturation

Aguilar, Rodrigo; Bustos, Fernando J; Nardocci, Gino; Van Zundert, Brigitte; Montecino, Martin

Article ISI
JOURNAL OF CELLULAR BIOCHEMISTRY  (2020)

Myosin Va Brain-Specific Mutation Alters Mouse Behavior and Disrupts Hippocampal Synapses

Pandian, Swarna; Zhao, Jian-Ping; Murata, Yasunobu; Bustos, Fernando J; Tunca, Cansu; Almeida, Ramiro D.; Constantine-Paton, Martha

Article ISI
ENEURO  (2020)

Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 in osteoblasts

Rojas, A; Sepulveda, H; Henriquez, B; Aguilar, R; Opazo, T; Nardocci, G; Bustos, F; Lian, JB; Stein, JL; Stein, GS; van Zundert, B; van Wijnen, AJ; ALLENDE, ML; Montecino, M

Article ISI SCOPUS
JOURNAL OF CELLULAR PHYSIOLOGY  (2019)

PSD95 regulates morphological development of adult-born granule neurons in the mouse hippocampus

Mardones, Muriel D.; Jorquera, Patricia V.; Herrera-Soto, Andrea; Ampuero, Estibaliz; Bustos, Fernando J; Van Zundert, Brigitte; Varela-Nallar, Lorena

Article ISI SCOPUS
JOURNAL OF CHEMICAL NEUROANATOMY  (2019)

Role of RUNX2 transcription factor in epithelial mesenchymal transition in non-small cell lung cancer lung cancer: Epigenetic control of the RUNX2 P1 promoter

Herreño, Angélica María; Ramírez, Andrea Carolina; Chaparro, Viviana Paola; Fernandez, María José; Cañas, Alejandra; Morantes, Carlos Fabian; Moreno, Olga María; Brugés, Ricardo Elias; Mejía, Juan Andrés; Bustos, Fernando José; Montecino, Martín; Rojas, Adriana P

Article SCOPUS
TUMOR BIOLOGY  (2019)

Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice

Bustos, Fernando J; Ampuero, Estibaliz; Jury, Nur; Aguilar, Rodrigo; Falahi, Fahimeh; Toledo, Jorge; Ahumada, Juan; Lata, Jaclyn; Cubillos, Paula; Henríquez, Berta; Guerra, Miguel V; Stehberg, Jimmy; Neve, Rachael L; Inestrosa, Nibaldo C; Wyneken, Ursula; Fuenzalida, Marco; Härtel, Steffen; Sena-Esteves, Miguel; Varela-Nallar, Lorena; Rots, Marianne G; Montecino, Martin; van Zundert, Brigitte

Article ISI SCOPUS
Brain  (2017)

NMDA receptor subunit composition controls dendritogenesis of hippocampal neurons through CAMKII, CREB-P, and H3K27ac

Bustos, Fernando J; Jury, Nur; Martínez, Pablo; Ampuero, Estibaliz; Campos, Matias; Abarzúa, Sebastian; Jaramillo, Karen; Ibing, Susanne; Mardones, Muriel D.; Haensgen, Henny; Kzhyshkowska, Julia; Tevy, Maria Florencia; Neve, Rachael; Sanhueza, Magdalena; Varela-Nallar, Lorena; Montecino, Martín; Van Zundert, Brigitte

Article ISI SCOPUS
JOURNAL OF CELLULAR PHYSIOLOGY  (2017)

ALS-linked protein disulfide isomerase variants cause motor dysfunction

Woehlbier, U; Colombo, A; Saaranen M.J.; Pérez V; Ojeda J.; Bustos F.J.; Andreu C.I.; Torres M.; Valenzuela, V.; Medinas D.B.; Rozas P.; Vidal R.L.; Lopez-Gonzalez R.; Salameh J.; Fernandez-Collemann S.; Muñoz, N.; Matus, S; Armisen, R; Sagredo A; Palma K.; Irrazabal T.; Almeida, S.; Gonzalez-Perez P.; Campero, M; Gao F.-B.; Henny, P; van Zundert, B; Ruddock L.W.; Concha, M. L.; Henríquez J.P.; Brown R.H.; hetz C.

Article ISI SCOPUS
EMBO JOURNAL  (2016)

Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus

Aguilar, Rodrigo; Bustos, Fernando J.; Saez, Mauricio; Rojas, Adriana; Allende, Miguel L.; van Wijnen, Andre J.; van Zundert, Brigitte; Montecino, Martin

Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS  (2016)

PSD95 Suppresses Dendritic Arbor Development in Mature Hippocampal Neurons by Occluding the Clustering of NR2B-NMDA Receptors

Bustos, Fernando J.; Varela-Nallar, Lorena; Campos, Matias; Henriquez, Berta; Phillips, Marnie; Opazo, Carlos; Aguayo, Luis G.; Montecino, Martin; Constantine-Paton, Martha; Inestrosa, Nibaldo C.; van Zundert, Brigitte

Article ISI SCOPUS
PLOS ONE  (2014)

Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons

Henriquez, B; Bustos, FJ; Aguilar R.; Becerra, A; Simon F.; Montecino, M.; van Zundert, B

Article ISI SCOPUS
MOLECULAR AND CELLULAR NEUROSCIENCE  (2013)

Differential Roles of NMDA Receptor Subtypes NR2A and NR2B in Dendritic Branch Development and Requirement of RasGRF1

Sepulveda, FJ; Bustos, FJ; Inostroza, E; Zuniga, FA; Neve, RL; Montecino, M.; van Zundert, B

Article ISI SCOPUS
JOURNAL OF NEUROPHYSIOLOGY  (2010)

Proyecto (4)

Center for Genome Regulation

FONDAP (15090007)

Proyecto
2011-2014
Tesista

Reactivation of dendritic arbor development and plasticity in developing and adult brain=> Role of NMDA receptors, CaMKII and PSD95

FONDECYT (1101012)

Proyecto
2010-2014
Tesista

Rol de la proteína de andamiaje PSD-95 en la regulación de la arquitectura dendrítica=> mecanismos epigenéticos involucrados en el control de su expresión durante el desarrollo.

PFCHA (24110099)

Proyecto
2010-2012
Inv. Responsable

Role of NMDA receptors and their scaffolding proteins PSD-95 and SAP102 in structural plasticity in vitro and in vivo.

FONDECYT (1070494)

Proyecto
2007-2009
Tesista

17
Fernando Bustos

Profesor Asistente

Facultad de Medicina

Universidad Andres Bello

Santiago, Chile

6
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

5
Rodrigo Aguilar

Assistant Professor

Institute for Biomedical Sciences

Universidad Andrés Bello

Santiago, Chile

3
Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

3
Gino Nardocci

Investigador / Profesor Asistente

Universidad de Los Andes

Santiago, Chile

3
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

2
Miguel Allende

Director

Biología

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Matias Campos

Jefe Negocios

Centro Tecnológico para la innovación alimentaria

Santiago, Chile

2
Berta Henriquez

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

2
estibaliz ampuero

Profesor Asistente

Facultad de Química y Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Danilo Bilches

Staff Scientist

Instituto de Neurociencia Biomedica

Santiago, Chile

1
Karina Palma

Postdoctorado

Instituto de Neurociencia Biomédica BNI

Universidad de Chile

Santiago, Chile

1
Jorge Ojeda

Académico investigador

Ciencias Básicas y Morfología

Universidad Católica de la Santisima Concepción

Concepción, Chile

1
Viviana Pérez

Profesor Asistente

Fisiología

Universidad de Concepción

Concepcion, Chile

1
Rodrigo Orrego

Ayudante

Ciencias

Universidad de Arica

Santiago, Chile

1
Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

1
Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Pablo Rozas

Investigador

SymbiOx

Santiago, Chile

1
Gloria Arriagada

Profesor Asociado-Investigador Principal

Instituto de Ciencias Biomédicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

1
Maria Tevy

investigadora invitada

INTA

Universidad de Chile

Santiago de Chile, Chile

1
Mauricio Sáez

Profesor Asistente

Centro de Genómica y Bioinformática

Universidad Mayor

Santiago, Chile

1
Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

1
Fernando Valiente

Profesor Asociado

ICBM

Universidad de Chile

Santiago, Chile

1
Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

1
Maria Magdalena Sanhueza

Profesora Asociada

Biología

Universidad de Chile

Santiago, Chile

1
Fernando Sepúlveda

Representante Legal

NeuroLabs

Talcahuano, Chile

1
Ute Wohlbier

Associate Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

1
Alfredo Sagredo

Investigador Postdoctoral

ICBM

Universidad de Chile

Santiago, Chile

1
Felipe Zuñiga

Profesor Asistente

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Catherine Andreu

Estudiante de Doctorado

Escuela de Psicología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
María Pertusa

Profesor Asociado

Biology

UNIVERSIDAD DE SANTIAGO DE CHILE. FACULTAD QUÍMICA Y BIOLOGÍA

Santiago, Chile

1
Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

1
Pablo Henny

Profesor Asociado

Anatomía Normal

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

1
Alicia Colombo

Profesora Asociada/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

1
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

1
Maria Otero

Profesor Asociado

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

1
Rodrigo Gutierrez

Full Professor

Molecular Genetics & Microbiology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile